Abstracts
Tolylfluanid
CAS No. 731-27-1

For more abstracts search PubMed or Toxnet
 
 

Return to
Index Page
Adverse Effects

ACTIVITY: Fungicide, Insecticide (phenylsulfamide)

CAS Name: 1,1-dichloro-N-[(dimethylamino)sulfonyl]-1-fluoro-N-(4-methylphenyl)methanesulfenamide

Structure:

 

Reports available from The National Technical Information Service (NTIS)
- see http://www.ntis.gov/
Order No. Title Keywords CAS Nos.

NTIS/OTS0559049

EPA/OTS; Doc #88970000062

1996 - INITIAL SUBMISSION: UNTERSUCHUNG AUF SENSIBILISIERENDE WIRKUNG BEI MEERSCHWEINCHEN, WITH TSCA HEALTH & SAFETY STUDY COVER SHEET DATED 11-19-1996

BAYER AG


BAYER CORP
TOLYFLUANID(PREVENTOL A5)
HEALTH EFFECTS
PRIMARY DERMAL SENSITIZATION
MAMMALS
GUINEA PIGS
DERMAL
731-27-1

NTIS/OTS0559050

EPA/OTS; Doc #88970000063

1996 - INITIAL SUBMISSION: KUE 13183b, EUPAREN M - WIRKSTOFF, GENERATIONSVERSUCH AN RATTEN, WITH TSCA HEALTH AND SAFETY STUDY COVER SHEET DATED 11-19-1996
BAYER CORP
TOLYFLUANID(PREVENTOL A5)
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
COMBINED TERATOGENICITY/REPRODUCTIVE EFFECTS
MAMMALS
RATS
ORAL
DIET
731-27-1

NTIS/OTS0545057

EPA/OTS; Doc #88-920006458

1992 - INITIAL SUBMISSION: TOXICITY STUDIES WITH DICHLOFLUANID & TOLYLFLUANID IN RATS, MICE, AND DOGS WITH COVER LETTER DATED 09-21-92
MILES INC
DICHLOFLUANID & TOLYLFLUANID
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
DOGS
RATS
MICE
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
RABBITS

731-27-1

1085-98-9

 

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16545431&query_hl=1&itool=pubmed_docsum

Sci Total Environ. 2006 Mar 15; [Epub ahead of print]
 
Comparative toxicity of alternative antifouling biocides on embryos and larvae of marine invertebrates.

Bellas J.

Departamento de Ecoloxia e Bioloxia Animal, Universidade de Vigo, Estrada, Colexio Universitario s/n, 36310 Vigo, Galicia, Spain.

This study evaluates the impact of commonly used "booster" biocides (chlorothalonil, Sea-Nine 211, dichlofluanid, tolylfluanid and Irgarol 1051) on early developmental stages of marine invertebrates of commercial and ecological relevance. Toxicity tests were conducted with embryos and larvae of the bivalve Mytilus edulis, the sea-urchin Paracentrotus lividus and the ascidian Ciona intestinalis. Toxicity was quantified in terms of the EC(50) (median effective concentration) and EC(10) reducing embryogenesis success, larval growth and larval settlement by 50% and 10% respectively. The EC(10) and EC(50) for chlorothalonil ranged from 2 to 108 and from 25 to 159 nM; for Sea-Nine 211 values were 6-204 and 38-372 nM; for dichlofluanid effective concentrations were 95-830 and 244-4311 nM; tolylfluanid yielded values between 99-631 and 213-2839 nM; and Irgarol 1051 was the least toxic compound showing values from 3145 to >25600 and from 6076 to >25600 nM. Those biocides may be ranked in the following order from highest to lowest toxicity to embryos and larvae of M. edulis, P. lividus and C. intestinalis: chlorothalonil>Sea-Nine 211>dichlofluanid=tolylfluanid>Irgarol 1051. The registered effective concentrations were compared to worst-case environmental concentrations reported in literature in order to evaluate the risk posed by these biocides to those invertebrate species. Our data support that chlorothalonil, Sea-Nine 211 and dichlofluanid predicted levels in marinas represent a threat to M. edulis, P. lividus, and C. intestinalis populations, whilst Irgarol 1051 showed no toxic effects on the biological responses tested here at worst-case environmental concentrations.

Excerpts:
This is, in our knowledge the first report of tolylfluanid and dichlofluanid toxicity to marine organisms.
• Reported maximum concentrations in marinas and polluted estuaries are shown in Table 3, except for tolylfluanid, since no data was found in literature.
• the embryonic development of P. lividus and M. edulis was more sensitive to chlorothalonil and Sea-Nine 211 than the embryogenesis and larval settlement of C. intestinalis, the settlement of C. intestinalis larvae was more sensitive to tolylfluanid and dichlofluanid.

PMID: 16545431 [PubMed - as supplied by publisher]


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16449059&query_hl=1&itool=pubmed_docsum

Food Addit Contam. 2006 Feb;23(2):164-73.
 
Monitoring of pesticide residues in apples, lettuce and potato of the Slovene origin, 2001-04.

Cesnik HB, Gregorcic A, Bolta SV, Kmecl V.

Agricultural Institute of Slovenia, Central Laboratories, Ljubljana, Slovenia. helena.basa@kis.si

Apples, lettuce and potatoes (404 samples) produced in the Republic of Slovenia were analysed for pesticide residues at the Agricultural Institute of Slovenia, Ljubljana, in 2001-04. Sampling from eight agricultural production areas was performed at market producers at the harvesting of products or in storehouses after the pre-harvest interval of plant protection products used. Samples exceeding the maximum residue levels were the following: three apple samples (2.0%) containing 0.33-2.24 mg kg(-1) (phosalone and tolylfluanid), three lettuce samples (3.1%) containing 0.14-6.36 mg kg(-1) (dimethoate, dithiocarbamates and metalaxyl) and 36 potato samples (23.1%) containing 0.06-0.51 mg kg(-1) (dithiocarbamates). Residues of two or more active substances were found in 73 apple samples (48.3%), of which the maximum residue limit (MRL) was exceeded by three samples (2.0%) with the values ranging from 0.33 to 2.24 mg kg(-1), and nine lettuce samples (9.3%), for which the MRL was exceeded by three samples (3.1%) with values from 0.14 to 6.36 mg kg(-1). In potato samples, only residues of dithiocarbamates or no residues at all were found. Residues of the dithiocarbamate group were the most frequently found, i.e. in 66 apple samples (43.7%), 30 lettuce samples (30.9%) and 38 potato samples (24.4%).

PMID: 16449059 [PubMed - in process]


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16356887&query_hl=1&itool=pubmed_docsum

Food Addit Contam. 2005 Dec;22(12):1231-42.
 
Baby food production chain: pesticide residues in fresh apples and products.

Stepan R, Ticha J, Hajslova J, Kovalczuk T, Kocourek V.

Department of Food Chemistry and Analysis, Institute of Chemical Technology (ICT) Prague, Technicka 5, Prague 6, 16628, Czech Republic.

During 3 years of a monitoring programme, 522 samples of fresh apples, six brands of fruit purees and various types of fruit baby food prepared from these materials were analysed. Each sample was examined for the presence of 86 GC amenable pesticide residues. The reporting limits of the procedure employed for sample analyses were in the range 0.003-0.01 mg kg(-1). Pesticide residues were detected in 59.5% of the samples of fresh apples. However, maximum residue levels (European Union MRLs) were exceeded only in 1.4% of samples. The levels of residues in 'positive' fruit purees were substantially lower, overall with residues detected in 33% of samples. Fruit baby food represented the commodity with the lowest incidence of residues being detected in only 16% of samples. The 0.01 mg kg(-1) MRL was exceeded in 9% of these products. Multiple residues were found in 25% of fresh apples and in 10% of fruit purees. None of fruit baby food samples contained more than a single residue. Organophosphorus insecticides and fungicides representing phtalimides, sulphamides and dicarboximides were the most frequently found residues. To obtain more knowledge on the fate of residues during fruit baby food production, processing experiments employing apples with incurred residues (fenitrothion, phosalone and tolylfluanid) were conducted. Washing of apples did not significantly reduce the content of pesticides. Steam boiling followed by removal of peels/stems was identified as the most efficient steps in terms of residues decrease (phosalone) or complete elimination (fenitrothion and tolylfluanid).

PMID: 16356887 [PubMed - in process]


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15941588&query_hl=1

Ecotoxicol Environ Saf. 2005 Jun 4; [Epub ahead of print]
 
Chromosomal aberrations and frequency of micronuclei in sheep subchronically exposed to the fungicide Euparen Multi (tolylfluanid).

Sutiakova I, Kovalkovicova N, Pistl J, Novotny J, Legath J, Kovac G, Hlincikova S, Sutiak V.

University of Veterinary Medicine, Komenskeho 73, 041 81 Kosice, Slovak Republic.

We analyzed chromosome aberrations, micronucleus frequency, mitotic index (MI), and nuclear division index (NDI) in peripheral lymphocytes of sheep subchronically exposed to the fungicide Euparen Multi (containing 50% tolylfluanid). Euparen Multi was administered by rumen sonde to group of Merino sheep (seven sheep/group) at 93mg/kg body weight (1/20 LD(50)) daily for 28 days to assess its genotoxic effects. The frequencies of aberrant cells (ABC) in the experimental and control groups were 5.50+/-1.38% and 2.40+/-1.14%, respectively, and the increase in ABC in the treated group was significant (P=0.003). Significantly increased numbers of chromatid breaks (5.67+/-1.21% against 2.40+/-1.14%; P=0.001), chromatid gaps (10.33+/-2.73% against 4.00+/-1.23%; P=0.001), and chromosome gaps (1.83+/-0.75% against 0.80+/-0.45%; P=0.025) and exchanges (3.17+/-1.94% against 0.20+/-0.45%; P=0.009) were observed in exposed animals in comparison to control animals. The frequency of micronuclei (MN) was 29.40+/-5.86 per 1000 binucleated cells in peripheral lymphocytes of sheep in the control group and 49.57+/-19.12 per 1000 binucleated cells in the treated group. A significant increase in the frequency of MN in peripheral lymphocytes also was observed between the two groups (P=0.0477). No statistical differences in MI and NDI values were found in the groups (P=0.181 and 0.761, respectively). Thus, our results suggest that exposure to Euparen Multi may cause genome damage in somatic cells.

PMID: 15941588 [PubMed - as supplied by publisher]


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15755314&query_hl=1

Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):309-15.
 
Xenobiotics and the glucocorticoid receptor: additive antagonistic effects on tyrosine aminotransferase activity in rat hepatoma cells.

Johansson M, Johansson N, Lund BO.

Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE-752 36 Uppsala, Sweden. maria.k.johansson@astra.zeneca.com

Methylsulfonyl-PCBs (MeSO2-PCBs) and some fungicides were studied for their functional effects on the glucocorticoid signal transduction in the Reuber rat hepatoma H-II-E-C3 cell line. 4-Substituted MeSO2-PCBs, tolylfluanid and ketoconazole displayed antagonistic effects on dexamethasone-induced tyrosine aminotransferase specific activity (IC50 ranging from 0.7-5.1 microM), but no agonist activity. These substances also had affinity to the mouse glucocorticoid receptor in competition binding studies, indicating that the inhibition of the middle cerebral artery occlusion-activity is indeed mediated by receptor binding. Thus, substances with a structural resemblance with a methyl sulfonyl group, such as the fungicide tolylfluanid, may inhibit glucocorticoid receptor-regulated gene transcription. In co-exposure experiments with three substances, multivariate modelling showed that the inhibitory effect of 4-MeSO2-2,5,6,2',4'-pentachlorobiphenyl (4-MeSO2-CB91), 4-MeSO2-2,3,6,2',4',5'-hexachlorobiphenyl (4-MeSO2-CB149) and tolylfluanid on tyrosine aminotransferase activity was close to additive. Thus, co-exposure to such different chemicals as persistent organic pollutants and pesticides may affect cells additively. Chemical interference with the glucocorticoid hormone system therefore deserves further attention in vivo.

PMID: 15755314 [PubMed - in process]


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14668155

Food Addit Contam. 2003 Nov;20(11):1044-63.

Distribution of multiple pesticide residues in apple segments after home processing.

Rasmusssen RR, Poulsen ME, Hansen HC.

Danish Veterinary and Food Administration, Morkhoj Bygade 19, DK-2860 Soborg, Denmark. riro@fdir.dk

The effects of washing, storing, boiling, peeling, coring and juicing on pesticide residue were investigated for field-sprayed Discovery and Jonagold apples. Residues of chlorpyrifos, cypermethrin, deltamethrin, diazinon, endosulfan, endosulfan sulfate, fenitrothion, fenpropathrin, iprodione, kresoxim-methyl, lambda-cyhalothrin, quinalphos, tolylfluanid and vinclozolin in the processed apples were analysed by gas chromatography. Statistical analysis showed that reductions of 18-38% were required to obtain significant effects of processing practices, depending on pesticide and apple variety. Juicing and peeling the apples significantly reduced all pesticide residues. In the case of detectable pesticide residues, 1-24% were distributed in the juice and in the peeled apple. None of the pesticide residues was significantly reduced when the apples were subject to simple washing or coring. Storing significantly reduced five of the pesticide residues: diazinon, chlorpyrifos, fenitrothion, kresoxim-methyl and tolylfluanid, by 25-69%. Residues of the metabolite endosulfan sulfate were increased by 34% during storage. Boiling significantly reduced residues of fenitrothion and tolylfluanid by 32 and 81%, respectively. Only a few of the observed effects of processing could be explained by the physical or chemical characteristics of the pesticides. No differences in effect of processing due to apple variety were identified.

PMID: 14668155 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=13129790

Food Addit Contam. 2003 Aug;20(8):728-41.

Processing factors and variability of pyrimethanil, fenhexamid and tolylfluanid in strawberries.

Christensen HB, Granby K, Rabolle M.

Danish Veterinary and Food Administration, Soborg, Denmark. hbc@fdir.dk

An HPLC-MS/MS method for the analysis of three pesticides in strawberries was developed and validated. Recoveries were measured at three spiking levels and ranged from 85 to 99% (mean recoveries). The effects of processing of strawberries ranging from rinsing to jam production were investigated for the three fungicides tolylfluanid, fenhexamid and pyrimethanil, which were applied under field conditions. Kresoxim-methyl was also applied in the field, but was not found in any of the samples investigated. The effect of parameters such as preharvest interval, dose, harvest time and observed pesticide concentration after harvest (initial concentration, mg kg(-1)), were examined with respect to possible reduction of the pesticides. The results from rinsing showed that all three pesticides were reduced on average by 37% for tolylfluanid, by 34% for fenhexamid and by 19% for pyrimethanil. For tolylfluanid and fenhexamid, the initial concentration significantly affected the reduction. For fenhexamid, dose could also have a minor influence on reduction. For pyrimethanil, none of the parameters significantly influenced the reduction. For jam production, cooking significantly reduced tolylfluanid by an average of 91%. For fenhexamid and pyrimethanil, a smaller reduction was seen, 25% and 33%, respectively. The reduction of tolylfluanid and pyrimethanil was affected by the preharvest interval, while fenhexamid was affected by the initial concentration. The unit-to-unit variability of fungicide contents was also investigated and the variability factors for the three fungicides were from 1.9 to 2.8.

PMID: 13129790 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11804510&dopt=Abstract

J Agric Food Chem 2002 Jan 30;50(3):441-8

Assessment of the stability of pesticides during cryogenic sample processing. 1. Apples.

Fussell RJ, Jackson Addie K, Reynolds SL, Wilson MF.

Central Science Laboratory, Sand Hutton, York YO41 1LZ, United Kingdom.

An assessment of the stability of a large number (106) of pesticides and related compounds during the cryogenic sample processing of apples has been undertaken. For the first time the procedure included an assessment of the losses during the freezing of the fruits, prior to processing. The stability of each pesticide during processing was assessed by comparing the mean recovery for the laboratory-spiked samples with the mean "survival" of the pesticides in cryogenically processed samples. The results clearly demonstrate that the vast majority, 94 of 106, of pesticides were stable during cryogenic processing. Of particular importance was that losses of several pesticides [bitertanol (95%), heptenophos (50%), isofephos (40%), and tolylfluanid (48%)] reported to occur during ambient processing of apples did not occur during cryogenic processing. Losses of dichlofluanid (54%), chlozolinate (22%), and etridiazole (40%), previously reported to occur during ambient processing of apples, were reduced to barely significant levels (10, 17, and 14%, respectively) by cryogenic processing. Small apparent losses for a few of the compounds were attributable to analytical and sample handling difficulties, rather than to losses during processing, and need further investigation.

PMID: 11804510 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10725174&dopt=Abstract

J Agric Food Chem 2000 Mar;48(3):917-20

Investigation on fungicide residues in greenhouse-grown strawberries.

Stensvand A, Christiansen A.

The Norwegian Crop Research Institute, Pesticide Laboratory, Osloveien 1, 1430 As, Norway.

Maximum residue limits (MRL's) for different agricultural food products in Norway are harmonized with EU standards. In field-grown strawberries in Norway, tolylfluanid has a 7 day quarantine from last application to harvest, while other approved fungicides have 14 days quarantine. Greenhouse production of strawberries is newly introduced to the country. Residue levels in strawberries of the cultivar Korona grown in a commercial greenhouse were investigated 4, 7, and 14 days after application of eight different fungicides at rates recommended by the manufacturers and at half rates. Iprodione, tolylfluanid, and vinclozolin were tested in two experiments, while chinomethionat, chlorothalonil, imazalil, penconazole, and triadimefon were tested once. For chinomethionat, imazalil, iprodione, penconazole, and vinclozolin, the residue levels were below MRL 2 weeks after application. Application of triadimefon in normal rate gave residues below MRL 14 days after application. However, its metabolite, triadimenol, was above MRL at the same time. Tolylfluanid gave very high residue levels, and except from half concentration in the second experiment, all other residue levels were above MRL. Seven days after application, residues in both experiments were approximately 3 times higher than MRL when normal rate of tolylfluanid was applied. For chlorothalonil at the recommended rate, the residue level was above MRL at any sampling time, while half rate gave residues below MRL 14 days after treatment. In view of the present results, tolylfluanid, chlorothalonil, and triadimefon will need longer time from last application to harvest and/or reduced application rates in greenhouse-grown compared to field-grown strawberries. In addition or as an alternative, recommended rates could be lowered.

PMID: 10725174 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10635545&dopt=Abstract

Am Ind Hyg Assoc J 1999 Nov-Dec;60(6):789-93

Exposure to fungicides in fruit growing: re-entry time as a predictor for dermal exposure.

Tielemans E, Louwerse E, de Cock J, Brouwer D, Zielhuis G, Heederik D.

Department of Environmental Sciences, University of Wageningen, The Netherlands.

As part of a European Concerted Action on Male Reproduction Capability an exposure assessment survey was conducted among seasonal workers in the fruit growing sector in the Netherlands. Dermal exposure to the fungicides captan and tolylfluanid was measured using cotton gloves (12 persons) and skin pads on several body parts (12 persons). In addition, a set of exposure data was used from a study conducted recently among Dutch fruit growers. For harvesting activities, re-entry time appeared to be an important determinant of dermal exposure to captan and tolyfluanid. Explained variance of regression models was moderate to high (range 0.30-0.87). For captan, calculated half-life times from the most recent exposure survey were lower (glove data: 5 days; pad data: 6 days) compared with half-life times based on the previously conducted study (11 days). Possible explanations for the discrepancy are discussed. For tolylfluanid, estimated half-life times during harvesting were 2 and 3 days, based on pad and glove data, respectively. Prediction of captan exposure during other crop activities appeared to be far more difficult (explained variance equal to 0.06), although the estimated half-life time was comparable with that for harvesting. The data suggest that re-entry time gives useful information to group workers in broad exposure categories. Nonetheless, it was concluded that large studies are needed to evaluate the importance of re-entry time in more detail.

Publication Types:

  • Multicenter Study

PMID: 10635545 [PubMed - indexed for MEDLINE]


From Toxline at Toxnet

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY; 37 (3). 1999. 415-423.

Human semen quality in relation to dietary pesticide exposure and organic diet.

JUHLER RK, LARSEN SB, MEYER O, JENSEN ND, SPANO M, GIWERCMAN A, BONDE JP

Department of Geochemistry, Geological Survey of Denmark and Greenland, GEUS, Thoravej 8, 2400, Copenhagen NV, Denmark.

BIOSIS COPYRIGHT: BIOL ABS. The objective of the study was to corroborate or refute the hypothesis that farmers having a high intake of organic grown commodities have a high semen quality due to their expected lower level of dietary pesticides intake. Food frequency data and semen were collected from 256 farmers (171 traditional farmers and 85 organic farmers, overall participation rate: 32%) who were selected from central registers. Each farmer delivered one semen sample before the spraying season started. The farmers wer ual mean intake of single commodities, such as rice, potato, and pork meat. The current individual dietary intake of 40 pesticides was estimated using food frequencies and generalized serving size data in combination with data on pesticide concentrations in food commodities as obtained from the National Danish Food Monitoring Program. The estimated pesticide intake was significantly lower among farmers of group H, but for all three groups of farmers the average dietary intake of 40 pesticides wa The group of men without organic food intake had a significant lower proportion of morphologically normal spermatozoa, but in relation to 14 other semen parameters no significant differences werefound between the groups. Intake of 40 individual pesticides was correlated with four semen parameters (concentration, percentage dead spermatozoa, percentage normal sperm heads, and motility (VCL)). Five significant correlations (p value 0.01) were found among the 160 comparisons in relation to percent sion, the estimated dietary intake of 40 pesticides did not entail a risk of impaired semen quality, but precautions should be taken when generalizing this negative result to populations with a higher dietary exposure level or an intake of other groups of pesticides.

CAS Registry Numbers:
50471-44-8 - Vinclozolin
32809-16-8 - procymidone
2595-54-2 - mecarbam
731-27-1 - Tefluthrin
36734-19-7 - iprodione
10605-21-7 - carbendazim
1825-21-4
10265-92-6 - methamidophos
13457-18-6 - pyrazophos
2597-03-7 - phenthoate
1897-45-6 - chlorothalonil
80-33-1 - chlorfenson
29232-93-7 - pirimiphos-methyl
13593-03-8 - quinalphos
18181-80-1 - bromopropylate
2310-17-0 - phosalone
148-79-8 - thiabendazole
30560-19-1 - acephate
2921-88-2 - chlorpyrifos
950-37-8 - methidathion
732-11-6 - phosmet
563-12-2 - ethion
333-41-5 - diazinon
298-00-0 - parathion-methyl
133-06-2 - captan
122-39-4 - diphenylamine
122-14-5 - fenitrothion
116-29-0 - tetradifon
115-32-2 - dicofol
115-29-7 - endosulfan
99-30-9 - dicloran
92-52-4 - biphenyl
90-43-7 - 2-phenylphenol
87-86-5 - pentachlorophenol
86-50-0 - azinphos-methyl
63-25-2 - carbaryl
60-51-5 - dimethoate
58-89-9 - lindane
56-38-2 - parathion


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1854993&dopt=Abstract

Bull Environ Contam Toxicol 1991 Apr;46(4):499-506

No Abstract available

Fate of the fungicide tolylfluanid in the pear cold stored in controlled or non controlled atmosphere.

Rouchaud J, Gustin F, Creemers P, Goffings G, Herregods M.

Laboratory of Phytopathology, Catholic University of Louvain, Belgium.

PMID: 1854993 [PubMed - indexed for MEDLINE]


From Toxline at Toxnet

FAO Plant production and protection paper Vol:93/2 (1988) pp 61-73

Tolylfluanid

FAO and WHO working groups

Level causing no toxicological effect
Rat: 300 ppm in the diet, equal to 15 mg/day bw/day
Dog: 12.5 mg/kg bw/day
Human: Estimate of acceptable daily intake for man 0-0.1 mg/kg bw

Studies which will provide information valuable for the continued evaluation of the compound Observations in man.


Return to Tolyfluanid Index page

 

 
Fluoride Action Network | Pesticide Project | 315-379-9200 | pesticides@fluoridealert.org