NTIS Reports
Teflon (PTFE: polytetrafluoroethylene)
CAS No. 9002-84-0
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Abstracts

ACTIVITY: US EPA Pesticide List 3 Inert.

Teflon is used in pesticides as an Inert. According to a US EPA Final Rule of April 28, 2004:
Montmorillonite-type clay treated with polytetrafluoroethylene. Carrier. PTFE content not greater than 0.5% of clay (w/w). To be used in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Also, component used in plastic slow release tag.

Structure:

Reports available from
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Order Number Date/Title Keywords / Abstract

NTIS/PB99-152175

24 p

1998. Health Hazard Evaluation Report HETA 96-0266-2702, Cooper Engineered Products, Bowling Green, Ohio.

Mattorano D, Trout D

National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Surveillance, Hazard Evaluations and Field Studies.

On September 13, 1996, the National Institute for Occupational Safety and Health (NIOSH) received a management request for a health hazard evaluation (HEE) at Cooper Engineered Products, in Bowling Green, Ohio. The request noted concerns about workers' exposure to a new, two-component, water-based polyurethane paint (water-based polyurethane paint with polytetrafluoroethylene and a polyfunctional aziridine cross-linker) that is applied to automotive/truck rubber seals (vehicle sealing) on the dual durometer (DD) extrusion lines. health effects described in the request included skin and upper respiratory problems. On October 16, 1996, NIOSH industrial hygienists conducted an initial site visit. Area air samples were collected on thermal desorption (TD) tube media to qualitatively identify volatile organic compounds (VOC). Bulk samples of the water-based polyurethane paint were also collected. A follow-up site visit was conducted on March 25-26, 1997, to collect additional air samples. On January [abstract truncated]

NTIS/OTS0539061-1

EPA/OTS; Doc #89-930000107

1993. SUPPORT: LETTER FROM E I DUPONT DE NEMOURS & CO TO USEPA RE PERFLUOROISOBUTYLENE DEGRADATION PRODUCT OF TEFLON PEP FLUOROPOLYMER DURING MELT EXTRUSION W/ATTACHMENTS DATED 05-11-93

E I DUPONT DE NEMOURS & CO
PERFLUOROISOBUTYLENE
ENVIRONMENTAL FATE
PRODUCTION AND PROCESS

CAS Registry Numbers:
382-21-8 (Perfluoroisobutylene)

NTIS/OTS0555860

EPA/OTS; Doc #88-920010591

1992. INITIAL SUBMISSION: SUBACUTE FEEDING STUDY OF TEFLON 7, TEFLON 6 WITH C8-APFC DISPERSING AGENT, TEFLON 6C WITH * IN RATS WITH COVER LETTER DATED 10/15/92

Corporate Name: HASKELL LABORATORY

E I DUPONT DE NEMOURS & CO
TEFLON 7, TEFLON 6 WITH C8-APFC DISPERSING AGENT, TEFLON 6C*
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION
BIOCHEMISTRY
CAS Registry Numbers: 9002-84-0

NTIS/OTS0571216

EPA/OTS; Doc #88-920009560

1992. INITIAL SUBMISSION: PROGRESS REPORT ON TEFLON PYROLYSIS PRODUCTS - INHALATION TOXICITY TESTS IN GUINEA PIGS WITH COVER LETTER DATED 10-15-92


DUPONT CHEM
PYROLYSIS PRODUCTS OF TETRALFUOROETHYLENE RESIN
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
GUINEA PIGS
INHALATION
CAS Registry Numbers: 9002-84-0

NTIS/OTS0555860

EPA/OTS; Doc #88-920010591

1992. INITIAL SUBMISSION: SUBACUTE FEEDING STUDY OF TEFLON 7, TEFLON 6 WITH C8-APFC DISPERSING AGENT, TEFLON 6C WITH * IN RATS WITH COVER LETTER DATED 10/15/92

Corporate Name: HASKELL LABORATORY

E I DUPONT DE NEMOURS & CO
TEFLON 7, TEFLON 6 WITH C8-APFC DISPERSING AGENT, TEFLON 6C*
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION
BIOCHEMISTRY

CAS Registry Numbers: 9002-84-0

NTIS/OTS0555698

EPA/OTS; Doc #88-920010279

1992. INITIAL SUBMISSION: TOXICITY STUDIES OF PYROLYSIS PRODUCTS OF FLUORINATED POLYMERS INCLUDING, PERFLUOROISOBUTYLENE, HEXAFLUOROPROPYLENE, * WITH COVER LETTER DATED 10/15/92

Corporate Name: HASKELL LABORATORY

E I DUPONT DE NEMOURS & CO
PERFLUOROISOBUTYLENE, HEXAFLUOROPROPYLENE,
CARBONYL FLUORIDE
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION

CAS Registry Numbers:
116-15-4 (Hexafluoropropene)
353-50-4 (Carbonyl difluoride, also known as Carbonyl difluoride)
382-21-8 (Perfluoroisobutylene)
9002-84-0

NTIS/OTS0571353

EPA/OTS; Doc #88-920009696

1992. INITIAL SUBMISSION: TOXICITY STUDIES OF PYROLYSIS PRODUCTS OF FLUORINATED POLYMERS (TEFLON POLYTETRAFLUOROETHYLENE) WITH COVER LETTER DATED 10-15-92

Corporate Name: HASKELL LABORATORY

DUPONT CHEM
PYROLYSIS PRODUCTS OF TEFLON POLYTETRAFLUOROETHYLENE
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY

CAS Registry Numbers:
116-15-4 (Hexafluoropropene)
353-50-4 (Carbonyl difluoride, also known as Carbonyl difluoride)
382-21-8 (Perfluoroisobutylene)
9002-84-0

NTIS/OTS0571752

EPA/OTS; Doc #88-920010441

1992. INITIAL SUBMISSION: 3-WEEK FEEDING STUDY IN RATS WITH POLYTETRAFLUOROETHYLENE RESINS (TEFLON) WITH COVER LETTER DATED 10-15-92

Corporate Name: HASKELL LABORATORY

DUPONT CHEM
POLYTETRAFLUOROETHYLENE RESINS
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
ORAL
DIET

CAS Registry Numbers: 9002-84-0

NTIS/DE91009941

17p

1990. Preliminary observations of lung injury produced by instillation of HF in acidic and neutral buffer.

Brainard JR, Kinkead SA, Kober EM, Sebring RJ, Stavert DM

Los Alamos National Lab., NM.

Supporting Agency: Department of Energy, Washington, DC.

Perfluoroisobutylene (PFIB) is an extremely toxic organofluoride that can be produced during pyrolysis of tetrafluoroethylene polymers, including Teflon (reg sign). Inhalation of PFIB at very low concentrations causes acute lung injury, the hallmark of which is pulmonary edema. Several lines of evidence have suggested that hydrolysis of PFIB and resulting production of hydrofluoric acid may be responsible for pulmonary damage. In order to investigate the potential involvement of hydrofluoric acid in producing lung injury and its relationship to the mechanism of fluorocarbon toxicity, we have compared the pulmonary injury produced by PFIB, by dissociated (H(sup +) and F(sup (minus))), and by undissociated (HF) hydrofluoric acid in the deep lung. By delivering hydrofluoric acid by intratracheal instillation in neutral buffer, we demonstrate that F(sup (minus)) produces no significant pulmonary injury as assessed by increased in lung weight and ultrastructural changes. Similarly, instillation of aci [abstract truncated]

NTIS/OTS0513528

EPA/OTS; Doc #86-870000450

1987. PRIMARY EYE IRRITATION OF LOCTITE PIPE SEALANT WITH TEFLON (PRODUCT 592) IN RABBITS (FINAL REPORT)

Corporate Name: AMR BIOL RESEARCH

LOCTITE CORP
HYDROQUINONE (123-31-9)
HEALTH EFFECTS
PRIMARY EYE IRRITATION
MAMMALS
RABBITS
DERMAL

CAS Registry Numbers:
80-15-9 (Cumene hydroperoxide)
123-31-9 (Hydroquinone)
9002-84-0

NTIS/PB87-174330

17p

1987. Information Profiles on Potential Occupational Hazards: Carbonyl Fluoride. Second Draft.

Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.

Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Information on potential occupational hazards from exposure to carbonyl fluoride (353-50-4) was reviewed. Topics discussed included chemical and physical properties, production, use, manufacturers and distributors, manufacturing processes, occupational exposure, and biological effects. Potential exposure to carbonyl fluoride occurs as a result of the thermal decomposition of polytetrafluoroethylene (PTFE) in air. Effects of acute exposure in animal studies included extreme malaise and weakness which preceded death. Subchronic exposure studies with PTFE pyrolysis products revealed pathologic changes in the respiratory tracts and livers of exposed animals. Protein, glucose, ketones, and occult blood appeared in the urine following exposure. No information was available concerning chronic exposures, carcinogenicity, mutagenicity, teratogenicity, or reproductive effects.

NTIS/PB88-170626

6p

1987. Mutagenicity of Teflon-Coated Glass Fiber Filters: A Potential Problem and Solutions

Houk VS, Zweidinger RB, Claxton LD

Health Effects Research Lab., Research Triangle Park, NC.

Journal article, Pub. in Environmental Science and Tech

Teflon-coated glass fiber filters, used in studies of airborne particulate matter, were tested for mutagenic activity using the Salmonella/mammalian-microsome (Ames) assay. For each sample, eight blank filters were simultaneously extracted with dichloromethane (DCM), and the extract was concentrated by rotary evaporation and a nitrogen purge. Samples were solvent exchanged into dimethylsulfoxide (DMSO) for bioassay. Mutagenicity testing was performed using tester strain TA98, with and without metabolic activation. Preliminary findings have indicated that both direct- and indirect-extracting frameshift mutagens were present on the blank filters. Pre-extracting the filters with DCM reduced the activity associated with the filters; however, forced-air baking enhanced the mutagenic response. Additional analyses have suggested that the interference caused by filter mutagenic is inversely proportional to extraction efficiency and particle load.

NTIS/OTS0215303

EPA/OTS; Doc #878220571

1983. THREE-WEEK FEEDING STUDY IN RATS WITH POLYTETRAFLUOROETHYLENE RESINS (TEFLON)

E I DUPONT DENEMOURS & CO INC
CHLORENDIC ACID (115-27-5)
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
ORAL

CAS Registry Numbers:
115-28-6 (Chlorendic acid)

NTIS/OTS0215306

EPA/OTS; Doc #878220598

1983. TOXICITY STUDIES OF PYROLYSIS PRODUCTS OF FLUORINATED POLYMERS

E I DUPONT DENEMOURS & CO INC
FLUOROALKENES
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY

CAS Registry Numbers:
116-15-4 (Hexafluoropropene)
303-50-4 (Desmethylcyclobenzaprine)
9002-84-0

NTIS/OTS0215306

EPA/OTS; Doc #878220692

1983. MEDICAL RESEARCH PROJECT NO. MR-127: POSSIBLE TOXICITY OF TETRAFLUOROETHYLENE (F-1114) AND TRIFLUOROCHLOROETHYLENE (F-1113)

E I DUPONT DENEMOURS & CO INC
FLUOROALKENES
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION
ACUTE TOXICITY
DOGS

CAS Registry Numbers:
79-38-9 (Chlorotrifluoroethylene)
116-14-3 (Tetrafluoroethylene)
9002-84-0

NTIS/OTS0215306

EPA/OTS; Doc #878220596

1983. PROGRESS REPORT ON TEFLON PYROLYSIS PRODUCTS MR-220 INHALATION TOXICITY TESTS

E I DUPONT DENEMOURS & CO INC
FLUOROALKENES
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
GUINEA PIGS

CAS Registry Numbers:
116-15-4 (Hexafluoropropene)
422-55-9 (Propane, 1-chloro-1,1,2,2,3,3-hexafluoro)

 
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