CAS No. 69377-81-7


Return to
Adverse Effects

ACTIVITY: Herbicide (pyridine)

CAS NAME: [(4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy]acetic acid

NOTES: This compound is normally used as a salt or an ester, the identity of which should be stated, for example fluroxypyr-butoxypropyl [154486-27-8], fluroxypyr-meptyl [81406-37-3].


Adverse Effects:

Body Weight Decrease
Endocrine: Adrenal
Endocrine: Testicular
Mesenteric Lymph Node

Environmental Effects:

Highly toxic to the eastern oyster

Highly toxic to terrestrial plants.

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 128959 
US Tolerances: CFR 180.535
FDA LMS Code: 797 
Registered use in
(includes only a limited list of countries)

Denmark, Finland, Germany, Hungary, India, Netherlands, New Zealand, South Africa, Tanzania, UK, US
US Maximum Residue Levels permitted in food commodities
Fluroxypyr is the metabolite of Fluroxypyr 1-Methylheptyl ester and both are permitted in or on 54 food commodities, including:
Aspirated grain fractions,
Barley (forage, grain, hay, straw),
Cattle (fat, kidney, meat, meat byproducts),
Corn (Field: forage, grain, stover; Sweet (forage, kernels, stover),
Goat (fat, kidney, meat, meat byproducts),
Grass (forage and hay),
Hog (fat, kidney, mean, meat byproducts),
Horse (fat, kidney, meat, meat byproducts),
Milk, Oat (forage, grain, hay, straw), Onion,
Sheep (fat, kidney, meat, meat byproducts),
Wheat (forage, grain, hay, straw)
Other Information
Entry Year: C7H5Cl2 F N2O3 
Inventing Company: Dow Elanco 
Manufacturers: Dow Agro (Dow Elanco), UAP 
Other Names: DOWCO 433 
Of special interest:
PAN Data
April 2002 - Beer in the UK: 23 organofluorine pesticides approved for use on malting barley. Published by the British Beer and Pubs Association and Brewing Research International. 
June 2002 - In Australia when Fluroxypyr is used as a "Herbicide on poppies" no maximum residue levels are required. Ref: June 2002. Table 5. Uses of substances where maximum residue limits are not necessary. Australian National Registration Authority for Agricultural Veterinary Chemicals. The MRL Standard. Maximum residue limits in food and animal feedstuff. http://www.nra.gov.au/residues/mrl5.pdf
March 1, 2000 - Fluroxypyr: European Commission Directive of March 1, 2000. Allowed for use up to November 30, 2010  
December 15, 1999 - European Commission. Review report for the active substance fluroxypyr. Finalised in the Standing Committee on Plant Health at its meeting on 30 November 1999 in view of the inclusion of fluroxypyr in Annex I of Directive 91/414/EEC 
August 2001 - IR-4: New Products/Transitional Solution List -  This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes: Fluroxypyr  
See also Fluroxypyr 1-Methylheptyl ester
October 2001 - Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.  

Fluroxypyr ranked number 9 for "Most Widely used pesticides in the UK (by Area Treated)"

Rank Formulation Method Area treated (ha) Weight applied (kg ai)
9 Fluroxypyr Spray 842,392 104,821

Ref: April 29, 2000. UK Department for Environment, Food & Rural Affairs in the online report, "Design of a Tax or Charge Scheme for Pesticides. " Annex C3: Overview of Pesticide Industry. http://www.fluorideaction.org/pesticides/pesticides.ranks.uk.2000.htm

US Federal Register
•• Note: Due to length, the following is a partial list. Click here to see full list of FR entries.

Date Published Docket Identification Number Details
April 4, 2007 EPA-HQ-OPP-2007-0114

IR-4. New tolerance proposed. PP 6E7168. Proposes to establish a tolerance for residues of fluroxypyr MHE, and its metabolite fluroxypyr (expressed as combined residues of total fluroxypyr) in or on food commodities. See November 21, 2006 submission from Down AgroSciences to EPA.


pome, fruit, group 11

This group includes 10 commodities.
• apple
• apple, dried pomace
• apple, juice
• apple, wet pomace
• crabapple
• fruit, pome
• loquat
• mayhaw
• pear
• pear, oriental
• quince

millet, grain
millet, forage
grass, hay
millet, proso, grain
millet, proso, straw
millet, proso, forage
millet, proso, hay
millet, pearl, grain
millet, pearl, forage
millet, pearl, hay

Adequate enforcement method for the combined residues of total fluroxypyr is available to enforce the tolerance expression in or on food. The analytical method uses capillary GC and mass selective
detection (MSD) with LOQ of 0.01 ppm. Fluroxypyr has also been tested through the Food and Drug Administration (FDA), Multi-residue Methodology, Protocols C, D, and E. The results have been published in the FDA Pesticide Analytical Manual, volume 1.

August 25, 2006 EPA-HQ-OPP-2006-0659 Pesticide Emergency Exemptions; Agency Decisions and State and Federal Agency Crisis Declarations
• Colorado: EPA authorized the use of fluroxypyr on onions to control volunteer potatoes; June 6, 2006 to July 31, 2006.
June 28, 2006 EPA-HQ-OPP-2006-0084

Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations.

Registration No. Product Name Registrant
062719 OR-99-0043 Starane Dow Agrosciences LLC,
9330 Zionsville Rd 308/2E,
Indianapol, IN 462681054.
April 21, 2006 EPA-HQ-OPP-2005-0536 IR-4 and Dow AgroSciences. Pesticide petition: PP 3E6775.
proposal to establish a tolerance for the combined residues of the herbicide fluroxypyr MHE and its metabolite fluroxypyr (expressed as total fluroxypyr) in or on food commodities
-- garlic and shallot (bulb) at 0.03 ppm
-- onion (dry bulb) at 0.03 ppm
August 31, 2005 OPP-2005-0223

Pesticide Emergency Exemptions:

• Colorado. Crisis: On May 16, 2005, for the use of fluroxypyr on onions to control volunteer potatoes. This program ended on July 15, 2005. Contact: (Stacey Groce).

Feb 10, 2005 OPP-2005-0025 Removal of Expired Time-limited Tolerances for Emergency Exemptions. FINAL RULE.
• 10. Fluroxypyr 1-methylheptyl ester. Time-limited tolerances for
cattle kidney, goat kidney, grass forage and hay, hog kidney, horse
kidney, milk and sheep kidney
are being removed
from Sec. 180.535
because they expired on December 31, 2004.

Jan 26, 2005


Pesticide Tolerances for Emergency Exemptions. FINAL RULE.
EPA, on its own initiative, in accordance with sections 408(e) and 408(l)(6) of the Federal Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a, is establishing a tolerance for combined residues of the herbicide fluroxypyr 1-methylheptyl ester 1-methylheptyl ((4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy)acetate and its metabolite fluroxypyr [((4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy)acetic acid], in or on

onion 0.02 ppm

This tolerance will expire and is revoked on June 30, 2007.

Although this tolerance will expire and is revoked on June 30, 2007, under section 408(l)(5) of the FFDCA, residues of the pesticide not in excess of the amounts specified in the tolerance remaining in or on onion after that date will not be unlawful, provided the pesticide is applied in a manner that was lawful under FIFRA, and the residues do not exceed a level that was authorized by this tolerance at the time of that application. EPA will take action to revoke this tolerance earlier if any experience with, scientific data on, or other relevant information on this pesticide indicate that the residues are not safe.

Because this tolerance is being approved under emergency conditions identified in the state of Colorado, EPA has not made any decisions about whether fluroxypyr 1-methylheptyl ester meets EPA's registration requirements for use on onion or whether a permanent tolerance for this use would be appropriate.

Nov 10, 2004 OPP-2004-0232

One Pesticide Emergency Exemption.
Colorado - Crisis: On June 21, 2004, for the use of fluroxypyr on onions to control volunteer potatoes. This program ended on July 21, 2004. Contact: (Stacey Groce)

•• Note: Due to length, the above is a partial list. Click here to see full list of FR entries.

Fluoride Action Network | Pesticide Project | 315-379-9200 | pesticides@fluoridealert.org