FLUORIDE ACTION NETWORK PESTICIDE PROJECT
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Up to 1967: Fluoride Abstracts.
| Abstracts
for the following years: Part 1 - mainly biochemistry and physiology (brain, hormonal, G-proteins, etc.) Part 2 ("b") - all other |
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1970
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| 1974
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1968
- 1969 |
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| 1972
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Up
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Biochem Pharmacol 1967 Jun;16(6):1083-9
Differential toxicity of fluoroacetate to heart, kidney and brain mitochondria of the living rat.
Corsi A, Granata AL.
PMID: 6040389 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=5973186&dopt=AbstractBiochem Pharmacol 1966 Dec;15(12):2130-1
Note upon the behaviour of rat brain tissue treated with fluoroacetate in vitro.
Peters RA, Shorthouse M.
PMID: 5973186 [PubMed - indexed for MEDLINE]
1948. Am J Physiol. 157:80Ð87.
Freedman AM, Willis A, Himwich HE.
Correlation between signs of toxicity and cholinesterase level of brain and blood during recovery from di-isopropyl fluorophosphate (DFP) poisoning.
As cited in: 1997. Medical Aspects of Chemical and Biological Warfare. Chapter 5 NERVE AGENTS by Frederick R. Sidell, M.D. Published by the Office of The Surgeon General at TMM Publications, Borden Institute, Walter Reed Army Medical Center, Washington, DC 20307-5001.
http://www.nbc-med.org/SiteContent/HomePage/WhatsNew/MedAspects/Ch-5electrv699.pdf
1947. Bull Johns Hopkins Hosp. 81:257Ð266.
Grob D, Harvey AM, Langworthy OR, Lilienthal JL Jr.
The administration of di-isopropyl fluorophosphate (DFP) to man, III: Effect on the central nervous system with special reference to the electrical activity of the brain.
As cited in: 1997. Medical Aspects of Chemical and Biological Warfare. Chapter 5 NERVE AGENTS by Frederick R. Sidell, M.D. Published by the Office of The Surgeon General at TMM Publications, Borden Institute, Walter Reed Army Medical Center, Washington, DC 20307-5001.
http://www.nbc-med.org/SiteContent/HomePage/WhatsNew/MedAspects/Ch-5electrv699.pdf
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=5855744&dopt=AbstractAnn Acad Med Stetin 1965;11:237-57
[Effect of sodium fluoride on endocrine glands in the white rat]
[Article in Polish]
Domzalska E.
PMID: 5855744 [PubMed - indexed for MEDLINE]
Poultry Science 1965; 45:1545-1550
- As cited and abstracted in Fluoride 1981; 14(1):41
The fluoride content of commercial broiler backs and necks
Pool MF, Tango WJ, Klose AA
The authors found, in the combined backs and necks of broiler chicks, about 20 times as much fluoide as in bone-free meat. The range of floride in various parts of a broiler carcass was 0.9 to 45 ppm (wet weight).
Among the commercial phosphate supplements administered to chicks, the fluoride content of "soft phosphate" was 17,100 ppm, of defluorinated rock phosphate 1820 ppm, and of fish meal 188 ppm.
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=5956782&dopt=Abstract
J Urol 1966 Dec;96(6):944-6
Fluoride osteosclerosis simulating carcinoma of the prostate with widespread bony metastasis: a case report.
Gilbaugh JH Jr, Thompson GJ.
PMID: 5956782 [PubMed - indexed for MEDLINE]
Experientia 1965 Aug 15;21(8):446-7
[Atrophy of the testis produced by sodium monofluoroacetate in albino rats]
[Article in Italian]
Mazzanti L, Lopez M, Berti MG.
PMID: 5870907 [PubMed - indexed for MEDLINE]
Neurology, Neurosurgery and Psychiatry 1966; 29:577-585
MM Webb-Peploe and WG Bradley
Sverdlovsk, 1967 pp 47-53. U.S.S.R.
Fluorosis and its Prophylaxis [Fljuoroz i ego profilaktika]
[Fljuoroz u rabocich aljuminievych i kriolitovych zavodov]
by E Ja Girskaja
The author presents extensive clinical studies on 113 cryolite workers from Polevo and Juzno-Uralsk and from the Eclectrolytic Facility of the aluminum factories in Uralsk Bogoslovskij, Volgograd, Sumgait and Novo-Kuzneck. The cases were divided into three clinical groups which the author believes present the three major stages of fluorosis:
1. The earliest manifestations of fluorosis involve the skin, the upper air passages and the gums. At this stage of the disease, vesicular and ulcerative dermatitis, atrophic rhinitis, pharyngitis, laryngitis and periodontal disease appear. Disorders of the stomach and duodenum are not infrequent, associated with pronounced motor and secretory changes which consist at first of a hyperacid and later of an achylic gastritis. In addition, the author observed a fluorogenic decreased activity of several important liver enzymes, especially enolase, cholesterase and serum GOT. Kidney damage is another early symtom as indicated by microlbuminuria and microhematuria. Changes in the nervous system occur, according to the author, by vaso-vegetative dystonia with pronounced hypotonia and bradycardia. Polyneuropathies and radiculitis are common manifestations suggestive of involvement of the peripheral nervous system. The first stage of the disease usually occurs after 4 to 7 years' exposure.2. With progressive exposure, the disease turns into its second stage which is characterized by changes in bones and tooth enamel, by toxic nephropathias, hepatitis and gastritis. According to the author both osteoporosis and osteosclerosis occur early in the disease. The osteoporosis can become so extensive it may give rise to cystic bone cavities. The long bones of the forearms and of the legs exhibit mainllly osteosclerosis. Characteristically, these changes show symmetrical localization. Bony apposition at the endosteum decreases the width of the medullary portion of these bones.3. The third stage of fluorosis is characterized by generalized osteosclerosis, joint deformities and, at the vertebral column, by ossification of ligaments and tendons. The author considers osteosclerosis the least reversible sign of fluoride intoxication. Even after an interruption of exposure to fluoride of 10 to 12 yeas, she observed further progression of the toxic processes...In concluding, the author expresses her views concerning the pathogenesis of fluorosis. She considers a functional involvement of the anterior lobe of the hypophysis, combined with a marked insufficiency of the adrenal cortex, the principal mechanism of the disease. As proof for the functional impairment of the hypophysis, she cites her observation that fluorotic patients are intolerant to corticosteroids...
Japan J Public Health 1967; 14:41-47
T Okamura and T Matsuhisa
Faculty of Agriculture, Meijo University, Kasugai, Aichi, Japan
Seikagaku 1967 Nov;39(11):872-6
[Trifluoroacetylation of calf thymus histones]
[Article in Japanese]
Senshu T, Iwai K.
PMID: 5626891 [PubMed - indexed for MEDLINE]
Zh Mikrobiol Epidemiol Immunobiol 1967 Apr;44(4):98-103
[A study of fluoroacetamide as a systemic poison]
[Article in Russian]
Alekseev AN, Turov IS.
PMID: 5597855 [PubMed - indexed for MEDLINE]
Proc Soc Exp Biol Med 1967 Jan;124(1):317-20
Effect of insulin on blood glucose and corticosterone levels in sodium fluoroacetate induced diabetes.
Ballard CL, Hyde PM.
PMID: 6017789 [PubMed - indexed for MEDLINE]
NOTE: Martin Rodbell (co-author of this report) and Alfred G. Gilman shared the 1994 Nobel Prize for the discovery of "G-proteins and the role of these proteins in signal transduction in cells."J Biol Chem 1967 Dec 25;242(24):5744-50
Metabolism of isolated fat cells. V. Preparation of "ghosts" and their properties; adenyl cyclase and other enzymes.
Rodbell M.
PMID: 4319670 [PubMed - indexed for MEDLINE]
Orvosi Hetilop 1967; IC8:306-7
- As cited (and abstracted) in Fluoride 1968; 1(2):123
Mass intoxication with fluorine in soda water
Horvath I, Palicska J, Hanny I (Hungary)
Wein-Wissenschaft 21 1966; 4:141-9
- As cited and abstracted in Fluoride 1979; 2(3):188.
Damage to vines by fluoride emissions
HH Hopp
In early August, 1965 a sudden outbreak of a serious disease to grape vines occurred in the southern part of Baden. It was attributed to fluoride emanating from a nearby brick factory. The investigation disclosed varying degress of injury in four zones at increasing distances from the brickworks. In the area 200 to 400 meters from the brickworks, the vines had lost about 1/3 of their leaves. The foliage exhibited typical fluoride damage. Leaves manifested a brownish discoloration and necrosis which progressed intercostally. The stems were not affected. Ripening of grapes was delayed.
Two unexpected findings were reported:
Where there was no visible damage, the leaves contained between 22 and 24 parts per million of fluoride (Table 1). In the area closest to the factory the leaves contained less fluoride than in the more distant areas. The author attributes this unexpected phenomenon to the fact that the leaves were completely dead. Therefore, the usual translocation of fluoride inside of the leaf did not occur. Furthermore, absorption of particulate fluoride hydrolized by rain ceases when the leaf becomes necrotic.
The secon unusual feature: In another polluted area little damage was encountered. Where this occurred, it was determined that the vines had been sprayed with a mixture containing copper and calcium. The calcium had combined with the fluoride forming the less soluble calcium fluoride and had thus prevented the fluoride ion from penetrting deeper into the leaf tissue.
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=5928195&dopt=AbstractJ Biol Chem 1966 Dec 10;241(23):5557-9
Carbon-fluorine bond cleavage. II. Studies on the mechanism of the defluorination of fluoroacetate.
Goldman P, Milne GW.
PMID: 5928195 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=5956065&dopt=AbstractNature 1966 Mar 26;209(30):1367-8
Persistence of fluoroacetate and fluoroacetamide in soil.
David WA, Gardiner BO.
PMID: 5956065 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=5956302&dopt=AbstractNature 1966 Mar 19;209(29):1197-8
Effect of sodium fluoroacetate on myocardial cells in vitro.
Noguchi TT, Ohnuki Y, Okigaki T.
PMID: 5956302 [PubMed - indexed for MEDLINE]
Journal of Food Science 1966; 31 (6):941-946
Significant increase in intake of fluoride in food due to fluoridation
JR Marier and Dyson Rose
Food Chemistry Section, Division of Biosciences, National Research Council, Ottawa, CanadaGig Tr Prof Zabol 1966 Mar;10(3):13-7
[Comparative assessment of trifluoro-acetic and pentafluoropropionic acid toxicity]
[Article in Russian]
Kheilo GI, Kremneva SN.
PMID: 5985689 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=5901837&dopt=AbstractJ Endocrinol 1966 Feb;34(2):227-31
Influence of oestradiol on citrate accumulation in the uterus and blood of fluoroacetate-treated rats.
Eckstein B, Shalem M.
PMID: 5901837 [PubMed - indexed for MEDLINE]
Acta Uniionis Internationalis Contra Cancrum 1963; 19:742-745
- As cited (and abstracted) in Fluoride 1969; 2(3):189-190.
Morbidity and mortality in man caused by pulmonary cancer and its relation to the pollution of the atmosphere in the areas of aluminum plants.
Litvinov NN, Goldberg MS, Kimina SN
A.N. Sysin Institute of General and Public Hygiene, USSR
Academy of Medical Sciences, Moscow, USSR
Urinary excretion of fluoride following defluoridation of a water supply.Likens RC, McClure FJ, Steere AC.
In: McClure FJ, ed. Fluoride drinking waters. 1962. Bethesda, MD: U.S. Department of Health, Education and Welfare, Public Health Service, National Institute of Dental Research, 421-423.
(As cited in: Toxicological profile for fluorine, hydrogen fluoride, and fluorides. Draft for public comment. Agency for Toxic Substances and Disease Registry. Atlanta, GA. 2001.
As cited in: Interaction Profile for Cyanide, fluoride, nitrate and uranium. Draft for public comment. Agency for Toxic Substances and Disease Registry. Atlanta, GA. 2002.)
International Congress on Occupational Health, July 25-29, 1960Fluorides and phosphates -- clinical observations of employees in phosphate operation.
Rye WA.
[FAN note: confusion to the date as "Rye WA 1961" was also used for this citation.]
(As cited in: Toxicological profile for fluorine, hydrogen fluoride, and fluorides. Draft for public comment. Agency for Toxic Substances and Disease Registry. Atlanta, GA. 2001.
As cited in: Interaction Profile for Cyanide, fluoride, nitrate and uranium. Draft for public comment. Agency for Toxic Substances and Disease Registry. Atlanta, GA. 2002.)
1958. J Clin Invest. 37:350Ð368.Grob D, Harvey JC.
Effects in man of the anticholinesterase compound sarin (isopropyl methyl phosphonofluoridate).
As cited in: 1997. Medical Aspects of Chemical and Biological Warfare. Chapter 5 NERVE AGENTS by Frederick R. Sidell, M.D. Published by the Office of The Surgeon General at TMM Publications, Borden Institute, Walter Reed Army Medical Center, Washington, DC 20307-5001.
http://www.nbc-med.org/SiteContent/HomePage/WhatsNew/MedAspects/Ch-5electrv699.pdf
1952 : NUTR ABSTR REV 21:787-804
THE FLUORINE PROBLEM IN LIVESTOCK FEEDING
MITCHELL HH, EDMAN M
Name of Agent (CAS RN): FLUORINE (7782-41-4)
1951: AMA Arch Ind Hyg Occup Med; 4:585-590Collings GH, Fleming RBL, May R.
Absorption and excretion of NaF tablets by children.
(As cited in: Toxicological profile for fluorine, hydrogen fluoride, and fluorides. Draft for public comment. Agency for Toxic Substances and Disease Registry. Atlanta, GA. 2001.
As cited in: Interaction Profile for Cyanide, fluoride, nitrate and uranium. Draft for public comment. Agency for Toxic Substances and Disease Registry. Atlanta, GA. 2002. )
1950. J Am Dent Assoc. 40:436Hodge HC.
The concentration of fluorides in drinking water to give the point of minimum caries with maximum safety.
(As cited in: Toxicological profile for fluorine, hydrogen fluoride, and fluorides. Draft for public comment. Agency for Toxic Substances and Disease Registry. Atlanta, GA. 2001.
As cited in: Interaction Profile for Cyanide, fluoride, nitrate and uranium. Draft for public comment. Agency for Toxic Substances and Disease Registry. Atlanta, GA. 2002. )
1949. Stokinger HE. Toxicity following inhalation of fluorine and hydrogen fluoride.In: Voegtlin C, Hodge HC, eds. Pharmacology and toxicology of uranium compounds. New York, NY: McGraw Hill Book Company, 1021-1057.
(As cited in: Interaction Profile for Cyanide, fluoride, nitrate and uranium. Draft for public comment. Agency for Toxic Substances and Disease Registry. Atlanta, GA. 2002.)
1947. Bull Johns Hopkins Hosp. 81:217Ð 244.Grob D, Lilienthal JL Jr, Harvey AM, Jones BF.
The administration of di-isopropyl fluorophosphate (DFP) to man, I: Effect on plasma and erythrocyte cholinesterase; general systemic effects; use in study of hepatic func-tion and erythropoieses; and some properties of plasma cholinesterase.
As cited in: 1997. Medical Aspects of Chemical and Biological Warfare. Chapter 5 NERVE AGENTS by Frederick R. Sidell, M.D. Published by the Office of The Surgeon General at TMM Publications, Borden Institute, Walter Reed Army Medical Center, Washington, DC 20307-5001.
http://www.nbc-med.org/SiteContent/HomePage/WhatsNew/MedAspects/Ch-5electrv699.pdf
1946. J Pharmacol Exp Ther; 88:232Ð237.Koelle GB.
Protection of cholinesterase against irreversible inactivation by di-isopropyl fluorophosphate in vitro.
As cited in: 1997. Medical Aspects of Chemical and Biological Warfare. Chapter 5 NERVE AGENTS by Frederick R. Sidell, M.D. Published by the Office of The Surgeon General at TMM Publications, Borden Institute, Walter Reed Army Medical Center, Washington, DC 20307-5001.
http://www.nbc-med.org/SiteContent/HomePage/WhatsNew/MedAspects/Ch-5electrv699.pdf
1946. J Pharmacol Exp Ther. 88:39Ð46.Koster R.
Synergisms and antagonisms between physostigmine and di-isopropyl fluorophosphate in cats.
As cited in: 1997. Medical Aspects of Chemical and Biological Warfare. Chapter 5 NERVE AGENTS by Frederick R. Sidell, M.D. Published by the Office of The Surgeon General at TMM Publications, Borden Institute, Walter Reed Army Medical Center, Washington, DC 20307-5001.
http://www.nbc-med.org/SiteContent/HomePage/WhatsNew/MedAspects/Ch-5electrv699.pdf
1945. J Ind Hyg Toxicol 27:159-170Balances of fluorine ingested from various sources in food and water by five young men.
McClure FJ, Mitchell HH, Hamilton TS, et al.
(As cited in: Toxicological profile for fluorine, hydrogen fluoride, and fluorides. Draft for public comment. Agency for Toxic Substances and Disease Registry. Atlanta, GA. 2001.
As cited in: Interaction Profile for Cyanide, fluoride, nitrate and uranium. Draft for public comment. Agency for Toxic Substances and Disease Registry. Atlanta, GA. 2002.)
1930 (March). J. of Indust. Hygiene and Toxicology 19:126-137The fog disaster in the Meuse Valley, 1930. A fluorine intoxification.
Kaj Roholm
- Article reprinted in Fluoride 1969; 2(1):62-70.
Summary that appears in Fluoride.
Roholm concludes that the Meuse Valley disaster which caused illness in several thousand persons and death in 60, was due to acute fluoride intoxication. Of 27 factories in the area, 15 either used F containing raw products or added F compounds to the raw materials. They emitted SiF4 and HF. Climatic and topographic conditions played an important role.
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