Return to Adverse
Effects
ACTIVITY: Fungicide
(Strobin)
CAS Name: methyl
(?E)-?-(methoxyimino)-2-[[[(E)-[1-[3-(trifluoromethyl)phenyl]ethylidene]amino]oxy]methyl]benzeneacetate
Structure:
Adverse
Effects:
Body
Weight Decrease
Bone
Endocrine: Pituitary
Endocrine: Thymus
Eye
Kidney
Liver
Mesenteric
Lymph Node
Pancreas
Spleen |
Environmental
Effects:
Very
Highly Toxic to Freshwater and Estuarine/Marine Fish and Invertebrates
Trifloxystrobin's
major metabolite, CGA-321113, is persistent and mobile and
has a potential to leach into groundwater. It has been found
in the soil profile at the 36 inch depth. |
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
Yes |
US
EPA PC Code: |
129112 |
California
Chemical Code |
CFR
180.555 |
Registered
use in
(includes only a limited list of countries)
|
Australia,
Canada, Germany, Hungary, New Zealand, South Africa, UK, US
Australia:
Grape
Canada
(As of March 2005):
Apple,
Crabapple, Grape, Grape (table), Grape (wine), Loquat mayhaw,
Pear, Pear (Oriental), Quince, Wheat (Canada prairie), Wheat
(durum), Wheat (hard red), Wheat (soft
white), Wheat (spring), Wheat (winter) - Ornamentals,
Turf |
US
Maximum Residue Levels permitted
in food commodities
|
Permitted
in or on 262 food commodities, including:
Almond, Apple, Aspirated Grain, Banana,
Beet, Citrus dried pulp, Citrus oil, Corn, Egg,, Cattle, Sheep,
Fruit (Pome), Grape, Goat, Hog, Horse, Milk, Nut tree group,
Peanut, Pistachio, Potato, Poultry (fat, meat, and byproducts),
Rice (grain, hulls and straw), Soybean (forage, hay, seed),
Vegetable (Cucurbits & Fruiting), Wheat |
UK
Temporary MRL's
|
Applicable
from: August 2003
Apple
& Pear:
0.3 ppm
Winter wheat: 0.02 ppm |
UK
Import Tolerances
|
Citrus
fruit: 0.3 ppm (as of 2002)
Cherry: 2.0 ppm (as of 2003)
Tomato: 1.0 ppm (as of 2003)
Soybean: 0.05 ppm (as of 2005)
|
Other
Information |
Molecular
Formula: |
C20H19
F3 N2O4 |
Entry
Year: |
1999 |
Manufacturers: |
Bayer
(Novartis/Syngenta) |
Other
Names: |
Flint
Twist
Stratego
Sphere
Compass
Tega,
CGA 27920
2 F 279
CG-233 |
Manufacture
site: |
SWITZERLAND:
Novartis, Munchwilen
SWITZERLAND:
Bayer,
Muttenz |
Of
special interest: |
PAN
Data |
Material
Safety Data Sheets & Labels |
July
19, 2005 - Canada.
Reduced-Risk Update. Report: RR2005-02. Canada Pest Management
Regulatory Agency (PMRA).
See excerpted list of
fluorinated pesticides. |
January
30, 2004 - Regulatory
Note REG2004-03. Canada Pest Management Regulatory Agency.
The active ingredient trifloxystrobin and associated end-use
products (EPs) Compass 50 WG, Flint
50 WG and Stratego 250 EC (containing the fungicides trifloxystrobin
and propiconazole) have been granted temporary registration
under Section 17 of the Pest Control Products (PCP) Regulations.
This Regulatory Note provides a summary of data reviewed and
the rationale for the regulatory decision for these products.
Also available at: http://www.hc-sc.gc.ca/pmra-arla/english/pdf/reg/reg2004-03-e.pdf |
April
7, 2003 -
Review report for the active substance trifloxystrobin. Trifloxystrobin.
SANCO/4339/2000-Final. Finalised in
the [European Commission] Standing Committee on the Food Chain
and Animal Health at its meeting on 15 April 2003 in view of
the inclusion of trifloxystrobin in Annex I of Directive 91/414/EEC. |
September
20, 1999 - US
EPA FACT SHEET |
Up
to January 1, 2004: Congressional
Request to allow this chemical to be Duty-Free up to Jan 1,
2004 (HR 3963 IH). |
March
28, 2002 - Residue
Data Sheet. Australia National Regulatory
Authority (NRA) for Agricultural & Veterinary Chemicals. |
April
2002 - Beer
in the UK: 23 organofluorine pesticides approved for use on
malting barley. Published by the British
Beer and Pubs Association and Brewing Research International.
|
Sept
2001 - June 2002
AUSTRALIA: Time-limited
permit for use on banana trees in the Tully Banana Production
Area. |
December
7, 2000 - BAYER
- Flint®
fungicide aquired by Bayer. December 7, 2000, Press Release
from Bayer Corporation. |
One
of 8 fluorinated pesticides used to cultivate grapes in Australia. |
Flint
500 WG. Used on Grapes in Australia. Australian Wine Research
Institute. |
In
October 2000, Novartis Agribusiness announced
the sale of its global trifloxystrobin business to Bayer for
$760 million to satisfy anti-trust concerns over the
planned merger with Zeneca’s agrochemical operation to
form Syngenta (Zeneca marketed the rival strobilurin product,
azoxystrobin, D0030L). The sale included the entire trifloxystrobin
(D0044) business including intellectual property rights, formulation
technologies, trade marks, registration rights and production
facilities in Muttenz, Switzerland. Bayer agreed to retain
the Muttenz workforce. Bayer estimates that the Flint
line has annual sales potential of €300 million and hopes
to exploit its full ‘blockbuster’ potential within
5 years. The sales potential will be further enhanced
by the combinations to be developed with Bayer’s existing
portfolio products and pipeline candidates. ... Crop
protection business sales reached €2,708 million ($2,418
million) in 2001, up 10.3% on the previous year. The acquisition
of trifloxystrobin and sulcotrione made a significant contribution
to this performance. http://www.pjbpubs.com/agroprojects/weed_company.htm |
Pesticide
products - partial list |
April
2000 - Stratego®
fungicide labeled for wheat by Don Hershman Ð Extension Plant
Pathologist. (Syngenta, Bayer, Novartis,
Zeneca, Quadris.) University of Kentucky Wheat Science News. |
August
2001 -
IR-4: New
Products/Transitional Solution List
- This
list contains brief descriptions of numerous new pest control
materials that have been introduced over the last several years.
Additionally, it contains information on some "older"
crop protection chemicals that are believed to have room for
new uses. This List includes: Trifloxystrobin |
October
2001 -
Glossary of Pesticide Chemicals.
A listing of pesticides subject to analysis of residues in foods
and feeds by the US Food and Drug Administration. |
US
Federal Register
••
Note: Due to length, the following is a partial
list. Click here
to see full list of FR entries.
|
Date
Published |
Docket
Identification Number |
Details |
September 19, 2007 |
EPA-HQ-OPP-2007-0539 |
Bayer CropScience. Pesticide tolerance. FINAL RULE. This regulation establishes a tolerance for combined residues of Trifloxystrobin and the acid metabolite CGA-321113, at higher levels than requested by Bayer, in or on
-- Grass, forage at 12 ppm (Bayer requested 10.0 ppm)
-- Grass, hay at 17 ppm (Bayer requested 14.0 ppm)
April 11, 2007: Human Health Risk Assessment for Section 3 Registration for the Proposed Uses on Grasses Grown for Seed.
Based upon review of the data supporting the petition, EPA has modified the tolerances proposed for grass, forage and grass, hay. The appropriate tolerances for grass forage and hay were calculated to be 12 and 17 ppm, respectively. Although residue data were also provided for grass straw and seed screenings, tolerances are not required on these commodities as the Agency no longer considers them to be significant livestock feedstuffs. The recommended tolerance levels for grass forage and hay were determined considering recent Agency Guidance (Guidance for Setting Pesticide Tolerances Based on Field Trial Data).
Conclusion. EPA has determined that reliable data show that it would be safe for infants and children to reduce the FQPA safety factor to 1X. That decision is based on the following findings:
i. The toxicity database for Trifloxystrobin is complete except for an acute neurotoxicity study which is classified as unacceptable. The toxicity database contains developmental toxicity studies in two species (rats and rabbits) and a 2-generation reproduction study in rats which are adequate to assess pre and/or post natal susceptibility to infants and children. Although the available, submitted acute neurotoxicity study was found to be unacceptable, based on a weight-of- the evidence review of the available data, the lack of this study does not impact the Agency's ability to make an FQPA safety factor decision. Given that there was no evidence of neurotoxicity in this study at the Limit Dose nor in the other subchronic and chronic studies in the database there is not an uncertainty concerning neurotoxic effects and EPA has reliable data to show that removal of the FQPA safety factor is safe for children. Additionally, these data demonstrate that a developmental neurotoxicity study is not required for this pesticide. |
August 1, 2007 |
EPA-HQ-OPP-2007-0539 |
Bayer CropScience.
Pesticide
Petition PP 6F7024. Proposal to establish a tolerance
for residues of the fungicide trifloxystrobin in or on food
commodities
-- grass, forage at 10.0 ppm
-- grass, hay at 14.0 ppm.
A practical analytical methodology for detecting
and measuring levels of trifloxystrobin in or on raw agricultural
commodities has been submitted. The limit of detection (LOD)
for each analyte of this method is 0.08 ng injected, and the
limit of quantitation (LOQ) is 0.02 ppm. The method is based
on crop specific cleanup procedures and determination by gas
chromatography with nitrogen-phosphorus detection. |
September 22, 2006 |
EPA-HQ-OPP-2005-0299 |
Bayer CropScience.
Pesticide
Tolerance. FINAL
RULE.
in or on
-- soybean, forage at 10.0 ppm
-- soybean, hay at 25.0 ppm
-- soybean, seed at 0.08 ppm.
|
September 13, 2006 |
EPA-HQ-OPP-2006-0730 |
IR-4.
Pesticide
petition: PP 6E7088.
Proposing the establishment of new tolerances in or on
-- asparagus at 0.07 ppm
-- papaya at 0.4 ppm
-- sapote, black at 0.4 ppm
-- canistel at 0.4 ppm
-- sapote, mamey at 0.4 ppm
-- mango at 0.4 ppm
-- sapodilla at 0.4 ppm
-- star apple at 0.4 ppm
-- radish, tops at 20 ppm
-- vegetable, root, except sugar beet, subgroup
1B at 0.2 ppm
This subgroup includes 19
commodities.
beet, garden • burdock, edible • carrot •
carrot culls • celeriac • chervil, turnip rooted
• chicory root • ginseng • horseradish
• parsley, turnip rooted • parsnip • radish
• radish, oriental • rutabaga • salsify
• salsify, black • salsify, spanish •
skirret • turnip
|
June 28, 2006 |
EPA-HQ-OPP-2006-0084 |
Notice
of Receipt of Requests to Voluntarily Cancel Certain Pesticide
Registrations.
EPA Registration No. |
Product Name |
Registrant |
000264 WA-01-003 |
Stratego Fungicide |
Bayer Cropscience LP
2 T.W. Alexander Drive
Research Triangle Park, NC 27709. |
|
March
29, 2006 |
EPA-HQ-OPP-2005-0299 |
Bayer
CropScience and IR-4.
Pesticide Tolerance.
FINAL RULE.
This
regulation establishes a tolerance for combined residues of
trifloxystrobin and the free form of its
acid metabolite CGA-321113 ((E,E)-methoxyimino-[2-[1-(3-trifluoromethylphenyl)-ethylideneaminooxymethyl]-
phenyl]acetic acid) pesticide petition (PP 4F6892) in or on
Commodity
|
Parts
per million |
Registrant |
Pesticide
Petition |
Barley,
grain |
0.05 |
IR-4 |
PP
3E6769 |
Barley,
hay |
0.3 |
IR-4 |
PP
3E6769 |
Barley,
straw |
5.0 |
IR-4 |
PP
3E6769 |
Corn,
sweet, cannery waste
|
0.6 |
BAYER |
PP
4F6892 |
Corn,
sweet, forage |
0.6 |
BAYER |
PP
4F6892 |
Corn,
sweet, kernel plus cob with husks removed |
0.04 |
BAYER |
PP
4F6892 |
Corn,
sweet, stover |
0.25 |
BAYER |
PP
4F6892 |
Oat,
forage |
0.3 |
IR-4 |
PP
3E6769 |
Oat,
grain |
0.05 |
IR-4 |
PP
3E6769 |
Oat,
hay |
0.3 |
IR-4 |
PP
3E6769 |
Oat,
straw |
5.0 |
IR-4 |
PP
3E6769 |
•
Specific information on the studies received and the nature
of the toxic effects caused by trifloxystrobin and CGA-321113
as well as the no-observed adverse effect level (NOAEL) and
the lowest observed adverse effect level (LOAEL) from the
toxicity studies can be found in the Federal
Register of May 22, 2002
•
Effects cited only from rat studies:
decreases in body weight, body weight gains, reduced
food consumption and histopathological lesions in the
liver, kidneys and spleen
•
Cancer.
EPA determined that trifloxystrobin should be classified as
a ``Not Likely Human Carcinogen.'' Due
to the classification, no cancer exposure assessment was performed.
•
Conclusion.
EPA determined that the 10X SF to protect infants and children
should be reduced to 1X. The
FQPA, SF is reduced because ...
iii. EPA determined that a developmental
neurotoxicity study in rats is not required;
iv. Although an acute neurotoxicity
study is required (the submitted study was unacceptable),
the lack of an acute neurotoxicity study does not impact EPA's
ability to make an FQPA safety factor decision because upgrading
the study would not result in a lower NOAEL than what is present
for the acute RfD ... |
••
Note: Due to length, the above is a partial list.
Click here
to see full list of FR entries.
|
|