CAS
Name: (2,3,5,6-tetrafluoro-4-methylphenyl)methyl [1?,3?(Z)]-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate
Structure:
Adverse
Effects:
Ataxia
Blood
Body
Weight Decrease
Bone
Brain
Cholesterol
Endocrine: Thyroid
Endocrine:
Uterus
Heart
Liver
Tremors |
Environmental
Effects:
Fish:
Very Highly Toxic
|
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
Yes |
US
EPA PC Code: |
128912 |
California
Chemical Code |
3839 |
US
Tolerances: |
CFR
180.440 |
FDA
LMS Code: |
B26 |
US
EPA Permit Date
and Registrant: |
1989,
ICI |
Registered
use in
(includes only a limited list of countries)
|
Australia,
Canada, Denmark, Germany, Hungary, Japan, Portugal, UK, US |
Japan's
Maximum Residue Levels (MRLs) |
Brussel sprouts, Cabbage, Corn, Peanuts
(dry), Radish, Sugarcane, Strawberry, Sweet potato |
US
Maximum Residue Levels permitted
in food commodities
|
Corn,
field:
fodder
and forage, pop and sweet, grain and pop,
and fresh with husk removed. |
Other
Information |
Molecular
Formula: |
C17H14Cl
F7 O2 |
Manufacturers: |
Zeneca
Syngenta |
Other
Names: |
Force
Forza,
PP 993
R 151993 |
Manufacture
site: |
UK:
Zeneca, Huddersfield |
Of
special interest: |
PAN
BAD ACTOR - Acute Toxicity |
Hazardous
Substances Data Base - full record on Tefluthin as of November
17, 2004. |
Tefluthrin.
UKPID Monograph. National Poisons Information Service Centre
in the UK. |
September
2001 - The pyrethroids discussed in this report are: Bifenthrin
(Type I), Cyfluthrin (Type II) , Cyhalothrin (Type II), Flucythrinate
(Type II) , Flumethrin (Type II), Fluvalinate (Type II), Tefluthrin
(Type I). DRAFT TOXICOLOGICAL PROFILE
FOR PYRETHRINS AND PYRETHROIDS. U.S. DEPARTMENT OF HEALTH AND
HUMAN SERVICES. Public Health Service Agency for Toxic Substances
and Disease Registry. September 2001. http://www.atsdr.cdc.gov/toxprofiles/tp155.pdf |
2000-2002
- Highly hazardous. WHO
Recommended Classification of Pesticides by Hazard and Guidelines
to Classification 2000-2002. Table
2. Highly hazardous (Class Ib) technical grade active ingredients
of pesticides, p 18. |
|
US
Map of Pesticide Use: 1992-1995 |
January
25, 1999 - Sediment
Toxicity and Fate of Synthetic Pyrethroids. The
synthetic pyrethroids were conditionally registered beginning
in 1984 for use on cotton and later for use on other major crops
including corn, soybeans, and sugarcane. Currently, EPA is assessing
risks to non-target organisms for ten synthetic pyrethroids:
bifenthrin, cyfluthrin, cypermethrin, deltamethrin, fenpropathrin,
fenvalerate, cyhalothrin, tefluthrin,
tralomethrin, and permethrin. Each of
these synthetic pyrethroids are conditionally registered for
use on cotton, with the exception of tefluthrin,
which is conditionally registered for use on corn. Each of these
chemicals is highly lipophilic and in aquatic environments tend
to strongly adsorb to sediments. Environmental Fate and Effects
Division Office of Pesticide Programs U.S. Environmental Protection
Agency Washington, D. C. |
Abstracts |
August
2001 - IR-4:
New
Products/Transitional Solution List This
list contains brief descriptions of numerous new pest control
materials that have been introduced over the last several years.
Additionally, it contains information on some "older"
crop protection chemicals that are believed to have room for
new uses. This List includes:
Tefluthrin |
Rationale
for US EPA to add Tefluthrin to the Toxic Release Inventory
Delayed
ossification was seen in the offspring of rats administered
5 mg/kg/day (LOEL) orally on days 7 through 16 of gestation.
The NOEL was 3 mg/kg/ day.
In
a 3-month rat study, dietary administration of 10 mg/kg/day
produced plasma, red blood cell, and brain cholinesterase
inhibition. The NOEL was 5 mg/kg/day. In a 6-month dog study,
dietary administration of 10 mg/kg/day (LOEL) produced plasma
cholinesterase inhibition. The NOEL was 1 mg/kg/day.
In
a 21-day rat dietary study, administration of 20 mg/kg/day
(LOEL for females) produced decreased platelet counts, increased
white blood cell, lymphocyte, and neutrophil counts in males
and females. The NOEL for females was 5 mg/kg/day. Increased
absolute and relative liver weights were observed at 5 mg/kg/day
in males, thus no NOEL could be established for males. Dietary
administration of 10 mg/kg/day (LOEL) for 3 months to rats
produced increased absolute liver weights, decreased bilirubin
levels, and hepatocellular hypertrophy. The NOEL was 5 mg/kg/day.
In a 6-month dog study, dietary administration of 10 mg/kg/day
(LOEL) produced hepatotoxicity (effects not reported). The
NOEL was 1 mg/kg/day. In a 2-year mouse study, dietary administration
of 13.5 mg/kg/day produced liver necrosis. The NOEL was
3.4 mg/kg/day.
EPA
believes that there is sufficient evidence for listing tefluthrin
on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B)
based on the available developmental, neurological, hepatic,
and hematological toxicity data for this chemical.
Aquatic
acute toxicity values for tefluthrin include a rainbow trout
96-hour LC 50 of 0.06 ppb, a bluegill 96-hour LC50
of 0.13 ppb, a sheepshead minnow 96-hour LC50 of 0.13
ppb, a daphnid 48-hour EC50 of 0.07 ppb, and a mysid*
96-hour EC 50 of 0.053 ppb. EPA believes that there
is sufficient evidence for listing teflurin on EPCRA section
313 pursuant to EPCRA section 313(d)(2)(C) based on the
available environmental toxicity data for this chemical.
Ref:
USEPA/OPP. Support Document for the Addition of Chemicals
from Federal Insecticide, Fungicide, Rodenticide Act (FIFRA)
Active Ingredients to EPCRA Section 313. U. S. Environmental
Protection Agency, Washington, DC (1993).
As cited by US EPA in: Federal
Register: January 12, 1994. Part IV. 40 CFR Part 372.
Addition of Certain Chemicals; Toxic Chemical Release Reporting;
Community Right-to-Know; Proposed Rule.
Note:
Addition
of Certain Chemicals; Toxic Chemical Release Reporting;
Community Right-to-Know. Final
Rule.
Teflutrin
was included in the deferral of 40 chemicals: EPA
is deferring final action on 40 chemicals and one chemical
category until a later date. These chemicals and the comments
received on them raised particularly difficult technical
or policy issues which will require additional time to address.
The Agency does not believe that it would be in the spirit
of community right-to-know to delay final action on the
remaining 286 chemicals and chemical categories, pending
completion of work on the more limited group. In a future
rulemaking, EPA will make a final determination as to whether
these chemicals should be added to EPCRA section 313. The
public comment that has been received specific to these
deferred chemicals will be addressed as part of the future
rulemaking discussed above.
|
Table
6-1. Trends of National Pyrethroid Use
September
2001. Draft
Toxicological Profile for Pyrethrins and Pyrethroids.
US Department of Health and Human Services. Public Health
Service Agency for Toxic Substances and Disease Registry.
Organofluorine pyrethroids discussed in the Profile: Bifenthrin
(Type 1), Cyfluthrin (Type 2), Cyhalothrin (Type 2), Flucythrinate
(Type 2), Flumethrin (Type 2), Fluvalinate (Type 2), Tefluthrin
(Type 1).
Note from EC: The following 4 organofluorine pesticides were
included in a list of 11 pesticides. |
Pyrethroid |
Amounts
applied
(pounds) 1992 |
Amounts
applied
(pounds) 1997 |
Percent
change |
Bifenthrin |
116,716 |
110,246 |
-5 |
Cyfluthrin |
124,360 |
177,782 |
+43 |
Lambda-cyhalothrin |
205,329 |
321,284 |
+57 |
Tefluthrin |
238,429 |
576,865 |
+142 |
|
Published
Date |
Docket
Identification Number |
Details |
Nov
26, 1997 |
OPP-300576 |
ZENECA
- Pesticide
Tolerance for Corn. - FINAL RULE. This regulation
establishes tolerances for combined residues of tefluthrin
and its metabolite in or on corn, grain, field and pop; corn,
forage and fodder, field, pop and sweet; and corn, fresh (including
sweet K and corn with husk removed (CWHR)) at 0.06 ppm. It
also removes time limitations for tolerances for residues
of tefluthrin on the same commodities that expire on November
15, 1997. |
Sept
25, 1997 |
PF-767 |
ZENECA
- 3 Pesticide
petitions. |
Aug
4, 1997 |
OPP-300523 |
Pesticides
Subject to Tolerance Reassessment. |
May
3, 1996 |
PP
4F4406/R2222 |
ZENECA
- Renewal
of Time-limited Tolerances. - FINAL RULE. This
rule establishes a tolerance for the combined residues of
the pyrethroid tefluthrin and its metabolites in or on the
raw agricultural commodity (RAC) corn, fresh (including sweet
K + CWHR) at 0.06 ppm, and corn, forage and fodder, sweet
at 0.06 ppm and renews time-limited tolerances for tefluthrin
on the RAC's corn, grain, field, and pop; corn forage and
fodder, field and pop. |
Feb
8, 1995 |
na |
ZENECA
- Pesticide
Tolerance Petition; to permit residues in or on corn,
fresh (including sweet K and CWHR) at 0.06 ppm, and corn,
forage and fodder, sweet at 0.06 ppm. |
November
30, 1994 |
OPPTS-400082B7 |
Addition
of Certain Chemicals; Toxic Chemical Release Reporting; Community
Right-to-Know. Final
Rule.
EPA is
deferring final action on 40 chemicals and one chemical category
until a later date. These chemicals and the comments received
on them raised particularly difficult technical or policy
issues which will require additional time to address. The
Agency does not believe that it would be in the spirit of
community right-to-know to delay final action on the remaining
286 chemicals and chemical categories,
pending completion of work on the more limited group. In a
future rulemaking, EPA will make a final determination as
to whether these chemicals should be added to EPCRA section
313. The public comment that has been received specific to
these deferred chemicals will be addressed as part of the
future rulemaking discussed above. These chemicals follow:
tefluthrin
|
Sept
30, 1994 |
na |
ZENECA
- Pesticide
Tolerances for Corn. - FINAL RULE. This document
extends tolerances for the combined residues of the synthetic
pyrethroid tefluthrin and its metabolite in or on the raw
agricultural commodities corn, grain, field, and pop at 0.2
ppm; corn, forage and fodder, field and pop at 0.6 ppm. Zeneca
Ag Products (previously, ICI Americas, Inc.) requested this
regulation to extend the effective date for tolerances for
maximum permissible levels of residues of this insecticide
in or on these commodities. |
August
3, 1994 |
na |
ZENECA
- Petition
for Pesticide Tolerances. Proposed Rule. This document
proposes to extend tolerances for the combined residues of
the synthetic pyrethroid tefluthrin and its metabolite in
or on the raw agricultural commodities corn, grain, field,
and pop at 0.02 ppm; corn, forage and fodder, field and pop
at 0.6 ppm. |
Jan
12, 1994 |
OPPTS-400082 |
EPA's
proposal to add 41
fluorine and organofluorine chemicals to the Toxics Release
Inventory (TRI). See excerpt in box
above. Also available at http://www.epa.gov/tri/frnotices/59fr1788.htm |
|