CAS No. 124495-18-7


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Adverse Effects

ACTIVITY: Fungicide (unclassified)

CAS Name: 5,7-dichloro-4-(4-fluorophenoxy)quinoline


Adverse Effects:

Body Weight Decrease

Endocrine: Pituitary
Endocrine: Testicular
Endocrine: Thymus

Environmental Effects:

Sweden: "... high persistence, high potential for bioaccumulation and indicated potential for long-range transport. Substances like quinoxyfen may accumulate in various environmental compartments, including biota, and the effects of such accumulation are unpredictable..."

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 055459 
US Tolerances: CFR 180.588
California Chemical Code 5787 
Registered use in
(includes only a limited list of countries)

Germany, Hungary, Portugal, South Africa, UK 
US Maximum Residue Levels permitted in food commodities

US: On Sept 29, 2003, EPA approved the first-time tolerances to be established for the residues of quinoxyfen
Cherry (sweet & tart), Grape, Hop (dried cones)

US. Time-Limited to Dec 2007:
Squash, winter
Vegetable, cucurbit, subgroup 9A (includes 19 commodities)

UK Temporary MRL's

Strawberries: 0.3 ppm (as of April 2005)
Hops: 1.0 ppm (as of
Feb 2005)

Other Information
Molecular Formula: C15H8Cl2 F NO 
Entry Year: 1997  
Manufacturers: Dow Agro  
Other Names: Arius
Of special interest:
PAN Data 
November 27, 2003 - Review report for the active substance quinoxyfen. 6781/VI/97-Final. European Commission. Health & Consumer Protection Directorate-General.
October 4, 2001 - SUMMARY OF TOXICOLOGY DATA QUINOXYFEN (XDE-795 & XR-795). California EPA, Department of Pesticide Regulation, Medical Toxicology Branch.

July 20, 2004. New York Bureau of Pesticides declares crisis and approves the use of Quintec on pumpkins in Long Island.

February 18, 2002 - European Commission decision to extend provisional authorisation granted for new active substances: carfentrazone-ethyl, cinidon-ethyl, cyhalofop-butyl, ethoxysulfuron, famoxadone, flazasulfuron, flufenacet, flumioxazine, flurtamone, fosthiazate, isoxaflutole, metalaxyl-M, prosulfuron, Pseudomonas chlororaphis, quinoxyfen, Spodoptera exigua nuclear polyhedrosis virus and sulfosulfuron  
2003 - US EPA 2003 work plan for registration of 19 conventional pesticides; 6 of the 19 are fluorinated. They are Butafenacil, Flonicamid, Flufenpyr-ethyl, Noviflumuron, Quinoxyfen, Trifloxysulfuron
December 7, 2001: European Commission. Short report of the meeting of the Standing Committee on Plant Health held on 7 December 2001 in Bruxelles. SCPH 5/01.  
February 14, 2001 - Ingredient in Fortress Duo Fungicide. Safety Data Sheet.  
August 2001 - IR-4: New Products/Transitional Solution List - This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes: Quinoxyfen 
October 2001 - Glossary of Pesticide Chemicals - A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.  

US Federal Register
Date Published Docket Identifiction Number Details
August 25, 2006 EPA-HQ-OPP-2006-0167

IR-4. Pesticide tolerance. FINAL RULE.
in or on commodities:
-- Lettuce, head at 7.0 ppm
-- Lettuce, leaf at 19 ppm
-- Pepper, bell at 0.35 ppm
-- Pepper, nonbell at 1.7 ppm
-- Strawberry at 0.90
-- Melon, subgroup 9A at 0.08 ppm
This subgroup includes 6 commodities.
cantaloupe • citron melon • melon • melon, citron • muskmelon • watermelon

August 25, 2006 EPA-HQ-OPP-2006-0659 Pesticide Emergency Exemptions; Agency Decisions and State and Federal Agency Crisis Declarations
• New York: Specific: EPA authorized the use of quinoxyfen on non-edible cucurbits to control powdery mildew; July 1, 2006 to September 30, 2006.
August 31, 2005 OPP-2005-0223

Pesticide Emergency Exemptions:

• Arizona. Crisis: On May 04, 2005, for the use of quinoxyfen on watermelons to
control powdery mildew. This program is expected to end on September 30, 2005. Contact: (Stacey Groce).
• New York. EPA authorized the use of quinoxyfen on melons, winter squash, gourds,
and pumpkin (non-edible cucurbits)
to control powdery mildew; June 30,
2005 to September 30, 2005. Contact: (Stacey Groce)

April 21, 2006 EPA-HQ-OPP-2006-0167 IR-4. Pesticide petitions: PP 3E6755, PP 5E6969, PP 5E6970.
PP 3E6755
-- eggplant at 1.0 ppm
-- peppers, bell and non-bell at.1.0 ppm;
PP 5E6969
-- Melon (Subgroup 9A) at 0.1 ppm;
This subgroup includes 6 commodities: cantaloupe • citron melon • melon • melon, citron • muskmelon • watermelon
PP 5E6970
-- Lettuce, head and leaf at 17.0 ppm
-- strawberry at.0.8 ppm.
Jan 28, 2005 OPP-2005-0009 Pesticide Tolerances for Emergency Exemptions for New York State. FINAL RULE. EPA, on its own initiative, in accordance with sections 408(e) and 408 (l)(6) of the Federal Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a, is establishing the following tolerances for residues of the fungicide quinoxyfen in or on
Commodity Parts per million Expiration/ revocation date
Pumpkin 0.30 12/31/07
Squash, winter 0.30 12/31/07
Vegetable, cucurbit, subgroup 9A * 0.30 12/31/07

* Vegetable, cucurbit, group 09 includes:
balsam apple • balsam pear • cantaloupe • chayote, fruit • cucumber • cucumber, chinese • cucurbits • gherkin, west indian • gourd, edible • melon • melon, citron • muskmelon • pumpkin • squash • squash, summer • squash, winter • vegetable, cucurbit, group • watermelon • waxgourd, chinese

The nature of the toxic effects caused by quinoxyfen are fully discussed in a Federal Register Notice published on September 29, 2003 (68 FR 55849) that
established tolerances for residues of quinoxyfen on cherries, grapes and hops.

Although this tolerance will expire and is revoked on December 31, 2007, under section 408(l)(5) of the FFDCA, residues of the pesticide not in excess of the amounts specified in the tolerance remaining in or on melon subgroup 9A, pumpkin and winter squash after that date will not be unlawful, provided the pesticide is applied in a manner that was lawful under FIFRA, and the residues do not exceed a level that was authorized by this tolerance at the time of that application. EPA will take action to revoke this tolerance earlier if any experience with, scientific data on, or other relevant information on this pesticide indicate that the residues are not safe.
Because this tolerance is being approved under emergency conditions, EPA has not made any decisions about whether quinoxyfen meets EPA's registration requirements for use on melons, winter squash, and pumpkins or whether a permanent tolerance for these uses would be appropriate. Under these circumstances, EPA does not believe that these tolerances serve as a basis for registration of quinoxyfen by a State for special local needs under FIFRA section 24(c). Nor do these tolerances serve as the basis for any State other than New York to use this pesticide on these crops under section 18 of FIFRA without following all provisions of EPA's regulations implementing FIFRA section 18 as identified in 40 CFR part 166

Dec 22, 2004 OPP-2004-0350 Pesticide Emergency Exemptions.
-- New YorkDepartment of Environmental Conservation
Crisis: On July 21, 2004, for the use of quinoxyfen on cucurbits to control powdery mildew. This program ended on September 30, 2004. Contact: (Stacey Groce)
Nov 26, 2003 OPP-2003-0358 3 Pesticide Emergency Exemptions.
-- Idaho Department of Agriculture. EPA authorized the use of quinoxyfen on hops to control powdery mildew; July 1, 2003 to September 15, 2003. This request was granted because the Agency has determined that the onset of the powdery mildew pest problem has created an urgent and non-routine situation which will result in a significant economic losses for hops growers.
-- Oregon Department of Agriculture. EPA authorized the use of quinoxyfen on hops to control powdery mildew; June 15, 2003 to September 15, 2003. This request was granted because the Agency has determined that the onset of the powdery mildew pest problem has created an urgent and non-routine situation which will result in a significant economic losses for hops growers.
-- Washington Department of Agriculture. EPA authorized the use of quinoxyfen on hops to control powdery mildew; July 1, 2003 to September 15, 2003. This request was granted because the Agency has determined that the onset of the powdery mildew pest problem has created an urgent and non-routine situation which will result in a significant economic losses for hops growers.
Sept 29, 2003 OPP-2003-0218

IR-4. Pesticide tolerances. FINAL RULE. These are the first tolerances to be established for the residues of quinoxyfen by US EPA.

Commodity Final Rule:
May 30:
requested by IR4-:

Cherry, sweet 0.30 0.4 ppm
Cherry, tart
Hop, dried cones 3.0 5 ppm
Grape 0.60 0.70

The primary target organs affected by quinoxyfen are the liver and kidney. Liver effects were seen in rat and mouse subchronic and dog chronic studies. Subchronic effects in rats and mice included increased liver weights, hepatocellular hypertrophy and individual cell hepatocellular necrosis. These effects were noted at high doses and not observed in the chronic rat and mouse studies since they were performed at lower doses. Chronic effects in the dog included increased liver weights, increased alkaline phosphatase levels and increased incidences of slight microscopic hepatic lesions (increased bile in canaliculi and increased hepatocyte size). Kidney effects were noted only in the rat combined chronic/carcinogenicity study which resulted in an increased severity of chronic progressive glomerulonephropathy in the males. Rabbits were much more susceptible to the effects of quinoxyfen than any other species. Systemic effects observed in the rabbit developmental study included inanition, loss of body weight, perineal soiling, blood in the cage pan associated with urine, and abortions. Body weight decrements were noted in the rat and/or mouse subchronic, chronic and carcinogenicity studies and the rabbit developmental and rat reproduction studies.

May 30, 2003 OPP-2003-0071 DOW AgroSciences; IR-4 - Pesticide Tolerance Petition; to establish tolerances in or on in or on the following raw agricultural commodities:
Two Pesticide Petitions:
1E6302: Grape at 0.70 ppm
1E6302: hop, dried at 5 ppm
2E6474: cherry at 0.4 ppm
Subchronic and chronic toxicity. Quinoxyfen caused increased liver weights and microscopic hepatocellular hypertrophy when given at sufficiently high dose levels in rats and mice for 13 weeks;
-- increased kidney weights, and an increase in the incidence of chronic progressive glomerulonephropathy, were seen after 24 months in female rats given high dose levels of quinoxyfen. Chronic toxicity seen in dogs included liver effects as noted above, along with regenerative anemia at high dose levels.
March 26, 2003 OPP-2003-0053

Application for Emergency Exemption; Solicitation of Public Comment. EPA has received specific exemption requests from the Idaho Department of Agriculture, the Oregon Department of Agriculture, and the Washington State Department of Agriculture to use the pesticide quinoxyfen to treat up to a total of 19,500 acres of hops to control powdery mildew; 3,000 acres in Idaho, 3,500 acres in Oregon, and 13,000 acres in Washington. The Applicants propose the use of a new chemical which has not been registered by EPA. The U.S. is the second largest producer of hops in the world. The States estimate that there will be an 8% to 30% loss of gross revenues without the use of quinoxyfen. No risk information is provided in this petition.

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