Adverse Effects
CAS No. 26399-36-0


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Activity: Herbicide (2,6-Dinitroaniline)

Adverse Effects:

• Very little toxicological data accessible.

• WHO: believed obsolete or discontinued

Cancer (click on for all fluorinated pesticides)

Abstract: TD3: The Health and Environmental Effects Profile for profluralin was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Resource Conservation and Recovery Act (RCRA). Both published literature and information obtained from Agency program office files were evaluated as the authors pertained to potential human health, aquatic life and environmental effects of hazardous waste constituents. Quantitative estimates have been presented provided sufficient data are available. Profluralin has been evaluated as a carcinogen. The human carcinogen potency factor (q(l)*) for profluralin is .028 (mg/kg bw/day)-1 for oral exposure.
Ref: Health and Environmental Effects Profile for Profluralin. US EPA. 1988. NTIS/PB88-162334, 26p

Liver (click on for all fluorinated pesticides)

(FAN NOTE: Very little Tox data available)
-- Lifetime feeding studies with high dose levels of profluralin technical have produced an increased incidence of hepatic tumors in mice.
Ref: March 1985. Profile of Herbicide (Tolban). Pesticide Management Education Program at Cornell Univeris

[The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 5: A Review of the Literature Published during 1976 and 1977. London: The Chemical Society, 1979. 487]
-- Profluralin was extensively metabolized in vitro by normal and phenobarbital-induced rat liver microsomes. Metabolites produced indicated that profluralin metabolism involved N-dealkylation, aliphatic hydroxylation, nitro reduction and cyclization. Analyses ... indicated the formation of 2,6-dinitro-N-(n-propan-3-ol)-alpha,alpha,alpha-trifluoro-p-toluidine and the corresponding N-(n-propan-2-ol) analog. N-dealkylation of profluralin gave the des-n-propyl and di-dealkylated analogs and 2-ethyl-7-nitro-5-trifluoromethyl benzimidazole ...
[Menzie, C.M. Metabolism of Pesticides-Update III. Special Scientific Report- Wildlife No. 232. Washington, DC: U.S.Department of the Interior, Fish and Wildlife Service, 1980. 254]
Ref. Hazardous Substances Data Bank for PROFLURALIN CASRN: 26399-36-0.

Environmental (click on for all fluorinated pesticides)

--Toxic to Honey Bees
-- Very High Bioconcentration in Aquatic Organisms

-- Environmental Bioconcentration: An estimated BCF value of 10,200 was calculated for profluralin(SRC), using an experimental log Kow of 5.58(1) and a recommended regression-derived equation(2). According to a classification scheme, this BCF value suggests that bioconcentration in aquatic organisms will be very high(3). [(1) Ellgehausen H et al; Pestic Sci 12: 219-27 (1981)(2) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington DC: Amer Chem Soc pp. 5-4, 5-10 (1990) (3) Franke C et al; Chemosphere 29: 1501-14 (1994)]
Ref: TOXNET profile from Hazardous Substances Data Bank.

Abstract: HEEP COPYRIGHT: BIOL ABS. The persistence and phytotoxicity of dinitramine (n4,N4-diethyl-alpha,alpha,alpha-trifluoro-3,5-dinitrotoluene-2,4-diamine), fluchloralin (N-(2-chloroethyl)-2, 6-dinitro- N-propyl-4- (trifluoromethyl)aniline), profluralin (N-(cyclopropylmethyl)alpha,alpha,alpha-trifluoro-2, 6-dinitro-N-propyl-p-toluidine) and trifluralin (alpha,alpha,alpha-trifluoro-2,6-dinitro-N-N-dipropyl-p-toluidine) were compared in 3 Manitoba soils: sandy loam, clay loam and clay. The phytotoxicities of all chemicals decreased with increased organic matter. The phytotoxicities of the dinitroanilines were: dinitramine > trifluralin > profluralin = fluchloralin. Increased organic matter increased the persistence of trifluralin and fluchloralin. Profluralin and dinitramine persistence increased with increased clay and organic matter content. Profluralin was the most persistent chemical over all soil types. Under environmental conditions that retard dinitroaniline loss from Manitoba soils, residues of some of these herbicides may cause crop injury the year after application.
Ref: PRITCHARD MK et al. (1980). Persistence and phytotoxicity of dinitroaniline herbicides in Manitoba, Canada, soils. CAN J PLANT SCI; 60 (1). 1980. 5-12.

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