Pyraflufen
CAS No. 129630-17-7

 
 

ACTIVITY: Herbicide (pyrazolylphenyl)

CAS Name: [2-chloro-5-[4-chloro-5-(difluoromethoxy)-1-methyl-1H-pyrazol-3-yl]-4-fluorophenoxy]acetic acid

NOTES: This compound is normally used as a salt or an ester, the identity of which should be stated, for example pyraflufen-ethyl.

Structure:

Regulatory Information
(only comprehensive for the US)
US EPA Registered:

Yes

US Tolerances: CFR 180.585
Registered use in
(includes only a limited list of countries)

Hungary, US 
US Maximum Residue Levels permitted in food commodities

13 residue tolerances for:
Corn, Cotton, Potato, Soybean
 

Other Information
Molecular Formula: C13H9Cl2 F3 N2O4 
Manufacturers: Nichino America 
Of special interest:
PAN Data 
Fact Sheet from Washington State Department of Transportation. This fact sheet is titled "pyraflufen." However the pesticide it refers to is Edict, which contains pyraflufen-ethyl.

Adverse Effects:

Data is only available for Pyraflufen-ethyl


US Federal Register

•• Note: Due to length, the following is a partial list. Click here to see full list of FR entries.

Date Published Docket Identification Number Details

May 21, 2003

OPP-2003-0163

NICHINO AMERICA. Pesticide Tolerance. FINAL RULE. This regulation establishes a tolerance for combined residues of pyraflufen and pyraflufen-ethyl in or on
-- Cotton, gin byproduct............ 1.5
-- Cotton, undelinted seed........0.04
-- Cancer
Classification: ``Likely to be Carcinogenic to Humans'' by the oral route Q1* = 3.32 x 10-2 (mg/kg/day)-1
-- Inhalation1 long-term (< 6 months) Oral NOAEL= 20 1X Mouse carcinogenicity. LOAEL = 98 mg/kg/day based on liver toxicity.
-- Inhalation1 intermediate-term (1-6 months) Oral NOAEL= 20 1X Mouse carcinogenicity. LOAEL = 98 mg/kg/day based on liver toxicity at interim sacrifice.
-- Inhalation1 short-term (1-30 days) Oral NOAEL= 20 1X Developmental toxicity- rabbit. LOAEL = 60 mg/kg/day based on decreases in bwt and food consumption, GI observations, and abortions.
-- Chronic dietary. Mouse carcinogenicity. Chronic RfD = 0.20 mg/ kg/day. LOAEL = 98 mg/kg/day. based on liver toxicity.
--
Pyraflufen-ethyl is currently registered for use on the following residential non-dietary sites: Airports, nurseries, ornamental turf, golf courses, roadsides, and railroads.

April 30, 2003 OPP-2003-0110.

Nichino America. Pesticide tolerances. FINAL RULE established for combined residues of the herbicide pyraflufen-ethyl (ethyl 2-chloro-5-(4-chloro-5-difluoromethoxy-1- methyl-1H-pyrazol-3-yl)-4-fluorophenoxyacetate) and its acid metabolite, E-1 (2-chloro-5-(4-chloro-5-difluoromethoxy-1-methyl-1H- pyrazol-3-yl)-4-fluorophenoxyacetic acid), expressed as the ester equivalent in or on

Commodity Parts per million
Corn, field, forage 0.01
Corn, field, grain 0.01
Corn, field, stover 0.01
Potato 0.02
Soybean, forage 0.01
Soybean, hay 0.01
Soybean, seed 0.01

-- Cancer Classification: ``Likely to be Carcinogenic to Humans'' by the oral route.
-- Mouse Carcinogenicity LOAEL = 98 mg/kg/day based on liver toxicty
-- Developmental toxicity- rabbit. LOAEL = 60 mg/kg/day based on decreases in bwt and food
consumption, GI observations, and abortions

-- Note from FAN; this metabolite is Pyraflufen.

 
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