Adverse Effects:

Anemia
Blood
Body Weight Decrease
Bone
Cancer: Likely to be a human carcinogen - PANCREAS (males) and LIVER
Clastogenic
Endocrine: Uterus
Liver
Pancreas

Environmental Effects:

Phototoxic Pesticide

Very highly toxic to fish

Permitted in or on 9 food commodities, including:
Corn, Soybean seed

Action,
Appeal,
Fluthiacet-methyl Technical,
KIH-9201,
CGA-248757,
100-EUP-98 

July 7, 2000 - Letter to Novartis from NYS DEC on Action herbicide. DEC stated:

... It is our position that registration of a product classified as "likely to be a human carcinogen" is not warranted unless it either replaces a product that poses greater risks or the need for the product is significant...

K-I Chemical U.S.A. Inc. Pesticide tolerance. FINAL RULE.for combined residues of fluthiacet-methyl in or on
-- cotton, gin byproducts at 0.20 ppm
-- cotton, undelinted seed at 0.020 ppm

Cancellation of Pesticides for Non-payment of Year 2005 Registration Maintenance Fees.

K-I CHEMICAL - Pesticide Tolerance. - FINAL RULE. For residues in on on corn ranging from 0.01 to 0.05 ppm. According to this Final Rule: In rabbits, in utero exposure at 1,000 mg/kg/day: Developmental toxicity was seen at this dose characterized as an increase in irregular sternebrae. Fluthiacet-methyl has been classified as "likely to be a human carcinogen" based upon the combined hepatocellular tumors (adenomas and carcinomas) in male mice. In soil, fluthiacet-methyl and its metabolites are considered to be mobile and persistent (effective or combined aerobic soil half-life of 305 days)... Fluthiacet-methyl is expected to be a ground and surface water contaminant.

NOVARTIS - Approval of Pesticide Product Registrations. This notice announces Agency approval of applications submitted by Novartis Crop Protection Inc., to conditionally register the pesticide products Action Herbicide for postemergence control of velvetleaf and certain other broadleaf weeds in soybeans (EPA Registration Number 100- 806); and Fluthiacet-Methyl Technical (formerly CGA-248757 Technical) for formulation use only into registered end-use herbicides (EPA Registration Number 100-805).

NOVARTIS - Pesticide Tolerance Approval for residues of the herbicide in or on soybean seed at 0.01 ppm.- FINAL RULE.

K-I CHEMICAL - Pesticide Tolerance Petition for residues in or on the raw agricultural commodities cottonseed at 0.02 ppm and cotton, gin by-products at 0.5 ppm.

K-I CHEMICAL - Pesticide Tolerance Petition; for residues in or on the raw agricultural commodity popcorn grain at 0.02 ppm

K-I CHEMICAL - Pesticide Tolerance Petition; for residues of the herbicide in or on the raw agricultural commodites field corn grain and sweet corn grain (K + CWHR) at 0.02 ppm and corn forage and fodder at 0.05 ppm.

NOVARTIS - Pesticide Tolerance Petition for Action pesticide. CGA-248757 [Fluthiacet-methyl] is a new herbicide active ingredient in the imide chemistry class. It will be formulated as a 4.75% wettable powder, packaged in water-soluble bags, and sold under the trade name Action

CIBA GEIGY - Petition for Pesticide Tolerance for residues of the herbicide in or on the raw agricultural commodity soybeans at 0.02 ppm.

CIBA GEIGY - Application to register the herbicide CGA-248757[Fluthiacet-methyl] Technical Herbicide; for formulation use only into registered end-use herbicides.

CIBA GEIGY - Experimental Use Permit (100-EUP-98). This experimental use permit allows the use of 16.066 pounds of the herbicide on 1,200 acres of corn and soybeans (200 acres of corn in 1995, 400 acres of corn in 1996 and 200 acres of soybeans in 1995 and 400 acres of soybeans in 1996) to evaluate the control of various weeds. The program is authorized only in the States of AR, DE, IA, IL, IN, KS, KY, LA, MD, MN, MI, MO, NE, NY, NC, ND, OH, PA, SD, TN, TX, VA, and WI. This experimental use permit is effective from March 27, 1995 to December 31, 1996. This permit is issued with the limitation that all treated crops will be destroyed or used for research purposes only.

Syngenta AG. June 8, 2001. Form 20-F. US Securities and Exchange Commission. "Divestments. Novartis, AstraZeneca and Syngenta made several divestments in order to satisfy conditions imposed by the FTC and the European Commission in connection with the formation of Syngenta. The divestments completed in 2000 included the sale of the acetochlor based herbicide products to Dow AgroSciences LLC and the selling of the strobilurin fungicide product line FLINT® to Bayer AG. The divestments completed in 2001 include the sales of the grass herbicide propaquizafop and the pyrethroid insecticide tau-fluvalinate to Makhteshim Agan Industries Ltd, the sale of its sulcotrione herbicide MIKADO ® in the European Economic Area to Bayer AG, the divestment of its global flutriafol fungicide business to Cheminova A/S and the divestment to Makhteshim Agan Ltd. of its former Novartis cereal fungicide product range in Denmark, Sweden and Finland (p 9)."... Active Substances include... Herbicides: Fluthiacet ... Nature of operations. Syngenta AG is a world leading crop protection and seeds business that is involved in the discovery, development, manufacture and marketing of a range of agricultural products designed to improve crop yields and food quality. Syngenta is headquartered in Basel, Switzerland and was formed by Novartis AG ("Novartis") and AstraZeneca PLC ("AstraZeneca") through an agreement to spin off and merge the Novartis crop protection and seeds businesses with the Zeneca agrochemicals business to create a dedicated agribusiness company whose shares were then the subject of a global offering (the "Transactions"). The Transactions were completed on November 13, 2000. In this annual report, for periods prior to November 13, 2000, we refer to the businesses contributed by Novartis as the "Novartis agribusiness"; and we refer to the businesses contributed to Syngenta by AstraZeneca as the "Zeneca agrochemicals business" (p i)." Also available at: http://www.syngenta.com/en/downloads/Syngenta_2000_Form_20-F1.pdf