FLUORIDE ACTION NETWORK PESTICIDE PROJECT
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1970 - 1971 Fluoride Abstracts.
| Abstracts
for the following years: Part 1 - mainly biochemistry and physiology (brain, hormonal, G-proteins, etc.) Part 2 ("b") - all other |
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| 1976
- 1977 |
1970
- 1971 |
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| 1974
- 1975 |
1968
- 1969 |
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| 1972
- 1973 |
Up
to 1967 |
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Ciba Found Symp 1971;2:77-93
Effect of fluoro compounds on metabolic control in brain mitochondria.
Gal EM.
PMID: 5212160 [PubMed - indexed for MEDLINE]
Biochem J 1970 Nov;120(2):345-51
Tricarboxylic acid-cycle metabolism in brain. Effect of fluoroacetate and fluorocitrate on the labelling of glutamate, aspartate, glutamine and gamma-aminobutyrate.
Clarke DD, Nicklas WJ, Berl S.
PMID: 5493856 [PubMed - indexed for MEDLINE]
Biochem Pharmacol 1970 Jun;19(6):1861-6
Biochemical effects of fluoroacetate administration in rat brain, heart and blood.
Stewart GG, Abbs ET, Roberts DJ.
PMID: 5513968 [PubMed - indexed for MEDLINE]
Eur J Pharmacol 1970 Mar;9(3):304-10
Inhibitory action of soman and some cholinolytics on the uptake of oxygen in the brain of rats and mice.
Jovic R, Milosevic M.
PMID: 5440300 [PubMed - indexed for MEDLINE]
Br Med J 1971 Jul 10;3(766):67-70
Chronic fenfluramine administration: some cerebral effects.
Lewis SA, Oswald I, Dunleavy DL.
PMID: 4326288 [PubMed - indexed for MEDLINE]
J Pharm Pharmacol 1971 Jul;23(7):509-13
Species-dependent effects of fenfluramine on the central nervous system.
Funderburk WH, Hash AM Jr, Hazelwood JC, Ward JW.
PMID: 4397450 [PubMed - indexed for MEDLINE]
Br J Pharmacol 1971 Jan;41(1):57-64
Action of fenfluramine on monoamine stores of rat tissues.
Costa E, Groppetti A, Revuelta A.
PMID: 5547762 [PubMed - indexed for MEDLINE]
From TOXNET
J NUTR 101:525-532,1971
PLACENTAL TRANSFER OF FLUORIDE AND TIN IN RATS GIVEN VARIOUS FLUORIDE AND TIN SALTSTHEUER RC, MAHONEY AW, SARETT HP
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=5535078&dopt=Abstract
Neurology 1970 Apr;20(4):416
The acute cerebellar syndrome in 5-fluorouracil chemotherapy: a manifestation of fluoroacetate intoxication.
Koenig H, Patel A.
PMID: 5535078 [PubMed - indexed for MEDLINE]
Biull Eksp Biol Med 1970 Jun;69(6):107-10
[The histomorphologic characteristics of various rat endocrine glands in fluorine poisoning]
[Article in Russian]
Zhavoronkov AA, Odinokova VA.
PMID: 5471706 [PubMed - indexed for MEDLINE]
Toxicol Appl Pharmacol 1970 Nov;17(3):573-84
Fluorine distribution in rats following acute intoxication with nitrogen and halogen fluorides and with sodium fluoride.
Dost FN, Reed DJ, Cooper TD, Wang CH.
PMID: 5495982 [PubMed - indexed for MEDLINE
Fluoride 1970; 3(4):192-200
Genetic effects of Hydrogen fluoride on Drosophila Melanogaster
AH Mohamed and PA Kemmer
Biology Department, University of Missouri, Kansas City
Summary: Drosophila males were fumigated with gaseous hydrogen fluoride in two series of experiments. In Series I, wild type Oregon-R males were treated by continuous flow of HF for 10 hours. In Series II, dp+/+b males were treated at a steady state level of HF for 9 hours. Treated and control males were crossed individually to virgin females of the genotype Pm dp b/Cy. The genetic analyses of the test generations of both series showed that homozygosity for one of the second chromosomes from a treated male resulted in a reduction in viability of the individuals which ranged from subvital to complete lethality. The viability of the controls and the heterozygous sibs was normal. Thre individuals of abnormal phenotypes were observed in the segregating generations. None of the crosses conducted to determine the mode of inheritance of these abnormal flies were successful. These limited studies indicate that HF may act as a mutagenic agent.
J Endocrinol 1971 Aug;50(4):709-10
Differential release of individual gonadotrophins by the human foetal pituitary gland after stimulation by cyclic AMP and sodium fluoride.
Groom GV, Cooke ID, Boyns AR.
PMID: 4327579 [PubMed - indexed for MEDLINE]
Biochim Biophys Acta 1971 May 18;237(2):296-300
The development of adenyl cyclase in rat liver, kidney, brain and skeletal muscle.
Hommes FA, Beere A.
PMID: 4328393 [PubMed - indexed for MEDLINE]
J Biol Chem 1971 Jan 10;246(1):62-8
Adenyl cyclase of rat cerebral cortex. Activation of sodium fluoride and detergents.
Perkins JP, Moore MM.
PMID: 5541774 [PubMed - indexed for MEDLINE]
J Biol Chem 1971 Jul 10;246(13):4166-73
Adenyl cyclase. Kinetic properties and nature of fluoride and hormone stimulation.
Drummond GI, Severson DL, Duncan L.
PMID: 5090039 [PubMed - indexed for MEDLINE]
Aust J Exp Biol Med Sci 1971 Oct;49(5):501-2
A study of the central action of flurothyl and methoxyflurane.
Schuck SL, Shulman A.
PMID: 4400855 [PubMed - indexed for MEDLINE]
Arch Neurol 1970 Aug;23(2):155-60
Biochemical basis for fluorouracil neurotoxicity. The role of Krebs cycle inhibition by fluoroacetate.
Koenig H, Patel A.
PMID: 5430334 [PubMed - indexed for MEDLINE]
J Neurochem 1971 Apr;18(4):621-8
Some neurochemical aspects of fluorocitrate intoxication.
Patel A, Koenig H.
PMID: 5581577 [PubMed - indexed for MEDLINE]
Biol Reprod 1970 Jun;2(3):369-75
Specific effect of fluoroacetamide on spermiogenesis.
Steinberger E, Sud BN.
PMID: 5527836 [PubMed - indexed for MEDLINE]Fluoride 1971; 4(1):21-24
The effect of hydrogen fluoride and cryolite dust upon plants and animals near a hydrogen fluoride factory
HG Dassler
Technical University Dresden, Forestry Section, Dept. of Plant chemistry, Tharandt 11B. Communication #101 of the A.G. Forestry Pollution Science, Tharandt.
Summary: In order to clarify damage due to fumigtion by F containing emission products, studies were carried out on forestry, agricultural and horticultural plantings in the emission area of a hydrofluoroic acid factory. The development of noxious symptoms, the diferences in sensititivity of plant species and extent of leaf and fruit damage are described. Through these studies which extended over several years, plants were classified according to their HF sensitivity. The fumigation experiments with hydrogen fluoride in air mixtures produced results which agreed closely with the observations in the emission area. Plants resistent to fluoride are sour cherries among fruit trees, raps, sugar beet and potatoes among agricultural plants, asters and roses among flowers. In fruit trees the sensitivity of leaves did not parallel that of fruit.
Fluoride 1971; 4(1):25-29
The influence of atmospheric hydrogen fluoride on the frequency of sex-linked recessive lethals and sterility in Drosophila melanogaster
RA Gerdes
Biology Department, Texas Woman's University, Denton, Texas
Summary: The influence of hydrogen fluoride as an atmospheric contaminant was investigated in the Oregon-r strain of Drosophila melanogaster. Two principal parameters of mutagenicity were used: sex-linked recessive lethals and sterility. The flies were subjected to various levels of HF in fumigation chamgers.Sex-linked recessive lethal mutation frequency increasd at each level of sub-lethal concentration. The frequencies of sterlity in both males and females were significantly increased as a result of increased treatment concentration. Upon testing populations treated for long periods, it was found that long-term treatment periods significantly increased sterility.Genetic differences were observed in the response of the progeny of treated flies. The maintenance of a population at sub-lethal concentrations of HF revealed an apparent accumulation of physiological aberrations resulting in sterlity in the treated flies. Results indicate that treatment increased the incidence of genetic aberations as measured by at least two parameters.
Biochim Biophys Acta 1971 Oct;252(1):83-91
Conversion of fluoroacetic acid to amino acids in the mammal.
Schaefer H, Machleidt H.
PMID: 5141830 [PubMed - indexed for MEDLINE]
Fluoride 1971; 4(1):30-36
Effects of fluorides on metabolism and visible injury in cut-flower crops and citrus
Woltz SS, Waters WE, Leonard DC
University of Florida, Bradenton, Apopka and Lake Alfred, Florida.
Florida Agricultural Experiment Stations, Journal Series No. 3650.
Summary: Fluoride taken up by gladiolus roots caused foliar damage only when soil pH was low and F containing superphosphate was applied in relatively excessive amounts. This damage to leaves occurred more to leaf interior than to margins and tips as in F fumigtion. Fluoride in leaves was found to move passively with the transpirational stream of water and accumulated at the terminus of translocation. Rose and gladiolus cut-flowers were damaged by low concentraions of F in vase water whereas the chrysanthemum was less affected. De novo chlorophyll synthesis in Vigna sinensis seedling leaves was inhibited by F absorbed by detached seedling tops. Yield of 'Valencia' orange fruit was depressed by air-borne F. 'Valencia' leves (a) were reduced in size, (b) had decreased photosynthetic rates and (c) had decreased chlorophyll content in response to increasing levels of air-borne F.
As cited (and abstracted) in Fluoride 1971; 4(1):40
Toxicity following methoxyflurane anesthesia
Under the above caption, the October 5, 1970 issue of the Journal of the American Medical Association published three papers dealing with various aspects of the general problem, issuing from the University of Rochester, School of Medicine and Dentistry, Rochester New York:
I. Clinical and pathological observations in two fatal cases
Paner, BJ, Freeman RB, Roth-Moyo A, Markowtich A
JAMA 1970; 214:86-90
II.Fluoride concentrations in nephrotoxicity
Taves DR, Fry BW, Freeman RB, Gillies AJ
JAMA 1970; 214:91-95
III. Hemodialysis of Metabolites
Taves DR, Gillies AJ, Freeman RB, Fry BW
JAMA 1970; 214:96-97
JAMA 1970; 214:81-85As cited (and abstracted) in Fluoride 1971; 4(1):41-42Cardiac toxicity of aerosol propellants
GJ Taylor and WS Harris
Department of Medicine, Section of Cardiology, University of Illinois Hospital, Chicago
Excerpt: ... Freons are used in many other spray dispensers for household purposes. They are also employed in hair sprays. The authors point out that persistent use of such sprays might cause increased susceptibility to coronary heart disease and irregularities in the heart rhythm. They recommend further investigation of the problem.
Fluoride 1971; 4(2):44-48
Guest editorial
Dietary fluoride intake in the USA
Robert Roy Kintner
Augustana College, Sioux Falls, South Dakota
Excerpt:
Food F levels (ppm)
Contaminated
(fresh wt)F levels (ppm)
Normal**
(fresh wt)Source San Jose Raspberries 54 0.3*** 1970. Analysed by Cook Research Lab, Inc. Menlo Park, CA. Spinach 16 0.2 - 1.8 1962. GL Waldbott: Fluoride in clinical medicine. Suppl. 1 ad Vol. 20, Intl. Arch Allergy and Applied Immunology. Lettuce 62 0.3 - 1.92 same as above Beans (cooked) 17.3 0.11 - 0.13 1969. GL Waldbott GL and VA Cecilioni: "Neighborhood" Fluorosis. Clinical Toxicology 2:387-396. December Lettuce 44 0.3 - 1.92 same as above Potatoes 20 - 30 0.07 - 0.2 1971. W Oelschlager: Fluoride uptake in soil and its depletion. Fluroide 4:82 Sugar beets 30 - 50 3.3 (dry wt) same as above Peaches 3.1 - 21.9
(dry wt)0.21 1960. OC Compton et al: miscellaneous Paper 95, Agric. Exp. Station, Oregon State College, Corvallis. August. p. 26. * The water content of these foods ranged from 75 to 90%. Conversion of a fresh weight value to dr weight for comaison purposes may be approximated by multiplying the fresh weight value by seven.
** From FJ McClure, Fluoride in foods, survey of recent data. Pub Health Reports 1949; 64:1061
*** From W Oelschlager, Fluoride 1970; 3:6
Fluoride 1971; 4(2):64-79
Human fluoride intoxication in Punjab
Jolly SS, Prasad S, Sharma R, and Rai B
Department of Medicine, Medical College, Patiala, India
Fluoride 1971; 4(2):80-84
Fluoride uptake in soil and its depletion
W Oelschlager
Institute for Animal Nutrition, Stuttgart University, Hohenheim, Germany
Fluoride 1971; 4(2):85-93
Long term effect of fluoride emission upon children
G Balazova
Research Institute for Hygiene, Bratislava, Czechoslovakia
Fluoride 1971; 4(2):89-92
Effect of fluoride emission on animal products
A Rippel
Research Institute for Hygiene, Bratislava, Czechoslovakia
Fluoride 1971; 4(2):93-96
Airborne fluoride in the Lake St. Clair - Detroit River areas
GL Waldbott
Summary: A study concerned with air pollution in the Lake St. Clair - Detroit River area was undertaken by a special board at the request of the "International Joint Commission" representing the governments of U.S.A. and Canada.A limited survey for atmospheric F yielded concentrations of 0.16 to 2.9 ppb. In comparison, the highest level obtained by the National Sampling Network in 1966 and 1967 was 2.4 ppb. Gladioli planted at five locations showed F levels up to 50 ppm. Tip and margin burns occurred within 5 weeks after the gladioli were planted. The sources of F emission were not determined.The author suggests that such variables as duration and continuity of sampling, height of sampling stations and their distance from the emitting sources, F levels in soil and edibles grown in the respective area should be considered in order to apply the above findings to the evaluation of health effects of F emissions upon humans.
J Physiol 1971 Jul;216(1):40P-41P
Oral toxicity of fluoroacetate and fluorocitrate in rats.
Peters RA, Shorthouse M.
PMID: 5558369 [PubMed - indexed for MEDLINE]
Ciba Found Symp 1971;2:9-33
Chemical characteristics of the carbon-fluorine bond.
Saunders BC.
PMID: 5212162 [PubMed - indexed for MEDLINE]
Ciba Found Symp 1971;2:55-76
Some metabolic aspects of fluoroacetate especially related to fluorocitrate.
Peters R.
PMID: 5212159 [PubMed - indexed for MEDLINE]
Ciba Found Symp 1971;2:303-30
Biochemical effects of fluoroacetate poisoning in rat liver.
Buffa P, Guarriera-Bobyleva V, Pasquali-Ronchetti I.
PMID: 5212155 [PubMed - indexed for MEDLINE]
Ciba Found Symp 1971;2:117-23
Fluorine metabolism in plants.
PMID: 5212148 [PubMed - indexed for MEDLINE]
Behav Neuropsychiatry 1971 Apr-May;3(1):10-2
Trifluperidol in chronic male psychiatric patients.
Serafetinides EA, Colmore JP, Rahhal DK, Clark ML.
PMID: 5566333 [PubMed - indexed for MEDLINE]
Nippon Rinsho 1971 Feb;29(2):864-70
[Organic fluorine poisoning]
[Article in Japanese]
Nanba M, Fujii Y, Hara A, Nawa H, Iwasaki I.
PMID: 5102721 [PubMed - indexed for MEDLINE]
NOTE: Martin Rodbell (co-author of this report) and Alfred G. Gilman shared the 1994 Nobel Prize for the discovery of "G-proteins and the role of these proteins in signal transduction in cells."
J Biol Chem 1971 Jul 25;246(14):4447-54
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. VI. Evidence for a role of membrane lipids.
Pohl SL, Krans HM, Kozyreff V, Birnbaumer L, Rodbell M.
PMID: 4328442 [PubMed - indexed for MEDLINE]
NOTE: Martin Rodbell (co-author of this report) and Alfred G. Gilman shared the 1994 Nobel Prize for the discovery of "G-proteins and the role of these proteins in signal transduction in cells."
J Biol Chem 1971 Mar 25;246(6):1872-6
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon.
Rodbell M, Krans HM, Pohl SL, Birnbaumer L.
PMID: 4993962 [PubMed - indexed for MEDLINE]
NOTE: Martin Rodbell (co-author of this report) and Alfred G. Gilman shared the 1994 Nobel Prize for the discovery of "G-proteins and the role of these proteins in signal transduction in cells."
J Biol Chem 1971 Mar 25;246(6):1849-56
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. I. Properties.
Pohl SL, Birnbaumer L, Rodbell M.
PMID: 4993961 [PubMed - indexed for MEDLINE]
NOTE: Martin Rodbell (co-author of this report) and Alfred G. Gilman shared the 1994 Nobel Prize for the discovery of "G-proteins and the role of these proteins in signal transduction in cells."
J Biol Chem 1971 Mar 25;246(6):1877-82
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role of guanylnucleotides in glucagon action.
Rodbell M, Birnbaumer L, Pohl SL, Krans HM.
PMID: 4926550 [PubMed - indexed for MEDLINE]
NOTE: Martin Rodbell (co-author of this report) and Alfred G. Gilman shared the 1994 Nobel Prize for the discovery of "G-proteins and the role of these proteins in signal transduction in cells."
J Biol Chem 1971 Mar 25;246(6):1857-60
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. II. Comparison between glucagon- and fluoride-stimulated activities.
Birnbaumer L, Pohl SL, Rodbell M.
PMID: 4323236 [PubMed - indexed for MEDLINE]
Fluoride 1970; 3(4):167-174
Fluoride content and microradiographic findings in skeletal fluorosis
Freita V, Oelschlager W and Loeffler K
Universitatsklinik und Poliklinik fur Zahn-, Mund-und Kieferkrankheiten, Homburg (Saar) and Universitat Hohenheim, Stuttgart, Germany
Fluoride 1970; 3(4):175-181
Fluoride effects on bone morphology and calcium kinetics
CF Ramberg Jr and SE Olsson
University of Pennsylvania School of Veterinary Medicine, Dept. of Clinical Studies and the Kungl Veterinarhogskolan fur Klinisk Radiologi, Stockholm, Sweden
Fluoride 1970; 3(4):181-187
Toxicology of chlorotrifluoroethylene
Walther H, Fischer H-D, Jager J, Kemmer C, and Kunze K
Institute of Pharmacology and Toxicology and the Institute of Pathology of the Medical Academy "Carl Gustav Carus," Dresden, West Germany
Summary: Chlorotrifluoroethylene (CTFE) an intermediate product in the manufacturing of plastics, fire extinguishing agents and such pharmaceuticals as halotane is an extremely toxic agent of the "c times t" [concentration times time] type. It is 40 times as toxic as tetrafluorethylene. Mice were exposed for 3 to 24 hours to air containing CTFE in concentrations of 0.1 to 0.8%. Biochemical, optical, electron-microscopic and enzyme-histochemical examinations were made. Exposure to CTFE leads to immediate, generalized damage of mitochondria which particularly affects the kidneys. Simultaneous changes occur in the mitochondria of the liver and the myocardum which appear to induce "immediate" and "follow-up" lethality. The "delayed" lethality is the result due to prolonged and serious damage to kidneys.
Am J Obstet Gynecol 1970 Jun 1;107(3):432-4
Placental transfer of fluoride and calcium.
Armstrong WD, Singer L, Makowski EL.
PMID: 5445015 [PubMed - indexed for MEDLINE]
J Nutr 1971 Apr;101(4):525-32
Placental transfer of fluoride and tin in rats given various fluoride and tin salts.
Theuer RC, Mahoney AW, Sarett HP.
PMID: 5580072 [PubMed - indexed for MEDLINE]
Fluoride 1970; 3(4):188-191
Effect of large doses of sodium fluoride on fluoride and minerals in blood serum, hair
and other bovine tissues
J Tusl and L Slesingr
Research Institute for Animal Nutrition, Food Science and Technology, Pohorelice, Czechoslovakia
Fluoride 1970; 3(4):204-207
Fluoride and nutritional osteoporosis
Henrikson PA, Lutwak L, Krook L, Kallfelz F, Sheffy BE, Skogerboe R, Belanger LF, Marier JR, Romanus B, Hirsch C
Cornell University, Ithaca NY; Colorado State University, Fort Collins; University of Ottawa, Canada; National Research Council, Ottawa, Canada; Karolinska Institute, Stockholm, Sweden
Summary: Osteoporosis was induced by feeding a low-Ca high-P diet for 41 weeks to Beagle dogs, and dietary fluoride supplements were given to obtain daily fluoride intakes of about 0, 25, 85, 300, and 1,000 ug/kg body weight. Bone radiography, specific gravity, bending and tension tests, and ash-per-volume revealed no effect of fluoride on the degree of osteoporosis. Hower, densitometry measurements showed that mineral mass decreased significantly with increased dietary fluoride, and this was accompanied by a marked increase in bone ash phosphorus and a slight decrease in ash calcium. Fluoride content of bone ash was proportional to dietary fluoride, and was higher in vertebrae than in long bones.
Fluoride 1970; 3(4):208
Endemic fluorosis
Bhaskara Reddy D, Mallikharjunarao C and Sarada D
Guntur Medical College, Guntur, India
Fluoride 1970; 3(4):211
Treatment of osteoporosis with sodium fluorde. Morphological skeletal findings in eight cases.
Kuhlencordt F, Kruse HP, Lozano-Tonkin C, Eckermeier L
First Medical University Clinic, Hamburg, W. Germany
Excerpt from Abstract: The authors point out that the structure of the newly formed bone is abnormal. They believe that at the present state of our knowledge F treatment for osteoporosis should not be employed by practicing physicians.
Fluoride 1970; 3(3):114-120
The effect of sodium fluoride upon the retina
N Orzalesi
Department of Pohthalmology, University of Cagliari, Italy
Summary: The author reviews the available research by others and his own group of workers on the retinotoxic effect of F. NaF administered intravenously in doses of 50 mg/kg of body weight in 2 to 4 successive injections causes degenerative changes in the retina in about 50% of treated rabbits. The resulting pathology was studied by fundoscopic and histologic examination, electroretinograpy and fluorescein-angiography. Within 10 to 20 hours of the first administration, edema of the retina was noted beneath the papilla. It was followed by development of a granular pigmentation and a straight line of pigmented dots. A coarser pigmentary disturbance was observed at the periphery of the fundus and above the papilla. In the advanced stage diffuse retinal atrophy occurred. Changes in the electroretinogram were also found. The lesions resemble closely those induced by sdium iodate. It is concluded that F attacks the retinal pigment epithelium primarily and the visual cells secondarily.
Fluoride 1970; 3(3):121-127
Agricultural organofluoride poisoning: 1. Carbohydrate metabolism
Iwasaki I, Nawa H, Hara A, Takagi S and Hyodo K.
Department of Internal Medicine, Okayama University, Medical School, Japan
Summary: Organofluoride intoxication is intimately associated with an abnormal carbohydrate metabolism. Hypoglycemia appears to be the result of rapid metabolic alteration of glucose into lactic acid via pyruvic acid due to blockade of the Krebs cycle. Intravenous injections of glucose are very effective in the treatment of organofluoride poisoning.
Fluoride 1970; 3(3):137-142
Fluorides and sulfur dioxides as causes of plant damage
H Bohne
Agricultural Chemical Laboratory, Bad Godesberg, Germany
Summary: Fluoride (F) and sulfur trioxide (SO3) levels were determined in three polluted industrial areas where the two pollutants had damaged vegetation. The appearance of the leaves was typical of F injury whereas no lesions indicated toxicity by sulfur oxides. Chemical analyses of the plants supported these findings. Fluoride levels in gladiolus ranged from 3.4 to 8.7 mg% and those of SO 3 from 0.77 to 1.15%. The author concludes that, by far, the greatest damage from gaseous combustion to horticulture, farming and forestry is caused by F containing compounds, primarily hydrogen fluoride.
Fluoride 1970; 3(3):143-152
Fluoride concentrations found in NASN [National Air Sampling Network] samples of suspended particles
RS Yunghans and TB McMullen
Division of Air Quality and Emission Data, US Department of Health, Education, and Welfare, Public Health Service, Consumer Protection and Enviromental Health Service, National Air Pollution Control Administration, Cincinnati, Ohio
Fluoride 1970; 3(3):153-159
RNA metabolism and fluoride action
PE Pilet
Plant Biology and Physiology, Faculty of Sciences, University of Lausanne, Switzerland
Summary: When the apical root sections of Lens culnaris was incubated for 12 hours on filter-paper in sterile conditions, the level of endogenous RNA, per cell, decreased. Fluoride was found to accelerate this decrease, while an auxin such as the B-indolylacetic acid (IAA) inhibits it. The RNase activity increased considerably after 12 hours' indubation. Fluoride produces a significant increase of the RNase activity whereas IAA brings about a lesser increase.
Fluoride 1970; 3(3):160-161
Effects from repeated inhalation of fluoride
ML Keplinger
Research and Teaching Center of Toxicology, University of Miami School of Medicine, Coral Gables, Florida
Fluoride 1970; 3(2):61-65
Fluoride emission during firing of pottery in continuous kilns
SG Luxon
Industrial Hygiene Laboratory, Bayhards House, London, England
Summary: In the manufacture of pottery, etching of glass in surrounding buildings was found to be due to the formation of ammoniumsilicofluoride. Calcium fluoride present in chinastone in the presence of organic matter is converted into ammonium fluosilicate. Acid gases, arising from products of combustion used to heat the kiln, liberate hydrofluoric acid which accounts for the etching of glass.
Fluoride 1970; 3(2):66-71
Injury to gladiolus by fluoridated water
F Spierings
Institute of Phytopathological Research (IPO), Wageningen, The Netherlands
Summary: In pursuance of studies on F damage to tulips and gladiolus, we determined the effect of fluoridated water on cut flowers. The "fluoridated" leaves contained up to 5 times more F than those in low F water. In the injured leaf tips the F levels were considerably higher than in the non-injured portions of the leaves.
Fluoride 1970; 3(2):80-84
Suicide with sodium silicofluoride
M Kovacs and L Varnai
Forensic Medical Laboratory, Budapest, Hungary
Summary: A case of suicide with sodiumsilicofluoride is reported. Segmentation and fragmentation of heart muscle cells, gastro-duodenal ulceration, focal necrosis in liver and tubular degeneration of kidneys featured the pathological findings. Hemorrhagic gastro-enteritis and circulatory failure characterized the clinical picture.
Fluoride 1970; 3(2):85-91
Some effects of the fumigant sulfuryl fluoride on the gross metabolism of insect eggs
I Outram
Imperial College of Science and Technology, University of London
Summary: In the eggs of the desert locust, Schistocerca gregaria, and the yellow mealworm, Tenebrio molitor, the insecticidal fumigant sulphuryl fluoride caused a reduction in oxygen uptake and changes in respiratory quotient. The relationship between inorganic and organic phosphate content of the egg was also disturbed. The fumigant only partially inhibited hydrolysis of fatty acid esters: The mechanisms responsible for the splitting of the lower esters were strongly inhibited, whereas those capable of splitting the higher esters were apparently insensitive to the treatment. Fumigated eggs contained less lipid material than untreated eggs. The fumigant had no apparent effect on the amino-acid balance of the egg. It is suggested that sulphuryl fluoride is non-specific in respect to the sites of attack in the insect egg and inhibits several metabolic processes.
Fluoride 1970; 3(2):91-96
Neurological complications of skeletal fluorosis with special reference to lesions in the cervical region
AH Siddiqui (Hyderabad, India)
Summary: Seventy cases of skeletal fluorosis observed in the endemic Nalgonda District of Andhra Pradesh, India had neurological manifestations. Special reference is made to lesions in the cervical region. In two cases surgical decompression of the cord relieved the quadriplegia. The mechanism of the neurological involvement in skeletal fluorosis is discussed.
Fluoride 1970; 3(2):97-99
Fluoride uptake from gypsum ponds
FL Cross Jr and RW Ross
National Air Pollution Control Administration, Durham, North Carolina
Summary: Gypsum (calcium sulfate) from the manufacture of triple phosphate fertilizer has been considered for use as an additive to row crops in order to increase the calcium content of soil. In its raw form the highly acid and F rich material gave rise to damaging levels of F in plants. Several washings with water reduced the F content of the gypsum and increased its pH.
Fluoride 1970; 3(2):100-101
Book Review
Toxic properties of inorganic fluorine compounds
by RY Eagers. 1969.
Laporte Industries, Ltd., Castleford, England. Elsevier Publishing Company, Ltd., Amsterdam - London - New York. Pg 152; 18 tables; 730 references; subject index. Price $8.00
Fluoride 1970; 3(1):6-11
Fluoride in food
W Oelschlager
Institute for Animal Nutrition, Stuttgart University, Hohenheim, Germany
Summary: Food from animal and plant life was anlayzed for F. The average daily F consumption through food in Germany ranged between 0.2 and 0.4 mg. Addition of such "high fluoride" foods as polished peas and rice, tea and fish may raise the daily average intake to 2 mg and above. Food originating in an air-contaminated area contains much higher F levels than food grown in non-polluted areas.
Fluoride 1970; 3(1):12-18
Fluoride intake through tea in British children
HA Cook
Summary: In a survey on 662 British school children between 5 and 15 years of age, 92.5% were found to drink tea regularly. The total daily fluid ntake per child is 1924 ml. Thirty varieties of tea consumed in Great Britain ranged from 121 to 260 mg F/kg with an average of 186.1 mgF/kig or 0.52 mg per cup. The daily fluoride intake from tea in children up to age 15 was calculated to be 1.26 mg as compared to 2.55 in adults. The average daily fluoride intake from all other beverages when prepared with fluoridated water is 2.05 mg.
Fluoride 1970; 3(1):18-21
Long term effect of fluoride emissions upon vegetation
A Rippel
Research Institute for Hygiene, Bratislava, Czechoslovakia
Summary: Fluoride determinations over an eight year period in the vicinity of an aluminum factory showed levels 6 times higher in vegetables, 5 times higher in fruit and 2.6 times higher in grain than in normal controls.
Fluoride 1970; 3(1):22-26
Fluoride in rainwater and vegetation
K Garber
State's Institute for Applied Botany, Hamburg, Germany
Summary: Fluoride levels of rainwater in industrial areas of Germany ranged from 0.28 mg/l to 14.1 mg/l depending on the kind of industry, the distance from the industrial complexes, and the extent to which coal is used. There was a direct correlation between the magnitudes of F in rainwater and F in test plants. Plants grown near industrial complexes which process F containing raw materials contain as much as 50 to 185 mg/100 grams of F (dry) compared to normal averages of 0.7 to 1.5 mg.
Fluoride 1970; 3(1):27-30
High fluoride levels in a citrus grove due to gypsum pond dyke break
FL Cross Jr and RW Ross
Mr. Cross is technical writer-editor at the National Air Pollution Control Administration, Durham, North Carolina. He was formerly Director of Environmental Engineering for Manatee County, Florida.
Summary: The break of the dam of an artificial lagoon constructed to accumulate the effluents from a fertilizer factory induced F contaimination in the surrounding area. The effluent water contained up to 5150 ppm of F and up to 21,500 phosphates. Levels in soil ranged upto 384 ppm, in leaves of citrus trees from 45 to 86 ppm, in roots of citrus trees up to 1656 pm.
Fluoride 1970; 3(1):36-39
Fluoride in poultry nutrition - a review
EE Gardiner
Canada Department of Agriculture, Research Station, Lethbridge, Alberta, Canada.
Summary: Relatively high F levels in the diet of chickens and turkeys have been shown to decrease growth rate, decrease feed consumption, increase F content of egg yolk, decrease the metabolizable energy value of the feed, produce changes in the intestinal tract, incease the iodine content of the thyroid gland with diets low in iodine, decrease or increase bone-ash depending upon the phosphorus level of the diet and F level used, and increase the alkaline phosphatase activity of some tissues.A Mg/F interaction has been reported which results in a characteristic leg weakness, depressed growth, reduced bone-ash, and decreased incorporation of 45C and 32P into femurs from young chicks. This interaction has not been completely explained.
NOTE: Martin Rodbell (co-author of this report) and Alfred G. Gilman shared the 1994 Nobel Prize for the discovery of "G-proteins and the role of these proteins in signal transduction in cells."J Biol Chem 1970 Feb 25;245(4):718-22
Adenyl cyclase in fat cells. 3. Stimulation by secretin and the effects of trypsin on the receptors for lipolytic hormones.
Rodbell M, Birnbaumer L, Pohl SL.
PMID: 4313606 [PubMed - indexed for MEDLINE]
NOTE: Martin Rodbell (co-author of this report) and Alfred G. Gilman shared the 1994 Nobel Prize for the discovery of "G-proteins and the role of these proteins in signal transduction in cells."
Adv Biochem Psychopharmacol 1970;3:185-208
The actions of hormones on the adenyl cyclase system.
Birnbaumer L, Pohl SL, Michiel H, Krans MJ, Rodbell M.
PMID: 4399634 [PubMed - indexed for MEDLINE]
Am J Med 1970 Dec;49(6):807-13
Fluoride metabolism in man.
Spencer H, Lewin I, Wistrowski E, Samachson J.
PMID: 5006619 [PubMed - indexed for MEDLINE]
(Cited in: Toxicological profile for fluorine, hydrogen fluoride, and fluorides. Draft for public comment. Agency for Toxic Substances and Disease Registry. Atlanta, GA. 2001.
Cited in: Interaction Profile for Cyanide, fluoride, nitrate and uranium. Draft for public comment. Agency for Toxic Substances and Disease Registry. Atlanta, GA. 2002.)
Naunyn Schmiedebergs Arch Pharmakol 1970;265(5):474-5
A note on the effect of trifluoroacetate on the growth of rat liver.
Blake DA, Barry JQ, Cascorbi HF.
PMID: 4244617 [PubMed - indexed for MEDLINE]
Monogr Ser World Health Organ 1970;59:225-71
Toxic effects of larger doses of fluoride.
Bhussry BR, Demole V, Hodge HC, Jolly SS, Singh A, Taves DR.
PMID: 4987964 [PubMed - indexed for MEDLINE]
J Med Chem 1970 Nov;13(6):1212-5
Perfluoroalkyl carbonyl compounds. 1. Perfluoroaldehyde and perfluorocarboxylic acid derivatives.
Crank G, Harding DR, Szinai SS.
PMID: 5479868 [PubMed - indexed for MEDLINE]
J Med Chem 1970 Nov;13(6):1215-7
Perfluoroalkyl carbonyl compounds. 2. Derivatives of hexafluoroacetone.
Crank G, Harding DR, Szinai SS.
PMID: 5479869 [PubMed - indexed for MEDLINE]
1970 Report
Environmental pollution by fluorides in Flathead National Forest and Glacier National Park
CE Carlson and JE Dewey
US Department of Agriculture, Forest Service, Region 1, Missoula, Montana
Inhaled Part 1970;1:201-8
Inhalation study on metabolism of insoluble uranium compounds.
Galibin GP, Parfenov YD.
PMID: 5527712 [PubMed - indexed for MEDLINE]
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