CAS No. 365400-11-9

Activity: Herbicide (phenyl pyrazolyl ketone)

CAS Name: (5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)[2-(methylsulfonyl)-4-(trifluoromethyl)phenyl]methanone


Regulatory Information
(only comprehensive for the US)
US EPA Registered: Pending
Other Information
Molecular Formula:



Bayer CropScience

Other Name(s):

AE 0317309

Of special interest:

April 2005 - Initial submission from Bayer to USEPA. One-generation reproduction study in wistar rats (pilot study for a two-generation reproduction study with administration in the diet):

The purpose of this one-generation study was to evaluate possible effects of AE 0317309 on the parental generation and the entire reproduction process in Wistar rats. This study was intended as a pilot study for a subsequent two-generation study. AE 0317309 was administered to groups of 10 male and 10 female rats at concentrations of 0 (control), 100, 600 or 3600 ppm in their diet. Survival, appearance and behavior of F0 rats were not affected up to 3600 ppm. The male F0 rat body weight depression was evident from 600 ppm onwards. In F0 females the body weight gain was decreased at some time points of gestation and lactation at 3600 ppm. At 3600 ppm F0 rats exhibited an increase in food intake per kg body weight. At necropsy parental rats showed no macroscopic treatment-related findings up to 3600 ppm. There was a non-dose related increased absolute and relative weights of the testes and epididymides in all treatment groups are not considered to reflect a toxic effect. From 600 ppm o nwards increased relative liver and kidney weights were calculated in males. The indices of insemination, fertility, gestation, rearing and life birthis as well as mating performance, duration of pregnancy, birth weights, number of pups born, percentages of males born and prenatal loss were not affected at levels of up to 3600 ppm. At 3600 ppm the number of implantation sites and the mean litter size were reduced. The pup weights were retarded from post-natal day 21 onwards.

There were no treatment related changes in viability or lactation indice at any dose level. Clinical observation of F1 pups revelealed no remarkable changes up to 3600 ppm. At 3600 ppm pups exhibited a slight incidence of renal pelvic dilation (6/94 vs 0/97 in controls). There was a tendency for reduced absolute and relative spleen weights in male and female F1 pups from 600 ppm onwards. Thus the no-effect levels (NOEL) for the parental animals and pup body weights from post-natal day 21 onwards was 100 ppm. The NOEL for reproduction parameters was 600 ppm.

• May 2005 - new pesticide

US Federal Register
Date Published Docket Identification Number Details
February 7, 2007 EPA-HQ-OPP-2006-1026

Bayer CropScience LLC. First-time petition for new tolerance. PP 6F7059. 27709. Proposal to establish a tolerance for residues of the herbicide
pyrasulfotole (AE 0317309) (5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)[2-
methanone and its metabolite (5-hydroxy-3-methyl-1H-pyrazol-4-yl)[2-(methylsulfonyl)-4-(trifluoromethyl)phenyl]methanone in or on food commodities
-- barley/oat/rye/triticale/wheat, grain at 0.07 ppm;
-- barley/oat/rye/wheat, straw and oat/rye/wheat, forage at 0.25 ppm;
--barley/oat/wheat, hay at 0.8 ppm;
-- wheat, aspirated grain fractions at 1.4 ppm;
pyrasulfotole (AE 0317309) in or on
-- cattle/goat/hog/horse/sheep, meat and fat at 0.01 ppm;
-- cattle/goat/hog/horse/sheep, meat byproducts at 0.3 ppm;
-- milk at 0.005 ppm.


Fluoride Action Network | Pesticide Project | 315-379-9200 |