Adverse Effects
Ethylene fluorohydrin
CAS No. 371-62-0


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Activity: Rodenticide

Adverse Effects:
Endocrine: Uterus

Ethylene fluorohydrin is a liquid fluoro alcohol compound which is miscible in water. Little specific data were available specifically about the toxicity of ethylene fluorohydrin; its toxicity is expected to be similar to that of FLUOROACETATE, as it is oxidized to fluoroacetate by tissue alcohol dehydrogenase. Ethylene fluorohydrin may be absorbed following ingestion, inhalation, or dermal contact. It is used as a rodenticide, although it is not registered for use as a pesticide in the US.

Mechanism of Action: The fluoroacetate ion is not poisonous itself but is converted to fluorocitric acid, which blocks the tricarboxylic acid cycle, an essential mechanism of energy production in mammalian cells ... This manifests itself principally in disturbed activities of the central nervous system and of the heart. [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. III-194]

Ref: Ethylene fluorohydrin. TOXNET profile from Hazardous Substances Data Base.

BoneEndocrine: Uterus Kidney Heart Teratogen
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Source: Teratology 1992 May;45(5):463

Teratogenic effects of the halogenated ethanol 2-fluoro ethanol in Long Evans rats.

Authors: Mankes RF, Lefevre R, Calvano CJ

Author Address: Department of Pharmacology and Toxicology, Albany Medical College, Albany, NY.

Abstract: The 2 substituted halo ethanols (e.g., 2-chloro ethanol-ethylene chlorohydrin-ECH, 2-bromo ethanol-ethylene bromohydrin-EBH, 2-fluoro ethanol-ethylene fluorohydrin-EFH) are contaminants of gas-sterilized foods and medical devices (EBH, ECH) and common industrial reagents (ECH, EBH, EFH). In a continuing effort to define the teratogenic potential of substituted ethanols, pregnant Long-Evans rats were given EFH (0.06, 0.36, and 0.6 mg/kg -I.G.) or water (20 ml/kg-isovolumetric vehicle control) from day 6 to day 15 of gestation. All dams were given lab chow and water ad libitum. Body weights were monitored during gestation. On gestation day 20, the dams were euthanized by halothane overdose and the products of conception examined according to Manson and Kang (1989). Soft tissue defects were evaluated by the free hand slice technique of Wilson (1965) and defects in skeletal development were assessed by the simultaneous double staining technique of McLeod (1980). Significance was set at P less than 0.05 (Yates X2 test). An increase in sternebral ossification defects were present in all experimental groups. Hydronephrosis was evident in the two highest doses. The high dose group had significant incidences of runting (pup weight less than 2.7 g) and variant rib ossifications. Cardiac septal defects appeared in the hearts of pups of the 0.36 mg/kg group. Pups of dams given 0.06 mg/kg of EFH revealed the presence of extra vertebral ossification centers. In the high dose group alone, intrauterine growth retardation was evident based on decreased pup weight (P less than 0.05, corrected T-test). There were no significant changes in either dam or gestational weight gain observed. Overall, the percentage of implantations resulting in malformed or dead pups in response to oral administration of EFH increases significantly in a dose-related manner with increasing alcohol concentrations.
Ref: Mankes RF et al. (1992). Teratogenic effects of the halogenated ethanol 2-fluoro ethanol in Long Evans rats. Teratology 1992 May;45(5):463 as cited by Toxnet.

HYDRONEPHROSIS - Pathological chronic enlargement of the collecting channels of a kidney, leading to compression and eventual destruction of kidney tissue, and diminishing kidney functionning.

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