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Adverse Effects
Abstracts
ACTIVITY:
Fungicide
(azole)
Synonyms for
Triflumizole [BSI:ISO] - CAS No. 68694-11-1
• (E)-4-Chloro-alpha,alpha,alpha-trifluoro-N-(1-imidazol-1-yl-2-propoxyethylidene)-o-toluidine
• 1-(1-((4-Chloro-2-(trifluoromethyl)phenyl)imino)-2-propoxyethyl)-1H-imidazole
• 4-Chloro-alpha,alpha,alpha-trifluoro-N-(1-imidazol-1-yl-2-propoxyethylidene)-o-toluidine
Structure
for CAS No. 99387-89-0 |
Structure
for CAS No. 68694-11-1 |
|
|
Adverse
Effects:
Anemia
Body
Weight Decrease
Bone
Endocrine:
Ovary
Endocrine:
Vaginal
Kidney
Liver
Reproductive Toxicant |
Environmental
Effects:
Fish:
Highly to Very Highy Toxic
Molluscs:
Very Highly Toxic
Zooplankton:
Very Highly Toxic
Ability
to potentiate the toxicity of other pesticides to
Honey
Bees
|
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
Yes |
US
EPA PC Code: |
128879
|
California
Chemical Code |
2260
|
US
Tolerances: |
CFR
180.476 |
US
EPA Permit Date
and Registrant: |
1991,
Nippon Soda Co., UNIROYAL |
Registered
use in
(includes only a limited list of countries)
|
Australia,
Hungary, India, Japan, Netherlands, Philippines,
US |
Japan's
Maximum Residual Levels (MRLs) |
Almond,
Apple, Apricot, Artichoke, Asparagus, Avocado, Banana, Barley,
Blackberry, Blueberry, Broccoli, Brussel Sprouts, Buckwheat,
Burdock, Cabbage, Carrot, Cauliflower, Celery, Cherry, Chestnut,
Chicory, Corn, Cotton oil seeds, Craneberry, Cucumber, Date,
Eggplant, Endive, Garlic, Ginger, Ginkgo nut, Grape, Grapefruit,
Guava, Horseradish, Huckleberry, Kale, Kidney beans, Kiwifruit,
Komatsuna, Konjac, Kyona, Lemon, Lettuce, Lime, Loquat, Makuwauri,
Mango, Melons, Mitsuba, Multiplying onion (inc. Shallot),
Mushroom (Button, Shitake, Other), Natsudaidai (whole), Nectarine,
Okra, Onion, Orange, Oriental pickling melon, Other Berries,
Other Cereal grains, Other Citrus fruits, Other Composite
vegs, Other Cucurbitaceous vegs, Other Cruciferous vegs, Other
Liliaceous vegs, Other Nuts, Other Oil seeds, Other Solanaceous
vegs, Other Umbelliferous vegs, Papaya, Parsley, Parsnip,
Passion fruit, Peach, Pear, Peas, Pecan, Persimon, Pimento,
Pineapple, Plum, Pumpkin (inc Squash), Quince, Radish, Rape
oil seeds, Raspberry, Rye, Safflower oil seeds, Salsify, Sesame
oil seeds, Shungiku, Soybeans, Spinach, Strawberry, Sunflower
oil seeds, Tea, Tomato, Turnip (inc Rutabaga), Unshu orange,
Walnut, Watercress, Watermelon, Welsh (inc Leek), Wheat
--
Note the very high levels - 15 ppm
- for Tea (Green, Black, Oolong, Wulung) |
US
Maximum Residue Levels permitted
in food commodities
|
Permitted
in or on over 49 food commodities, including:
Apple, Grape, Pear, Cattle, Egg, Goat,
Hog, Horse, Milk, Poultry, Sheep, Cherry, Strawberry |
Other
Information |
Molecular
Formula: CAS
No. 99387-89-0 |
C15-H15-CL-F3-N3-O
|
Molecular
Formula: CAS
No. 68694-11-1 |
C15-H15-Cl-F3-N3-O
|
Discovered/Developed by: |
Nippon Soda Co., Ltd. |
Manufacturers: |
Crompton
Corp.
Certis Europe B.V. |
Other
Names for
CAS No. 68694-11-1 |
A815
TECHNICAL
NF-114
Procure
Terraguard
Triflumizol
Triflumizole
Trifmine |
Manufacture
site: |
JAPAN:
Nippon Soda, Takaoka City, Toyama Prefecture |
Of
special interest: |
March 28, 2007: EPA DOCUMENTS
IN FEDERAL REGISTER DOCKET |
Triflumizole Summary Document including
Preliminary Work Plan Document (51
pages)
EPA-HQ-OPP-2006-0115-0003
|
List of Products Containing Triflumizole
Pesticide Products Registered Under Section 3 of FIFRA
(1 page)
EPA-HQ-OPP-2006-0115-0004
|
Health
Effects Documents |
Review of Triflumizole Incidents Reports.
August 15, 2006 (3
pages)
EPA-HQ-OPP-2006-0115-0005
|
Section 18 Specific Exemption for
the Use of Triflumizole on Parsley, Dandelion, Swiss
Chard, Collards, Kale, Kohlrabi, Mustard Greens, Chinese
Napa Cabbage, Broccoli, Cilantro, and Turnip Greens
in Texas. March 1, 2006. (12
pages)
EPA-HQ-OPP-2006-0115-0006
|
Triflumizole – Exposure/Risk
Assessment for the FIFRA Section 18 Use of Triflumizole
on Leafy Green Vegetable in Texas. February 1, 2006.
(10 pages)
EPA-HQ-OPP-2006-0115-0007
|
Request for Permanent Tolerance for
Residues of Triflumizole in/on Imported Greenhouse-Grown
Tomatoes and Section 18 Specific Exemption for the
Use of Triflumizole on Turnip Greens in Texas. May
26, 2005. (12
pages)
EPA-HQ-OPP-2006-0115-0008
|
Section 18 Specific Exemptions for
the Use of Triflumizole on parsley, Dandelion, Swiss
Chard, Collards, Kale, Kohlrabi, Mustard Greens, Chinese
Napa Cabbage, Broccoli, and Cilantro. January 28,
2005. (14 pages)
EPA-HQ-OPP-2006-0115-0009
|
Triflumizole – Waiver Request
for 28-Day Inhalation Study September 23, 2004. (3
pages)
EPA-HQ-OPP-2006-0115-0010
|
Triflumizole – Amendment to:
Human Exposure and Risk Assessment for Proposed New
Uses on Cherries, Hazelnuts, Cucurbits, Strawberries,
Outdoor Ornamentals, and Institutional, Recreational
and Residential Landscapes. April 26, 2002. (15
pages)
EPA-HQ-OPP-2006-0115-0011
|
Triflumizole in/on Strawberries, Cucurbit
Vegetables, Cherries, and Hazelnuts. April 25, 2002.
(44 pages)
EPA-HQ-OPP-2006-0115-0012
|
Minutes of 9/17/03 Chem SAC Meeting.
1/20/04. Render Food/Non-Food use Decision on the
Proposed Use of Procure 50WS Fungicide to Treat Pineapple
Seed Pieces. January 20, 2003.
(1 page)
EPA-HQ-OPP-2006-0115-0013
|
HED SOP 2002.01 Standard Operating
Procedure – Waiver Criteria for Multiple-Exposure
Inhalation Toxicity Studies August 15, 2002. (7
pages)
EPA-HQ-OPP-2006-0115-0014
|
Triflumizole – Revised Report
of the Hazard Identifiaction assessment Review committee.
March 19, 2002. (30 pages)
EPA-HQ-OPP-2006-0115-0015
|
Triflumizole – Report of the
FQPA Safety Factor Committee. March 21, 2002. (9
pages)
EPA-HQ-OPP-2006-0115-0016
|
Triflumizole. Issues to be Presented
to the Health Effects Division (HED) Metabolism Assessment
Review Committee (MARC) Meeting on 2/26/2002. February
26, 2002. (24
pages)
EPA-HQ-OPP-2006-0115-0017
|
Ecological
Fate & Effects Documents |
Section 3 Request for Uses of Triflumizole
on Foliage for Filberts. February 7, 2006. (130
pages)
EPA-HQ-OPP-2006-0115-0018
|
Tier 1 Drinking Water Assessment for
Use of Triflumizole on Filberts. January 5, 2006.
(8 pages)
EPA-HQ-OPP-2006-0115-0019
|
Tier 1 Estimated Drinking Water Concentrations
for Triflumizole including Degradates. March 13, 2002.
(14 pages)
EPA-HQ-OPP-2006-0115-0020
|
Section 3 Request for Use of Triflumizole
(Chemical #128879) on Cherries, Strawberries, Cucurbits,
and Ornamentals. May 21, 2001.
(44 pages)
EPA-HQ-OPP-2006-0115-0021
|
Triflumizole Screening Level Estimated
of Agricultural Uses March 29, 2006. (2
pages)
EPA-HQ-OPP-2006-0115-0022
|
Triflumizole Appendix A. October 26,
2006. (3
pages)
EPA-HQ-OPP-2006-0115-0023
|
|
PAN
Data |
Material
Safety Data Sheets & Labels |
Fungicide
products - older partial list |
August,
2001 -
IR-4: New
Products/Transitional Solution List -
This
list contains brief descriptions of numerous new pest control
materials that have been introduced over the last several years.
Additionally, it contains information on some "older"
crop protection chemicals that are believed to have room for
new uses. This List includes: Triflumizole
|
2002
- NIPON
SODA ANNUAL REPORT 2002
- cites the following organofluorine pesticides
and their product names: Chlorfenapyr * Fluacrypyrim * Fluazinam
* Fluvalinate * Triflumizole |
Abstracts |
October
2001 - Glossary
of Pesticide Chemicals. A listing
of pesticides subject to analysis of residues in foods and feeds
by the US Food and Drug Administration. |
April
2000 -
Food and Drug Administration
Pesticide Residue Monitoring. - Table
3. Pesticides detectable by methods used in 1999 regulatory
monitoring. |
US
Federal Register
••
Note: Due to length, the following is a partial
list. Click here
to see full list of FR entries.
|
Date
Published |
Docket
Identification Number |
Details |
June 27, 2007 |
EPA-HQ-OPP-2007-0312 |
IR-4.
Pesticide
Petition. PP 7E7183. Proposal to establish a tolerance
for residues of the fungicide triflumizole and its metabolites
containing the 4-chloro-2-trifluoromethylaniline moiety, calculated
as the parent compound in or on food commodity
leafy Brassica (subgroup
5B)
This subgroup includes
8 commodities.
broccoli raab • cabbage, chinese bok choy •
collards • kale • mizuna • mustard
greens • mustard spinach • rape greens
|
20.0 ppm |
The analytical method is suitable for analyzing
crops for residues of triflumizole and its aniline
containing metabolites at the proposed tolerance levels. The
analytical method has been independently validated. Residue
levels of triflumizole are converted to FA-1-1 by acidic and
alkaline reflux, followed by distillation. Residues are then
extracted and subjected to solid phase extraction (SPE) purification.
Detection and quantitation are conducted by a GC equipped
with nitrogen phosphorus detector, electron capture detector
or mass spectrometry detection. The LOQ of the method has
been determined at 0.05 ppm for the combined residues of triflumizole
and FA-1-1 in mustard greens. The enforcement methodology
has been submitted to the Food and Drug Administration (FDA)
for publication in the PAM II. |
March
28, 2007 |
EPA-HQ-OPP-2006-0115 |
Pesticide
Registration Review; New Docket Opened for Review and Comment.
As directed by FIFRA section 3(g), EPA is periodically reviewing
pesticide registrations to assure that they continue to satisfy
the FIFRA standard for registration--that is, they can still
be used without unreasonable adverse effects on human health
or the environment. The implementing regulations establishing
the procedures for registration review appear at 40 CFR part
155. A pesticide's registration review begins when the Agency
establishes a docket for the pesticide's registration review
case and opens the docket for public review and comment. At
present, EPA is opening registration review for triflumizole.
Comments must be received on or before
June 26, 2007.
DOCUMENTS IN FEDERAL REGISTER
DOCKET |
Triflumizole Summary Document including
Preliminary Work Plan Document (51
pages)
EPA-HQ-OPP-2006-0115-0003 |
List of Products Containing Triflumizole
Pesticide Products Registered Under Section 3 of FIFRA
(1 page)
EPA-HQ-OPP-2006-0115-0004 |
HEALTH EFFECTS
DOCUMENTS |
Review of Triflumizole Incidents Reports.
August 15, 2006 (3
pages)
EPA-HQ-OPP-2006-0115-0005 |
Section 18 Specific Exemption for the
Use of Triflumizole on Parsley, Dandelion, Swiss Chard,
Collards, Kale, Kohlrabi, Mustard Greens, Chinese Napa
Cabbage, Broccoli, Cilantro, and Turnip Greens in Texas.
March 1, 2006. (12
pages)
EPA-HQ-OPP-2006-0115-0006 |
Triflumizole – Exposure/Risk Assessment
for the FIFRA Section 18 Use of Triflumizole on Leafy
Green Vegetable in Texas. February 1, 2006. (10
pages)
EPA-HQ-OPP-2006-0115-0007 |
Request for Permanent Tolerance for Residues
of Triflumizole in/on Imported Greenhouse-Grown Tomatoes
and Section 18 Specific Exemption for the Use of Triflumizole
on Turnip Greens in Texas. May 26, 2005.
(12 pages)
EPA-HQ-OPP-2006-0115-0008 |
Section 18 Specific Exemptions for the
Use of Triflumizole on parsley, Dandelion, Swiss Chard,
Collards, Kale, Kohlrabi, Mustard Greens, Chinese Napa
Cabbage, Broccoli, and Cilantro. January 28, 2005. (14
pages)
EPA-HQ-OPP-2006-0115-0009 |
Triflumizole – Waiver Request for
28-Day Inhalation Study September 23, 2004. (3
pages)
EPA-HQ-OPP-2006-0115-0010 |
Triflumizole – Amendment to: Human
Exposure and Risk Assessment for Proposed New Uses on
Cherries, Hazelnuts, Cucurbits, Strawberries, Outdoor
Ornamentals, and Institutional, Recreational and Residential
Landscapes. April 26, 2002. (15
pages)
EPA-HQ-OPP-2006-0115-0011 |
Triflumizole in/on Strawberries, Cucurbit
Vegetables, Cherries, and Hazelnuts. April 25, 2002. (44
pages)
EPA-HQ-OPP-2006-0115-0012 |
Minutes of 9/17/03 Chem SAC Meeting.
1/20/04. Render Food/Non-Food use Decision on the Proposed
Use of Procure 50WS Fungicide to Treat Pineapple Seed
Pieces. January 20, 2003. (1
page)
EPA-HQ-OPP-2006-0115-0013 |
HED SOP 2002.01 Standard Operating Procedure
– Waiver Criteria for Multiple-Exposure Inhalation
Toxicity Studies August 15, 2002. (7
pages)
EPA-HQ-OPP-2006-0115-0014 |
Triflumizole – Revised Report of
the Hazard Identifiaction assessment Review committee.
March 19, 2002. (30 pages)
EPA-HQ-OPP-2006-0115-0015 |
Triflumizole – Report of the FQPA
Safety Factor Committee. March 21, 2002. (9
pages)
EPA-HQ-OPP-2006-0115-0016 |
Triflumizole. Issues to be Presented
to the Health Effects Division (HED) Metabolism Assessment
Review Committee (MARC) Meeting on 2/26/2002. February
26, 2002. (24
pages)
EPA-HQ-OPP-2006-0115-0017 |
ECOLOGICAL
FATE & EFFECTS DOCUMENTS |
Section 3 Request for Uses of Triflumizole
on Foliage for Filberts. February 7, 2006. (130
pages)
EPA-HQ-OPP-2006-0115-0018 |
Tier 1 Drinking Water Assessment for
Use of Triflumizole on Filberts. January 5, 2006.
(8 pages)
EPA-HQ-OPP-2006-0115-0019 |
Tier 1 Estimated Drinking Water Concentrations
for Triflumizole including Degradates. March 13, 2002.
(14 pages)
EPA-HQ-OPP-2006-0115-0020 |
Section 3 Request for Use of Triflumizole
(Chemical #128879) on Cherries, Strawberries, Cucurbits,
and Ornamentals. May 21, 2001. (44
pages)
EPA-HQ-OPP-2006-0115-0021 |
Triflumizole Screening Level Estimated
of Agricultural Uses March 29, 2006. (2
pages)
EPA-HQ-OPP-2006-0115-0022 |
Triflumizole Appendix A. October 26,
2006. (3
pages)
EPA-HQ-OPP-2006-0115-0023 |
|
August 23, 2006 |
EPA-HQ-OPP-2006-0461 |
Pesticide
tolerance. FINAL
RULE.
This regulation establishes time-limited tolerances for
combined residues of triflumizole in or on turnip, greens. Additionally,
this regulation increases the tolerance levels and extends time-limited
tolerances for Chinese Napa cabbage, collards, coriander leaves
(cilantro), kale, kohlrabi, mustard greens and parsley. Further,
this regulation extends time-limited tolerances for broccoli,
dandelion and Swiss chard.
Commodity |
PPM |
Expiration
date |
Broccoli |
1.0 |
12/31/09 |
Cabbage,
chinese, napa |
20 |
12/31/09 |
Collards |
20 |
12/31/09 |
Coriander,
leaves |
20 |
12/31/09 |
Dandelion,
leaves |
7.0 |
12/31/09 |
Kale |
20 |
12/31/09 |
Kohlrabi |
20 |
12/31/09 |
Mustard,
greens |
20 |
12/31/09 |
Parsley,
leaves |
20 |
12/31/09 |
Swiss
chard |
7.0 |
12/31/09 |
Turnip,
greens |
20 |
12/31/09 |
|
March
15, 2006 |
EPA-HQ-OPP-2006-0103 |
IR-4.
Pesticide Tolerance.
FINAL RULE. (Pesticide
Petition 3E6535).
This regulation establishes a tolerance for combined residues
of triflumizole and its metabolites
containing the 4-chloro-2-trifluoromethylaniline moiety,
calculated as the parent compound in or on filberts
at 0.05 ppm.
-- A
summary of the toxicological endpoints for triflumizole used
for human risk assessment is discussed in Unit VI.A. of the
final rule published in the
Federal Register of April 8, 2005 (70 FR 17908) (FRL-7701-6).
-- Specific
information on the studies received and the nature of the
toxic effects caused by triflumizole as well as the no observed
adverse effect level (NOAEL) and the lowest observed adverse
effect level (LOAEL) from the toxicity studies can be found
at
http://www.epa.gov/EPA-PEST/2002/June/Day-12/p14768.htm |
••
Note: Due to length, the above is a partial list.
Click here
to see full list of FR entries.
|
|