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available from
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Order
Number |
Date/Title |
Keywords
/ Abstract |
NTIS/PB99-152175
24 p |
1998.
Health Hazard Evaluation Report HETA
96-0266-2702, Cooper Engineered Products, Bowling Green,
Ohio.
Mattorano
D, Trout D
National
Inst. for Occupational Safety and Health, Cincinnati, OH.
Div. of Surveillance, Hazard Evaluations and Field Studies.
|
On September
13, 1996, the National Institute for Occupational Safety and
Health (NIOSH) received a management request for a health
hazard evaluation (HEE) at Cooper Engineered Products, in
Bowling Green, Ohio. The request noted concerns about workers'
exposure to a new, two-component, water-based polyurethane
paint (water-based polyurethane paint
with polytetrafluoroethylene and a polyfunctional aziridine
cross-linker) that is applied to automotive/truck rubber seals
(vehicle sealing) on the dual durometer (DD) extrusion lines.
health effects described in the request included skin and
upper respiratory problems. On October 16, 1996, NIOSH
industrial hygienists conducted an initial site visit. Area
air samples were collected on thermal desorption (TD) tube
media to qualitatively identify volatile organic compounds
(VOC). Bulk samples of the water-based polyurethane paint
were also collected. A follow-up site visit was conducted
on March 25-26, 1997, to collect additional air samples. On
January [abstract truncated] |
NTIS/OTS0539061-1
EPA/OTS;
Doc #89-930000107 |
1993.
SUPPORT: LETTER FROM E I DUPONT DE NEMOURS & CO TO USEPA
RE PERFLUOROISOBUTYLENE DEGRADATION PRODUCT OF TEFLON PEP
FLUOROPOLYMER DURING MELT EXTRUSION W/ATTACHMENTS DATED 05-11-93
|
E
I DUPONT DE NEMOURS & CO
PERFLUOROISOBUTYLENE
ENVIRONMENTAL FATE
PRODUCTION AND PROCESS
CAS
Registry Numbers:
382-21-8 (Perfluoroisobutylene) |
NTIS/OTS0555860
EPA/OTS;
Doc #88-920010591 |
1992.
INITIAL SUBMISSION: SUBACUTE FEEDING STUDY OF TEFLON 7,
TEFLON 6 WITH C8-APFC DISPERSING AGENT, TEFLON 6C WITH *
IN RATS WITH COVER LETTER DATED 10/15/92
Corporate
Name: HASKELL LABORATORY
|
E I DUPONT
DE NEMOURS & CO
TEFLON 7, TEFLON 6 WITH C8-APFC DISPERSING AGENT, TEFLON 6C*
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION
BIOCHEMISTRY
CAS Registry Numbers: 9002-84-0 |
NTIS/OTS0571216
EPA/OTS;
Doc #88-920009560 |
1992.
INITIAL SUBMISSION: PROGRESS REPORT ON TEFLON PYROLYSIS
PRODUCTS - INHALATION TOXICITY TESTS IN GUINEA PIGS WITH
COVER LETTER DATED 10-15-92
|
DUPONT CHEM
PYROLYSIS PRODUCTS OF TETRALFUOROETHYLENE RESIN
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
GUINEA PIGS
INHALATION
CAS
Registry Numbers: 9002-84-0
|
NTIS/OTS0555860
EPA/OTS;
Doc #88-920010591 |
1992.
INITIAL SUBMISSION: SUBACUTE FEEDING STUDY OF TEFLON 7,
TEFLON 6 WITH C8-APFC DISPERSING AGENT, TEFLON 6C WITH *
IN RATS WITH COVER LETTER DATED 10/15/92
Corporate
Name: HASKELL LABORATORY
|
E
I DUPONT DE NEMOURS & CO
TEFLON 7, TEFLON 6 WITH C8-APFC DISPERSING AGENT, TEFLON
6C*
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION
BIOCHEMISTRY
CAS
Registry Numbers: 9002-84-0 |
NTIS/OTS0555698
EPA/OTS;
Doc #88-920010279 |
1992.
INITIAL SUBMISSION: TOXICITY STUDIES OF PYROLYSIS PRODUCTS
OF FLUORINATED POLYMERS INCLUDING, PERFLUOROISOBUTYLENE,
HEXAFLUOROPROPYLENE, * WITH COVER LETTER DATED 10/15/92
Corporate
Name: HASKELL LABORATORY
|
E
I DUPONT DE NEMOURS & CO
PERFLUOROISOBUTYLENE, HEXAFLUOROPROPYLENE,
CARBONYL FLUORIDE
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
CAS
Registry Numbers:
116-15-4 (Hexafluoropropene)
353-50-4 (Carbonyl difluoride, also known as Carbonyl difluoride)
382-21-8 (Perfluoroisobutylene)
9002-84-0 |
NTIS/OTS0571353
EPA/OTS;
Doc #88-920009696 |
1992.
INITIAL SUBMISSION: TOXICITY STUDIES OF PYROLYSIS PRODUCTS
OF FLUORINATED POLYMERS (TEFLON POLYTETRAFLUOROETHYLENE)
WITH COVER LETTER DATED 10-15-92
Corporate
Name: HASKELL LABORATORY
|
DUPONT
CHEM
PYROLYSIS PRODUCTS OF TEFLON POLYTETRAFLUOROETHYLENE
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY
CAS
Registry Numbers:
116-15-4 (Hexafluoropropene)
353-50-4 (Carbonyl difluoride, also known as Carbonyl difluoride)
382-21-8 (Perfluoroisobutylene)
9002-84-0 |
NTIS/OTS0571752
EPA/OTS;
Doc #88-920010441 |
1992.
INITIAL SUBMISSION: 3-WEEK FEEDING STUDY IN RATS WITH POLYTETRAFLUOROETHYLENE
RESINS (TEFLON) WITH COVER LETTER DATED 10-15-92
Corporate
Name: HASKELL LABORATORY |
DUPONT
CHEM
POLYTETRAFLUOROETHYLENE RESINS
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
ORAL
DIET
CAS
Registry Numbers: 9002-84-0 |
NTIS/DE91009941
17p |
1990.
Preliminary observations of lung injury produced by instillation
of HF in acidic and neutral buffer.
Brainard JR, Kinkead SA, Kober EM, Sebring RJ, Stavert DM
Los
Alamos National Lab., NM.
Supporting
Agency: Department of Energy, Washington, DC. |
Perfluoroisobutylene
(PFIB) is an extremely toxic organofluoride that can be produced
during pyrolysis of tetrafluoroethylene polymers, including
Teflon
(reg sign). Inhalation of PFIB at very
low concentrations causes acute lung injury, the hallmark
of which is pulmonary edema. Several lines of evidence
have suggested that hydrolysis of PFIB and resulting production
of hydrofluoric acid may be responsible for pulmonary damage.
In order to investigate the potential involvement of hydrofluoric
acid in producing lung injury and its relationship to the
mechanism of fluorocarbon toxicity, we have compared the pulmonary
injury produced by PFIB, by dissociated (H(sup +) and F(sup
(minus))), and by undissociated (HF) hydrofluoric acid in
the deep lung. By delivering hydrofluoric acid by intratracheal
instillation in neutral buffer, we demonstrate that F(sup
(minus)) produces no significant pulmonary injury as assessed
by increased in lung weight and ultrastructural changes. Similarly,
instillation of aci [abstract truncated] |
NTIS/OTS0513528
EPA/OTS;
Doc #86-870000450 |
1987.
PRIMARY EYE IRRITATION OF LOCTITE PIPE SEALANT WITH TEFLON
(PRODUCT 592) IN RABBITS (FINAL REPORT)
Corporate
Name: AMR BIOL RESEARCH
|
LOCTITE
CORP
HYDROQUINONE (123-31-9)
HEALTH EFFECTS
PRIMARY EYE IRRITATION
MAMMALS
RABBITS
DERMAL
CAS
Registry Numbers:
80-15-9 (Cumene hydroperoxide)
123-31-9 (Hydroquinone)
9002-84-0 |
NTIS/PB87-174330
17p |
1987.
Information Profiles on Potential Occupational
Hazards: Carbonyl Fluoride. Second Draft.
Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.
Sponsored by National Inst. for Occupational Safety and Health,
Rockville, MD. |
Information
on potential occupational hazards from exposure to carbonyl
fluoride (353-50-4) was reviewed. Topics discussed included
chemical and physical properties, production, use, manufacturers
and distributors, manufacturing processes, occupational exposure,
and biological effects. Potential exposure
to carbonyl fluoride occurs as a result of the thermal decomposition
of polytetrafluoroethylene (PTFE) in air. Effects of
acute exposure in animal studies included
extreme malaise and weakness which preceded death.
Subchronic exposure studies with PTFE pyrolysis products revealed
pathologic changes in the respiratory
tracts and livers of exposed animals. Protein, glucose,
ketones, and occult blood appeared in the urine following
exposure. No information was available concerning chronic
exposures, carcinogenicity, mutagenicity, teratogenicity,
or reproductive effects. |
NTIS/PB88-170626
6p |
1987.
Mutagenicity
of Teflon-Coated Glass Fiber Filters: A Potential Problem
and Solutions
Houk VS, Zweidinger RB, Claxton LD
Health
Effects Research Lab., Research Triangle Park, NC.
Journal article, Pub. in Environmental Science and Tech |
Teflon-coated
glass fiber filters, used in studies of airborne particulate
matter, were tested for mutagenic activity using the Salmonella/mammalian-microsome
(Ames) assay. For each sample, eight blank filters were simultaneously
extracted with dichloromethane (DCM), and the extract was
concentrated by rotary evaporation and a nitrogen purge. Samples
were solvent exchanged into dimethylsulfoxide (DMSO) for bioassay.
Mutagenicity testing was performed using tester strain TA98,
with and without metabolic activation. Preliminary
findings have indicated that both direct- and indirect-extracting
frameshift mutagens were present on the blank filters.
Pre-extracting the filters with DCM reduced the activity associated
with the filters; however, forced-air baking enhanced the
mutagenic response. Additional analyses have suggested that
the interference caused by filter mutagenic is inversely proportional
to extraction efficiency and particle load. |
NTIS/OTS0215303
EPA/OTS;
Doc #878220571 |
1983.
THREE-WEEK FEEDING STUDY IN RATS WITH POLYTETRAFLUOROETHYLENE
RESINS (TEFLON)
|
E
I DUPONT DENEMOURS & CO INC
CHLORENDIC ACID (115-27-5)
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
ORAL
CAS
Registry Numbers:
115-28-6 (Chlorendic acid) |
NTIS/OTS0215306
EPA/OTS;
Doc #878220598 |
1983.
TOXICITY STUDIES OF PYROLYSIS PRODUCTS OF FLUORINATED POLYMERS |
E
I DUPONT DENEMOURS & CO INC
FLUOROALKENES
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY
CAS
Registry Numbers:
116-15-4 (Hexafluoropropene)
303-50-4 (Desmethylcyclobenzaprine)
9002-84-0 |
NTIS/OTS0215306
EPA/OTS;
Doc #878220692 |
1983.
MEDICAL RESEARCH PROJECT NO. MR-127: POSSIBLE TOXICITY OF
TETRAFLUOROETHYLENE (F-1114) AND TRIFLUOROCHLOROETHYLENE (F-1113)
|
E
I DUPONT DENEMOURS & CO INC
FLUOROALKENES
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION
ACUTE TOXICITY
DOGS
CAS
Registry Numbers:
79-38-9 (Chlorotrifluoroethylene)
116-14-3 (Tetrafluoroethylene)
9002-84-0 |
NTIS/OTS0215306
EPA/OTS;
Doc #878220596 |
1983.
PROGRESS REPORT ON TEFLON PYROLYSIS PRODUCTS MR-220 INHALATION
TOXICITY TESTS
|
E
I DUPONT DENEMOURS & CO INC
FLUOROALKENES
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
GUINEA PIGS
CAS
Registry Numbers:
116-15-4 (Hexafluoropropene)
422-55-9 (Propane, 1-chloro-1,1,2,2,3,3-hexafluoro) |