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Trichlorotrifluoromethane (CFC-113; Freon 113) . US EPA IRIS.


US Environmental Protection Agency Integrated Risk Information System

http://www.epa.gov/iris/subst/0123.htm

1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)
CASRN 76-13-1

Contents


0123
1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113); CASRN 76-13-1  


Health assessment information on a chemical substance is included in IRIS only 
after a comprehensive review of chronic toxicity data by U.S. EPA health 
scientists from several Program Offices and the Office of Research and 
Development.  The summaries presented in Sections I and II represent a 
consensus reached in the review process.  Background information and 
explanations of the methods used to derive the values given in IRIS are 
provided in the Background Documents. 


STATUS OF DATA FOR  CFC-113

File On-Line 01/31/1987

Category (section)                           Status      Last Revised
-----------------------------------------    --------    ------------

Oral RfD Assessment (I.A.)                   on-line       02/01/1996

Inhalation RfC Assessment (I.B.)             no data     

Carcinogenicity Assessment (II.)             no data     



_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS __I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD) Substance Name -- 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) CASRN -- 76-13-1 Last Revised -- 02/01/1996 The oral Reference Dose (RfD) is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. It is expressed in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. Please refer to the Background Document for an elaboration of these concepts. RfDs can also be derived for the noncarcinogenic health effects of substances that are also carcinogens. Therefore, it is essential to refer to other sources of information concerning the carcinogenicity of this substance. If the U.S. EPA has evaluated this substance for potential human carcinogenicity, a summary of that evaluation will be contained in Section II of this file. NOTE: The Oral RfD for 1,1,2-trichloro-1,2,2-trifluoroethane may change in the near future pending the outcome of a further review now being conducted by the Oral RfD Work Group. ___I.A.1. ORAL RfD SUMMARY Critical Effect Experimental Doses* UF MF RfD -------------------- ----------------------- ----- --- --------- Psychomotor impair- NOAEL: 5358 mg/cu.m 10 1 3E+1 ment converted to mg/kg/day 273 mg/kg/day Epidemiologic Study: Human Occupational Exposure Imbus and Adkins, 1972
*Conversion Factors: 10 cu.m/day (8-hour human breathing volume), 5 days/7 days, 0.5 absorption factor, 70 kg bw; thus, 5358 mg/cu.m x 10 cu.m/day x 5 days/7 days x 0.5/70 kg = 273 mg/kg/day ___I.A.2. PRINCIPAL AND SUPPORTING STUDIES (ORAL RfD) Imbus, H.R. and C. Adkins. 1972. Physical examination of workers exposed to trichlorotrifluoroethane. Arch. Environ. Health. 24(4): 257-261. Several animal inhalation studies reported negative results in dogs, rabbits, and rats chronically exposed to very high concentrations of trichlorotrifluoroethane (U.S. EPA, 1983). No apparent adverse effects have been reported in humans occupationally exposed to trichlorotrifluoroethane at either 500 mg/cu.m levels for 11 years or 5358 mg/cu.m levels for 2.77 years (Imbus and Adkins, 1972). Slight impairment of psychomotor performance was reported in male volunteers exposed to trichlorotrifluoroethane concentrations of 19,161 mg/cu.m for 2.75 hours (Stopps and McLaughlin, 1967). This exposure period was too brief to consider a NOAEL for chronic exposure. Therefore, the RfD of 30 mg/kg/day is considered protective. ___I.A.3. UNCERTAINTY AND MODIFYING FACTORS (ORAL RfD) UF -- The uncertainty factor of 10 accounts for the expected interhuman variability to the toxicity of this chemical in lieu of specific data. MF -- None ___I.A.4. ADDITIONAL COMMENTS (ORAL RfD) None. ___I.A.5. CONFIDENCE IN THE ORAL RfD Study -- Low Data Base -- Low RfD -- Low Confidence in the chosen study, data base, and RfD are all considered low. Despite the fact that the chosen study describes human data and the fact that several chronic studies in animals are supportive, uncertainties in both the exposure levels and route extrapolation preclude higher confidence ratings. ___I.A.6. EPA DOCUMENTATION AND REVIEW OF THE ORAL RfD Source Docuemnt -- U.S. EPA, 1983 Other EPA Documentation -- None Agency Work Group Review -- 06/24/1985, 07/08/1985 Verification Date -- 07/08/1985 ___I.A.7. EPA CONTACTS (ORAL RfD) Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (301) 345-2870 (phone), (301) 345-2876 (FAX) or Hotline.IRIS@epamail.epa.gov (internet address).
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC) Substance Name -- 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) CASRN -- 76-13-1 Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE Substance Name -- 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) CASRN -- 76-13-1 Not available at this time.
_VI. BIBLIOGRAPHY Substance Name -- 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) CASRN -- 76-13-1 Last Revised -- 01/01/1990 __VI.A. ORAL RfD REFERENCES Imbus, H.R. and C. Adkins. 1972. Physical examination of workers exposed to trichlorotrifluoroethane. Arch. Environ. Health. 24(4): 257-261. Stopps, G.J. and M. McLaughlin. 1967. Psychophysiological testing of human subjects exposed to solvent vapors. Amer. Ind. Hyg. Assoc. J. 28: 43-50. U.S. EPA. 1983. Health Assessment Document for 1,1,2-trichloro-1,2,2- trifluoroethane (chlorofluorocarbon CFC 113). Office of Air Quality Planning and Standards, Research Triangle Park, NC. EPA-600/8-82-002F. NTIS PB84- 118843. (Final Report)
__VI.B. INHALATION RfC REFERENCES None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES None
_VII. REVISION HISTORY Substance Name -- 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) CASRN -- 76-13-1 -------- -------- -------------------------------------------------------- Date Section Description -------- -------- -------------------------------------------------------- 04/06/1987 I.A.1. RfD corrected 03/01/1988 I.A.1. Dose conversion factor corrected 12/01/1988 I.A. RfD noted as pending change 01/01/1990 I.A.6. Added U.S. EPA citation 01/01/1990 VI. Bibliography on-line 06/01/1990 IV.A.1. Area code for EPA contact corrected 01/01/1992 I.A.7. Primary contact changed 01/01/1992 IV. Regulatory actions updated 04/01/1992 IV.A.1. CAA regulatory action withdrawn 08/01/1995 I.A. EPA's RfD/RfC and CRAVE workgroups were discontinued in May, 1995. Chemical substance reviews that were not completed by September 1995 were taken out of IRIS review. The IRIS Pilot Program replaced the workgroup functions beginning in September, 1995. 02/01/1996 I.A.7. Contact changed 04/01/1997 III.,IV., Drinking Water Health Advisories, EPA Regulatory Actions, and V. Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
VIII. SYNONYMS Substance Name -- 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) CASRN -- 76-13-1 Last Revised -- 01/31/1987 76-13-1 ARCTON 63 ARKLONE P CFC-113 DAIFLON S 3 ETHANE, 1,1,2-TRICHLORO-1,2,2-TRIFLUORO- FLUOROCARBON 113 FREON 113 FREON 113TR-T FREON F113 FREON TF FRIGEN 113a FRIGEN 113 TR-T GENETRON 113 HALOCARBON 113 ISCEON 113 KHLADON 113 R 113 REFRIGERANT 113 TRICHLOROTRIFLUOROETHANE 1,1,2-Trichloro-1,2,2-trifluoroethane Trichloro-1,2,2-trifluoroethane, 1,1,2- 1,1,2-TRIFLUORO-1,2,2- TRICHLOROETHANE UCON 113 UCON 113/HALOCARBON 113 UCON FLUOROCARBON 113 .
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/subst/0123.htm