CAS No. 103055-07-8


ACTIVITY: Insecticide (Benzoylurea)

CAS Name: N-[[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]amino]carbonyl]-2,6-difluorobenzamide


Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
Registered use in
(includes only a limited list of countries)

Australia, Hungary, India, Japan, New Zealand, Portugal, South Africa, US, Vietnam

July 2003: EPA issued two Experimental Use Permits for use as termite baits. Both permits are active for 3 years.

Japan's Maximum Residue Levels (MRLs) Apple, Brussel Sprouts, Cabbage, Corn, Eggplant, Grape, Grapefruit, Lemon, Lime, Loquat, Multiplying onion (inc Shallot), Natsudaidai (whole), Orange, Other citrus fruits, Pear, Pimento, Quince, Radish, Strawberry, Sugar beet, Tea, Tomato, Unshu orange, Welsh (inc Leek), Yam
- Note the very high levels - 10 ppm - in Tea (Green, Black, Oolong, Wulung) 
Other Information
Molecular Formula: C17H8Cl2 F8 N2O3 
Entry Year: 1994 
Manufacturers: Novartis, Syngenta 
Other Names: Axor
CGA 184699,
Sentinel (FDA approved)

Manufacture site: UK:
Novartis, Grimsby, NE Lincolnshire
Of special interest:
PAN Data 
Lufenuron7. Canadian Ministry report on rejection due to residues in poultry breast meat. - Ontario Agriculture, Food, and Rural Affairs (Canada)  
Current Uses in Pets: FDA registered because it was given orally and absorbed systemically.  
Warning from Pet Consumer Report. 
August, 2001 - IR-4: New Products/Transitional Solution List - This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes: Lufenuron  
Glossary of Pesticide Chemicals, October 2001. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.  

Adverse Effects:

As of Oct 2003: No data available

Pest Manag Sci. 2006 Aug;62(8):752-8.

Hazards and uptake of chitin synthesis inhibitors in bumblebees Bombus terrestris.

Mommaerts V, Sterk G, Smagghe G.

Department of Biology, Faculty of Sciences, Free University of Brussels, Brussels, Belgium.

This research project examined the potential hazards of a major class of insect growth regulators (IGRs) to survival, reproduction and larval growth in bumblebees Bombus terrestris L. Eight chitin synthesis inhibitors (CSIs) were tested: buprofezin, cyromazine, diflubenzuron, flucycloxuron, flufenoxuron, lufenuron, novaluron and teflubenzuron. These different IGRs, which are important in the control of pest insects in greenhouses, were applied via three different routes of exposure under laboratory conditions: dermal contact, and orally via the drinking of sugar/water and via pollen. The compounds were tested at their respective maximum field recommended concentrations (MFRC) and also in dose-response assays to calculate LC(50) values. In general, none of the CSIs showed acute worker toxicity. However, there was a dramatic reduction in brood production, especially after oral treatment with pollen and sugar/water. Conspicuously, egg fertility was reduced in all treatments with diflubenzuron and teflubenzuron. In addition to egg mortality, the worker bumblebees removed larvae from the treated nest, and in most cases these individuals were dead first-second instars. Under a binocular microscope, such larvae showed an abnormally formed cuticle leading to mechanical weakness and death. In another series of experiments using (14)C-diflubenzuron and (14)C-flufenoxuron, cuticular penetration in workers was studied for a better understanding of the differences in toxicity. With (14)C-diflubenzuron, transovarial transport and accumulation in the deposited eggs supported the strong reproductive effects. Overall, the present results suggest that CSIs should be applied with caution in combination with bumblebees. The compatibility of each compound to be used in combination with B. terrestris is discussed in relation to calculated LC(50) values, routes of uptake and effects.

PMID: 16786494 [PubMed - indexed for MEDLINE]

NOTE from FAN: 6 of the 8 pesticides tested are fluorinated: diflubenzuron, flucycloxuron, flufenoxuron, lufenuron, novaluron and teflubenzuron

US Federal Register
Date Published Docket Identification Number Details
July 18, 2003 OPP-2003-0197 SYNGENTA -Issuance of Experimental Use Permit: 100-EUP-112. to Syngenta Crop Protection, 410 Swing Road, Greensboro, NC 27419-8300. This EUP allows the use of 74 pounds active ingredient of the insecticide Lufenuron around 125 structures to be used as an outdoor in-ground termite bait. The program is authorized in the States of Alabama, Arizona, Arkansas, California, Florida, Georgia, Hawaii, Indiana, Kansas, Kentucky, Louisiana, Maryland, Mississippi, Missouri, Nebraska, Nevada, North Carolina, Ohio, Oklahoma, Pennsylvania, South Carolina, Texas, and Virginia. The EUP is effective from April 3, 2003 to April 3, 2006.
July 18, 2003 OPP-2003-0197 SYNGENTA -Issuance of Experimental Use Permit: 100-EUP-113 to Syngenta Crop Protection, 410 Swing Road, Greensboro, NC 27419-8300. This EUP allows the use of 1 pound active ingredient of the insecticide Lufenuron around 25 structures to be used as an above ground termite bait. The program is authorized only in the States of Arizona, California, Florida, Georgia, Hawaii, Louisiana, Ohio, South Carolina, and Texas. The EUP is effective from May 7, 2003 to May 7, 2006.
Oct 2, 1998 HFA-305

NOVARTIS - Oral Dosage Form New Animal Drugs; Lufenuron Tablets. FINAL RULE. The Food and Drug Administration is amending the animal drug regulations to reflect approval of a supplemental new animal drug application (NADA) filed by Novartis Animal Health US, Inc. The supplemental NADA provides for revising the specifications and conditions of use of lufenuron tablets for dogs and cats for control of flea populations.

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