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Adverse Effects
Abstracts
ACTIVITY:
Antifoulant, Fungicide, Microbiocide (Organotin)
Structure:
| Adverse
Effects:
Brain
Developmental / Reproductive
Diabetes
Eye
Endocrine: Suspected Disruptor |
| Environmental
Effects:
Acute
Aquatic Toxicity Values
Very Highly Toxic to Amphibians
Very Highly Toxic to Fish |
Regulatory
Information
(only comprehensive for the US) |
| US
EPA Registered: |
No |
| US
EPA PC Code: |
083112 |
| California
Chemical Code |
1030 |
Registered
use in
(includes only a limited list of countries)
|
Canada |
| Other
Information |
| Molecular
Formula: |
C12H27FSn
|
| Manufacturers: |
Atochem |
| Other
Names: |
Poly
Cop Blue.
EPA product Reg.#s:
5204-19, 5204-61, 5204-64
BRN 4125568
Caswell No. 867C
EINECS 217-847-9
Fluorotributylstannane
Fluorotributyltin
NSC 179737
NSC 195319
Stannane, fluorotributyl-
Tin, tributyl-, fluoride
Tin, tributylfluoro-
Tri-n-butylstannyl fluoride
Tributylfluorostannane
Tributylstannane fluoride |
| Of
special interest: |
| PAN
Data |
A
little history...
In the early 1960s, both tributyltin oxide
(TBTO) and TBT fluoride were tested, mainly in Africa, as molluscicides
against several freshwater snail species that are vectors of
the disease schistosomiasis, the snails being the intermediate
hosts of the trematode parasite. This use led to the introduction
of TBT, during the mid 1960s, as an antifouling paint on boats.
At the same time TBT compounds were being registered as wood
preservatives (the first registration was in 1958).
Ref:
Tributyltin Compounds. Environmental
Health Criteria Report Number 116. World
Health Organization. International
Programme on Chemical Safety. |
2005
- Schedule for Reregistration & Tolerance Reassessment (RED)
for "tbt-containing compounds"
is expected to be September 2008. Contact at EPA: Rebecca Miller
(703) 305-0012; miller.rebecca@epa.gov . According to EPA:
Through the pesticide reregistration and tolerance reassessment
programs, EPA is assessing risks and making risk management
decisions for older pesticides. These decisions are summarized
in documents known as REDs, IREDs, and TREDs. By making decisions
according to the schedule below, EPA will meet its statutory
deadlines for completing reregistration and tolerance reassessment.
Some of the decision dates presented in the schedule may change
due to the dynamic nature of the review process. Any pesticide
decisions that are not completed during the current fiscal year
will be rescheduled for the following year. EPA is committed
to meeting its reregistration and tolerance reassessment deadlines.
http://www.epa.gov/pesticides/reregistration/decision_schedule.htm
|
| In
Japan: Listed since Sept 12, 1990, as a Class 2 specified chemical
substance. A substance which, either
in itself or one of its degradation products, is not easily
degradable and which may be harmful to human health when ingested
continuously and which is considered to cause or expected to
cause harm to human health due to significant residues of the
substance in a wide range of areas. A person who manufactures
or imports this substance or who imports product in which this
substance is contained shall submit a notification on planned
manufacturing or import quantities. Authorities concerned may
order a change of the amount in order to prevent damage to human
health by environmental pollution. Ref: Division of Chem-Bio
Informatics, National Institute of Health Sciences, Japan. (Online
as of Dec 2, 2001). |
| In
Japan: Listed as a "Deleterious Substance" under the
"Poisonous and and Deleterious Substances Control Law"
by the National Institute of Health Sciences, Japan. (Online
as of Dec 2, 2001). |
| Pesticide
products - partial list |
| Abstracts |
Rationale
for US EPA to add Tributyltin Fluoride to the Toxic Release
Inventory
Aquatic
acute toxicity values for tributyltin fluoride include a
bleak fish 96-hour LC 50
of 2.3 ppb, an algae 72-hour EC50 of 9.3 ppb, and a
Harpacticoid copepod 96-hour LC 50 of 0.8 ppb. EPA
believes that there is sufficient evidence for listing tributyltin
fluoride on EPCRA section 313 pursuant to EPCRA section
313(d)(2)(C) based on the available environmental toxicity
data.
Ref:
USEPA/OPP. Support Document for the Addition of Chemicals
from Federal Insecticide, Fungicide, Rodenticide Act (FIFRA)
Active Ingredients to EPCRA Section 313. U. S. Environmental
Protection Agency, Washington, DC (1993).
As cited by US EPA in: Federal
Register: January 12, 1994. Part IV. 40 CFR Part 372.
Addition of Certain Chemicals; Toxic Chemical Release Reporting;
Community Right-to-Know; Proposed Rule.
|
| Table
9 Organotin compounds suspected of being endocrine disruptors. |
| Common
name |
CAS-no. |
Y
/µg l Ð1 |
log P
ow |
| Bis(tributyltin)oxide |
56-35-9 |
8000 Ð10
000 |
3.62 |
| Triphenyltinhydroxide |
76-87-9 |
400 |
- |
| Tributyltin
fluoride |
1983-10-4 |
- |
- |
Ysat
:Water solubility in seawater at 22 ¡C.
P ow :Partition coefficient octanol/water. |
Ref:
Endocrine Disruptors in the Environment (IUPAC Technical
Report). Prepared for publication by J.LINTELMANN et al. INTERNATIONAL
UNION OF PURE AND APPLIED CHEMISTRY. Pure Appl.Chem.,Vol.75,No.5,pp.631
Ð681,2003. ©2003 IUPAC.
Full report available at
http://www.iupac.org/publications/pac/2003/pdf/7505x0631.pdf
|
| June
14, 2001 - Implementation
of the Community Strategy for Endocrine Disruptors - a
range of substances suspected of interfering with the hormone
systems of humans and wildlife. Communication from the Commission
to the Council and the European Parliament. Commission of
the European Communities, Brussels COM (2001) 262 final. (More
information available at: http://europa.eu.int/comm/environment/docum/01262_en.htm
)
This
document presents a "priority list of substances for
further evaluation of their role in endocrine disruption.
During 2000, a candidate list of 553 man-made substances and
9 synthetic/natural hormones has been identified."
Organofluorine
pesticides in this list include: |
| Substances
included on the Endocrine Disruptor Liist |
CAS
No. |
Substances
included on the Endocrine Disruptor Liist |
CAS
No. |
| Bifenthrin |
82657-04-3
|
Flutriafol |
76674-21-0 |
| Cyhalothrin
(@Karate) |
91465-08-6 |
Fluvalinate |
69409-94-5 |
| Diflubenzuron |
35367-38-5 |
Prodiamine |
29091-21-2 |
| Epoxiconazole |
- |
Stannane,
tributylfluoro [Tributyltin fluoride] |
1983-10-4 |
| Fipronil |
- |
Thiazopyr |
- |
| Fluazifop-butyl |
69806-50-4
|
Trifluralin |
- |
| US
Federal Register |
| Nov
30, 1994 |
ATOCHEM
- Cancellation
Order. This Order, issued pursuant to section 6(f)(1) of
the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA),
7 U.S.C. 136 et seq., announces EPA's cancellation of the registrations
for ELF ATOCHEM North America, Inc. (``Atochem'') products containing
Tributyltin Fluoride (TBTF). Further, this Order announces the
Agency's decision prohibiting Atochem's sale, distribution and
use of existing stocks of its TBTF products as of this date. |
| Jan
12, 1994 |
EPA's
proposal to add 41
fluorine and organofluorine chemicals to the Toxics Release
Inventory (TRI). See excerpt in box
above. Also available at http://www.epa.gov/tri/frnotices/59fr1788.htm |
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