Fibrosarcoma is a malignant tumor that arises from fibroblasts
(cells that produce connective tissue). This is a type of
sarcoma that is predominantly found in the area around bones
or in soft tissue.
Fibrosarcomas are the result of fibroblasts, which produce
connective tissue such as collagen. Fibrosarcoma tumors are
consequently rich in collagen fibers. The immature, proliferating
fibroblasts take on an interlacing, or herringbone, pattern.
Fibrosarcomas can form from fibroblasts in soft tissue such
as muscles, connective tissues, blood vessels, joints, and
fat. Soft tissue fibrosarcoma normally occurs in fibrous tissue
of the body's trunk and the extremities such as the arms and
legs. Soft tissue fibrosarcomas are extremely rare, with approximately
500 new cases reported each year.
Sarcomas of the bone
Fibrosarcoma can also occur in bones. While a bone is made
up of inorganic molecules such as calcium phosphate, it also
has an organic element made up of 95% collagen, similar to
the collagen found in the skin. Fibrosarcomas of the bone
usually occur in long bones in the bone marrow cavity where
collagen is formed. The bones that predominantly yield fibrosarcomas
are those in the legs, arms, pelvis, and hip.
Sarcomas of the bone are rare and represent about 0.2 percent
of all new cancer cases each year. The two most common forms
of bone cancer are osteosarcoma and Ewing's sarcoma. Among
the less common are chondrosarcoma, fibrosarcoma, and malignant
fibrous histiocytoma, all of which arise from spindle cell
Fibrosarcomas typically develop in people between the ages
of 25-79. The peak age of occurrence is 55-69 years. Generally,
fibrosarcomas develop equally in men and women, though they
are rare in children.
Infantile fibrosarcoma, also known as congenital fibrosarcoma
or juvenile fibrosarcoma, is unique. Under microscopic examination,
it is similar to fibrosarcomas seen in adults. However, infantile
fibrosarcomas have a more positive prognosis with a post-treatment,
five-year survival rate of 83% to 94%.
Causes and symptoms
Fibrosarcomas of the bone are sometimes connected with underlying
benign bone tumors. Both fibrosarcomas of soft tissue and
of the bone can develop as a result of exposure to radiation.
This can result as a side effect from previous radiation therapy
for unrelated primary cancer treatment. Individuals with other
bone diseases, such as Paget's disease and osteomyelitis,
are at a higher risk for developing fibrosarcomas.
There are many symptoms associated with the onset of fibrosarcomas.
The following is a list of the main symptoms that may be present:
* firm lump just under the skin or on a bone
* broken bone
* impeded normal range of motion
* neurologic symptoms
* gastrointestinal bleeding (seen in soft tissue abdominal
* urinary frequency (seen in pelvic fibrosarcomas)
* urinary obstruction (seen in pelvic fibrosarcomas)
Encyclopedia of Cancer | Fibrosarcoma
use of high doses increases the likelihood that potentially
significant toxic effects will be identified. Findings
of adverse effects in any one species do not necessarily
indicate such effects might be generated in humans. From
a conservative risk assessment perspective however, adverse
findings in animal species are assumed to represent potential
effects in humans, unless convincing evidence of species
specificity is available.
Food and Agricultural Organization of the United Nations
This is not an exhaustive list.
When time allows more information will be added.
- Herbicide - CAS No. 29091-21-2
C -- Possible Human Carcinogen. Thyroid
cell neoplasia (M & F); Pancreatic
adenomas (F) in Sprague-Dawley rats. Fibrosarcomas;
CD-1 mice (M).
26, 2006 . Chemicals Evaluated for Carcinogenic Potential by
the Office of Pesticide Programs. From: Jess Rowland, Chief
Science Information Management Branch Health Effect Division
(7509C) Office of Pesticide Programs, USEPA.