CAS No. 68085-85-8

Return to Cyhalothrin Adverse Effects

ACTIVITY: Acaricide, Insecticide (Pyrethroid)

CAS Name: cyano(3-phenoxyphenyl)methyl [1?,3?(Z)]-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate


Adverse Effects:

Body Weight Decrease
Endocrine: Suspected Disruptor
Endocrine: Testicular

Environmental Effects:

Highly Toxic to Fish, Aquatic Invertebrates, and Honeybees

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Pending  
US EPA PC Code: 128867 
US EPA Permit Date
and Registrant:
1992, Zeneca  
European Commission: Not allowed to be used as an active ingredient after July 25, 2003. 
Registered use in
(includes only a limited list of countries)

Africa: Burkina Faso, Cape Verde, Chad, Gambia, Guinea-Bissau, Mali, Mauritania, Niger, Senegal
Japan's Maximum Residue Levels (MRLs) Partial List: Almond • Apple • Apricot • Artichoke • Asparagus • Avocado • Banana • Barley • Beans • Blackberry • Blueberry • Button mushroom • Broccoli • Brussels sprouts • Burdock • Cabbage • Carrot • Cauliflower • Celery • Cherry • Chestnut • Chicory • Cotton seeds • Cranberry • Cucumber (including Gherkin) • Date • Eggplant • Endive • Garlic • Ginger • Grape • Grapefruit • Guava • Horseradish • Huckleberry • Kale • Japanese pear • Japanese persimon • Japanese plum (including Prunes) • Kiwifruit • KOMATSUNA • Konjac • KYONA • Lemon • Lime • Loquat • MAKUWAURI • Mango • Melons • MITSUBA • Mume plum • Lettuce (Cos lettuce, Leaf lettuce) • NATSUDAIDAI (whole) • Nectarine • Okra • Onion • Orange (including Navel) • Other berries • Other cereal grains • Other Citrus fruits • Other Fruits • Other Legumes/pulses • Other mushrooms • Other nuts • Other oil seeds • Other Vegetables • Papaya • Parsley • Parsnip • Passion fruit • Peach • Peanuts (dry) • Pear • Peas • Peas (with pods, immature) • Pecan • Pimento (Sweet pepper) • Pineapple • Potato • Pumpkin (including Squash) • Quince • Rape seeds • Raspberry • Safflower seeds • Salsify • Sesame seeds • Soybeans • SHIITAKE • SHUNGIKU • Spinach • Strawberry • Sugar beet • Sunflower seeds • Sweet potato • Taro • Tea • Tomato • Turnip (including Rutabaga) • UNSHU orange • Walnut • Watercress • Watermelon • Wheat • Yam  
Other Information
Molecular Formula: C23H19Cl F3 NO3  
Entry Year: 1977 
Inventing Company: ICI 
Other Names:

Cyhalothrine (French)
PP 561
PP 563

Of special interest:
PAN Data 
TOXNET profile from Hazardous Substances Data Bank 
June 2002 - In Australia when Cyhalothrin is used as "- Crack and crevice treatment and barrier strip" no maximum residue levels are required. Ref: June 2002. Table 5. Uses of substances where maximum residue limits are not necessary. Australian National Registration Authority for Agricultural Veterinary Chemicals. The MRL Standard. Maximum residue limits in food and animal feedstuff.  
September 2001 - The pyrethroids discussed in this report are: Bifenthrin (Type I), Cyfluthrin (Type II), Cyhalothrin (Type II), Flucythrinate (Type II) , Flumethrin (Type II), Fluvalinate (Type II), Tefluthrin (Type I). DRAFT TOXICOLOGICAL PROFILE FOR PYRETHRINS AND PYRETHROIDS. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES. Public Health Service Agency for Toxic Substances and Disease Registry. September 2001. 
January 25, 1999 - Sediment Toxicity and Fate of Synthetic Pyrethroids. The synthetic pyrethroids were conditionally registered beginning in 1984 for use on cotton and later for use on other major crops including corn, soybeans, and sugarcane. Currently, EPA is assessing risks to non-target organisms for ten synthetic pyrethroids: bifenthrin, cyfluthrin, cypermethrin, deltamethrin, fenpropathrin, fenvalerate, cyhalothrin, tefluthrin, tralomethrin, and permethrin. Each of these synthetic pyrethroids are conditionally registered for use on cotton, with the exception of tefluthrin, which is conditionally registered for use on corn. Each of these chemicals is highly lipophilic and in aquatic environments tend to strongly adsorb to sediments. Environmental Fate and Effects Division Office of Pesticide Programs U.S. Environmental Protection Agency Washington, D. C.  
1990 - Environmental Health Criteria Report No. 99 . WHO International Programme on Chemical Safety.

See also:
Gamma-Cyhalothrin (76703-62-3)
Lambda-Cyhalothrin (91465-08-6)

October 2001 - Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration. 

June 14, 2001 - Implementation of the Community Strategy for Endocrine Disruptors - a range of substances suspected of interfering with the hormone systems of humans and wildlife. Communication from the Commission to the Council and the European Parliament. Commission of the European Communities, Brussels COM (2001) 262 final. (More information available at: )

This document presents a "priority list of substances for further evaluation of their role in endocrine disruption. During 2000, a candidate list of 553 man-made substances and 9 synthetic/natural hormones has been identified." Organofluorine pesticides in this list include:

Substances included on the Endocrine Disruptor Liist CAS No. Substances included on the Endocrine Disruptor Liist CAS No.
Bifenthrin 82657-04-3 Flutriafol 76674-21-0
Cyhalothrin (@Karate) 91465-08-6 Fluvalinate 69409-94-5
Diflubenzuron 35367-38-5 Prodiamine 29091-21-2
Epoxiconazole - Stannane, tributylfluoro [Tributyltin fluoride] 1983-10-4
Fipronil - Thiazopyr -
Fluazifop-butyl 69806-50-4 Trifluralin - 

US Federal Register
Date Published
Docket Identification Number
Oct 30, 1996
Emergency Exemptions. For use on rice.
Oct 9, 1996
Emergency Exemptions. For use on rice and sugarcane.
Jan 12, 1994
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