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Return to Novaluron
Adverse Effects
ACTIVITY:
Insecticide (Benzoylurea)
CAS Name:
N-[[[3-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy]phenyl]amino]carbonyl]-2,6-
difluorobenzamide
Structure:
| Adverse
Effects:
Anemia
Blood
Body Weight Decrease
CNS
Endocrine: Testes
Liver
Reproductive
and Developmental
Spleen
ENVIRONMENTAL
|
Regulatory
Information
(only comprehensive for the US) |
| US
EPA Registered: |
Yes |
| US
EPA PC Code: |
124002 |
| California
Chemical Code |
5754
|
| US
Tolerances: |
CFR
180.598 |
Registered
use in
(includes only a limited list of countries)
|
Argentina,
Australia, Italy, Japan, South Africa, US |
| Japan's
Maximum Residue Levels (MRLs) |
Apple
• Cabbage • Cotton seeds • Eggplant •
Japanese pear • Loquat • Pear • Quince •
Tomato |
| US
Maximum Residue Levels permitted in food commodities |
Permitted
in or on 65 food
commodities including:
Apple, Cattle, Eggs, Goat, Hog, Milk,
Pear, Potato, Poultry, Sheep |
| Other
Information |
| Molecular
Formula: |
C17H9Cl
F8 N2O4 |
| Manufacturers: |
Isagro-Ricerca
Makhteshim Agan
UNIROYAL |
| Other
Names: |
GR-572
MCW-275
Mosquiron
100
Rimon 10 EC
Rimon Technical |
| Manufacture
site: |
ISRAEL:
Makhteshim, Beer-Sheva 84100 |
| Of
special interest: |
| PAN
Data |
| Material
Safety Data Sheets & Labels |
| Abstracts |
April
27, 2007: CANADA. Proposed
Maximum Residue Limit. PMRL2007-04. Canada "has granted
full registration to technical grade novaluron and the end-use
product Rimrom 10 EC Novaluron Insecticide..".
Proposed
Maximum Residue Level (MRL) (ppm) |
Foods |
2 |
Apples, crabapples, loquats,
mayhaws, oriental pears, pears, qunices |
0.05 |
Arracacha, arrowroot,
cassava roots, chayote roots, Chinese artichokes, chufa,
edible canna, ginger roots, Jerusalem artichokes, lerens,
potatoes, sweet potato roots, tanier corms, taro corms,
true yam tubers, turmeric roots, yam bean roots |
8.0 |
Milk, fat |
7.0 |
Fat of cattle, goats,
horses and sheep |
0.5 |
Milk |
0.4 |
Kidney, liver, meat and
meat byproducts (except kidney and liver) of cattle, goats,
horses and sheep |
0.01 |
Fat, kidney, liver, meat
and meat byproducts (except kidney and liver) of hogs
|
| Comparison
of Canadian MRLs, American Tolerances (where different)
(see Table 2, page 3) |
| Food |
Canadian
MRL (ppm) |
American
Tolerances (ppm) |
| Milk, fat |
8.0 |
20 |
| Fat of cattle, goats,
horses and sheep |
7.0 |
11 |
| Milk |
0.5 |
1.0 |
| Kidney and liver of cattle,
goats, horses and sheep |
0.4 |
1.0 |
| Meat and meat by-products
(except kidney and liver) of cattle, goats, horses and
sheep |
0.4 |
0.6 |
| Fat of Hogs |
0.01 |
0.05 |
|
December
22, 2006. CANADA. Proposed
Registration Decision. PRD2006-05.
Toxicology Summary...
The main toxicological effect noted in the animal database
was oxidative stress and destruction of red blood cells
(RBCs), most
likely due to the action of an aniline metabolite (3-chloro-4-(1,1,2-trifluoromethoxy)
aniline).... (page
10)
Ref: Proposed Registration Decision. PRD2006-05. Health
Canada Pest Management Regulatory Agency. December 22, 2006.
http://www.fluorideaction.org/pesticides/novaluron.canada.12-22-06.pdf
|
December
25, 2005 - ITALY: The Ministry of Agriculture has
approved MA Industries' (Makhteshim Agan) proprietary insecticide
Rimon for use and sale. Rimon contains the active ingredient
Novaluron. The approval is for use in potato crops. MA Industries
said it was working to broaden the approval to include uses
in other crops. This is the first approval for Rimon in any
of the European Union countries where EU registration procedures
apply. MA Industries says it is confident that this approval
will assist in expanding operations involving Rimon in other
EU countries.
Published
by Globes [online], Israel business news - www.globes.co.il
|
| August
2005 - Summary of toxicological
data. California EPA, Department of Pesticide Regulation,
Medical Toxicology Branch. |
| February
9, 2005 - Makhteshim Agan
gains approval of World Health Organization for the marketing
of Novaluron as part of a broad-gauge plan for battling mosquito-borne
diseases. Press release from
Makhteshim Agan Industries Ltd. |
| December
2003: Evaluation
Report NOVALURON. JAPAN Food Safety Commission. Pesticides
Expert Committee. |
| November
6, 2001 -
Application for approval
for use. Australia National Registration
Authority for Agricultural and Veterinary Chemicals (NRA). Commonwealth
of Australia Gazette NO. NRA 11, 6 November 2001-11-06 Agricultural
and Veterinary Chemicals Code Act 1999. |
| September
2001 -
US EPA Pesticide Fact
Sheet |
| March
23, 2001 -
Summary of toxicology data. California
EPA. |
| Insecticide
Products - Partial list |
| October
2001
- Glossary of Pesticide
Chemicals. A listing of pesticides
subject to analysis of residues in foods and feeds by the US
Food and Drug Administration. |
August
2001 - IR-4
New Products/Transitional Solution List
This
list contains brief descriptions of numerous new pest control
materials that have been introduced over the last several years.
Additionally, it contains information on some "older"
crop protection chemicals that are believed to have room for
new uses. This List includes:
Novaluron |
http://allafrica.com/stories/200503220616.html
March
22, 2005
New
Vision (Kampala)
Muhwezi
Advises On Malaria
By James Odomel and Herbert Sempogo
Kampala
THE
Government has urged the private sector to fight malaria
through vector control, writes James Odomel and Herbert
Sempogo.
This
was said by health minister Maj. Gen. Jim Muhwezi during
a seminar on Mosquiron 100 (Novaluron),
a new treatment course for malaria at Speke Resort Munyonyo
recently.
"We
are emphasising indoor residual spraying and insecticide
treated nets to control malaria," Muhwezi said in a
speech read by health state health minister, Capt. Mike
Mukula.
Mosquiron
100 is a new insect growth regulator for vector control
against malaria.
|
| US
Federal Register
••
Note: Due to length, the following is a partial list. Click
here to see full list of FR entries. |
| Date
Published |
Docket
Identification Number |
Details |
| July 25, 2007 |
EPA-HQ-OPP-2007-0438 |
IR-4
/ Makhteshim-Agan of North America..
Pesticide
Petition PP 7E7199. Proposal to establish a tolerance for
residues of the insecticide novaluron in or on food commodities:
Tomato at 0.40 ppm;
tomato, paste at 0.80 ppm
sugarcane, cane at 0.50 ppm.
Makhteshim-Agan of North America, Inc., 4515 Falls of Neuse
Road, Raleigh, NC 27609, the manufacturer and basic registrant
of novaluron, prepared and summarized the following information
in support of the pesticide petition for novaluron. An adequate
analytical method, gas chromatography/electron capture detector
(GC/ECD), is available for enforcing tolerances of novaluron
residues in or on tomatoes, sugarcane and its processed commodities,
as published in the Federal
Register of April 5, 2006 (71 FR 17009) (FRL-7756-8). Based
on the sample size and dilution factors, the limit of quantitation
(LOQ) in matrix was equal to the lowest concentration level
for the validation analyses. The method verification trial supports
a LOQ of 0.05 ppm in the different tomato and sugarcane matrices.
The LOQ = 0.05 ppm was taken as the lowest level validated by
this method. |
| April 13, 2007 |
EPA-HQ-OPP-2007-0005 |
Notice
of Receipt of Requests to Voluntarily Cancel Certain Pesticide
Registrations.
| Registration No. |
Product Name |
Registrant |
| 066222 WA-05-0003 |
Rimon 0.83 EC |
Makhteshim-Agan
of North America Inc.
4515 Falls of Neuse Rd Ste 300
Raleigh, NC 27609 |
|
| October 20, 2006 |
EPA-HQ-OPP-2006-0815 |
Pesticide
Tolerance for Emergency Exemption. FINAL RULE.
A time-limited tolerance, up to 12/31/09, established for residues
of the fungicide in connection with use of the pesticide under
a section 18 emergency exemption granted by EPA.
-- Sugarcane, cane at 0.15 ppm. |
| April
5, 2006 |
EPA-HQ-OPP-2005-0525 |
IR-4
/ Makhteshim-Agan of North America.
Pesticide tolerance.
FINAL RULE. (PP 4E6834).
Specific
information on the studies received and the nature of the
toxic effects caused by novaluron as well as the no observed
adverse effect level (NOAEL) and the lowest observed adverse
effect level (LOAEL) from the toxicity studies, and summary
of the toxicological endpoints for novaluron used for human
risk assessment is discussed in the Federal
Register of June 2, 2004.
| Commodity |
Parts per million |
Brassica,
head and stem, subgroup 5A
This
subgroup includes 10 commodities.
• broccoli
• broccoli, cavalo
• broccoli, chinese
• brussels sprout
• cabbage
• cabbage, chinese mustard
• cabbage, chinese napa
• cauliflower
• cavalo broccolo
• kohlrabi
|
0.50 |
•
a quantitative acute dietary exposure assessment is unnecessary.
• A cancer dietary exposure assessment was not conducted
because novaluron was classified as ``not likely to be carcinogenic
to humans.''
•
EPA determined that the 10X SF (safety factor) to protect
infants and children should be reduced to 1X.
•
The Agency lacks sufficient monitoring exposure data to complete
a comprehensive dietary exposure analysis and risk assessment
for novaluron in drinking water. |
| Jan
18, 2006 |
EPA-HQ-OPP-2005-0531
|
IR-4
/ MAKHTESHIM-AGAN.
Amendment
to Existing Tolerance. Pesticide
Petition (PP) 4E6834.
IR-4, 681 U.S. Highway #1 South, North Brunswick, NJ 08902,
proposes to amend 40 CFR 180.598 by establishing tolerances
for residues of the insecticide novaluron (1-[3-chloro-4-
(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-[2,6-difluorobenzoyl]urea)
in or on the food commodities Brassica
vegetables, head and stem (Subgroup 5A )at 0.5 ppm.
Makhteshim-Agan of North America, Inc.,
551 Fifth Avenue, Suite 1100, New York, NY 10176
is the manufacturer and basic registrant of novaluron.
Makhteshim-Agan of North America, Inc. prepared and summarized
the information in support of this pesticide petition for
novaluron. An adequate analytical method, gas chromatography/electron
capture detector (GC/ECD), is available for enforcing tolerances
of novaluron residues in or on head and stem Brassica vegetables,
as recently published in the Federal Register of June 2, 2004.
The limit of quantitation (LOQ = 0.05
ppm) was taken as the lowest level validated by this method.
| Subgroup
5A includes 10 commodities. |
| Commodity |
PPM |
| broccoli |
0.5 |
| broccoli,
cavalo |
0.5 |
| broccoli,
chinese |
0.5 |
| brussels
sprout |
0.5 |
| cabbage |
0.5 |
| cabbage,
chinese mustard |
0.5 |
| cabbage,
chinese napa |
0.5 |
| cauliflower |
0.5 |
| cavalo
broccolo |
0.5 |
| kohlrabi |
0.5 |
|
| ••
Note: Due to length, the above is a partial list. Click
here to see full list of FR entries. |
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