Fluazuron
CAS No. 86811-58-7
 
 

Return to Fluazuron Adverse Effects

ACTIVITY: Acaricide (benzoylphenyl urea)

CAS Name: N-[[[4-chloro-3-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]amino]carbonyl]-2,6-difluorobenzamide

Structure:

Potential Adverse Effects:

Brain

Regulatory Information
(only comprehensive for the US)
US EPA Registered: No
Registered use in
(includes only a limited list of countries)

Australia, Canada, Korea 
Maximum Residue Levels permitted in food commodities
(includes only a limited list of countries) 
Canada:
Cattle fat, Meat byproducts of cattle
Other Information
Molecular Formula: C20H10Cl2 F5 N3O3 
Manufacturers: Novartis 
Other Names: Acatak, CGA-157419  
Manufacture site: SWITZERLAND:
Syngenta, Munchwilen
 
Of special interest:

March 11, 2005 - Summary Opinion of the Committee for Medicinal Products for Veterinary Use on the Establishment of Maximum Residue Limits. European Medicines Agency. EMEA/CVMP/77306/2005.

"Not for use in animals from which milk is produced for human consumption. Provisional MRLs expire on January 1, 2007."

Fluazuron: Material Safety Data Sheets & Labels
May 26, 1998 - KOREA: FDA accepts provisional MRL in beef  
1997 - FAO/WHO recommended maximum residue limits in Cattle
02/12/1998. Description of content: Fluazuron is a tick development inhibitor which controls the cattle tick Boophilus microplus, present in tropical areas including Australia. It is not currently registered under the Pest Control Products Act for use in Canada since the product is not manufactured, used or sold in Canada.
The Pest Management Regulatory Agency of Health Canada has been requested to establish Maximum Residue Limits (MRLs) for fluazuron in meat and meat by-products from cattle imported into Canada.
After the review of all available data, it is proposed to amend the Food and Drug Regulations to establish MRLs for fluazuron in fat of cattle at 7.0 ppm and in meat by-products of cattle at 0.5 ppm. Residues of fluazuron in cattle meat will be covered under the general tolerance of 0.1 ppm specified in subsection B.15.002(1).
Ref: N/CAN/37. USDA. Foreign Agricultural Service - FAS Online.
http://www.fas.usda.gov/itp/ofsts/WTONOT2.HTML
October 2001 - Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.  

Excerpt from the following report:
There is a transfer and accumulation of fluazuron in calves suckling cows which have been treated with fluazuron pour-on (Strong and Swindale, 1993).

Report available at: http://www.fao.org/docrep/W8338E/w8338e09.htm#fluazuron

World Health Organ Tech Rep Ser. 1998;879:i-vi, 1-73.

Evaluation of certain veterinary drug residues in food. Forty-eighth report of the Joint FAO/WHO Expert Committee on Food Additives.

[No authors listed]

This report presents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in foods and to recommend maximum levels for such residues in food. The first part of the report considers standards for the performance of studies, residues at the injection site, and several initiatives to promote transparency of the process for setting Maximum Residue Limits (MRLs). A summary follows of the Committee's evaluations of toxicological and residue data on a variety of veterinary drugs: two anthelminthic agents (moxidectin and tiabendazole), eight antimicrobial agents (ceftiofur, danofloxacin, dihydrostreptomycin, streptomycin, enrofloxacin, flumequine, gentamicin and spiramycin), one glucocorticosteroid (dexamethasone), and two insecticides (cyfluthrin and fluazuron). Annexed to the report are a summary of the Committee's recommendations on these drugs, including Acceptable Daily Intakes and MRL's and further toxicological studies and other information required.

Publication Types: Technical Report

PMID: 9727328 [PubMed - indexed for MEDLINE]

 

 
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