CAS No. 116714-46-6

Return to Novaluron Adverse Effects

ACTIVITY: Insecticide (Benzoylurea)

CAS Name: N-[[[3-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy]phenyl]amino]carbonyl]-2,6-


Adverse Effects:

Body Weight Decrease

Endocrine: Testes
Reproductive and Developmental


Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 124002 
California Chemical Code 5754  
US Tolerances: CFR 180.598
Registered use in
(includes only a limited list of countries)

Argentina, Australia, Italy, Japan, South Africa, US  
Japan's Maximum Residue Levels (MRLs) Apple • Cabbage • Cotton seeds • Eggplant • Japanese pear • Loquat • Pear • Quince • Tomato
US Maximum Residue Levels permitted in food commodities Permitted in or on 65 food commodities including:
Apple, Cattle, Eggs, Goat, Hog, Milk, Pear, Potato, Poultry, Sheep
Other Information
Molecular Formula: C17H9Cl F8 N2O4 
Manufacturers: Isagro-Ricerca Makhteshim Agan
Other Names:

Mosquiron 100
Rimon 10 EC
Rimon Technical

Manufacture site: ISRAEL:
Makhteshim, Beer-Sheva 84100
Of special interest:
PAN Data
Material Safety Data Sheets & Labels

April 27, 2007: CANADA. Proposed Maximum Residue Limit. PMRL2007-04. Canada "has granted full registration to technical grade novaluron and the end-use product Rimrom 10 EC Novaluron Insecticide..".

Proposed Maximum Residue Level (MRL) (ppm)
Apples, crabapples, loquats, mayhaws, oriental pears, pears, qunices
Arracacha, arrowroot, cassava roots, chayote roots, Chinese artichokes, chufa, edible canna, ginger roots, Jerusalem artichokes, lerens, potatoes, sweet potato roots, tanier corms, taro corms, true yam tubers, turmeric roots, yam bean roots
Milk, fat
Fat of cattle, goats, horses and sheep
Kidney, liver, meat and meat byproducts (except kidney and liver) of cattle, goats, horses and sheep
Fat, kidney, liver, meat and meat byproducts (except kidney and liver) of hogs

Comparison of Canadian MRLs, American Tolerances (where different) (see Table 2, page 3)
Canadian MRL (ppm)
American Tolerances (ppm)
Milk, fat
Fat of cattle, goats, horses and sheep
Kidney and liver of cattle, goats, horses and sheep
Meat and meat by-products (except kidney and liver) of cattle, goats, horses and sheep
Fat of Hogs

December 22, 2006. CANADA. Proposed Registration Decision. PRD2006-05.

Toxicology Summary... The main toxicological effect noted in the animal database was oxidative stress and destruction of red blood cells (RBCs), most likely due to the action of an aniline metabolite (3-chloro-4-(1,1,2-trifluoromethoxy) aniline).... (page 10)
Ref: Proposed Registration Decision. PRD2006-05. Health Canada Pest Management Regulatory Agency. December 22, 2006.

December 25, 2005   - ITALY: The Ministry of Agriculture has approved MA Industries' (Makhteshim Agan) proprietary insecticide Rimon for use and sale. Rimon contains the active ingredient Novaluron. The approval is for use in potato crops. MA Industries said it was working to broaden the approval to include uses in other crops. This is the first approval for Rimon in any of the European Union countries where EU registration procedures apply. MA Industries says it is confident that this approval will assist in expanding operations involving Rimon in other EU countries.
Published by Globes [online], Israel business news -
August 2005 - Summary of toxicological data. California EPA, Department of Pesticide Regulation, Medical Toxicology Branch.
February 9, 2005 - Makhteshim Agan gains approval of World Health Organization for the marketing of Novaluron as part of a broad-gauge plan for battling mosquito-borne diseases. Press release from Makhteshim Agan Industries Ltd.
December 2003: Evaluation Report NOVALURON. JAPAN Food Safety Commission. Pesticides Expert Committee.
November 6, 2001 - Application for approval for use. Australia National Registration Authority for Agricultural and Veterinary Chemicals (NRA). Commonwealth of Australia Gazette NO. NRA 11, 6 November 2001-11-06 Agricultural and Veterinary Chemicals Code Act 1999. 
September 2001 - US EPA Pesticide Fact Sheet 
March 23, 2001 - Summary of toxicology data. California EPA. 
Insecticide Products - Partial list 
October 2001 - Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration. 
August 2001 - IR-4 New Products/Transitional Solution List
This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes: Novaluron

March 22, 2005

New Vision (Kampala)

Muhwezi Advises On Malaria

By James Odomel and Herbert Sempogo

THE Government has urged the private sector to fight malaria through vector control, writes James Odomel and Herbert Sempogo.

This was said by health minister Maj. Gen. Jim Muhwezi during a seminar on Mosquiron 100 (Novaluron), a new treatment course for malaria at Speke Resort Munyonyo recently.

"We are emphasising indoor residual spraying and insecticide treated nets to control malaria," Muhwezi said in a speech read by health state health minister, Capt. Mike Mukula.

Mosquiron 100 is a new insect growth regulator for vector control against malaria.

US Federal Register

•• Note: Due to length, the following is a partial list. Click here to see full list of FR entries.

Date Published Docket Identification Number Details
July 25, 2007 EPA-HQ-OPP-2007-0438 IR-4 / Makhteshim-Agan of North America.. Pesticide Petition PP 7E7199. Proposal to establish a tolerance for residues of the insecticide novaluron in or on food commodities:
Tomato at 0.40 ppm;
tomato, paste at 0.80 ppm
sugarcane, cane at 0.50 ppm.

Makhteshim-Agan of North America, Inc., 4515 Falls of Neuse Road, Raleigh, NC 27609, the manufacturer and basic registrant of novaluron, prepared and summarized the following information in support of the pesticide petition for novaluron. An adequate analytical method, gas chromatography/electron capture detector (GC/ECD), is available for enforcing tolerances of novaluron residues in or on tomatoes, sugarcane and its processed commodities, as published in the Federal Register of April 5, 2006 (71 FR 17009) (FRL-7756-8). Based on the sample size and dilution factors, the limit of quantitation (LOQ) in matrix was equal to the lowest concentration level for the validation analyses. The method verification trial supports a LOQ of 0.05 ppm in the different tomato and sugarcane matrices. The LOQ = 0.05 ppm was taken as the lowest level validated by this method.
April 13, 2007 EPA-HQ-OPP-2007-0005

Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations.

Registration No. Product Name Registrant
066222 WA-05-0003 Rimon 0.83 EC Makhteshim-Agan of North America Inc.
4515 Falls of Neuse Rd Ste 300
Raleigh, NC 27609
October 20, 2006 EPA-HQ-OPP-2006-0815 Pesticide Tolerance for Emergency Exemption. FINAL RULE.
A time-limited tolerance, up to 12/31/09, established for residues of the fungicide in connection with use of the pesticide under a section 18 emergency exemption granted by EPA.
-- Sugarcane, cane at 0.15 ppm.
April 5, 2006 EPA-HQ-OPP-2005-0525

IR-4 / Makhteshim-Agan of North America. Pesticide tolerance. FINAL RULE. (PP 4E6834).

Specific information on the studies received and the nature of the toxic effects caused by novaluron as well as the no observed adverse effect level (NOAEL) and the lowest observed adverse effect level (LOAEL) from the toxicity studies, and summary of the toxicological endpoints for novaluron used for human risk assessment is discussed in the Federal Register of June 2, 2004.

Parts per million

Brassica, head and stem, subgroup 5A

This subgroup includes 10 commodities.
• broccoli
• broccoli, cavalo
• broccoli, chinese
• brussels sprout
• cabbage
• cabbage, chinese mustard
• cabbage, chinese napa
• cauliflower
• cavalo broccolo
• kohlrabi


• a quantitative acute dietary exposure assessment is unnecessary.

• A cancer dietary exposure assessment was not conducted because novaluron was classified as ``not likely to be carcinogenic to humans.''

• EPA determined that the 10X SF (safety factor) to protect infants and children should be reduced to 1X.

• The Agency lacks sufficient monitoring exposure data to complete a comprehensive dietary exposure analysis and risk assessment for novaluron in drinking water.

Jan 18, 2006


IR-4 / MAKHTESHIM-AGAN. Amendment to Existing Tolerance. Pesticide Petition (PP) 4E6834.
IR-4, 681 U.S. Highway #1 South, North Brunswick, NJ 08902, proposes to amend 40 CFR 180.598 by establishing tolerances for residues of the insecticide novaluron (1-[3-chloro-4-
(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-[2,6-difluorobenzoyl]urea) in or on the food commodities Brassica vegetables, head and stem (Subgroup 5A )at 0.5 ppm.
Makhteshim-Agan of North America, Inc., 551 Fifth Avenue, Suite 1100, New York, NY 10176 is the manufacturer and basic registrant of novaluron. Makhteshim-Agan of North America, Inc. prepared and summarized the information in support of this pesticide petition for novaluron. An adequate analytical method, gas chromatography/electron capture detector (GC/ECD), is available for enforcing tolerances of novaluron residues in or on head and stem Brassica vegetables, as recently published in the Federal Register of June 2, 2004. The limit of quantitation (LOQ = 0.05 ppm) was taken as the lowest level validated by this method.

Subgroup 5A includes 10 commodities.
broccoli, cavalo
broccoli, chinese
brussels sprout
cabbage, chinese mustard
cabbage, chinese napa
cavalo broccolo

•• Note: Due to length, the above is a partial list. Click here to see full list of FR entries.

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