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Profluralin. TOXNET profile from Hazardous Substances Data Bank.


See for Updates: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB

PROFLURALIN
CASRN: 26399-36-0
For other data, click on the Table of Contents

Human Health Effects:

Emergency Medical Treatment:

Emergency Medical Treatment:

EMT Copyright Disclaimer:
Portions of the POISINDEX(R) database are provided here for general reference. THE COMPLETE POISINDEX(R) DATABASE, AVAILABLE FROM MICROMEDEX, SHOULD BE CONSULTED FOR ASSISTANCE IN THE DIAGNOSIS OR TREATMENT OF SPECIFIC CASES. Copyright 1974-1998 Micromedex, Inc. Denver, Colorado. All Rights Reserved. Any duplication, replication or redistribution of all or part of the POISINDEX(R) database is a violation of Micromedex' copyrights and is strictly prohibited.

The following Overview, *** GENERAL OR UNKNOWN CHEMICAL ***, is relevant for this HSDB record chemical.

Life Support:
  o   This overview assumes that basic life support measures
      have been instituted.                           
Clinical Effects:
  SUMMARY OF EXPOSURE
   0.2.1.1 ACUTE EXPOSURE
     o   A SPECIFIC REVIEW on the clinical effects and treatment
         of individuals exposed to this agent HAS NOT YET BEEN
         PREPARED.  The following pertains to the GENERAL
         EVALUATION and TREATMENT of individuals exposed to
         potentially toxic chemicals.
     o   GENERAL EVALUATION -
      1.  Exposed individuals should have a careful, thorough
          medical history and physical examination performed,
          looking for any abnormalities.  Exposure to chemicals
          with a strong odor often results in such nonspecific
          symptoms as headache, dizziness, weakness, and nausea.
     o   IRRITATION -
      1.  Many chemicals cause irritation of the eyes, skin, and
          respiratory tract.  Respiratory tract irritation, if
          severe, can progress to pulmonary edema, which may be
          delayed in onset for up to 24 to 72 hours in some
          cases.
      2.  Irritation or burns of the esophagus or
          gastrointestinal tract are also possible if caustic or
          irritant chemicals are ingested.
     o   HYPERSENSITIVITY -
      1.  A number of chemical agents produce an allergic
          hypersensitivity dermatitis or asthma with
          bronchospasm and wheezing with chronic exposure.
Laboratory:
  o   A number of chemicals produce abnormalities of the
      hematopoietic system, liver, and kidneys.  Monitoring
      complete blood count, urinalysis, and liver and kidney
      function tests is suggested for patients with significant
      exposure.
  o   If respiratory tract irritation or respiratory depression
      is evident, monitor arterial blood gases, chest x-ray, and
      pulmonary function tests.                 
Treatment Overview:
  SUMMARY EXPOSURE
    o   A specific review on the clinical effects and treatment
        of individuals exposed to this agent has not yet been
        prepared.  The following pertains to the general
        evaluation and treatment of individuals exposed to
        potentially toxic chemicals.
    o   Move victims of inhalation exposure from the toxic
        environment and administer 100% humidified supplemental
        oxygen with assisted ventilation as required.  Exposed
        skin and eyes should be copiously flushed with water.
     1.  Rescuers must not enter areas with potential high
         airborne concentrations of this agent without
         SELF-CONTAINED BREATHING APPARATUS (SCBA) to avoid
         becoming secondary victims.
    o   Measures to decrease absorption may be useful.  The
        decision to induce or not to induce emesis in ingestions
        must be carefully considered.  If the patient has any
        signs of esophageal or gastrointestinal tract irritation
        or burns, or has evidence of a decreased sensorium, a
        depressed gag reflex, or impending shock, INDUCED EMESIS
        SHOULD BE AVOIDED.
  ORAL EXPOSURE
    o   GASTRIC LAVAGE
     1.  Significant esophageal or gastrointestinal tract
         irritation or burns may occur following ingestion.  The
         possible benefit of early removal of some ingested
         material by cautious gastric lavage must be weighed
         against potential complications of bleeding or
         perforation.
     2.  GASTRIC LAVAGE:  Consider after ingestion of a
         potentially life-threatening amount of poison if it can
         be performed soon after ingestion (generally within 1
         hour).  Protect airway by placement in Trendelenburg
         and left lateral decubitus position or by endotracheal
         intubation.  Control any seizures first.
      a.  CONTRAINDICATIONS:  Loss of airway protective reflexes
          or decreased level of consciousness in unintubated
          patients; following ingestion of corrosives;
          hydrocarbons (high aspiration potential); patients at
          risk of hemorrhage or gastrointestinal perforation;
          and trivial or non-toxic ingestion.
    o   ACTIVATED CHARCOAL
     1.  Activated charcoal binds most toxic agents and can
         decrease their systemic absorption if administered soon
         after ingestion.  In general, metals and acids are
         poorly bound and patients ingesting these materials
         will not likely benefit from activated charcoal
         administration.
      a.  Activated charcoal should not be given to patients
          ingesting strong acidic or basic caustic chemicals.
          Activated charcoal is also of unproven value in
          patients ingesting irritant chemicals, where it may
          obscure endoscopic findings when the procedure is
          justified.
     2.  ACTIVATED CHARCOAL:  Administer charcoal as slurry (240
         mL water/30 g charcoal).  Usual dose:  25 to 100 g in
         adults/adolescents, 25 to 50 g in children (1 to 12
         years), and 1 g/kg in infants less than 1 year old.
    o   DILUTION -
     1.  Immediate dilution with milk or water may be of benefit
         in caustic or irritant chemical ingestions.
     2.  DILUTION:  Following ingestion and/or prior to gastric
         evacuation, immediately dilute with 4 to 8 ounces (120
         to 240 mL) of milk or water (not to exceed 15 mL/kg in
         a child).
    o   IRRITATION -
     1.  Observe patients with ingestion carefully for the
         possible development of esophageal or gastrointestinal
         tract irritation or burns.  If signs or symptoms of
         esophageal irritation or burns are present, consider
         endoscopy to determine the extent of injury.
    o   OBSERVATION CRITERIA -
     1.  Carefully observe patients with ingestion exposure for
         the development of any systemic signs or symptoms and
         administer symptomatic treatment as necessary.
     2.  Patients symptomatic following exposure should be
         observed in a controlled setting until all signs and
         symptoms have fully resolved.
  INHALATION EXPOSURE
    o   DECONTAMINATION -
     1.  INHALATION:  Move patient to fresh air.  Monitor for
         respiratory distress.  If cough or difficulty breathing
         develops, evaluate for respiratory tract irritation,
         bronchitis, or pneumonitis.  Administer oxygen and
         assist ventilation as required.  Treat bronchospasm
         with beta2  agonist and corticosteroid aerosols.
    o   IRRITATION -
     1.  Respiratory tract irritation, if severe, can progress
         to pulmonary edema which may be delayed in onset up to
         24 to 72 hours after exposure in some cases.
    o   PULMONARY EDEMA/NON-CARDIOGENIC -
     1.  PULMONARY EDEMA (NONCARDIOGENIC):  Maintain ventilation
         and oxygenation and evaluate with frequent arterial
         blood gas or pulse oximetry monitoring.  Early use of
         PEEP and mechanical ventilation may be needed.
    o   BRONCHOSPASM -
     1.  If bronchospasm and wheezing occur, consider treatment
         with inhaled sympathomimetic agents.
    o   OBSERVATION CRITERIA -
     1.  Carefully observe patients with inhalation exposure for
         the development of any systemic signs or symptoms and
         administer symptomatic treatment as necessary.
     2.  Patients symptomatic following exposure should be
         observed in a controlled setting until all signs and
         symptoms have fully resolved.
  EYE EXPOSURE
    o   DECONTAMINATION:  Irrigate exposed eyes with copious
        amounts of tepid water for at least 15 minutes.  If
        irritation, pain, swelling, lacrimation, or photophobia
        persist, the patient should be seen in a health care
        facility.
  DERMAL EXPOSURE
    o   DERMAL DECONTAMINATION -
     1.  DECONTAMINATION:  Remove contaminated clothing and wash
         exposed  area thoroughly with soap and water.  A
         physician may need to  examine the area if irritation
         or pain persists.
    o   PESTICIDES -
     1.  DECONTAMINATION:  Remove contaminated clothing and
         jewelry.  Wash  the skin, including hair and nails,
         vigorously; do repeated soap washings.  Discard
         contaminated clothing.
    o   IRRITATION -
     1.  Treat dermal irritation or burns with standard topical
         therapy.  Patients developing dermal hypersensitivity
         reactions may require treatment with systemic or
         topical corticosteroids or antihistamines.
    o   DERMAL ABSORPTION -
     1.  Some chemicals can produce systemic poisoning by
         absorption through intact skin.  Carefully observe
         patients with dermal exposure for the development of
         any systemic signs or symptoms and administer
         symptomatic treatment as necessary.  
Range of Toxicity:
  o   No specific range of toxicity can be established for the
      broad field of chemicals in general.          

[Rumack BH: POISINDEX(R) Information System. Micromedex, Inc., Englewood, CO, 2001; CCIS Volume 110, edition exp November, 2001. Hall AH & Rumack BH (Eds):TOMES(R) Information System. Micromedex, Inc., Englewood, CO, 2001; CCIS Volume 110, edition exp November, 2001.] **PEER REVIEWED**

Antidote and Emergency Treatment:

1. WASH CONTAMINATED SKIN WITH SOAP & WATER. 2. FLUSH CONTAMINATED EYES WITH COPIOUS AMT OF FRESH WATER FOR 15 MIN. 3. INGESTIONS OF SMALL AMT (LESS THAN 10 MG/KG BODY WT) OCCURRING LESS THAN AN HR BEFORE TREATMENT, ARE PROBABLY BEST TREATED BY: A. SYRUP OF IPECAC, FOLLOWED BY 1-2 GLASSES OF WATER. DOSE FOR ADULTS & CHILDREN OVER 12 YR: 30 ML. DOSE FOR CHILDREN UNDER 12 YR: 15 ML. B. ACTIVATED CHARCOAL ADMIN.../PRC- 30 G IN 3-4 OZ OF WATER (CHILDREN), 100 G IN 8-10 OZ OF WATER (ADULTS)/. C. SODIUM OR MAGNESIUM SULFATE, 0.25 G/KG IN TAP WATER, AS A CATHARTIC. /PESTICIDES OF LOW OR MODERATE TOXICITY/
[Morgan, D.P. Recognition and Management of Pesticide Poisonings. EPA 540/9-80-005. Washington, DC: U.S. Government Printing Office, Jan. 1982. 86]**PEER REVIEWED**

4. INGESTIONS OF LARGE AMT (MORE THAN 10 MG/KG) OCCURRING LESS THAN AN HR BEFORE TREATMENT, SHOULD PROBABLY BE TREATED BY GASTRIC LAVAGE: A. INTUBATE STOMACH & ASPIRATE CONTENTS. B. LAVAGE STOMACH WITH SLURRY OF ACTIVATED CHARCOAL.../PRC- 30 G IN 3-4 OZ OF WATER (CHILDREN), 100 G IN 8-10 OZ OF WATER (ADULTS)/. LEAVE 30-50 G ACTIVATED CHARCOAL IN THE STOMACH BEFORE WITHDRAWING TUBE. C. SODIUM SULFATE, 0.25 G/KG IN TAP WATER, AS A CATHARTIC. /PESTICIDES OF LOW OR MODERATE TOXICITY/
[Morgan, D.P. Recognition and Management of Pesticide Poisonings. EPA 540/9-80-005. Washington, DC: U.S. Government Printing Office, Jan. 1982. 87]**PEER REVIEWED**

CAUTION: HYDROCARBONS (KEROSENE, PETROLEUM DISTILLATES) ARE INCL IN SOME FORMULATIONS... INGESTION OF VERY LARGE AMT MAY CAUSE CNS DEPRESSION. IN THIS CASE, IPECAC IS CONTRAINDICATED. ALSO, GASTRIC INTUBATION INCURS RISK OF...PNEUMONITIS. FOR THIS REASON...(1) IF VICTIM IS UNCONSCIOUS OR OBTUNDED & FACILITIES ARE AT HAND, INSERT AN ENDOTRACHEAL TUBE (CUFFED, IF AVAIL) PRIOR TO GASTRIC INTUBATION. (2) KEEP VICTIM'S HEAD BELOW LEVEL OF STOMACH DURING INTUBATION & LAVAGE (TRENDELENBURG, OR LEFT LATERAL DECUBITUS, WITH HEAD OF TABLE TIPPED DOWNWARD). KEEP VICTIM'S HEAD TURNED TO LEFT. (3) ASPIRATE PHARYNX AS REGULARLY AS POSSIBLE TO REMOVE GAGGED OR VOMITED STOMACH CONTENTS. /PESTICIDES OF LOW OR MODERATE TOXICITY/
[Morgan, D.P. Recognition and Management of Pesticide Poisonings. EPA 540/9-80-005. Washington, DC: U.S. Government Printing Office, Jan. 1982. 87]**PEER REVIEWED**

5. INGESTIONS OCCURRING MORE THAN AN HR BEFORE TREATMENT ARE PROBABLY BEST TREATED ONLY BY ACTIVATED CHARCOAL../PRC- 30 G IN 3-4 OZ WATER (CHILDREN), 100 G IN 8-10 OZ WATER (ADULTS)/ & SODIUM OR MAGNESIUM SULFATE, 0.25 G/KG, AS DESCRIBED ABOVE. 6. THERE IS NO SPECIFIC ANTIDOTE FOR THESE CHEMICALS. BECAUSE MANIFESTATIONS OF TOXICITY DO OCCASIONALLY OCCUR IN PECULIARLY PREDISPOSED INDIVIDUALS, MAINTAIN CONTACT WITH VICTIM FOR AT LEAST 72 HR SO THAT UNEXPECTED ADVERSE EFFECTS CAN BE TREATED PROMPTLY. /PESTICIDES OF LOW OR MODERATE TOXICITY/
[Morgan, D.P. Recognition and Management of Pesticide Poisonings. EPA 540/9-80-005. Washington, DC: U.S. Government Printing Office, Jan. 1982. 87]**PEER REVIEWED**


Animal Toxicity Studies:

Non-Human Toxicity Excerpts:

IT IS...TOXIC TO HONEY BEES.
[Worthing, C. R. (ed.). Pesticide Manual. 6th ed. Worcestershire, England: British Crop Protection Council, l979. 439]**PEER REVIEWED**

THE INFLUENCE OF SGA-10832 ON RHIZOPODA, FLAGELLATA & INFUSORIA WAS STUDIED IN THE UPPER 20-CM LAYER OF CHERNOZEM TYPE SOIL AT DIFFERENT DATES AFTER TREATMENT IN EARLY MAY. WHEN APPLIED AT A RATE OF 250 CC/10 SQ M, IT HAD AN INHIBITORY EFFECT ON THE RHIZOPODS AND FLAGELLATES, WHILE THE INFUSORIA POPULATION REMAINED UNCHANGED.
[MITEVA D; EKOLOGIYA 2: 56-60 (1976)]**PEER REVIEWED**

THE EFFECT OF A PRE-EMERGENCE HERBICIDE ON THE GROWTH OF ROTTBOELLIA EXALTATA WAS DETERMINED USING DIFFERENT CONCN OF PROFLURALIN. CONCN OF 5, 10, 25 AND 50 PPM INDUCED INHIBITION OF ROOT AND SHOOT GROWTH ACCOMPANIED BY SWELLING OF ROOT TIPS AND COLEOPTILAR NODES. ABNORMAL ENLARGEMENT OF THE CELLS WAS APPARENT IN ALL SWOLLEN TISSUES. MULTI-NUCLEARITY OF THE CELLS IN THE PERICYCLIC LAYER & INCR IN THE NUMBER OF ROOT & LEAF PRIMORDIUM INITIALS WERE OBSERVED.
[IGNACIO-GALINATO M; ANN TROP RES 2 (4): 219-23 (1980)]**PEER REVIEWED**


Non-Human Toxicity Values:

LD50 Rat oral about 10000 mg/kg
[Worthing, C. R. (ed.). Pesticide Manual. 6th ed. Worcestershire, England: British Crop Protection Council, l979. 439]**PEER REVIEWED**

LD50 Rat percutaneous greater than 3170 mg/kg
[Worthing, C. R. (ed.). Pesticide Manual. 6th ed. Worcestershire, England: British Crop Protection Council, l979. 439]**PEER REVIEWED**


Metabolism/Pharmacokinetics:

Metabolism/Metabolites:

PRESENT DATA INDICATE THAT MINUTE QUANTITIES OF POLAR METABOLITES ARE GENERATED IN COTTON AND SOYBEANS.
[Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983. 388]**PEER REVIEWED**

...IN RAT-LIVER MICROSOMES...PROFLURALIN WAS METABOLIZED ANALOGOUSLY /TO TRIFLURALIN, BY HYDROXYLATION OF THE PROPYL RESIDUE AND/OR N-DEALKYLATION/... THE BENZIMIDAZOLE WAS A METABOLITE.
[The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 5: A Review of the Literature Published during 1976 and 1977. London: The Chemical Society, 1979. 487]**PEER REVIEWED**

Profluralin was extensively metabolized in vitro by normal and phenobarbital-induced rat liver microsomes. Metabolites produced indicated that profluralin metabolism involved N-dealkylation, aliphatic hydroxylation, nitro reduction and cyclization. Analyses ... indicated the formation of 2,6-dinitro-N-(n-propan-3-ol)-alpha,alpha,alpha-trifluoro-p-toluidine and the corresponding N-(n-propan-2-ol) analog. N-dealkylation of profluralin gave the des-n-propyl and di-dealkylated analogs and 2-ethyl-7-nitro-5-trifluoromethyl benzimidazole ... .
[Menzie, C.M. Metabolism of Pesticides-Update III. Special Scientific Report- Wildlife No. 232. Washington, DC: U.S.Department of the Interior, Fish and Wildlife Service, 1980. 254]**PEER REVIEWED**

The metabolism of profluralin was studied in rats. Male Sprague-Dawley rats were administered 1 g/kg or 600 mg/kg profluralin by stomach tube. Bulk urine samples were collected from rats given 600 mg/kg profluralin for 2 weeks and analyzed for metabolites using chromatographic methods fluorine-l9 nuclear magnetic resonance spectroscopy and mass spectrometry. Urine samples were collected 4, 13, 56, or 72 hr after dosing from rats given 1 g/kg profluralin to study the time course of metabolite excretion. At least 20 metabolites were detected in the bulk urine samples from their nuclear magnetic resonance chemica1 shifts. A didea1ky1ated monoreduced compound was the major metabolite. A hydroxylamine derivative was the first and major profluralin metabolite observed during the first 4 hr after dosing. 2-Diamino-4-(trifluoromethyl)-6-nitro-benzenamine was the major metabolite at later times. Approximately 10 to 15 percent of the profluralin dose was excreted during the first 72 hours after dosing. /It was/ concluded that profluralin is metabolized by rats into many species that can be distinguished on the basis of their fluorine-19 chemical shifts. Fluorine-19 nuclear magnetic resonance spectroscopy is a feasib1e technique for detecting fluorine containing species in biological fluids and monitorinq the time course of their appearance.
[Jacobson AR, Gerig JT; Chemical Research in Toxicology 1 (5): 304-11 (1988)]**PEER REVIEWED**


Absorption, Distribution & Excretion:

ROOTS OR SHOOTS OF OATS AND PEAS WERE EXPOSED TO VAPORS OF (14)C-LABELED PROFLURALIN. THE HERBICIDE WAS ABSORBED BY ROOTS AND SHOOTS OF GERMINATING OATS AND PEAS. SOME ROOT-SHOOT TRANSLOCATION WAS OBSERVED IN PEAS, BUT NO SHOOT-ROOT TRANSPORT COULD BE DETECTED IN EITHER PEAS OR OATS. IN PEAS, (14)C FROM ROOT-ABSORBED PROFLURALIN WAS DETECTED IN SHOOTS.
[JACQUES GL, HARVEY RG; WEED SCI 27 (4): 371-4 (1979)]**PEER REVIEWED**

SORGHUM, BARNYARDGRASS, SOYBEAN, AND PALMER AMARANTH WERE TREATED WITH (14)C-LABELED PROFLURALIN IN NUTRIENT SOLN FOR 24 HR @ 26 OR 38 DEG C. PROFLURALIN ACCUM IN ROOTS TO A GREATER EXTENT AT 16 DEG, WHEREAS METAB WAS GREATEST AT 35 DEG. VERY LITTLE PROFLURALIN WAS TRANSLOCATED TO THE TOPS OF PLANTS. THESE EFFECTS MAY RELATE TO EXCESS TOXICITY OF PROFLURALIN AT 16 DEG IN SPECIES WHICH NORMALLY EXHIBIT RESISTANCE TO THE HERBICIDES.
[HAWXBY K, BASLER E; WEED SCI 24 (6): 545-8 (1976)]**PEER REVIEWED**


Mechanism of Action:

CGA-10832 (AT 1X10-6 MOLAR) INHIBITED CYCLIC PHOTOPHOSPHORYLATION OF ISOLATED PEA CHLOROPLASTS AND DECR STATE-3 RESPIRATION OF BOTH ISOLATED BEAN HYPOCOTYLS AND RAT LIVER MITOCHONDRIA.
[PILLAI CGP, DAVIS DE; PROC, S WEED SCI SOC 27: 360-4 (1974)]**PEER REVIEWED**

CGA 10832 PARTIALLY INHIBITED THE PHOTOSYNTHESIS (MEASURED BY OXYGEN EVOLUTION) OF SPINACH LEAF DISCS.
[MORELAND DE ET AL; PESTIC BIOCHEM PHYSIOL 2 (3): 354-63 (1972)]**PEER REVIEWED**


Interactions:

TOBACCO TISSUE CULTURES WERE USED IN A BIOASSAY SYSTEM FOR DETERMINING THE EFFECT OF PROFLURALIN ON GROWTH. THE MOLAR CONCN REQUIRED TO INHIBIT FRESH WT GAIN BY 50% (I50) WAS DETERMINED. EXOGENOUSLY APPLIED D-ALPHA-TOCOPHEROL ACETATE AT 100 TIMES THE I50 CONCN DECR THE INHIBITION OF TISSUE GROWTH BY PROFLURALIN.
[HUFFMAN JB, CAMPER ND; WEED SCI 26 (6): 527-30 (1978)]**PEER REVIEWED**


Pharmacology:

Interactions:

TOBACCO TISSUE CULTURES WERE USED IN A BIOASSAY SYSTEM FOR DETERMINING THE EFFECT OF PROFLURALIN ON GROWTH. THE MOLAR CONCN REQUIRED TO INHIBIT FRESH WT GAIN BY 50% (I50) WAS DETERMINED. EXOGENOUSLY APPLIED D-ALPHA-TOCOPHEROL ACETATE AT 100 TIMES THE I50 CONCN DECR THE INHIBITION OF TISSUE GROWTH BY PROFLURALIN.
[HUFFMAN JB, CAMPER ND; WEED SCI 26 (6): 527-30 (1978)]**PEER REVIEWED**


Environmental Fate & Exposure:

Environmental Fate/Exposure Summary:

Profluralin's production and former use as a selective pre-planting herbicide has in the past resulted in its release to the environment through various herbicidal applications. Profluralin has been detected in one groundwater well out of 86. If released to the atmosphere, profluralin will exist in both the vapor and particulate phases. Vapor-phase profluralin will react with photochemically produced hydroxyl radicals with an estimated half-life of 167 hours. Particulate-phase profluralin may be physically removed from the air by wet and dry deposition. If released to water, profluralin will adsorb to suspended solids and sediment in the water. Profluralin may volatilize from water surfaces with estimated half-lives for a model pond of 150-178 days. Hydrolysis is expected to be very slow for profluralin in water. Bioconcentration in aquatic organisms will be an important fate process for profluralin. If released to soil, profluralin will be immobile. Volatilization from moist soil and photodegradation of profluralin may be important from soil surfaces. Profluralin is persistent in soil and may carryover to the following growing season. Biodegradation of profluralin can occur in both aerobic and anaerobic conditions but may not be important in comparison to volatility and chemical decomposition. (SRC)
**PEER REVIEWED**


Artificial Pollution Sources:

Profluralin's former production and use as a selective pre-planting herbicide(1) resulted in its release to the environment through various herbicidal applications(SRC).
[(1) Budavari S et al; The Merck Index 11th ed Rahway, NJ: Merck & Co Inc pg. 1234 (1989)]**PEER REVIEWED**


Environmental Fate:

TERRESTRIAL FATE: Experimental Koc values of 8600(2) and 10,232(3) indicate that profluralin will have no mobility in soil(SRC) according to a suggested classification scheme(1). Volatilization of profluralin may be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 3.15X10-4 atm-cu m/mole(SRC) calculated from experimental values of water solubility(5) and vapor pressure(6). Vapor losses of profluralin from moist Lakeland soil at 50 deg C approached 25 percent after 3 hours(7). A number of studies have examined the persistence (which includes degradation, chemical decomposition, and volatilization) of profluralin in soils(8-11). The following results were obtained: In Crowley silt loam used for soybeans and rice (at 0.84 kg/ha) profluralin had a half-life of approximately 11 weeks(8); at 1.5 kg/ha, 20 percent of the profluralin applied remained after one year on sandy loam, heavy clay, and silty clay(9); Profluralin remained at 90.6, 92, 72, and 84 percent of the initial concentration 48, 115, 187, and 248 days after application on a Plano silt loam at 5 deg C(10); Profluralin had half-lives of 60 and 124 days, on Bosket sandy loam and Sharkey clay, respectively(11). Photodegradation may also contribute to the loss of profluralin from soil surfaces(12-15). Biodegradation of profluralin can occur in both aerobic and anaerobic conditions but may not be important in comparison to volatility and chemical decomposition(8).
[(1) Swann RL et al; Res Rev 85: 23 (1983) (2) Kenaga EE; Ecotox Environ Safety 4: 26-38 (1980) (3) Sekusak S, Sabjlic A; J Math Chem 11: 271-80 (1992) (4) Meylan WM, Howard PH; Environ Toxicol Chem 10: 1283-93 (1991) (5) Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5 (1992) (6) Beste CE (ed); Herbicide Handbook of the Weed Science Society of America 5th ed. Champaign, IL: Weed Science Society of America pg. 386 (1983) (7) Parochetti JV et al; Weed Sci 24: 529-32 (1976) (8) Brewer F et al; Weed Sci 30: 531-9 (1982) (9) Hayden BJ, Smith AE; Can J Plant Sci 60: 311-3 (1980) (10) Jaques GL, Harvey RG; Weed Sci 27: 660-5 (1979) (11) Savage KE; Weed Sci 26: 465-71 (1978) (12) Draper WM; in ACS Symp Ser, Zika RG, Cooper WJ (eds) Washington, DC: 327 (Photochemistry of Environmental Aquatic Systems): 270-81 (1987) (13) Marcheterre L et al; Rev Environ Contam Toxicol 103: 61-125 (1988) (14) Parochetti JV, Dec GWJR; Weed Sci 26: 153-6 (1978) (15) Kennedy JM, Talbert RE; Weed Sci 25: 373-81 (1977)]**PEER REVIEWED**

AQUATIC FATE: Based on a recommended classification scheme(1), experimental Koc values of 8600(2) and 10232(3) indicate that profluralin may adsorb to suspended solids and sediment(SRC) in the water. Profluralin may volatilize from water surfaces based on an estimated Henry's Law constant of 3.15X10-4 atm-cu m/mole(SRC), calculated from its experimental values for vapor pressure, 6.9X10-5 mm Hg at 20 deg C(6), and water solubility, 0.1 mg/L at 20 deg C(7). Taking adsorption to sediment and suspended solids into account, the half-life for a model pond has been estimated to be 150-178 days(5,SRC). An estimated BCF value of 10,200(6,SRC), from an experimental log Kow(4), suggests that bioconcentration of profluralin in aquatic organisms will be very high(SRC) according to a classification scheme(9). At 20 deg C, hydrolysis half-lives for profluralin were: 29 days at a pH of 13, 150 days at a pH of 1, and 1200 days in deionized water(10). Biodegradation of profluralin can occur in both aerobic and anaerobic conditions but may not be important in comparison to volatility and chemical decomposition(11).
[(1) Swann RL et al; Res Rev 85: 23 (1983) (2) Kenaga EE; Ecotoxicol Environ Safety 4: 26-38 (1980) (3) Sekusak S, Sabjlic A; J Math Chem 11: 271-80 (1992) (4) Ellgehausen H et al; Pestic Sci 12: 219-27 (1981) (5) US EPA; EXAMS II Computer Simulation (1987) (6) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington DC: Amer Chem Soc pp. 4-9, 5-4, 5-10, 15-1 to 15-29 (1990) (7) Beste CE (ed); Herbicide Handbook of the Weed Science Society of America 5th ed. Champaign, IL: Weed Science Society of America pg. 386 (1983) (8) Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5 (1992) (9) Franke C et al; Chemosphere 29: 1501-14 (1994) (10) Menzie CM; Metabolism of Pesticides Update III. NTIS PB83-165498. Washington DC: Fish and Wildlife Service pp. 743 (1980) (11) Brewer F et al; Weed Sci 30: 531-9 (1982)]**PEER REVIEWED**

ATMOSPHERIC FATE: According to a suggested classification scheme(1), an experimental vapor pressure of 6.9X10-5 mm Hg at 20 deg C(2) indicates that profluralin will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase profluralin is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 17 hours(3,SRC). Particulate-phase profluralin may be physically removed from the air by wet and dry deposition(SRC).
[(1) Bidleman TF; Environ Sci Technol 22: 361-367 (1988) (2) Beste CE (ed); Herbicide Handbook of the Weed Science Society of America 5th ed. Champaign, IL: Weed Science Society of America pg. 386 (1983) (3) Meylan WM, Howard PH; Chemosphere 26: 2293-99 (1993)]**PEER REVIEWED**


Environmental Biodegradation:

INVESTIGATIONS WERE CARRIED OUT ON THE DEGRADATION OF PROFLURALIN BY SOIL MICROORGANISMS. THE MOST ACTIVE DEGRADERS WERE TENTATIVELY IDENTIFIED AS ARTHROBACTER SIMPLEX, CELLULOMONAS FLAVIGENUM, AND MICROBACTERIUM FLAVUM. STEPS IN THE DEGRADATION PATHWAY INVOLVE DEALKYLATION OF THE AMINO NITROGEN AND REDN OF AT LEAST ONE OF THE NITRO GROUPS. CO-METABOLIC PROCESSES WERE APPARENTLY INVOLVED, & EXOGENOUS CARBON AND NITROGEN WERE REQUIRED FOR DEGRADATION.
[STRALKA KA, CAMPER ND; MICROBIAL DEGRADATION OF PROFLURALIN; SOIL BIOL BIOCHEM 13 (1): 33-8 (1981)]**PEER REVIEWED**

SAMPLES OF (14)C-LABELED PROFLURALIN WERE INCUBATED WITH SEWAGE AEROBICALLY AND UNDER DISCONTINUOUS ANAEROBIOSIS FOR 88 DAYS AND FRESH SEWAGE WAS ADDED AT INTERVALS. YIELD OF RECOVERED PRODUCTS REACHED 87%. NONE OF THE RADIOACTIVITY FROM THE HERBICIDE ENTERED THE NUCLEOSIDE POOL OF THE SEWAGE MICROFLORA.THE LACK OF INCORPORATION OF SUBSTRATE C INTO CELLS AND THE ALMOST STOICHIOMETRIC CONVERSION OF THE SUBSTRATE TO ORGANIC PROD INDICATE THAT MEMBERS OF THE MICROBIAL COMMUNITY WERE COMETABOLIZING THE TEST CMPD.
[JACOBSON SN ET AL; EVIDENCE FOR COMETABOLISM IN SEWAGE; APPL ENVIRON MICROBIOL 40 (5): 917-21 (1980)]**PEER REVIEWED**

CGA 10832 WAS METABOLIZED BY ASPERGILLUS FUMIGATUS, FUSARIUM OXYSPORUM, AND PAECILOMYCES SPECIES FUNGI.
[LAANIO TL ET AL; MICROBIAL METABOLISM OF DINITRAMINE; PESTIC BIOCHEM PHYSIOL 3 (3): 271-7 (1973)]**PEER REVIEWED**

Profluralin has a half-life of 110 days in soil(1). Profluralin metabolites were recovered at yields of 87 and 23 percent in aerobic and discontinuous anaerobic conditions, respectively, in sewage(2). Cometabolism appears to be involved in the microbial degradation of profluralin since detection of profluralin's isolates only occurred when the cultures were provided with additional sources of nitrogen and carbon(3). Two pathways have been proposed for the degradation of dinitroaniline herbicides in soil: under aerobic conditions, the herbicides are first dealkylated and the nitro groups are reduced; under anaerobic conditions, the process is reversed(4).
[(1) Augustijn-Beckers PWM et al; Rev Environ Contam Toxicol 137: 1-82 (1994) (2) Jacobson SN et al; Appl Environ Microbiol 40: 917-21 (1980) (3) MacRae IC; Rev Environ Contam Toxicol 109: 1-87 (1989) (4) Brewer F et al; Weed Sci 30: 531-9 (1982)]**PEER REVIEWED**


Environmental Abiotic Degradation:

PROFLURALIN IS SUBJECT TO LOSS FROM THE SOIL BY VAPORIZATION AND PHOTODEGRADATION. RATE OF DISSIPATION IS MOST RAPID WHEN PROFLURALIN IS APPLIED TO A WET OR DAMP SOIL SURFACE. A HOT, PACKED, OR SMOOTH SOIL SURFACE, WIND, OR STRONG SUNLIGHT MAY ALSO STIMULATE THE RATE OF PROFLURALIN DISAPPEARANCE.
[Weed Science Society of America. Herbicide Handbook. 4th ed. Champaign, IL: Weed Science Society of America, 1979. of America, 1979. 361]**PEER REVIEWED**

The rate constant for the vapor-phase reaction of profluralin with photochemically produced hydroxyl radicals has been estimated as 2.28X10-11 cu cm/molecule-sec at 25 deg C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 17 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). At 20 deg C, hydrolysis half-lives for profluralin were: 29 days @ pH 13, 150 days @ pH 1, and 1200 days in deionized water(2). The half-life for the photodecomposition of profluralin was 44 minutes using UV light (310-410 nm)(3). After exposure to sunlight on soil thin layer plates for 7 days, profluralin did not degrade to any appreciable extent(4). Profluralin, in soil, degraded 47.6 percent in another study when exposed to sunlight after 7 days(5). Using UV light of 385-395 nm, 94 and 53 percent of the initial profluralin remained on a dry Taloka silt loam thin-layer surface at 5 and 45 deg C, respectively, after 24 hours(6). Abiotic reduction of profluralin in homogeneous solutions of quinone redox couples (used to imitate the redox-labile functional groups in natural organic matter) occurred as a second order reaction with a rate constant of 79.0 L/min mol(7).
[(1) Meylan WM, Howard PH; Chemosphere 26: 2293-99 (1993) (2) Menzie CM; Metabolism of Pesticides Update III. NTIS PB83-165498. Washington DC: Fish and Wildlife Service pp. 743 (1980) (3) Draper WM; in ACS Symp Ser, Zika RG, Cooper WJ (eds) Washington, DC: 327 (Photochemistry of Environmental Aquatic Systems): 270-81 (1987) (4) Marcheterre L et al; Rev Environ Contam Toxicol 103: 61-125 (1988) (5) Parochetti JV, Dec GWJR; Weed Sci 26: 153-6 (1978) (6) Kennedy JM, Talbert RE; Weed Sci 25: 373-81 (1977) (7) Tratnyek PG, Macalady DL; J Agric Food Chem 37: 248-54 (1989)]**PEER REVIEWED**


Environmental Bioconcentration:

An estimated BCF value of 10,200 was calculated for profluralin(SRC), using an experimental log Kow of 5.58(1) and a recommended regression-derived equation(2). According to a classification scheme, this BCF value suggests that bioconcentration in aquatic organisms will be very high(3).
[(1) Ellgehausen H et al; Pestic Sci 12: 219-27 (1981)(2) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington DC: Amer Chem Soc pp. 5-4, 5-10 (1990) (3) Franke C et al; Chemosphere 29: 1501-14 (1994)]**PEER REVIEWED**


Soil Adsorption/Mobility:

DUE TO THE STRONG SOIL ADSORPTION CHARACTERISTICS AND APPLICATION METHODS (SOIL INCORPORATION), THE POSSIBILITY OF HAZARDOUS CONDITIONS TO FISH RESULTING FROM RECOMMENDED USAGE IS NIL.
[Weed Science Society of America. Herbicide Handbook. 4th ed. Champaign, IL: Weed Science Society of America, 1979. of America, 1979. 361]**PEER REVIEWED**

PROFLURALIN IS STRONGLY ADSORBED TO ORGANIC MATTER AND CLAY. THEREFORE, IT IS NOT LEACHED THROUGH THE SOIL OR CARRIED ACROSS THE SOIL SURFACE AS RUNOFF UNLESS SOIL MOVEMENT OR EROSION TAKES PLACE. EVEN WHEN MINOR EROSION OCCURS, RELATIVELY LITTLE PROFLURALIN WILL BE CARRIED FROM THE TREATED AREA IF IT HAS BEEN MECHANICALLY INCORPORATED INTO THE SOIL.
[Weed Science Society of America. Herbicide Handbook. 4th ed. Champaign, IL: Weed Science Society of America, 1979. of America, 1979. 360]**PEER REVIEWED**

The Koc of profluralin is estimated as approximately 25,800(SRC), using an experimental log Kow of 5.58(1) and a regression-derived equation(2,SRC). The Koc for profluralin has also been experimentally determined to be 8,600(4) and 10,232(5). According to a recommended classification scheme(3), these Koc values suggest that profluralin is immobile in soil(SRC). Profluralin was adsorbed 66 to 74 percent by organic matter and 9 to 10 percent by montmorillonite after 4 hours of equilibration in an experimental study(6). Desorption solutions of water and CaCl2 (1 normal) desorbed profluralin 12.8 and 11.8 percent, respectively, from organic matter and 93.3 and 69 percent, respectively, from montmorillonite(6).
[(1) Ellgehausen H et al; Pestic Sci 12: 219-27 (1981) (2) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington DC: Amer Chem Soc pp. 4-9 (1990) (3) Swann RL et al; Res Rev 85: 23 (1983) (4) Kenaga EE; Ecotoxicol Environ Safety 4: 26-38 (1980) (5) Sekusak S, Sabljic A; J Math Chem 11: 271-80 (1992) (6) Carringer RE et al; J Agr Food Chem 23: 568-72 (1975)]**PEER REVIEWED**


Volatilization from Water/Soil:

The Henry's Law constant for profluralin is estimated as 3.15X10-4 atm-cu m/mole(SRC) from its experimental values for vapor pressure, 6.9x10-5 mm Hg at 20 deg C(1), and water solubility, 0.1 mg/l at 20 deg C(2). This value indicates that profluralin will volatilize from water surfaces(3,SRC). Taking adsorption to sediment and suspended solids into account, the estimated half-life for a model pond is 150-178 days(5,SRC). Profluralin's high Henry's Law constant(1,2,SRC) indicates that volatilization from moist soil may occur(SRC).
[(1) Beste CE; Herbicide Handbook of the Weed Science Society of America 5th ed. Champaign, IL: Weed Science Society of America pg. 386 (1983) (2) Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5 (1992) (3) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington DC: Amer Chem Soc pp. 15-1 to 15-29 (1990) (4) USEPA; EXAMS II Computer Simulation (1987)]**PEER REVIEWED**


Environmental Water Concentrations:

GROUNDWATER: Of 86 wells in Georgia that were sampled for profluralin during 1984-1991, only one well contained profluralin (concentration = 20 ug/l)(1).
[(1) USEPA; Pesticides in Groundwater Database. A compilation of Monitoring Studies: 1971-1991. National Summary. USEPA Off Pest Programs Prevention Pesticides and Toxic Substances (H7507C) USEPA-734-12-92-001 (1992)]**PEER REVIEWED**


Sediment/Soil Concentrations:

PROFLURALIN WAS INCUBATED IN AN ETOWAH SILT LOAM SOIL @ 0.5 PPM AT 73 AND 95 DEG F FOR 7-17 DAYS USING 3 PH LEVELS (5.3, 6.4 AND 7.5). MAX DISAPPEARANCE OF PROFLURALIN OCCURRED AT A PH OF 6.4.
[DUSEJA DR; SOIL DISSIPATION OF 3 HERBICIDES; J ENVIRON SCI HEALTH PART A ENVIRON SCI ENG 17 (1): 21-30 (1982)]**PEER REVIEWED**

RESIDUES RESULTING FROM 1.7 KG CGA10832/HA IN SEQUATCHIE LOAM SOIL 120 DAYS AFTER HERBICIDE APPLICATION WERE 0.54-0.86 PPM.
[DAVIS GG, JEFFERY LS; BIOASSAY OF DINITROANILINES IN SEQUATCHIE LOAM; PROC, S WEED SCI SOC 26: 390-7 (1973)]**PEER REVIEWED**

THE AVERAGE PERSISTENCE AT RECOMMENDED RATES OF PROFLURALIN IN SOILS SUCH AS: SANDY LOAM, FINE SANDY LOAM, SILT LOAM, SILTY CLAY LOAM, CLAY LOAM IS DEGRADED IN SIX MO 70%, 74%, 74%, 75% AND 82% RESPECTIVELY.
[Weed Science Society of America. Herbicide Handbook. 4th ed. Champaign, IL: Weed Science Society of America, 1979. of America, 1979. 361]**PEER REVIEWED**


Food Survey Values:

Profluralin was analyzed for but not detected (detection limit = 0.050 ppm) on 6970 produce samples(1).
[(1) Schattenberg HJIII, Hsu JP; J AOAC Interntl 75: 925-33 (1992)]**PEER REVIEWED**


Environmental Standards & Regulations:

FIFRA Requirements:

Removed (means the info was taken out of the source).
[40 CFR 180.348 (58 FR 32299, 6/9/93)]**PEER REVIEWED**


Chemical/Physical Properties:

Molecular Formula:

C14-H16-F3-N3-04
**PEER REVIEWED**


Molecular Weight:

347.33
[U.S. Department of Health and Human Services, Public Health Service, Center for Disease Control, National Institute for Occupational Safety Health. Registry ofToxic Effects of Chemical Substances (RTECS). National Library of Medicine's current MEDLARS file.,p. 84/8310]**PEER REVIEWED**


Color/Form:

YELLOW-ORANGE CRYSTALS OR LIQUID
[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 1234]**PEER REVIEWED**


Odor:

NO APPRECIABLE ODOR
[Weed Science Society of America. Herbicide Handbook. 4th ed. Champaign, IL: Weed Science Society of America, 1979. of America, 1979. 358]**PEER REVIEWED**


Melting Point:

33-36 DEG C
[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 1234]**PEER REVIEWED**


Corrosivity:

NON-CORROSIVE
[Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983. 386]**PEER REVIEWED**


Octanol/Water Partition Coefficient:

Log Kow = 5.58
[Ellgehausen H et al; Pestic Sci 12: 219-27 (1981)]**PEER REVIEWED**


Solubilities:

O.1 PPM IN WATER AT 27 DEG C; GREATER THAN 1 G/G OF ACETONE
[Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983. 386]**PEER REVIEWED**

GREATER THAN 1 G/G OF XYLENE, ETHANOL, ULTRACENE, SINCLAIR 90, N-HEXANE, AROMATIC AND ALIPHATIC HYDROCARBONS, KETONES; GREATER THAN 1 G/3 G OF LOWER ALCOHOLS
[Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983. 386]**PEER REVIEWED**

READILY SOL IN MOST ORG SOLVENTS
[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 1234]**PEER REVIEWED**

Water solubility = 0.1 mg/L at 20 deg C.
[Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5 (1992)]**PEER REVIEWED**

Spectral Properties:

Intense mass spectral peaks: 318 m/z (100%), 330 m/z (54%), 69 m/z (28%), 264 m/z (21%)
[Hites, R.A. Handbook of Mass Spectra of Environmental Contaminants. Boca Raton, FL: CRC Press Inc., 1985. 161]**PEER REVIEWED**


Vapor Pressure:

6.9X10-5 MM HG @ 20 DEG C
[Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983. 386]**PEER REVIEWED**


Other Chemical/Physical Properties:

DECOMPOSITION TEMP APPROX 180 DEG C
[Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983. 386]**PEER REVIEWED**

SPECIFIC GRAVITY: 1.45 @ 25 DEG C /TECHNICAL/
[Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983. 386]**PEER REVIEWED**


Chemical Safety & Handling:

Stability/Shelf Life:

SHELF-LIFE OF AT LEAST 3 TO 5 YR
[Farm Chemicals Handbook 1983. Willoughby, Ohio: Meister Publishing Co., 1983.,p. C-237]**PEER REVIEWED**

DECOMP BY UV IRRADIATION
[Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983. 386]**PEER REVIEWED**


Storage Conditions:

STORE...IN DRY PLACE...MINIMUM STORAGE TEMP (-20 DEG F)...
[Farm Chemicals Handbook 1983. Willoughby, Ohio: Meister Publishing Co., 1983.,p. C-237]**PEER REVIEWED**


Disposal Methods:

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
**PEER REVIEWED**


Occupational Exposure Standards:

Manufacturing/Use Information:

Major Uses:

SELECTIVE PRE-PLANTING HERBICIDE (FORMER USE)
[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 1234]**PEER REVIEWED**


Manufacturers:

Ciba-Geigy Corp, Hq, Saw Mill River Road, Ardsley. NY 10502, (914)478-3131. Agricultural Div., P.O. Box 18300, Swing Road at I-40, Greensboro, NC 27419, (919)292-7100. Production site: McIntosh, Ala 36553.
[SRI; 1984 Directory of Chemical Producers-United States of America. Menlo Park, CA: SRI International (1984)]**PEER REVIEWED**


Methods of Manufacturing:

IT CAN BE MADE BY REACTING 4-CHLORO-3,5-DINITRO BENZOTRIFLUORIDE WITH N-CYCLOPROPYLMETHYL-N-N-PROPYLAMINE.
[Spencer, E. Y. Guide to the Chemicals Used in Crop Protection. 7th ed. Publication 1093. Research Institute, Agriculture Canada, Ottawa, Canada: Information Canada, 1982. 475]**PEER REVIEWED**


General Manufacturing Information:

PROFLURALIN SHOULD BE MECHANICALLY INCORPORATED FOR MAXIMUM BIOLOGICAL ACTIVITY. SUITABLE INCORPORATION EQUIPMENT INCLUDES PTO-DRIVEN CULTIVATORS, HOES, TILLERS, DOUBLE DISK, ROLLING CULTIVATORS, AND BED CONDITIONERS. APPLICATION AND INCORPORATION CAN BE PREPLANTING, POST PLANTING, OR AT LAYBY. RATES: SAND, LOAMY SAND, SANDY LOAM (LIGHT) 0.5 TO 0.75 LB/ACRE; LOAM, SILT LOAM, SILT (MEDIUM) 0.75 TO 1.50 LB/ACRE; CLAY LOAM, SILTY CLAY, CLAY (HEAVY) 1.0 TO 1.5 LB/ACRE. DO NOT USE ON MUCK AND PEAT.
[Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983. 386]**PEER REVIEWED**

IN THE GREENHOUSE, SEEDING IN SOIL TREATED WITH PROFLURALIN (1-2 LB/ACRE) INCR THE SUSCEPTIBILITY OF SOYBEAN TO ROOT ROT, CAUSED BY FUSARIUM OXYSPORUM. IT DECR ROOT DEVELOPMENT AND CAUSED HYPOCOTYL SWELLING, THUS PREDISPOSING THE PLANTS TO FUNGAL INFESTATION.
[TODT P ET AL; PROC- NORTH CENT WEED CONTROL CONF 36: 28-31 (1981)]**PEER REVIEWED**

COTTON ROOT PRUNING OCCURRED IN PLOTS TREATED WITH PROFLURALIN (1.5 AND 3.0 LB/ACRE) AT TEMP OF 17-24 DEG C USING OVERHEAD IRRIGATION.
[HENSLEY JR, NORTON JA; PROC, SOUTH WEED SCI SOC 29: 115-24 (1976)]**PEER REVIEWED**

Discontinued by Ciba-Geigy Corp.
[Farm Chemicals Handbook 1994. Willoughby, OH: Meister, 1994.,p. C359]**PEER REVIEWED**


Formulations/Preparations:

WATER AT 10 TO 40 GAL PER ACRE IS THE CARRIER FOR THE 4 LB/GAL EMULSIFIABLE CONCENTRATE.
[Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983. 386]**PEER REVIEWED**


Laboratory Methods:

Analytic Laboratory Methods:

...BY GLC WITH INTERNAL STANDARD.
[Worthing, C.R. and S.B. Walker (eds.). The Pesticide Manual - A World Compendium. 8th ed. Thornton Heath, UK: The British Crop Protection Council, 1987. 695]**PEER REVIEWED**

PROFLURALIN WAS SEPARATED FROM OTHER PESTICIDES BY CAPILLARY GAS CHROMATOGRAPHY. DETECTION LIMITS OF 50 PG WERE ATTAINED.
[DELEU R, COPIN A; HRC CC, J HIGH RESOLUT CHROMATOGR CHROMATOGR COMMUN 5 (12): 682-3 (1982)]**PEER REVIEWED**

RESIDUES MAY BE DETERMINED, AFTER COLUMN CHROMATOGRAPHIC CLEAN-UP, BY GLC WITH MICROCOULOMETRIC DETECTION.
[Worthing, C. R. (ed.). Pesticide Manual. 6th ed. Worcestershire, England: British Crop Protection Council, l979. 439]**PEER REVIEWED**

PROFLURALIN WAS DETERMINED IN INDUSTRIAL OR MUNICIPAL WASTEWATER BY GAS CHROMATOGRAPHY.
[PRESSLEY TA, LONGBOTTOM JE; THE DETERMINATION OF DINITROANILINE PESTICIDES IN INDUSTRIAL AND MUNICIPAL WASTEWATER: METHOD 627; REPORT: 21 PAGES (1982) ISS EPA-600/4-82-009; ORDER NO PB82-156035]**PEER REVIEWED**

THE EXTRACTION FROM SEVERAL FIELD SOILS OF PROFLURALIN APPLIED AT LEAST 6 MO PREVIOUSLY WAS COMPARED USING SIX SOLVENT SYSTEMS. THE RESIDUES WERE QUANTIFIED USING GAS CHROMATOGRAPHY TECHNIQUES.
[SMITH AE; PESTIC SCI 9 (1): 7-11 (1978)]**PEER REVIEWED**


Special References:

Synonyms and Identifiers:

Synonyms:

B 4576
**PEER REVIEWED**

BENZENAMINE, N-(CYCLOPROPYLMETHYL)-2,6-DINITRO-N-PROPYL-4-(TRIFLUOROMETHYL)-
**PEER REVIEWED**

CGA 10832
**PEER REVIEWED**

N-CYCLOPROPYLMETHYL-2,6-DINITRO-N-PROPYL-4-TRIFLUOROMETHYLANILINE
**PEER REVIEWED**

N-(CYCLOPROPYLMETHYL)-2,6-DINITRO-N-PROPYL-4-(TRIFLUOROMETHYL)BENZENAMINE
**PEER REVIEWED**

N-CYCLOPROPYLMETHYL-N-N-PROPYL-4-TRIFLUOROMETHYL-2,6-DINITROANILINE
**PEER REVIEWED**

N-(CYCLOPROPYLMETHYL)-ALPHA,ALPHA,ALPHA-TRIFLUORO-2,6-DINITRO-N-PROPYL-P- TOLUIDINE
**PEER REVIEWED**

ER5461
**PEER REVIEWED**

GA-10832
**PEER REVIEWED**

PREGARD
**PEER REVIEWED**

SGA 10832
**PEER REVIEWED**

TOLBAN
**PEER REVIEWED**

P-TOLUIDINE, N-(CYCLOPROPYLMETHYL)-2,6-DINITRO-N-PROPYL-ALPHA,ALPHA,ALPHA-TRIFLUORO
**PEER REVIEWED**

P-TOLUIDINE, N-(CYCLOPROPYLMETHYL)-ALPHA,ALPHA,ALPHA-TRIFLUORO-2,6-DINITRO-N-PROPYL-
**PEER REVIEWED**


Formulations/Preparations:

WATER AT 10 TO 40 GAL PER ACRE IS THE CARRIER FOR THE 4 LB/GAL EMULSIFIABLE CONCENTRATE.
[Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983. 386]**PEER REVIEWED**


RTECS Number:

NIOSH/XU5785000


Administrative Information:

Hazardous Substances Databank Number: 3923

Last Revision Date: 20010809

Last Review Date: Reviewed by SRP on 5/16/1996


Update History:

Complete Update on 08/09/2001, 1 field added/edited/deleted.
Complete Update on 05/15/2001, 1 field added/edited/deleted.
Complete Update on 06/12/2000, 1 field added/edited/deleted.
Complete Update on 02/08/2000, 1 field added/edited/deleted.
Complete Update on 02/02/2000, 1 field added/edited/deleted.
Complete Update on 09/21/1999, 1 field added/edited/deleted.
Complete Update on 08/27/1999, 1 field added/edited/deleted.
Complete Update on 06/02/1998, 1 field added/edited/deleted.
Complete Update on 03/08/1998, 1 field added/edited/deleted.
Complete Update on 10/31/1997, 1 field added/edited/deleted.
Complete Update on 01/28/1997, 1 field added/edited/deleted.
Complete Update on 08/07/1996, 37 fields added/edited/deleted.
Field Update on 05/13/1996, 1 field added/edited/deleted.
Field Update on 01/27/1996, 1 field added/edited/deleted.
Complete Update on 12/30/1994, 1 field added/edited/deleted.
Complete Update on 03/25/1994, 1 field added/edited/deleted.
Field update on 12/31/1992, 1 field added/edited/deleted.
Complete Update on 01/28/1992, 1 field added/edited/deleted.
Complete Update on 03/06/1990, 1 field added/edited/deleted.
Field update on 03/06/1990, 1 field added/edited/deleted.
Complete Update on 12/19/1989, 1 field added/edited/deleted.
Complete Update on 10/03/1986