Acaricide, Insecticide (benzoylurea)
(only comprehensive for the US)
EPA PC Code:
(Old US EPA PC Code: 225100)
allowed to be used as an active ingredient after July 25,
(includes only a limited list of countries)
26, 2002 - European
Commission: Flucycloxuron is one of 320 pesticides to be withdrawn
in July 2003. Some
320 substances used in plant protection products (PPPs) - including
insecticides, fungicides and herbicides - are to be withdrawn
from the market by 25 July 2003 as part of the European Commission's
new approach to the evaluation of active substances in plant
protection products. This aims to improve safeguards to ensure
that all such products in use are safe for the environment and
human health. Users, wholesalers and retailers of plant protection
products will need to be aware of whether the products they
use or sell are likely to be withdrawn, so as to prevent them
being left with stocks of unusable material. Those concerned
should contact their national authority to check the authorisation
status for any particular product. The Regulation (ní 2076/2002
of 20 November 2002), with the list of the 320 substances, has
now been published in the Offical Journal. Ref: MIDDAY EXPRESS.
News from the Press and Communication Service's midday briefing.
of Pesticide Chemicals, October 2001.
A listing of pesticides subject to analysis of residues in foods
and feeds by the US Food and Drug Administration.
of Dec 2003: No data available
Manag Sci. 2006 Aug;62(8):752-8.
and uptake of chitin synthesis inhibitors in bumblebees
V, Sterk G, Smagghe G.
of Biology, Faculty of Sciences, Free University of Brussels,
research project examined the potential hazards of a major
class of insect growth regulators (IGRs) to survival, reproduction
and larval growth in bumblebees Bombus terrestris L. Eight
chitin synthesis inhibitors (CSIs) were tested: buprofezin,
cyromazine, diflubenzuron, flucycloxuron,
flufenoxuron, lufenuron, novaluron
These different IGRs, which are important in the control
of pest insects in greenhouses, were applied via three different
routes of exposure under laboratory conditions: dermal contact,
and orally via the drinking of sugar/water and via pollen.
The compounds were tested at their respective maximum field
recommended concentrations (MFRC) and also in dose-response
assays to calculate LC(50) values. In general, none of the
CSIs showed acute worker toxicity.
However, there was a dramatic reduction in brood production,
especially after oral treatment with pollen and sugar/water.
Conspicuously, egg fertility was reduced
in all treatments with diflubenzuron and teflubenzuron.
In addition to egg mortality, the worker bumblebees removed
larvae from the treated nest, and in most cases these individuals
were dead first-second instars. Under a binocular microscope,
such larvae showed an abnormally formed cuticle leading
to mechanical weakness and death. In another series
of experiments using (14)C-diflubenzuron and (14)C-flufenoxuron,
cuticular penetration in workers was studied for a better
understanding of the differences in toxicity. With (14)C-diflubenzuron,
transovarial transport and accumulation in the deposited
eggs supported the strong reproductive effects. Overall,
the present results suggest that CSIs should be applied
with caution in combination with bumblebees. The
compatibility of each compound to be used in combination
with B. terrestris is discussed in relation to calculated
LC(50) values, routes of uptake and effects.
16786494 [PubMed - indexed for MEDLINE]
from FAN: 6 of the 8 pesticides tested
are fluorinated: diflubenzuron, flucycloxuron,
flufenoxuron, lufenuron, novaluron and teflubenzuron
of benzoylurea insecticide teflubenzuron and flucycloxuron
in soil environment.
Authors: KIM T-H, KIM J-E
Author Address: Dep. Agric. Chem., Kyungpook National University,
Taegu 702-701, KOR.
Source: JOURNAL OF THE KOREAN AGRICULTURAL CHEMICAL SOCIETY;
36 (6). 1993. 510-516.
BIOSIS COPYRIGHT: BIOL ABS. The degradation and leaching
pattern of benzoylurea insecticide teflubenzuron and flucycloxuron
in soil environment and their effect on urease activity
were investigated. The half-life of teflubenzuron was 39.1
days and 20.9 days in Chilgok and Ansim soil of nonsterilized
condition, respectively, and that of flucycloxuron was 102.3
days and 50.1 days. Teflubenzuron and flucycloxuron were
degraded more rapidly in Ansim soil with rich organic matter
than Chilgok soil, and were degraded very slowly under sterilized
condition. Their degradation seemed to be mainly mediated
by microorganisms in soil. Teflubenzuron was degraded 63.2
days and 29.2 days faster than flucycloxuron under nonsterilized
condition of Chilgok and Ansim soil. The inhibition of urease
by the pesticides in two kinds of soil was strongly affected
(37.6 42.4%) in the early stage of their treatment but hardly
affected or increased a little after 120 days. The teflubenzuron
and flucycloxuron remained in the
activity of flucycloxuron, a novel benzoylphenylurea derivative,
on Tenebrio molitor: Comparison with diflubenzuron and triflumuron.
Authors: SOLTANI N, CHEBIRA S, DELBECQUE JP, DELACHAMBRE
Author Address: Dep. de Biologie Animale, Universite de
Annaba, BP 12, 23000 Annaba, ALG.
Source: EXPERIENTIA (BASEL); 49 (12). 1993.
BIOSIS COPYRIGHT: BIOL ABS. Flucycloxuron, a novel benzoylphenylurea
(BPU) derivative, exhibited insecticidal activity when injected
into newly ecdysed pupae of Tenebrio molitor. Mortality
occurs because of defective adult ecdysis. Treatment caused
a reduction in both cuticle thickness and incorporation
of 14C-labelled precursor into chitin, although it had no
significant effect on the protein synthesis. The potencies
of other BPU compounds as inhibitors of chitin biosynthesis
have been examined and results showed that diflubenzuron
was less effective than either flucycloxuron or triflumuron.
POISONING HAZARD PROSSER 1990-1991
Authors: MAYER DF, LUNDEN JD, HUSFLOEN MR
Source: BURDITT, A. K. JR. (ED.). INSECTICIDE & ACARICIDE
TESTS, VOL. 18. II+405P. ENTOMOLOGICAL SOCIETY OF AMERICA:
LANHAM, MARYLAND, USA.; 0 (0). 1993.