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Trichlorofluoromethane (CAS No. 75-69-4). US EPA IRIS.


US Environmental Protection Agency

Integrated Risk Information System

Trichlorofluoromethane
CASRN 75-69-4

Contents


0120
Trichlorofluoromethane; CASRN 75-69-4  


Health assessment information on a chemical substance is included in IRIS only 
after a comprehensive review of chronic toxicity data by U.S. EPA health 
scientists from several Program Offices and the Office of Research and 
Development.  The summaries presented in Sections I and II represent a 
consensus reached in the review process.  Background information and 
explanations of the methods used to derive the values given in IRIS are 
provided in the Background Documents. 


STATUS OF DATA FOR  Trichlorofluoromethane

File On-Line 01/31/1987

Category (section)                           Status      Last Revised
-----------------------------------------    --------    ------------

Oral RfD Assessment (I.A.)                   on-line       08/01/1992

Inhalation RfC Assessment (I.B.)             no data     

Carcinogenicity Assessment (II.)             no data     



_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS __I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD) Substance Name -- Trichlorofluoromethane CASRN -- 75-69-4 Last Revised -- 08/01/1992 The oral Reference Dose (RfD) is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. It is expressed in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. Please refer to the Background Document for an elaboration of these concepts. RfDs can also be derived for the noncarcinogenic health effects of substances that are also carcinogens. Therefore, it is essential to refer to other sources of information concerning the carcinogenicity of this substance. If the U.S. EPA has evaluated this substance for potential human carcinogenicity, a summary of that evaluation will be contained in Section II of this file. ___I.A.1. ORAL RfD SUMMARY Critical Effect Experimental Doses* UF MF RfD -------------------- ----------------------- ----- --- --------- Survival and NOAEL: none 1000 1 3E-1 histopathology mg/kg/day LOAEL: 488 mg/kg/day Cancer Bioassay converted to 349 mg/ Studies in Rats and kg/day Mice NCI, 1978
*Conversion Factors: 5 days/7 days; thus, 488 mg/kg/day x 5 days/7 days = 349 mg/kg/day ___I.A.2. PRINCIPAL AND SUPPORTING STUDIES (ORAL RfD) NCI (National Cancer Institute). 1978. Bioassay of trichlorofluoromethane for possible carcinogenicity. Report. No. 106, PHS/NIH, DHEW Publ. No. 78- 1356. The NCI bioassay was performed on rats and mice exposed to various doses of trichloromonofluoromethane by gavage over a period of 78 weeks (50 animals/species/sex/dose for each of two doses with 20 animals/species/sex for each of two control groups). A statistically significant positive association between increased dosage and accelerated mortality by the Tarone test in male and female rats and female mice were observed. In treated rats of both sexes there were also elevated incidences of pleuritis and pericarditis not seen in controls. Inhalation studies which employed multispecies exposures to higher levels of the compound than used by NCI (Leuschner et al., 1983) reported no adverse clinical/pathologic signs of toxicity due to subchronic or short-term exposures. The LOAEL of 488 mg/kg/day (based on mortality in rats) was converted to 349 mg/kg/day on a 7-day exposure basis. ___I.A.3. UNCERTAINTY AND MODIFYING FACTORS (ORAL RfD) UF -- An uncertainty factory of 1000 (10 for LOAEL, 10 for species conversion, and 10 for sensitive human population), results in an RfD of 0.3 mg/kg/day. MF -- None ___I.A.4. ADDITIONAL COMMENTS (ORAL RfD) None. ___I.A.5. CONFIDENCE IN THE ORAL RfD Study -- Medium Data Base -- Medium RfD -- Medium The chosen study is given a medium confidence rating because large numbers of animals/sex were tested in two doses for chronic exposures, but the study did not establish a NOEL. The data base is given a medium confidence rating because of the support of chronic data, but the lack of reproductive data. Medium confidence in the RfD follows. ___I.A.6. EPA DOCUMENTATION AND REVIEW OF THE ORAL RfD Source Document -- This assessment is not presented in any existing U.S. EPA document. Other EPA Documentation -- None Agency Work Group Review -- 05/20/1985, 05/31/1985 Verification Date -- 05/31/1985 ___I.A.7. EPA CONTACTS (ORAL RfD) Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (301) 345-2870 (phone), (301) 345-2876 (FAX) or Hotline.IRIS@epamail.epa.gov (internet address).
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC) Substance Name -- Trichlorofluoromethane CASRN -- 75-69-4 Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE Substance Name -- Trichlorofluoromethane CASRN -- 75-69-4 This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_VI. BIBLIOGRAPHY Substance Name -- Trichlorofluoromethane CASRN -- 75-69-4 Last Revised -- 07/01/1992 __VI.A. ORAL RfD REFERENCES Leuschener, F., B.W. Neumann and F. Hubscher. 1983. Report on the subacute toxicological studies with several fluorocarbons in rats and dogs by inhalation. Arzneim-Forsch. 33(10): 1475-1476. NCI (National Cancer Institute). 1978. Bioassay of trichlorofluoromethane for possible carcinogenicity. Report No. 106, PHS/NIH, DWEH, Publ. No. 78- 1356.
__VI.B. INHALATION RfC REFERENCES None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES None
_VII. REVISION HISTORY Substance Name -- Trichlorofluoromethane CASRN -- 75-69-4 -------- -------- -------------------------------------------------------- Date Section Description -------- -------- -------------------------------------------------------- 03/31/1987 I.A.6. Documentation corrected 03/01/1988 I.A.5. Confidence levels revised 08/01/1990 I.A. Text edited 08/01/1990 IV.F.1. EPA contact changed 01/01/1992 I.A.7. Primary contact changed 01/01/1992 IV. Regulatory actions updated 07/01/1992 I.A.2. Citations removed 07/01/1992 VI.A. Oral RfD references on-line 08/01/1992 I.A.3. Minor text change 04/01/1997 III.,IV., Drinking Water Health Advisories, EPA Regulatory Actions, and V. Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
VIII. SYNONYMS Substance Name -- Trichlorofluoromethane CASRN -- 75-69-4 Last Revised -- 01/31/1987 75-69-4 ALGOFRENE TYPE 1 ARCTON 9 ELECTRO-CF 11 ESKIMON 11 F 11 FC 11 FLUOROCARBON NO. 11 FLUOROTRICHLOROMETHANE FLUOROTROJCHLOROMETAN FREON 11 FREON 11A FREON 11B FREON HE FREON MF FRIGEN 11 GENETRON 11 HALOCARBON 11 ISCEON 131 ISOTRON 11 LEDON 11 MONOFLUOROTRICHLOROMETHANE NCI-C04637 RCRA WASTE NUMBER U121 Trichlorofluoromethane TRICHLOROMONOFLUOROMETHANE UCON FLUROCARBON 11 UCON REFRIGERANT 11

Last updated: 5 May 1998
URL: http://www.epa.gov/iris/subst/0120.htm