Fluroxypyr 1-Methylheptyl ester
CAS No. 81406-37-3

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Adverse Effects
MSDS & Labels

ACTIVITY: Herbicide

Systemic Name: 1-Methylheptyl ((4-amino-3,5-dichloro-6-fluoropyridin-2-yl)oxy)acetate

NOTES: When Fluroxypyr is normally used as a salt or an ester, the identity of which should be stated, for example fluroxypyr-butoxypropyl [154486-27-8], fluroxypyr-meptyl [81406-37-3].


Adverse Effects:

Endocrine: Adrenal
Endocrine: Testicular


Environmental Effects:

Highly Toxic to Crustaceans and Zooplankton

Slightly to Highly Toxic to Fish

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 128968 
US Tolerances: CFR 180.535 
Registered use in
(includes only a limited list of countries)

Australia, Canada, Hungary, US
US Maximum Residue Levels permitted in food commodities
Permitted in or on 54 food commodities, including:
Aspirated grain fractions,
Barley (forage, grain, hay, straw),
Cattle (fat, kidney, meat, meat byproducts),
Corn (Field: forage, grain, stover; Sweet (forage, kernels, stover),
Goat (fat, kidney, meat, meat byproducts),
Grass (forage and hay),
Hog (fat, kidney, mean, meat byproducts),
Horse (fat, kidney, meat, meat byproducts),
Milk, Oat (forage, grain, hay, straw), Onion,
Sheep (fat, kidney, meat, meat byproducts),
Wheat (forage, grain, hay, straw)
Other Information
Molecular Formula: C15-H21-Cl2-F-N2-O3
Manufacturers: DowAgro 
Other Names:

Starane + saber
Starane plus salvo
Starance plus sword.




Manufacture site: ISRAEL:
Agan Chemical, Ashdod

Dow Elanco, Drusenheim
Of special interest:
PAN Data 
Material Safety Data Sheets & Labels
See also Fluroxypyr
Australia: Time-limited permit from 10 November 2003 to 31 October 2005 for use of the pesticide product Starane 200 Herbicide on Non-Crop Areas. (Note: Victoria is not included in this permit because their ‘control-of-use’ legislation means that a permit is not required to legalise this off-label use in VIC).
June 2002 - In Australia when Fluroxypyr is used as a "Herbicide on poppies" no maximum residue levels are required. Ref: June 2002. Table 5. Uses of substances where maximum residue limits are not necessary. Australian National Registration Authority for Agricultural Veterinary Chemicals. The MRL Standard. Maximum residue limits in food and animal feedstuff. http://www.nra.gov.au/residues/mrl5.pdf  
September 30, 1998 - Pesticide Fact Sheet. US EPA 
October 2001 - Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.  

US Federal Register

•• Note: Due to length, the following is a partial list. Click here to see full list of FR entries.

Date Published Docket Identification Number Details
August 25, 2006 EPA-HQ-OPP-2006-0659 Pesticide Emergency Exemptions; Agency Decisions and State and Federal Agency Crisis Declarations
• Colorado: EPA authorized the use of fluroxypyr on onions to control volunteer potatoes; June 6, 2006 to July 31, 2006.
April 21, 2006 EPA-HQ-OPP-2005-0536 IR-4 and Dow AgroSciences. Pesticide petition: PP 3E6775.
proposal to establish a tolerance for the combined residues of the herbicide fluroxypyr MHE and its metabolite fluroxypyr (expressed as total fluroxypyr) in or on food commodities
-- garlic and shallot (bulb) at 0.03 ppm
-- onion (dry bulb) at 0.03 ppm
Feb 10, 2005 OPP-2005-0025 Removal of Expired Time-limited Tolerances for Emergency Exemptions. FINAL RULE.
• 10. Fluroxypyr 1-methylheptyl ester. Time-limited tolerances for
cattle kidney, goat kidney, grass forage and hay, hog kidney, horse
kidney, milk and sheep kidney
are being removed
from Sec. 180.535
because they expired on December 31, 2004.

Jan 26, 2005


Pesticide Tolerances for Emergency Exemptions. FINAL RULE.
EPA, on its own initiative, in accordance with sections 408(e) and 408(l)(6) of the Federal Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a, is establishing a tolerance for combined residues of the herbicide fluroxypyr 1-methylheptyl ester 1-methylheptyl ((4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy)acetate and its metabolite fluroxypyr [((4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy)acetic acid], in or on

onion 0.02 ppm

This tolerance will expire and is revoked on June 30, 2007.

Although this tolerance will expire and is revoked on June 30, 2007, under section 408(l)(5) of the FFDCA, residues of the pesticide not in excess of the amounts specified in the tolerance remaining in or on onion after that date will not be unlawful, provided the pesticide is applied in a manner that was lawful under FIFRA, and the residues do not exceed a level that was authorized by this tolerance at the time of that application. EPA will take action to revoke this tolerance earlier if any experience with, scientific data on, or other relevant information on this pesticide indicate that the residues are not safe.

Because this tolerance is being approved under emergency conditions identified in the state of Colorado, EPA has not made any decisions about whether fluroxypyr 1-methylheptyl ester meets EPA's registration requirements for use on onion or whether a permanent tolerance for this use would be appropriate.

Jan 14, 2004 OPP-2003-0402

Extension of Tolerances for Emergency Exemptions. FINAL RULE. EPA has authorized under FIFRA
section 18 the use of fluroxypyr 1-methylheptyl ester on field corn and sweet corn for control of volunteer potatoes in Washington, Oregon, Idaho, and Wisconsin. This regulation extends time-limited tolerances for residues of the herbicide fluroxypyr 1-methylheptyl ester and its metabolite fluroxypyr in or on

corn, sweet, K + CWHR 0.05 ppm
corn, sweet, forage 2.0 ppm
corn, sweet, stover 2.5 ppm
corn, field, grain 0.05 ppm
corn, field, forage 2.0 ppm
corn, field, stover 2.5 ppm

for an additional 3-year period. These tolerances will expire and are revoked on December 31, 2006. Time-limited tolerances were originally published in the Federal Register of August 5, 1998

Dec 31, 2003 OPP-2003-0377

Dow AgroSciences. Pesticide tolerance. FINAL RULE. Tolerances are established for combined residues of fluroxypyr 1-methylheptyl ester and its metabolite Fluroxypyr [((4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy) acetic acid], free and conjugated, all expressed as fluroxypyr.
-- 870.4300 Carcinogenicity--Rats NOAEL = 100 mg/kg/day. LOAEL = 500 mg/kg/day based on chronic progressive kidney glomerulonephropathy. no evidence of carcinogenicity
-- 870.3800 Reproduction and fertility Parental/Systemic NOAEL = 100 mg/kg/day effects (Males) / 500 mg/kg/day (Females) LOAEL = 500 mg/kg/day (Males) / 1,000 mg/kg/ day (Females), based on kidney effects (M&;F) and increased deaths (F).

Commodity PPM
Cattle, kidney 1.5
Corn, field, forage 1.0
Corn, field, grain 0.02
Corn, field, stover 0.5
Corn, sweet, forage 1.0
Corn, sweet, kernel plus cob with husks removed 0.02
Corn, sweet, stover 2.0
Goat, kidney 1.5
Grass, forage 120
Grass, hay 160
Hog, kidney 1.5
Horse, kidney 1.5
Milk 0.3
Sheep, kidney 1.5
Sorghum, grain, forage 2.0
Sorghum, grain, grain 0.02
Sorghum, grain, stover 4.0

i. Additional field trials - conduct and submit four (4) additional field trials in Regions III (1 trial), V(1 trial), XI(1 trial), and XII(1 trial). Residue analysis of sweet corn field trial samples should avoid using the DowElanco Method ACR 90.8, due to matrix interference cited in PP#2G04066.
ii. Storage stability data - submit to support the sweet corn field trial data.

iii. 28-Day Inhalation Toxicity Study

•• Note: Due to length, the above is a partial list. Click here to see full list of FR entries.

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