Benfluralin also known as Benefin
CAS No. 1861-40-1

Return to Benfluralin Adverse Effects

ACTIVITY: Herbicide (2,6-dinitroaniline)

CAS Name: N-butyl-N-ethyl-2,6-dinitro-4-(trifluoromethyl)benzenamine


Adverse Effects:

Body Weight Decrease
Suggestive Evidence of Carcinogenicity: LIVER.
Endocrine: Thyroid

Environmental Effects:

Fish: Slightly to Very Highly Toxic

Zooplankton: Moderately to Highly Toxic.

Appendix 2 - Potential Hazardous Polluting Substance. 1978 Agreement between Canada and the US on Great Lakes Water Quality.

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes  
US EPA PC Code: 084301
California Chemical Code 53
FDA LMS Code: 191
US Tolerances: CFR 180.208

Registered use in
(includes only a limited list of countries)

Hungary, South Africa, Taiwan, US

Dry beans - 0.5 ppm

US Maximum Residue Tolerance Levels:
Alfalfa, Clover, Lettuce, Peanut, Trefoil
Other Information
Molecular Formula: C13H16 F3 N3O4  
Inventing Co.: Elanco
Entry Year: 1965 
Manufacturers: Dow Elanco  
Other Names: Benefin, Balan, EL110,
Carpidor, Balfin, Benafine, Benalan, Benefex,Bonalan,
Bhulan, Quilan, Bethrodine, Benfluraline, Binnell, Emblem, Pel-Tech, Benefine, Flubalex
Manufacture sites: CHINA: Dongyang Kangfeng Organic Fluorine Chemicals Plant in Dongyang City, Zhejiang province. (see box below)
Of special interest:
PAN Data
2004: July 31. EPA Fact Sheet on Benfluralin. EPA-738-F-007.
Material Safety Data Sheets & Labels

• 2004: Availability of Reregistration Eligibility Decision (RED) document


Docket ID Number Date of Document Number of pages

Reregistration Eligibility Decision for Benfluralin 

OPP-2004-0210-0002  07-01-2004

Benfluralin. Chronic Dietary Exposure Assessment for the Reregistration Eligibility Decision (RED)

OPP-2004-0210-0003 05-01-2003

Benfluralin: HED Response to Comments Submitted by the Registrant (Dow Agrosciences) on April 26, 2004

OPP-2004-0210-0004  06-08-2004

Benfluralin: Residue Chemistry Chapter for the Reregistration Eligibility Decision.

OPP-2004-0210-0005  05-23-2003

Response to Dow AgroSciences' Comments on EFED RED Chapter for Benfluralin.

OPP-2004-0210-0006  06-04-2004

Revised Benfluralin Environmental Fate and Ecological Effects Risk Assessment - note: there is no title page to this document.

OPP-2004-0210-0007 06-04-2004

Benfluralin, List B Reregistration Case 2030.PC Code 084301. Product Chemistry Chapter for the Reregistration Eligibilty Decision (RED)  

OPP-2004-0210-0008 03-27-2003

Availability of Risk Assessments (Interim Process).

Feb 11, 2003 Overview of the Benfluralin Risk Assessment (15 pages)
Feb 11, 2003 - Benfluralin Summary (2 pages)
Oct 30, 2003 - MEMORANDUM : Benfluralin: Human Health Risk Assessment (Revised) (64 pages)
April 29, 2003
- Benfluralin: Health Effects Division (HED) Metabolism Assessment. Review Committee (MARC) Decision Document.

• Many more documents are available in the Federal Register Docket OPP-2003-0381.

2002 California use data - the major use for benfluralin:

Commodity Total Lbs Active Ingredient
Lettuce, head 12,454
Alfalfa 2,960
Lettuce, leaf 2,651
Tomato, processing 139
Tomato 86
Corn (forage - fodder) 60
Other uses were non-food
Ref: May 27, 2004 letter
From: Rick Melnicoe, Director, Western Region Integrated Pest Management Center
To: Harold D. Coble, Agronomist, USDA/ARS/OA, Cary, NC
Subject: Benfluralin (Benefin)
Two maps of US pesticide use based on 1991-1995 and 1995-1998 data. These maps were compiled by the Pesticide National Synthesis Project of the U. S. Geological Survey's National Water Quality Assessment Program.
Profile from Hazardous Substances Data Bank
April 2000 - SUMMARY OF TOXICOLOGY DATA BENEFIN. California EPA, Department of Pesticide Regulation, Medical Toxicology Branch
March 1985 - Herbicide Profile. Cornell University Pesticide Management Education Program
List of pesticide products
June 2002- In Australia when Benefin (Benfluralin) is used "As an insecticide and acaricide on ornamentals - Seed Lucerne treatment" no maximum residue levels are required. Ref: June 2002. Table 5. Uses of substances where maximum residue limits are not necessary. Australian National Registration Authority for Agricultural Veterinary Chemicals. The MRL Standard. Maximum residue limits in food and animal feedstuff.
2000 - "P" is for Poison. Update on Pesticide Use in California Schools, by TM Olle. A report by Californians for Pesticide Reform. Also available at:
Fluorinated pesticides cited include Ben
February 2000 - Hungary's Pesticide Industry produces the fluorinated pesticides: Benefin (BENFLURALIN); Flufenzin; Fluometuron; Trifluralin. Hungary's pesticide industry includes partnerships with DuPont, Rhone Poulenc, and the American CEDAR group. Hungary's Ministry of Economic Affairs.
US EPA's Index of Cleared Science Reviews
April 2000 - Food and Drug Administration Pesticide Residue Monitoring. Table 3. Pesticides detectable by methods used in 1999 regulatory monitoring.
October 2001-Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.
2000 Toxic Release Inventory. Brief Summary.

Rationale for US EPA to add Benfluralin to the Toxic Release Inventory

Increased relative liver weights, decreased red blood cell counts and decreased hematocrit and hemoglobin levels were observed in dogs orally administered benfluralin at a dose of 125 mg/kg/day for 2 years. The NOAEL was 25 mg/kg/day. Based on the NOAEL, EPA has established an oral RfD of 0.003 mg/kg/day. EPA believes that there is sufficient evidence for listing benfluralin on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available hematological toxicity data for this chemical.

Ref: USEPA/OPP. Support Document for the Addition of Chemicals from Federal Insecticide, Fungicide, Rodenticide Act (FIFRA) Active Ingredients to EPCRA Section 313. U. S. Environmental Protection Agency, Washington, DC (1993). As cited by US EPA in: Federal Register: January 12, 1994. Part IV. 40 CFR Part 372. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know; Proposed Rule.

Dongyang Kangfeng Organic Fluorine Chemical Factory
Dongyang Kangfeng Organic Fluorine Chemicals Plant was established in 1995, it’s a key enterprise for production and development of organic fluorine series products, which is one of the hundred tax-payers in Dongyang City. Now, the plant has a fixed asset of more than USD 500 million, a working staff of 81 persons including 18 researchers, and contains more than 20,000 square meters, and has established a good cooperation with some chemical research institutes all over the world.
Our plant is located in Xueshi Zai Industrial Zone of Huailu Dongyang city, which is in the middle of Zhejiang province P.R. China where is abundant of fluorine ore. We have a strong technology research group, advanced production technicals and first class production equipments, a perfect quality control system and advantageous location. We have established a set of environmental protection system. At present, our annual production of benzotrifluoride, p-chlorobenzotrifluoride and their series products are over 10,000 tons including Herbicides-Trifluralin and Benefin technical with 4,000 tons 1,000 tons respectively. They are of good quality and are mainly sold abroad.
We are sticking to the principle of leading by science and technology, depending on products' good quality and developing on good credit and keep our efforts in deep development of trifluoromethyl series, fluobenzene series medicine and pesticide, dyeing staff intermediates...
Online as of April 17, 2005, at

US Federal Register

•• Note: Due to length, the following is a partial list. Click here to see full list of FR entries.

Published Date Docket Identification Number Details
April 13, 2007 EPA-HQ-OPP-2007-0005

Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations.

Registration No. Product Name Registrant
062719-00096 Balan 2.5G Dow Agrosciences LLC
9330 Zionsville Rd 308/2E,
Indianapolis IN 46268-1054
062719-00127 Balan Dry Flowable
062719-00146 Turf Fertilizer contains Balan 0.92%
062719-00147 Turf Fertilizer contains Balan 1.15%
062719-00148 Turf Fertilizer contains Balan 1.25%
February 28, 2007 EPA-HQ-OPP-2007-0005 Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations.
Registration No. Product Name Registrant
007401-00046 Ferti-Lome Professional Crabgrass Control Brazos Associates, Inc., Agent
For: Voluntary Purchasing
Group Inc., 1806 Auburn Drive,
Carrollton, TX 75007-1451
007401-00298 Ferti-Lome Crabgrass Preventer
007401-00413 Ferti-Lome Winterizer & Weed Preventer
007401-00415 Ferti-Lome Weed and Feed Special
November 8, 2006 EPA-HQ-OPP-2006-0084

Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations.

EPA Registration no. Product Name Registrant
000228-00158 Riverdale Pre- Emergent Crabgrass Control Concentrate Nufarm Americas Inc.
150 Harvester Drive Suite 200,
Burr Ridge IL 6052
000228-00172 Riverdale 34-0-10 & Benefin Crabgrass Preventer same
000228-00174 Riverdale 2.5g Pre-Emergent Herbicide same
000228-00207 Riverdale Team .87 Lawn Weed and Feed same
000228-00256 Riverdale Team 1.33% Lawn Weed
and Feed
009198-00030 The Andersons Fertilizer with 0.92% Balan The Andersons Lawn Fertilizer
Division, Inc., dba/ Free Flow
PO Box 119,
Maumee OH 43537
009198-00091 The Andersons Tee Time Plus 0.57% Team same
009198-00091 The Andersons Tee Time Plus 0.57% Team same
009198-00101 The Andersons Fertilizer with 0.87% Team same
009198-00130 The Andersons Fertilizer with 1.50% Team same
010404-00036 Lesco 2.5 Benefin Granular Lesco Inc.,
1301 E. 9th Street,
Suite 1300, Cleveland OH
010404-00056 Lesco Turf Fertilizer with 1.15% Team
June 28, 2006 EPA-HQ-OPP-2006-0084

Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations.

EPA Registration no. Product Name Registrant
000829-00211 SA-50 Brand Balfin Granules Southern Agricultural
Insecticides, Inc.
PO Box 218
Palmet, FL 34220.
008660-00006 Sta-Green Crabgrass Preventer with Fertilizer 25-3-3 United Industries Corp. d/b/a
Sylorr Plant Corp.
PO Box 142642
St. Lou, MO 631140642.
008660-00008 Sta-Green Pre-Emergence Crabgrass Preventer with Balan same
008660-00016 Sta-Green ``C-G'' Preventer Plus W/30-2-9 Fertilizer same
008660-00019 Sta-Green Crabgrass Preventer Plus Lawn Fertilizer same
008660-00026 Vertagreen Weed and Feed for Professional Turf same
008660-00027 Vertagreen Crabgrass Preventer with Balan same
008660-00030 Vertagreen Fertilizer for Professional Turf w/Balan same
008660-00037 Vertagreen Crabgrass Control same
008660-00038 Vertagreen Fertilizer for Prof. Use 22-3-9 same
008660-00039 Vertagreen for Professional Use with Balan 16-6-8 same
008660-00040 Vertagreen Crabgrass Preventer Plus Turf Food same
008660-00042 Vertagreen Lawn Food and Crabgrass Prevent. 25-3-5 same
008660-00074 Pro-Teck with Balan same
008660-00096 Vertagreen for Professional Use w/balan 25% Granules same
008660-00099 Proteck-Plus-- contains Balan same
008660-00104 Vertagreen Proteck 3-Way same
008660-00107 Greenup Benefin - 10 Plus same


Vertagreen Fertilizer for Professional Use with Balan same
008660-00130 Turf-Pro Balan 2.5% Plus Pre-Emergent Herbicide Plus 30 same
008660-00143 Vertagreen Fertilizer for Professional Use with Team same
008660-00146 Vertagreen Pre-Emergence Weed and Feed same
008660-00149 Vertagreen Lawn Food with Crabgrass Control same
008660-00151 Vertagreen for Professional Turf with Team same


Gro-Tone Crabgrass Preventer Plus Lawn Fertilizer same
008660-00192 HWI R Your Link To Value R Lawn Fertilizer same
008660-00225 Premium Fairway Food with Crabgrass and POA same
008660-00235 Vigoro Crabgrass Preventer Plus Lawn Fertilizer same
008660-00236 Vigoro Crabgrass Preventer Plus Lawn Food Northern Form same
008660-00237 Vigoro Crabgrass Preventer with Benefin same
008660-00238 Vigoro Deep Green Crabgrass Preventer + Lawnfood same
008660-00243 Vigoro Weed and Crabgrass Preventer contains Balan same
032802-00007 All Season Balan Granular 2.5G. Howard Johnson's Enterprises Inc.
700 W. Virginia St
Ste 222,
Milwauk, WI 532041548.
032802-00008 All Season Crabgrass Preventer Plus same
032802-00009 Crabgrass Preventer Plus Turf Food same
032802-00010 Benefin Plus 25-3-25 Fertilizer same
032802-00011 Benefin 1.3% Plus same
032802-00024 Excel-N-Plus W/ crabgrass Control + Lawn Food same
032802-00030 Excel-S-Plus same
032802-00033 Hi-Tech Crabgrass Control same
032802-00035 Lawn Service Crabgrass Control same
032802-00040 Proteck 58 same

US Federal Register

•• Note: Due to length, the above is a partial list. Click here to see full list of FR entries.

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