1,1,1,2-Tetrafluoroethane (HFC-134a)
CAS No. 811-97-2


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Adverse Effects
MSDS & Labels

ACTIVITY: Aerosol propellant, US EPA List 4B Inert (Halogenated organic)


Adverse Effects:

Body Weight Decrease
Ringing in Ears

Environmental Effects:

A non-ozone depleting alternative to dichlorodifluoromethane. The atmospheric lifetime of 1,1,1,2-tetrafluoroethane has been estimated to range from 12.5 to 24 years.

Organic Agriculture:

Approved for use in the new USDA Organic Standards. USDA has approved all List 4 Inerts for use in US Organic agriculture.

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes
List 4B Inert 
US EPA PC Code: 100895 
Registered use in
(includes only a limited list of countries)

Other Information
Molecular Formula: C2H2 F4 
Inventing Company: DuPont 
Manufacturers: DuPont
Halocarbon Products Corp.
Other Names: 1,1,1,2-Tetrafluorethan
Arcton 134a
CCRIS 7214
EINECS 212-377-0
F 134a
FC 134a
Fron 134a
HCFC 134a
HFA 134a
HFC 134a
HSDB 6756
Khladon 134a
Norflurano [INN-Spanish]
Norfluranum [INN-Latin]
R 134a
Refrigerant R134a
TG 134a
Of special interest:
PAN Data 
Material Safety Data Sheets & Labels
August 17, 1997 - Human Inhalation of Halon 1301, HFC-134a and HFC-227ea for Collection of Pharmacokinetic Data. An important and compelling 1997 report on inhalation experiments on human subjects. 
NTIS reports on human and animals studies
TOXNET profile from Hazardous Substances Data Bank 
1998 - Concise International Chemical Assessment Document, No. 11.  

2003 - US EPA List of Inerts. (This substance is on List 4B.)

Note: US EPA allows so-called "Inert" ingredients to be commonly mixed with the "active" pesticidal ingredient to create a formulated pesticide product. According to EPA, "The term `inert' is not intended to imply nontoxicity; the ingredient may or may not be chemically active." "Inert" ingredients include solvents, emulsifiers, spreaders, and other substances mixed into pesticide products to increase the effectiveness of the active ingredients, make the product easier to apply, or to allow several active ingredients to mix in one solution. Both US EPA and California Department of Pesticide Regulation require pesticide manufacturers to identify inert ingredients in their products but do not disclose this information to the general public because the pesticide industry considers product formulations trade secrets, protected by law and by the US EPA. The US EPA category of Inerts:
List 1 - Of Toxicological Concern
List 2 - Potentially Toxic / High Priority for Testing
List 3 - Of Unknown Toxicity
List 4A - Generally Regarded as Safe
List 4B - EPA states it has Sufficient Information to Reasonably Conclude that the Current Use Pattern in Pesticide Products will not Adversely Affect Public Health or the Environment
See good report:
Toxic Secrets": "Inert" Ingredients in Pesticides 1987-1997, published by Northwest Coalition for Alternatives to Pesticides.

US Federal Register
Date Published Docket Identification Number Details
April 28, 2004 OPP-2003-0368 Pesticides; Tolerance Exemptions for Active and Inert Ingredients for Use in Antimicrobial Formulations (Food-Contact Surface Sanitizing Solutions). FINAL RULE.
-- Aerosol propellant - used in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.
June 21, 2001   Hazardous Materials Regulations for Fluoride/fluorinated substances. Harmonization of international shipment of Dangerous Goods. Final Rule.
June 19, 1996  

WHITMIRE - Tolerance Exemption when used as an Inert ingredient (aerosol propellant). - FINAL RULE. This document establishes an exemption from the requirement of a tolerance for residues of 1,1,1,2-tetrafluoroethane when used as an inert ingredient (aerosol propellant) in insecticide formulations intended to be applied in food handling establishments.

April 10, 1996  

WHITMIRE - Request for Tolerance Exemption. This document proposes that residues of 1,1,1,2- tetrafluoroethane be exempted from the requirement of a tolerance when used as an inert ingredient (aerosol propellant) in insecticide aerosol formulations intended to be applied in food handling establishments.

Material Safety Data Sheets (MSDS):
Name of Product Manufacturer / Districutor MSDS

"Dymel" 134a


Vari-Air, Dust-Pro

(Inert dusting gas in metal can)

Peca Products, Inc. MSDS

Aero-Duster Compressed Air Supply

Allied HIgh Tech Products, Inc. MSDS

Duster Spray ("Canned Air")

Albatross USA Inc. / Expert Worldwide

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