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Adverse Effects
Abstracts
ACTIVITY: Herbicide
(pyridine)
CAS NAME: [(4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy]acetic
acid
NOTES:
This compound is normally used as a salt or an ester, the identity
of which should be stated, for example fluroxypyr-butoxypropyl
[154486-27-8], fluroxypyr-meptyl
[81406-37-3].
Structure:
| Adverse
Effects:
Ataxia
Body
Weight Decrease
Bone
Endocrine: Adrenal
Endocrine: Testicular
Kidney
Mesenteric Lymph Node |
| Environmental
Effects:
Highly
toxic to the eastern oyster
Highly
toxic to terrestrial
plants. |
Regulatory
Information
(only comprehensive for the US) |
| US
EPA Registered: |
Yes |
| US
EPA PC Code: |
128959 |
| US
Tolerances: |
CFR
180.535 |
| FDA
LMS Code: |
797 |
Registered
use in
(includes only a limited list of countries)
|
Denmark,
Finland, Germany, Hungary, India, Netherlands, New Zealand,
South Africa, Tanzania, UK, US |
US
Maximum Residue Levels permitted
in food commodities
|
Fluroxypyr
is the metabolite of Fluroxypyr 1-Methylheptyl ester and both
are permitted in or on 54 food commodities, including:
Aspirated grain fractions,
Barley (forage, grain, hay, straw),
Cattle (fat, kidney, meat, meat byproducts),
Corn (Field: forage, grain, stover; Sweet (forage, kernels,
stover),
Goat (fat, kidney, meat, meat byproducts),
Grass (forage and hay),
Hog (fat, kidney, mean, meat byproducts),
Horse (fat, kidney, meat, meat byproducts),
Milk, Oat (forage, grain, hay, straw), Onion,
Sheep (fat, kidney, meat, meat byproducts),
Wheat (forage, grain, hay, straw) |
| Other
Information |
| Entry
Year: |
C7H5Cl2
F N2O3 |
| Inventing
Company: |
Dow Elanco |
| Manufacturers: |
Dow
Agro (Dow Elanco), UAP |
| Other
Names: |
DOWCO
433 |
| Of
special interest: |
| PAN
Data |
| April
2002 -
Beer in the UK: 23 organofluorine
pesticides approved for use on malting barley. Published
by the British Beer and Pubs Association and Brewing Research
International. |
| June
2002 - In Australia when Fluroxypyr is used as a "Herbicide
on poppies" no
maximum residue levels are required. Ref:
June 2002. Table 5. Uses of substances where maximum
residue limits are not necessary. Australian National Registration
Authority for Agricultural Veterinary Chemicals. The MRL Standard.
Maximum residue limits in food and animal feedstuff. http://www.nra.gov.au/residues/mrl5.pdf |
| March
1, 2000 - Fluroxypyr:
European Commission
Directive of March 1, 2000. Allowed
for use up to November 30, 2010 |
| December
15, 1999 -
European Commission. Review
report for the active substance fluroxypyr. Finalised
in the Standing Committee on Plant Health at its meeting on
30 November 1999 in view of the inclusion of fluroxypyr in Annex
I of Directive 91/414/EEC |
| Abstracts |
| August
2001 - IR-4:
New
Products/Transitional Solution List -
This
list contains brief descriptions of numerous new pest control
materials that have been introduced over the last several years.
Additionally, it contains information on some "older"
crop protection chemicals that are believed to have room for
new uses. This List includes:
Fluroxypyr |
| See also Fluroxypyr
1-Methylheptyl ester |
| October
2001 - Glossary
of Pesticide Chemicals. A listing
of pesticides subject to analysis of residues in foods and feeds
by the US Food and Drug Administration. |
| Fluroxypyr
ranked number
9 for "Most Widely used pesticides in the UK (by Area
Treated)"
| Rank
|
Formulation |
Method |
Area
treated (ha) |
Weight
applied (kg ai) |
| 9 |
Fluroxypyr |
Spray |
842,392 |
104,821 |
Ref:
April 29, 2000. UK Department for Environment, Food &
Rural Affairs in the online report, "Design of a Tax
or Charge Scheme for Pesticides. " Annex C3: Overview
of Pesticide Industry. http://www.fluorideaction.org/pesticides/pesticides.ranks.uk.2000.htm
|
US
Federal Register
••
Note: Due to length, the following is a partial
list. Click here
to see full list of FR entries.
|
| Date
Published |
Docket
Identification Number |
Details |
| April 4, 2007 |
EPA-HQ-OPP-2007-0114 |
IR-4. New
tolerance proposed. PP 6E7168. Proposes to establish a
tolerance for residues of fluroxypyr MHE, and its metabolite
fluroxypyr (expressed as combined residues of total fluroxypyr)
in or on food commodities. See November
21, 2006 submission from Down AgroSciences to EPA.
| Commodity |
PPM |
pome, fruit, group
11
This group includes
10 commodities.
• apple
• apple, dried pomace
• apple, juice
• apple, wet pomace
• crabapple
• fruit, pome
• loquat
• mayhaw
• pear
• pear, oriental
• quince
|
0.02 |
| millet, grain |
0.5 |
millet, forage
|
12.0 |
| grass, hay |
20.0 |
| millet, proso, grain |
0.5 |
| millet, proso, straw |
12.0 |
| millet, proso, forage |
12.0 |
| millet, proso, hay |
20.0 |
| millet, pearl, grain |
0.5 |
| millet, pearl, forage |
12.0 |
| millet, pearl, hay |
20.0 |
Adequate enforcement method for the combined
residues of total fluroxypyr is available to enforce the tolerance
expression in or on food. The analytical method uses capillary
GC and mass selective
detection (MSD) with LOQ of 0.01 ppm. Fluroxypyr has also
been tested through the Food and Drug Administration (FDA),
Multi-residue Methodology, Protocols C, D, and E. The results
have been published in the FDA Pesticide Analytical Manual,
volume 1.
|
| August 25, 2006 |
EPA-HQ-OPP-2006-0659 |
Pesticide
Emergency Exemptions; Agency Decisions and State and Federal
Agency Crisis Declarations
• Colorado: EPA authorized the use of fluroxypyr on onions
to control volunteer potatoes; June 6, 2006 to July 31, 2006. |
| June 28, 2006 |
EPA-HQ-OPP-2006-0084 |
Notice
of Receipt of Requests to Voluntarily Cancel Certain Pesticide
Registrations.
| Registration No. |
Product Name |
Registrant |
| 062719 OR-99-0043 |
Starane |
Dow Agrosciences LLC,
9330 Zionsville Rd 308/2E,
Indianapol, IN 462681054. |
|
| April 21, 2006 |
EPA-HQ-OPP-2005-0536 |
IR-4 and Dow
AgroSciences. Pesticide
petition: PP 3E6775.
proposal to establish a tolerance for the combined residues
of the herbicide fluroxypyr MHE and its metabolite fluroxypyr
(expressed as total fluroxypyr) in or on food commodities
-- garlic and shallot (bulb) at 0.03 ppm
-- onion (dry bulb) at 0.03 ppm |
| August
31, 2005 |
OPP-2005-0223 |
Pesticide
Emergency Exemptions:
•
Colorado. Crisis: On May 16, 2005, for
the use of fluroxypyr on onions
to control volunteer potatoes. This program ended on July
15, 2005. Contact: (Stacey Groce). |
| Feb
10, 2005 |
OPP-2005-0025 |
Removal
of Expired Time-limited Tolerances for Emergency Exemptions.
FINAL
RULE.
• 10. Fluroxypyr 1-methylheptyl ester. Time-limited
tolerances for
cattle kidney, goat kidney, grass forage
and hay, hog kidney, horse
kidney, milk and sheep kidney are being removed from
Sec. 180.535
because they expired on December 31, 2004. |
| Jan
26, 2005 |
OPP-2005-0008 |
Pesticide
Tolerances for Emergency Exemptions. FINAL RULE.
EPA, on its own initiative, in accordance with sections 408(e)
and 408(l)(6) of the Federal Food, Drug, and Cosmetic Act
(FFDCA), 21 U.S.C. 346a, is establishing a tolerance for combined
residues of the herbicide fluroxypyr 1-methylheptyl ester
1-methylheptyl ((4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy)acetate
and its metabolite fluroxypyr
[((4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy)acetic acid],
in or on
This
tolerance will expire and is revoked on June 30, 2007.
Although this tolerance will expire and is revoked on June
30, 2007, under section 408(l)(5) of the FFDCA, residues of
the pesticide not in excess of the amounts specified in the
tolerance remaining in or on onion after that date will not
be unlawful, provided the pesticide is applied in a manner
that was lawful under FIFRA, and the residues do not exceed
a level that was authorized by this tolerance at the time
of that application. EPA will take action
to revoke this tolerance earlier if any experience with, scientific
data on, or other relevant information on this pesticide indicate
that the residues are not safe.
Because
this tolerance is being approved under emergency conditions
identified in the state of Colorado,
EPA has not made any decisions about whether fluroxypyr 1-methylheptyl
ester meets EPA's registration requirements for use on onion
or whether a permanent tolerance for this use would be appropriate.
|
| Nov
10, 2004 |
OPP-2004-0232 |
One
Pesticide Emergency Exemption.
• Colorado
- Crisis: On June 21, 2004, for the use of fluroxypyr
on onions
to control volunteer potatoes. This program ended on July
21, 2004. Contact: (Stacey Groce)
|
••
Note: Due to length, the above is a partial list.
Click here
to see full list of FR entries.
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