Adverse Effects
Fomesafen, sodium
CAS No.
108731-70-0

 
 

Return to Fomesafen, sodium Index Page

Activity: Herbicide
Structure for "Fomesafen"

Adverse Effects:
Cancer: Possible Human Carcinogen - LIVER

• SEE ALSO: FOMESAFEN

US: As of September 13, 2003, residues of Fomesafen and its sodium salt are permitted in or on soybean in the United States.

Cancer: Possible Human Carcinogen - LIVER (click on for all fluorinated pesticide)

There are eight diphenyl ethers that are structurally similar to diclofop-methyl. Of the chemicals, fomesafen sodium, haloxyfop-methyl (Verdict), oxyfluorfen, acifluorfen sodium, nitrofen, and lactofen were reviewed in the initial CPRC report. All of these chemicals induced liver adenomas and carcinomas in rats and/or mice. Except for haloxyfop-methyl, all of the other chemicals produced positive results in at least one of the mutagenicity assays... For fomesafen (P.C.Code 123802) the data included, a 4-week feeding study in the mouse (MRID 40786709), a 28-day feeding study in the hamster (MRID 40910801) and an in vitro study (MRID 40910802, Elcombe et al., Annals NY Acad Sci. 804: 628-635 [1996]) with rat, mouse, guinea pig and human hepatocytes...
May 24, 2000 - Cancer Assessment Document. Evaluation of the Carcinogenic Potential of Diclofop-Methyl. (Second Review). Final Report. Cancer Assessment Review Committee, Health Effects Division, US EPA Office of Pesticide Programs.
Note: Except for Nitrofen, all the pesticides cited above are fluorinated.

Possible Carcinogen [Liver]
Ref: PAN Pesticides Database.

http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC35964

See also Fomesafen

A February 17, 2005, check at the Code of Federal Regulations for the Sodium salt of fomesafen: this herbicide is permitted in or on 1 food commodity in the United States.

Note:

• In 2003, the CFR listed both Fomesafen (CAS No. 72178-02-0) and the Sodium salt of fomesafen with a tolerance of 0.05 ppm on Soybean.

• EPA grants several Emergency Exemptions for the use of "Fomesafen" - see examples.

[Code of Federal Regulations]
[Title 40, Volume 22]
[Revised as of July 1, 2004]
From the U.S. Government Printing Office via GPO Access
[CITE: 40CFR180.433]
[Page 447]

TITLE 40--PROTECTION OF ENVIRONMENT

CHAPTER I--ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)

PART 180_TOLERANCES AND EXEMPTIONS FROM TOLERANCES FOR PESTICIDE CHEMICALS
IN FOOD--Table of Contents

Subpart C_Specific Tolerances

Sec. 180.433 Sodium salt of fomesafen; tolerance for residues.
(a) General. Tolerances are established for the residues of sodium
salt of fomesafen, 5-[2-chloro-4-(trifluoromethyl)phenoxy]-N-
(methylsulfonyl)-2-nitrobenzamide, in or on soybean at 0.05 part per
million.

(b) Section 18 emergency exemptions. [Reserved]
(c) Tolerances with regional registrations. [Reserved]
(d) Indirect or inadvertent residues. [Reserved]
Commodity

As of
September 13,
2003

PPM

As of
February 17,
2005

PPM

CFR
Soybean 0.05 0.05 180.433

 

 
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