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Adverse Effects
Abstracts
ACTIVITY: Antifoulant,
Algaecide, Herbicide (Organotin)
Structure:
Adverse
Effects:
Blood
Body Weight Decrease
Diabetes
Eye
Lung
Pancreas
Teratogen
|
Environmental
Effects:
Severe marine pollutant.
Fish:
Highly to Very Highly Toxic
Zooplankton:
Very Highly Toxic
Molluscs:
Very Higly Toxic |
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
No |
US
EPA PC Code: |
083602
(Old US EPA PC Code = 496900 ) |
California
Chemical Code |
2212 |
US
EPA Permit Date
and Registrant: |
1975,
M & T |
Registered
use in
(includes only a limited list of countries)
|
Netherlands |
Other
Information |
Molecular
Formula: |
C18H15
F Sn |
Manufacturers: |
Hempel
Coatings (USA)
Atofina |
Other
Names: |
Synonyms
Biomet 204
Caswell No. 896H
EINECS 206-833-8
Fluorotriphenylstannane
TPTF
Tin, fluorotriphenyl-
Systematic Names
Fentin fluoride
Stannane, fluorotriphenyl- |
Of
special interest: |
PAN
BAD ACTOR - Acute Toxicity |
Material
Safety Data Sheet |
INITIAL
SUBMISSION: ACUTE TOXICITY STUDY OF TRIPHENYLTIN FLUORIDE IN
EMBRYOS OF CRASSOSTREA VIRGINICA WITH COVER LETTER
DATED
07/24/92
Corporate
Name:
EG&G BIONOMICS
Source: EPA/OTS;
Doc #88-920008707
Order
Number: NTIS/OTS0555205 |
THE
ENVIRONMENTAL CHEMISTRY OF THREE ORGANOTIN CHEMICALS
Year
of Publication: 2000
Corporate Name:
M & T CHEM INC
Source:
EPA/OTS; Doc #40+7863020
Order
Number: NTIS/OTS0509272
|
DISSIPATION
AND DETOXIFICATION OF ORGANOTINS IN THE ENVIRONMENT
Year
of Publication: 2000
Corporate Name: M
& T CHEM INC
Source:
EPA/OTS; Doc #40+7863021
Order
Number: NTIS/OTS0509273
|
California
EPA list of products. |
Abstracts |
In
Japan: Listed since Dec 27, 1989, as a Class 2 specified chemical
substance. A substance
which, either in itself or one of its degradation products,
is not easily degradable and which may be harmful to human health
when ingested continuously and which is considered to cause
or expected to cause harm to human health due to significant
residues of the substance in a wide range of areas. A person
who manufactures or imports this substance or who imports product
in which this substance is contained shall submit a notification
on planned manufacturing or import quantities. Authorities concerned
may order a change of the amount in order to prevent damage
to human health by environmental pollution. Ref: Division of
Chem-Bio Informatics, National Institute of Health Sciences,
Japan. (Online as of Dec 2, 2001). |
Federal
Register |
Date
Published |
Docket
No. |
Details |
Oct
20, 2000 |
OPP-30000/42A |
Triphenyltin
Hydroxide; Proposed Determination To Terminate Special Review.
2. Comment. American Hoechst Corporation disagrees with the
Agency's [US EPA] position that TPTH produces teratogenic effects
and that a NOAEL has not been determined in the two previously
reviewed rat teratogenicity studies [Refs. 5 and 46]. American
Hoechst and M&T Chemicals had the rat teratology study by
Battelle Columbus Laboratories [Ref. 3] peer reviewed by two
independent sources and submitted the results of those reviews.
One reviewer found that 2.8 mg/ kg/day
was clearly a NOAEL for teratogenicity while the second
reviewer was unable to identify a no effect level from the data
available. In addition, American Hoechst submitted the results
of a teratology study of triphenyltin
fluoride (TPTF) that had been previously submitted to
EPA. The NOAEL for this study was 3.0 mg/kg/day.
Response. The submissions from American Hoechst Corporation
do not satisfactorily eliminate concerns regarding the teratogenicity
of TPTH because no new information was presented to the Agency.
Although these studies provided sufficient data to assure that
TPTH is not teratogenic in rats at dose levels up to and including
8.0 mg/kg/day, these studies did result in developmental and
maternal toxicity. Second, the registrant did not provide new
information indicating that a NOAEL exists in the two rat studies.
Third, the teratology study with TPTF
also indicated hydroureter as a fetal lesion. The initial reviewer
of this study classified this compound as a teratogen. |
|