CAS No. 94125-34-5


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Adverse Effects

ACTIVITY: Herbicide (sulfonylurea)

CAS Name: N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]-2-(3,3,3-trifluoropropyl)benzenesulfonamide


Adverse Effects:

Body Weight Decrease
Endocrine: Breast
Endocrine: Testicular
: Uterus

Environmental Effects:

EU: Particular attention should be given to the potential for groundwater contamination, when the active substance is applied in regions with vulnerable soil and/or climate conditions.

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes
US EPA PC Code: 129031 
California Chemical Code 5115  
US Tolerances: CFR 180.481 
Registered use in
(includes only a limited list of countries)

Canada, Germany, Hungary, Portugal, South Africa, UK, US
Other Information
Molecular Formula: C15H16 F3 N5O4S 
Entry Year: 1992 
Inventing Company: Ciba Geigy 
Manufacturers: Novartis 
Other Names:

CGA 152005

Of special interest:
PAN Data 
Material Safety Data Sheets & Labels
May 9, 2005 - U.S. Congressman John Coble (R-NC) introduced a bill "To suspend temporarily the duty on formulations of Prosulfuron" up to December 31, 2008. The bill was referred to the House Committee on Ways and Means.
July 2, 2002 - Review report for the active substance prosulfuron. European Commission Health & Consumer Protection Directorate-General. 
February 18, 2002 - European Commission decision to extend provisional authorisation granted for new active substances: carfentrazone-ethyl, cinidon-ethyl, cyhalofop-butyl, ethoxysulfuron, famoxadone, flazasulfuron, flufenacet, flumioxazine, flurtamone, fosthiazate, isoxaflutole, metalaxyl-M, prosulfuron, Pseudomonas chlororaphis, quinoxyfen, Spodoptera exigua nuclear polyhedrosis virus and sulfosulfuron.
-- Organofluorine pesticides highlighted in red.
Up to December 31, 1999 - U.S. Residue limits for pesticides in meat, poultry and egg products. USDA.  
August 2001 - IR-4: New Products/Transitional Solution List - This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes: Prosulfuron  
October 2001 - Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.  

US Federal Register

•• Note: Due to length, the following is a partial list. Click here to see full list of FR entries.

Date Published Docket Identification Number Details
Dec 31, 2002 OPP-2002-0343

SYNGENTA - Pesticide Tolerance Petition; for residues in or on the raw agricultural commodities

Commodity PPM
cereal grains group (except rice and wild rice) grain 0.10
cereal grains group (except rice and wild rice) fodder 0.10
cereal grains group (except rice and wild rice) straw 0.02
cereal grains group (except rice and wild rice) hay 0.20
milk 0.01
meat, fat, kidney, liver, and meat by-products of cattle, goats, hogs, horses, and sheep 0.05

-- Acute toxicity. EPA has set an acute reference dose of 0.1 milligram/kilogram/day (mg/kg/day) based upon a no observed adverse effect level (NOAEL) of 10 mg/kg/day from the rat acute neurotoxicity study (lowest observed adverse effect level (LOAEL) of 250 mg/kg/day due to reduced motor activity and body temperature in males and impaired righting reflex in females) and a 100-fold uncertainty factor (UF).
-- In a rat teratology study, evidence of maternal toxicity (decreased body weight gain and reduced food consumption) and developmental toxicity (increased incidence of skeletal variations that was not significantly different from the historical control) was found at the maximum tolerated dose of 400 mg/kg.
-- Chronic toxicity. In the 1-year dog chronic dosing study, the NOAEL was 1.84 mg/kg/day based on hematologic and clinical chemistry effects and incidence of lipofuscin accumulation in the liver at 18.6 mg/kg/day.
-- In the 18-month mouse carcinogenicity study, there was no evidence of carcinogenic effects up to the highest dose tested (HDT) of 1,062 mg/kg/day. The NOAEL was 1.71 mg/kg/day in males, and 100 mg/kg/ day in females based on increased incidence/severity of centrilobular hepatocellular hypertrophy.
-- A 2-year chronic feeding/carcinogenicity study in rats indicated systemic NOAEL of 7.9 mg/kg/day was based on decreased body weight and body weight gain, hematopoietic effects (males), and possibly increased serum GGT and decreased liver, kidney, and adrenal weights (females) at 79.9 mg/kg/ day. There was uncertain evidence of carcinogenicity with slight increases in the incidence of mammary gland adenocarcinomas in females at 95.7 and 205.8 mg/kg/day, slight increase in incidence of benign testicular interstitial cell tumors at 79.9 and 160.9 mg/kg/day (significant trend only). Considering the weight of the evidence, the EPA Reference Dose Committee previously concluded that the chemical should be classified as a Group D carcinogen (inadequate evidence), not classifiable as to human carcinogenicity. The HIARC (meeting December 2, 1999) accepted the previous conclusions and updated the cancer classification to the new classification: ``data are inadeqate,'' with no new studies required. EPA has set a chronic reference dose of 0.02 mg/kg based on a NOAEL of 1.84 mg/kg in a dog feeding study and a 100-fold UF.

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