Tefluthrin
CAS No. 79538-32-2

 
 

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Adverse Effects
Abstracts

ACTIVITY: Insecticide (pyrethroid)

CAS Name: (2,3,5,6-tetrafluoro-4-methylphenyl)methyl [1?,3?(Z)]-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate

Structure:

Adverse Effects:

Ataxia
Blood
B
ody Weight Decrease
Bone
Brain
Cholesterol
Endocrine: Thyroid
Endocrine:
Uterus
Heart
Liver
Tremors

Environmental Effects:

Fish: Very Highly Toxic

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 128912 
California Chemical Code 3839 
US Tolerances: CFR 180.440 
FDA LMS Code: B26 
US EPA Permit Date
and Registrant:
1989, ICI 
Registered use in
(includes only a limited list of countries)

Australia, Canada, Denmark, Germany, Hungary, Japan, Portugal, UK, US 
Japan's Maximum Residue Levels (MRLs) Brussel sprouts, Cabbage, Corn, Peanuts (dry), Radish, Sugarcane, Strawberry, Sweet potato 
US Maximum Residue Levels permitted in food commodities
Corn, field:
fodder and forage, pop and sweet, grain and pop, and fresh with husk removed.
Other Information
Molecular Formula: C17H14Cl F7 O2  
Manufacturers: Zeneca
Syngenta
 
Other Names: Force
Forza,
PP 993
R 151993
 
Manufacture site: UK:

Zeneca, Huddersfield
 
Of special interest:
PAN BAD ACTOR - Acute Toxicity 
Hazardous Substances Data Base - full record on Tefluthin as of November 17, 2004.
Tefluthrin. UKPID Monograph. National Poisons Information Service Centre in the UK.
September 2001 - The pyrethroids discussed in this report are: Bifenthrin (Type I), Cyfluthrin (Type II) , Cyhalothrin (Type II), Flucythrinate (Type II) , Flumethrin (Type II), Fluvalinate (Type II), Tefluthrin (Type I). DRAFT TOXICOLOGICAL PROFILE FOR PYRETHRINS AND PYRETHROIDS. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES. Public Health Service Agency for Toxic Substances and Disease Registry. September 2001. http://www.atsdr.cdc.gov/toxprofiles/tp155.pdf
2000-2002 - Highly hazardous. WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 2000-2002. Table 2. Highly hazardous (Class Ib) technical grade active ingredients of pesticides, p 18. 
April 2002 - Beer in the UK: 23 organofluorine pesticides approved for use on malting barley. Published by the British Beer and Pubs Association and Brewing Research International.
US Map of Pesticide Use: 1992-1995
January 25, 1999 - Sediment Toxicity and Fate of Synthetic Pyrethroids. The synthetic pyrethroids were conditionally registered beginning in 1984 for use on cotton and later for use on other major crops including corn, soybeans, and sugarcane. Currently, EPA is assessing risks to non-target organisms for ten synthetic pyrethroids: bifenthrin, cyfluthrin, cypermethrin, deltamethrin, fenpropathrin, fenvalerate, cyhalothrin, tefluthrin, tralomethrin, and permethrin. Each of these synthetic pyrethroids are conditionally registered for use on cotton, with the exception of tefluthrin, which is conditionally registered for use on corn. Each of these chemicals is highly lipophilic and in aquatic environments tend to strongly adsorb to sediments. Environmental Fate and Effects Division Office of Pesticide Programs U.S. Environmental Protection Agency Washington, D. C.  
Abstracts
August 2001 - IR-4: New Products/Transitional Solution List This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes: Tefluthrin  

Rationale for US EPA to add Tefluthrin to the Toxic Release Inventory

Delayed ossification was seen in the offspring of rats administered 5 mg/kg/day (LOEL) orally on days 7 through 16 of gestation. The NOEL was 3 mg/kg/ day.

In a 3-month rat study, dietary administration of 10 mg/kg/day produced plasma, red blood cell, and brain cholinesterase inhibition. The NOEL was 5 mg/kg/day. In a 6-month dog study, dietary administration of 10 mg/kg/day (LOEL) produced plasma cholinesterase inhibition. The NOEL was 1 mg/kg/day.

In a 21-day rat dietary study, administration of 20 mg/kg/day (LOEL for females) produced decreased platelet counts, increased white blood cell, lymphocyte, and neutrophil counts in males and females. The NOEL for females was 5 mg/kg/day. Increased absolute and relative liver weights were observed at 5 mg/kg/day in males, thus no NOEL could be established for males. Dietary administration of 10 mg/kg/day (LOEL) for 3 months to rats produced increased absolute liver weights, decreased bilirubin levels, and hepatocellular hypertrophy. The NOEL was 5 mg/kg/day. In a 6-month dog study, dietary administration of 10 mg/kg/day (LOEL) produced hepatotoxicity (effects not reported). The NOEL was 1 mg/kg/day. In a 2-year mouse study, dietary administration of 13.5 mg/kg/day produced liver necrosis. The NOEL was 3.4 mg/kg/day.

EPA believes that there is sufficient evidence for listing tefluthrin on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available developmental, neurological, hepatic, and hematological toxicity data for this chemical.

Aquatic acute toxicity values for tefluthrin include a rainbow trout 96-hour LC 50 of 0.06 ppb, a bluegill 96-hour LC50 of 0.13 ppb, a sheepshead minnow 96-hour LC50 of 0.13 ppb, a daphnid 48-hour EC50 of 0.07 ppb, and a mysid* 96-hour EC 50 of 0.053 ppb. EPA believes that there is sufficient evidence for listing teflurin on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available environmental toxicity data for this chemical.
Ref: USEPA/OPP. Support Document for the Addition of Chemicals from Federal Insecticide, Fungicide, Rodenticide Act (FIFRA) Active Ingredients to EPCRA Section 313. U. S. Environmental Protection Agency, Washington, DC (1993).
As cited by US EPA in: Federal Register: January 12, 1994. Part IV. 40 CFR Part 372. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know; Proposed Rule.

Note:
Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know. Final Rule.
Teflutrin was included in the deferral of 40 chemicals: EPA is deferring final action on 40 chemicals and one chemical category until a later date. These chemicals and the comments received on them raised particularly difficult technical or policy issues which will require additional time to address. The Agency does not believe that it would be in the spirit of community right-to-know to delay final action on the remaining 286 chemicals and chemical categories, pending completion of work on the more limited group. In a future rulemaking, EPA will make a final determination as to whether these chemicals should be added to EPCRA section 313. The public comment that has been received specific to these deferred chemicals will be addressed as part of the future rulemaking discussed above.


Table 6-1. Trends of National Pyrethroid Use

September 2001. Draft Toxicological Profile for Pyrethrins and Pyrethroids. US Department of Health and Human Services. Public Health Service Agency for Toxic Substances and Disease Registry. Organofluorine pyrethroids discussed in the Profile: Bifenthrin (Type 1), Cyfluthrin (Type 2), Cyhalothrin (Type 2), Flucythrinate (Type 2), Flumethrin (Type 2), Fluvalinate (Type 2), Tefluthrin (Type 1).

Note from EC: The following 4 organofluorine pesticides were included in a list of 11 pesticides.

Pyrethroid Amounts applied
(pounds) 1992
Amounts applied
(pounds) 1997
Percent change
Bifenthrin 116,716 110,246 -5
Cyfluthrin 124,360 177,782 +43
Lambda-cyhalothrin 205,329 321,284 +57
Tefluthrin 238,429 576,865 +142

US Federal Register

Published Date Docket Identification Number Details
Nov 26, 1997 OPP-300576

ZENECA - Pesticide Tolerance for Corn. - FINAL RULE. This regulation establishes tolerances for combined residues of tefluthrin and its metabolite in or on corn, grain, field and pop; corn, forage and fodder, field, pop and sweet; and corn, fresh (including sweet K and corn with husk removed (CWHR)) at 0.06 ppm. It also removes time limitations for tolerances for residues of tefluthrin on the same commodities that expire on November 15, 1997.

Sept 25, 1997 PF-767 ZENECA - 3 Pesticide petitions.
Aug 4, 1997 OPP-300523 Pesticides Subject to Tolerance Reassessment.
May 3, 1996 PP 4F4406/R2222

ZENECA - Renewal of Time-limited Tolerances. - FINAL RULE. This rule establishes a tolerance for the combined residues of the pyrethroid tefluthrin and its metabolites in or on the raw agricultural commodity (RAC) corn, fresh (including sweet K + CWHR) at 0.06 ppm, and corn, forage and fodder, sweet at 0.06 ppm and renews time-limited tolerances for tefluthrin on the RAC's corn, grain, field, and pop; corn forage and fodder, field and pop.

Feb 8, 1995 na

ZENECA - Pesticide Tolerance Petition; to permit residues in or on corn, fresh (including sweet K and CWHR) at 0.06 ppm, and corn, forage and fodder, sweet at 0.06 ppm.

November 30, 1994 OPPTS-400082B7

Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know. Final Rule.

EPA is deferring final action on 40 chemicals and one chemical category until a later date. These chemicals and the comments received on them raised particularly difficult technical or policy issues which will require additional time to address. The Agency does not believe that it would be in the spirit of community right-to-know to delay final action on the remaining 286 chemicals and chemical categories,
pending completion of work on the more limited group. In a future rulemaking, EPA will make a final determination as to whether these chemicals should be added to EPCRA section 313. The public comment that has been received specific to these deferred chemicals will be addressed as part of the future rulemaking discussed above. These chemicals follow:

tefluthrin

Sept 30, 1994 na

ZENECA - Pesticide Tolerances for Corn. - FINAL RULE. This document extends tolerances for the combined residues of the synthetic pyrethroid tefluthrin and its metabolite in or on the raw agricultural commodities corn, grain, field, and pop at 0.2 ppm; corn, forage and fodder, field and pop at 0.6 ppm. Zeneca Ag Products (previously, ICI Americas, Inc.) requested this regulation to extend the effective date for tolerances for maximum permissible levels of residues of this insecticide in or on these commodities.

August 3, 1994 na

ZENECA - Petition for Pesticide Tolerances. Proposed Rule. This document proposes to extend tolerances for the combined residues of the synthetic pyrethroid tefluthrin and its metabolite in or on the raw agricultural commodities corn, grain, field, and pop at 0.02 ppm; corn, forage and fodder, field and pop at 0.6 ppm.

Jan 12, 1994 OPPTS-400082 EPA's proposal to add 41 fluorine and organofluorine chemicals to the Toxics Release Inventory (TRI). See excerpt in box above. Also available at http://www.epa.gov/tri/frnotices/59fr1788.htm
 
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