CAS No. 117337-19-6

Return to Fluthiacet-methyl Adverse Effects

ACTIVITY: Herbicide (unclassified)

Scientific Name: acetic acid, [2-chloro-4-fluoro-5-[(tetrahydro-3-oxo-1H,3H- [1,3,4]thiadiazolo[3,4-a]pyridazin-1- ylidene)amino]phenyl]thio]-methyl ester)

See also Fluthiacet

Structure for Fluthiacet:

Adverse Effects:

Body Weight Decrease
Cancer: Likely to be a human carcinogen - PANCREAS (males) and LIVER
Endocrine: Uterus

Environmental Effects:

Phototoxic Pesticide

Very highly toxic to fish

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 108803 
US Tolerances: CFR 180.551 
US Maximum Residue Levels permitted in food commodities

Permitted in or on 9 food commodities, including:
Corn, Soybean seed

Other Information
Molecular Formula: C15 H15 N3 O3 Cl F S2 
Entry Year: 1988  
Inventing Company: Ciba Geigy 
Manufacturers: Syngenta, Novartis, Entek, Kumiari  
Other Names:

Fluthiacet-methyl Technical,

Of special interest:
PAN BAD ACTOR (Carcinogen)  
March 7, 2001 - Fluthiacet-methyl: Phototoxic Pesticides: US EPA Memo Requesting Phototoxicity Study Protocol for Light-Dependent Peroxidizing Herbicides 

July 7, 2000 - Letter to Novartis from NYS DEC on Action herbicide. DEC stated:

... It is our position that registration of a product classified as "likely to be a human carcinogen" is not warranted unless it either replaces a product that poses greater risks or the need for the product is significant...

April 1999 - US EPA Pesticide Fact Sheet 
2001 - Highly toxic to fish. See: Illinois Agricultural Pest Management Handbook - Chapter 13
October 2001 - Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration. 
August 2001 - IR-4: New Products/Transitional Solution List - This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes Fluthiacet-methyl  

US Federal Register
Date Published Docket Identification Number Details
December 27, 2006 EPA-HQ-OPP-2006-0788

K-I Chemical U.S.A. Inc. Pesticide tolerance. FINAL RULE.for combined residues of fluthiacet-methyl in or on
-- cotton, gin byproducts at 0.20 ppm
-- cotton, undelinted seed at 0.020 ppm

September 20, 2006 EPA-HQ-OPP-2006-078 K-I Chemical U.S.A. Inc. Pesticide petition: PP 7F4821.
In or on the food/feed commodities:
-- cotton, gin byproducts at 0.20 ppm
-- cotton seed, undelinted at 0.020 ppm.
August 3, 2005 OPP-2005-0201

Cancellation of Pesticides for Non-payment of Year 2005 Registration Maintenance Fees.

Section 3 registrations canceled for non-payment of the 2005
maintenance fee are shown in the following table 2:

Table 2.--Section 3 Registrations Canceled for Non-Payment of
Maintenance Fee

Registration no. Product Name
000100-00957 Action EC Herbicide
Dec 21, 2001 OPP-301184

K-I CHEMICAL - Pesticide Tolerance. - FINAL RULE. For residues in on on corn ranging from 0.01 to 0.05 ppm. According to this Final Rule: In rabbits, in utero exposure at 1,000 mg/kg/day: Developmental toxicity was seen at this dose characterized as an increase in irregular sternebrae. Fluthiacet-methyl has been classified as "likely to be a human carcinogen" based upon the combined hepatocellular tumors (adenomas and carcinomas) in male mice. In soil, fluthiacet-methyl and its metabolites are considered to be mobile and persistent (effective or combined aerobic soil half-life of 305 days)... Fluthiacet-methyl is expected to be a ground and surface water contaminant.

June 30, 1999 na

NOVARTIS - Approval of Pesticide Product Registrations. This notice announces Agency approval of applications submitted by Novartis Crop Protection Inc., to conditionally register the pesticide products Action Herbicide for postemergence control of velvetleaf and certain other broadleaf weeds in soybeans (EPA Registration Number 100- 806); and Fluthiacet-Methyl Technical (formerly CGA-248757 Technical) for formulation use only into registered end-use herbicides (EPA Registration Number 100-805).

April 14, 1999 OPP-300829

NOVARTIS - Pesticide Tolerance Approval for residues of the herbicide in or on soybean seed at 0.01 ppm.- FINAL RULE.

Oct 6, 1998 PF-837

K-I CHEMICAL - Pesticide Tolerance Petition for residues in or on the raw agricultural commodities cottonseed at 0.02 ppm and cotton, gin by-products at 0.5 ppm.

Oct 8, 1997 PF-837

K-I CHEMICAL - Pesticide Tolerance Petition; for residues in or on the raw agricultural commodity popcorn grain at 0.02 ppm

April 14, 1997 PF-730

K-I CHEMICAL - Pesticide Tolerance Petition; for residues of the herbicide in or on the raw agricultural commodites field corn grain and sweet corn grain (K + CWHR) at 0.02 ppm and corn forage and fodder at 0.05 ppm.

March 26, 1997 PF-727

NOVARTIS - Pesticide Tolerance Petition for Action pesticide. CGA-248757 [Fluthiacet-methyl] is a new herbicide active ingredient in the imide chemistry class. It will be formulated as a 4.75% wettable powder, packaged in water-soluble bags, and sold under the trade name Action

Herbicide. Action is a highly selective herbicide for use in soybeans postemergence, and is particularly effective in controlling velvetleaf. Control of other broadleaf weeds in soybeans is enhanced and the spectrum of control is broadened when Action is tank mixed with other postemergence herbicides registered for use in soybeans.
June 12, 1996 PF-646

CIBA GEIGY - Petition for Pesticide Tolerance for residues of the herbicide in or on the raw agricultural commodity soybeans at 0.02 ppm.

May 8, 1996 OPP-30406

CIBA GEIGY - Application to register the herbicide CGA-248757[Fluthiacet-methyl] Technical Herbicide; for formulation use only into registered end-use herbicides.

July 26, 1995 na

CIBA GEIGY - Experimental Use Permit (100-EUP-98). This experimental use permit allows the use of 16.066 pounds of the herbicide on 1,200 acres of corn and soybeans (200 acres of corn in 1995, 400 acres of corn in 1996 and 200 acres of soybeans in 1995 and 400 acres of soybeans in 1996) to evaluate the control of various weeds. The program is authorized only in the States of AR, DE, IA, IL, IN, KS, KY, LA, MD, MN, MI, MO, NE, NY, NC, ND, OH, PA, SD, TN, TX, VA, and WI. This experimental use permit is effective from March 27, 1995 to December 31, 1996. This permit is issued with the limitation that all treated crops will be destroyed or used for research purposes only.

Syngenta AG. June 8, 2001. Form 20-F. US Securities and Exchange Commission. "Divestments. Novartis, AstraZeneca and Syngenta made several divestments in order to satisfy conditions imposed by the FTC and the European Commission in connection with the formation of Syngenta. The divestments completed in 2000 included the sale of the acetochlor based herbicide products to Dow AgroSciences LLC and the selling of the strobilurin fungicide product line FLINT® to Bayer AG. The divestments completed in 2001 include the sales of the grass herbicide propaquizafop and the pyrethroid insecticide tau-fluvalinate to Makhteshim Agan Industries Ltd, the sale of its sulcotrione herbicide MIKADO ® in the European Economic Area to Bayer AG, the divestment of its global flutriafol fungicide business to Cheminova A/S and the divestment to Makhteshim Agan Ltd. of its former Novartis cereal fungicide product range in Denmark, Sweden and Finland (p 9)."... Active Substances include... Herbicides: Fluthiacet ... Nature of operations. Syngenta AG is a world leading crop protection and seeds business that is involved in the discovery, development, manufacture and marketing of a range of agricultural products designed to improve crop yields and food quality. Syngenta is headquartered in Basel, Switzerland and was formed by Novartis AG ("Novartis") and AstraZeneca PLC ("AstraZeneca") through an agreement to spin off and merge the Novartis crop protection and seeds businesses with the Zeneca agrochemicals business to create a dedicated agribusiness company whose shares were then the subject of a global offering (the "Transactions"). The Transactions were completed on November 13, 2000. In this annual report, for periods prior to November 13, 2000, we refer to the businesses contributed by Novartis as the "Novartis agribusiness"; and we refer to the businesses contributed to Syngenta by AstraZeneca as the "Zeneca agrochemicals business" (p i)." Also available at: http://www.syngenta.com/en/downloads/Syngenta_2000_Form_20-F1.pdf

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