Return to Ethylene
fluorohydrin Adverse Effects
ACTIVITY: Rodenticide
Structure:
Uses:
Ethylene Fluorohydrin is used as a rodenticide
(Hayes 1982, p. 500), insecticide
(Gosselin 1984, p. III-193), and acaricide
(Buchel 1983, p. 177). Not registered as a pesticide in the
U.S. (USEPA/Active Ingredients 1985).
Ref: Ethylene fluorohydrin.
Extremely Hazardous Substance. US EPA Chemical Profile. November
30, 1987. http://www.fluorideaction.org/pesticides/ethylene.fluorohydrin.epa87.htm
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Ethylene
fluorohydrin is a liquid fluoro alcohol compound which is
miscible in water. Little specific data were available specifically
about the toxicity of ethylene fluorohydrin; its toxicity
is expected to be similar to that of FLUOROACETATE, as it
is oxidized to fluoroacetate by tissue alcohol dehydrogenase.
Ethylene fluorohydrin may be absorbed following ingestion,
inhalation, or dermal contact. It is used as a rodenticide,
although it is not registered for use as a pesticide in
the US.
Mechanism
of Action: The fluoroacetate ion is not poisonous itself
but is converted to fluorocitric acid,
which blocks the tricarboxylic acid cycle, an essential
mechanism of energy production in mammalian cells ... This
manifests itself principally in disturbed activities of
the central nervous system and of the heart. [Gosselin,
R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial
Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p.
III-194]
Ref:
Ethylene fluorohydrin. TOXNET
profile from Hazardous Substances Data Base.
http://www.fluorideaction.org/pesticides/ethylene.fluorohydri.toxnet.htm
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