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Mefluidide. 1975 - 1993. US EPA Index of Cleared Science Reviews


http://www.epa.gov/opppmsd1/foia/reviews/114001.htm

US EPA. Office of Pesticide Programs

Mefluidide (Pc Code 114001)

Undated. Appendix. 7 Page(s).
Appendix 11
Summary of Toxicology, Fish and Wildlife, and Environmental
Studies Conducted with Vistar 29 and Its Active Ingredient,
Mefluidide.
Attachment(s) following:

November 29, 1990. Memorandum. 8 Page(s).
James Hetrick. Environmental Fate & Groundwater Branch.
Review of Phase IV Package for Mefluidide. PC Code 114002,
114003. Case 2370.

Undated. Memo For File. 1 Page(s).
Joseph Cummings. no affiliation.
PP# 7G1944, Embark on Sugarcane.

December 1, 1975. Review. 13 Page(s).
Scott Fredericks. Efficacy and Ecological Effects Branch.
EPA Reg. No. 7182-EUP. EUP on turf.

December 4, 1975. Review. 11 Page(s).
Ronald Ney. Efficacy and Ecological Effects Branch.
Application for Experimental Use Permit. Inert ingredient
information on page 2 is not included.

February 12, 1976. Memorandum. 8 Page(s).
Robert Coberly. Toxicology Branch.
Product Name: MBR12325 4-S Plant Growth Regulator
Registration No.: 7182-EUP
Inert ingredient information on pages 1, 2, 3, and 4 and
manufacturing process info on pages 3 and 7 not included.
Tox review 007471.

December 3, 1976. Review. 7 Page(s).
Gerald Gavin. Efficacy and Ecological Effects Branch.
EPA Reg. No. 7182-I. Registration - turf.

January 13, 1977. Review. 8 Page(s).
anonymous. Toxicology Branch.
EPA # 7182-I, 7182-T; Embark-4S & 2S
Acute oral (Rat); Acute Dermal (Rabbit); Acute Inhalation
(Rat); Primary Eye Irritation (Rabbit); Skin Irritation
Manufacturing process info on page 1 not included.
Tox review 007472.

April 8, 1977. Review. 7 Page(s).
Gerald Gavin. Efficacy and Ecological Effects Branch.
EPA Reg. No. 7182-EUP. EUP on Soybeans.

April 20, 1977. Review. 20 Page(s).
Ronald Ney. Efficacy and Ecological Effects Branch.
EUP on Soybeans.

May 13, 1977. Memorandum. 2 Page(s).
Douglas Campt. Registration Division.
Experimental Use Permit for Use Over 5,000
Acres of Land
PP# 7G1916
Manufacturing process information on page 2 is not included.

May 18, 1977. Review. 7 Page(s).
Thomas O'Brien. Efficacy and Ecological Effects Branch.
EPA Reg. No. 7182-EUP-20. Embark 2S. EUP Sugarcane Ripener.

August 5, 1977. Review. 4 Page(s).
Karen Sampson. Efficacy and Ecological Effects Branch.
EUP on Sugarcane.

October 3, 1977. Memorandum. 5 Page(s).
Edwin Budd. Toxicology Branch.
EPA # 7182-I and 7182-T, Embark 4-S and Embark 2-S
Respectively. Request for Registration. Manufacturing
process information on page 3 is not included, and inert
ingredient information on page 5 is not included.
Tox review 007473.

October 5, 1977. Memorandum. 2 Page(s).
D. Ritter. Toxicology Branch.
PP# 7G1944: Mefluidide in Sugarcane; Proposal to Establish
a Temporary Tolerance of 0.2 ppm, 3M Corp., Minneapolis, MN.

November 22, 1977. Review. 29 Page(s).
Ronald Ney. Efficacy and Ecological Effects Branch.
Registration of 7182-I and -T: Use on Turf.
Product impurity information on pages 3 and 4 is not
included.

January 23, 1978. Memorandum. 2 Page(s).
Edwin Budd. Toxicology Branch.
EPA #7182-I and 7182-T, Embark 4-S Plant Growth Regulator
and Embark 2-S Plant Growth Regulator. Validation of IBT
Studies Submitted in Support of Registration.

January 26, 1978. Memorandum. 6 Page(s).
Ellis Gunderson. Registartion Division.
PP# 7G1916. Mefluidide in or on soybeans. Evaluation
of analytical methods and residue data.
Inert ingredient information on pages 2,3 not included.
Manufacturing process information on page 2 not included.

February 3, 1978. Memorandum. 1 Page(s).
D. Ritter. Toxicology Branch.
PP#7G1944/7182-T/I-Embark (Mefluidide) in Sugarcane. Letter
with data, 1/11/78.

February 22, 1978. Memorandum. 1 Page(s).
D. Ritter. Toxicology Branch.
Embark 2-S and 4-S; PP #7G1944, Mefluidide in Sugarcane and
on Lawns. EPA #7182-T/I.

February 22, 1978. Memorandum. 1 Page(s).
Reto Engler. Toxicology Branch.
Embark Plant Growth Regulator
Registration No. 7182-T/I, Caswell No. 333-AA, Petition
No. 7G1944.

February 23, 1978. Memorandum. 1 Page(s).
R.J. Hummel. Chemistry Branch.
Nitrosamine Content of Mefluidide, Diethanolamine Salt.

March 9, 1978. Memorandum. 9 Page(s).
Ellis Gunderson. Chemistry Branch.
PP# 7G1944. Mefluidide in or on sugarcane. Evaluation
of analytical methods and residue data and amendment of
2/1/78.
Inert ingredient info on pages 1,2,3 and 4 is not included.
Maufacturing process info on pages 1 and 3 is not included.

May 17, 1978. Memorandum. 6 Page(s).
J.A. Ruddick. Government of Canada.
Validation Report on Embark (MBR 12325) by 3M.

June 6, 1978. Memorandum. 3 Page(s).
D.J. Clegg. Government of Canada.
Embark.

August 17, 1978. Memorandum. 1 Page(s).
A. Rathman. Residue Chemistry Branch.
PP# 7G1944. Mefluidide on sugarcane. Request for extension
of temporary tolerance along with a revision in Sec. B.

November 14, 1978. Memorandum. 1 Page(s).
Chan S-L. Toxicology Branch.
Meeting with 3-M representatives on 10/3/78
EPA#7182-EUP-19, 7G1916.

April 18, 1979. Review. 10 Page(s).
R.W. Cook. Environmental Fate Branch.
Use on Soybeans.

May 4, 1979. Review. 3 Page(s).
Efficacy and Ecological Effects Branch.
Section 18. Vistar 2S Tank Mix. Emergency use on soybeans in
Louisiana.

May 4, 1979. Memorandum. 2 Page(s).
Albin Kocialski. Toxicology Branch.
Section 18, Emergency Specific Exemption, for the Use of
Basagran, EPA Reg. No. 7969-45, in Conjunction with Vistar,
EPA File Symbol 7182-O, on Soybeans.

November 6, 1979. Memorandum. 1 Page(s).
Alfred Smith. Residue Chemistry Branch.
PP# 9F2157 : Method Trials for Mefluidide in Soybeans.

November 14, 1979. Memorandum. 9 Page(s).
Alfred Smith. Residue Chemistry Branch.
PP #9F2157: Mefluidide in Soybeans. Evaluation of Residue
Data and Analytical Method. Inert ingredient information
on page 2 is not included.

December 4, 1979. Review. 7 Page(s).
Clayton Bushong. Ecological Effects Branch.
EPA Reg. No. 7182-O. PP# 9F2157. Vistar 2-S. Tolerance
petition - soybeans.

January 10, 1980. Memorandum. 1 Page(s).
A. Rathman. Residue Chemistry Branch.
PP #7G1916. 7182-EUP-19. Mefluidide on Soybeans. Request
for Extension of Temporary Tolerances.

January 10, 1980. Memorandum. 29 Page(s).
Larry Anderson. Toxicology Branch.
Permanent Tolerance for Vistar 2-S Postemergence Herbicide
... on Soybeans. Inert ingredient, product impurity, and
manufacturing process information on pages 2-4, 7-8, and 16
are not included. Page 29 removed, statement of formula.
Tox review 003825.

January 18, 1980. Memorandum. 2 Page(s).
N.K. Whetzel. Residue Chemistry Branch.
Proposed Section 18 Exemption for Vistar and Basagran on
Soybeans in Arkansas and Mississippi.

January 18, 1980. Memorandum. 6 Page(s).
Gary Burin. Toxicology Branch.
Section 18 Emergency Exemption for use of Basagran (EPA Reg.
No. 7969-45) and Vistar (EPA File Symbol 7182-O) on Soybeans
in Mississippi. Inert ingredient information on page 1 is
not included. Manufacturing process information on page 4
is not included.

January 23, 1980. Memorandum. 5 Page(s).
Gary Burin. Toxicology Branch.
Section 18 Emergency Exemption for use of Basagran (EPA Reg.
No. 7969-45) and Vistar (EPA Reg. No. 7182-O) on Soybeans in
Arkansas. Manufacturing process information on page 4 is
not included.

January 25, 1980. Memorandum. 1 Page(s).
P. Errico. Residue Chemistry Branch.
PP# 9F2157. Mefluidide in/on soybeans.

January 30, 1980. Review. 2 Page(s).
R.W. Cook. Environmental Fate Branch.
Section 18 Exemption for a Tank Mixture of Basagran and
Vistar for use on Soybeans to Control Red Rice.

February 11, 1980. Memorandum. 3 Page(s).
R. W. Storherr. CBIB.
PP #9F2157: Results of the Method Trial for Mefluidide,
MBR 12325, in Soybeans.

February 26, 1980. Memorandum. 2 Page(s).
Alfred Smith. Residue Chemistry Branch.
PP#9F2157: Mefluidide in Soybeans. Report
on method trial.

March 6, 1980. Memorandum. 2 Page(s).
Larry Anderson. Toxicology Branch.
Response to Reply by Registrant on Toxicology Branch
Recommendations Regarding Issuance of Permanent Tolerances
for Mefluidide in or on Soybeans
Tox review 003826.

March 12, 1980. Memorandum. 1 Page(s).
P.V. Errico. Residue Chemistry Branch.
PP #9F2157. Mefluidide. Amendment (2-15-80) and Method
Trial Report for Mefluidide in/on Soybeans.

March 18, 1980. Memorandum. 2 Page(s).
Douglas Campt. Registration Division.
PP 9F2157 Mefluidide in/on Soybeans, EPA File Symbol 7182-O.

March 26, 1980. Memorandum. 4 Page(s).
Gunter Zweig. Environmental Fate Branch.
Request for Exposure Analysis on Mefluidide.

March 28, 1980. Memorandum. 1 Page(s).
Robert Coberly. Toxicology Branch.
Vistar - 9F2157.

April 18, 1980. Memorandum. 1 Page(s).
Robert Coberly. Toxicology Branch.
Inquiry from Cara Jablon of OGC Concerning Oncogenicity of
Vistar. PP #9F2157.

October 22, 1980. Memorandum. 1 Page(s).
George Robinson. Toxicology Branch.
Vistat 2-S Postemergence Soybean Herbicide (EPA Registration
No. 7182-9). Protocol for Subchronic Nonrodent Feeding
Study.

January 26, 1981. Review. 9 Page(s).
Willa Garner. Environmental Fate Branch.
7182-EUP-EE. EUP on Pasture Grass, Forage Grass and Legumes.
Pages 4-9 removed, registrant submission.

January 28, 1981. Review. 3 Page(s).
Clayton Bushong. Ecological Effects Branch.
EPA Reg. No. 7182-EUP-22 (IG2453). MBR 12325 2-S. EUP for
use on tall fescue pasturegrass including mixed stamps
with other forage grasses and legumes.

May 22, 1981. Memorandum. 7 Page(s).
Nancy Dodd. Residue Chemistry Branch.
PP #1G2453 Mefluidide on Pasture Grass. Evaluation of
Analytical Methods and Residue Data. Inert ingredient
information on page 3 is not included.
Tox review 007476.

May 29, 1981. Memorandum. 1 Page(s).
Nancy Dodd. Residue Chemistry Branch.
Memorandum of Conference on PP #1G2453, Mefluidide on Tall
Fescue Pasture Grass.

June 12, 1981. Memorandum. 2 Page(s).
Alex Arce. Toxicology Branch.
EPA Experimental Use Permit No. 7182-EUP Request for
Temporary Tolerance and EUP for use of Mefluidide (MBR 12325
2S) in or on Fescue Pasture Grass
Tox review 007475.

July 13, 1981. Memorandum. 2 Page(s).
Nancy Dodd. Residue Chemistry Branch.
PP #1G2453. Mefluidide on Pasture Grass. Amendment of
6/3/81.

July 21, 1981. Memorandum. 3 Page(s).
Deloris Graham. Fungicide/Herbicide Branch.
EPA File Symbol: 7182-RU and 7182-RG. Embark 2-L Plant
Growth Regulator and Embark 1-L Plant Growth Regulator.

August 12, 1981. Memorandum. 2 Page(s).
Robert Coberly. Toxicology BRAnch.
Mefluidide (1G2453) revised Section F.

November 25, 1981. Memorandum. 4 Page(s).
Alex Arce. Toxicology Branch.
Vistar 1F2545 (Mefluidide)
Vistar 7182-9-MBR 12325 Caswell No. 333-AA
Inert ingredient information on page 3 not included.
Tox review 001346.

December 24, 1981. Memorandum. 2 Page(s).
Richard Loranger. Residue Chemistry Branch.
PP #1G2453. Mefluidide on Pasture Grass. Amendment of
10/15/81.

January 15, 1982. Memorandum. 4 Page(s).
Alex Arce. Toxicology Branch.
Vistar 1F2545 (Mefluidide). Vistar 7182-9 - MBR 12325.
Inert ingredient information on page 3 is not included.

May 10, 1983. Memorandum. 2 Page(s).
John Worthington. Residue Chemistry Branch.
EPA File No. 7182-RL. New Technical Mefluidide.
Manufacturing process information on pages 1 and 2 is
not included.

May 25, 1984. Memorandum. 13 Page(s).
Alex Arce. Toxicology Branch.
Vistar ID # 7182-9, Caswell # 333AA, Accession No. 251957.
Inert ingredient information on page 2 is not included.
Tox review 003824.

December 6, 1984. Record. 1 Page(s).
Clifton Fletcher. Exposure Assessment Branch.
Notes to File re: Environmental Fate of Mefluidide.

April 30, 1985. Review. 4 Page(s).
Joseph Reinert. Exposure Assessment Branch.
Exposure Assessment.

June 27, 1985. Review. 5 Page(s).
Ken Clark. Ecological Effects Branch.
Proposed Conditional Registration of Lawn Uses.
Page 5 removed, draft label.

November 22, 1985. Review. 3 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Submission in Response to GWDCI
Acc. 259275.

February 21, 1986. Review. 3 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Response to GWDCI
Acc. 259275.

March 13, 1986. Memorandum. 3 Page(s).
Alfred Smith. Residue Chemistry Branch.
ID No. 114001. Mefluidide Groundwater Data Call-In.
Accession No. 259274. RCB No. 126.

May 2, 1986. Memorandum. 1 Page(s).
Michael Metzger. Residue Chemistry Branch.
Mefluidide Groundwater Data Call-In. Accession No. 259275.
RCB No. 881.

September 11, 1986. Review. 4 Page(s).
Samuel Creeger. Exposure Assessment Branch.
GWDCI
Acc. 097685, 259275.
Attachment(s) following:

September 4, 1986. Memorandum. Page(s).
Ruby Whiters. no affiliation.
EAB Reviews on the Active ingredient - Mefluidide.

September 22, 1986. Review. 1 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Approval of Which Studies are Needed to Complete the GWDCI
for Mefluidide.
Attachment(s) following:

July 21, 1986. Memorandum. 2 Page(s).
Ruby Whiters. Data Call-In.
EAB Reviews on the Active Ingredient - Mefluidide.

June 9, 1987. Memorandum. 4 Page(s).
W.T. Chin. Residue Chemistry Branch.
ID No. 114001. Mefluidide Groundwater Data Call-In.
Accession No. 259274. RCB No. 2133.

January 14, 1988. Memorandum. 1 Page(s).
Kenneth Dockter. Residue Chemistry Branch.
ID No. 114001. Mefluidide; Letter Submitted as Fourth
Response to Groundwater Data Call-In. RCB No. 3155.

January 30, 1989. Memorandum. 2 Page(s).
Leung Cheng. Dietary Exposure Branch.
ID # 114001-1. Mefluidide. Octanol/Water Partition
Coefficient. MRID # 406186-01. Branch # 4663.

July 27, 1989. EFGWB One Liner. 3 Page(s).
J. Hannan. Environmental Fate & Groundwater Branch.
EFGWB One Liner.

November 10, 1989. DER. 25 Page(s).
Gail Maske. Environmental Fate & Groundwater Branch.
MRID 00058949, 00047535, 00047541, 00155172, 00135362,
00058950, 00155173, 00155170, 00155171, 0004742.

November 10, 1989. DER. 21 Page(s).
Gail Maske. Environmental Fate & Groundwater Branch.
Mefluidide. MRID 00058953, 00136864, 00135015, 00058951.
163-1 Leaching, Adsorption/Desorption.

November 10, 1989. DER. 2 Page(s).
Gail Maske. Environmental Fate & Groundwater Branch.
Mefluidide. Mobility in in soil: soil column leaching; 163-1.

November 10, 1989. DER. 2 Page(s).
Gail Maske. Environmental Fate & Groundwater Branch.
Mefluidide. Mobility in soil: soil column leaching; 163-1.
MRID 00058953.

November 10, 1989. DER. 2 Page(s).
Gail Maske. Environmental Fate & Groundwater Branch.
Mefluidide. 163-1. Adsorption and Leaching of Mefluidide-C14
in Five Hawaiian Soils.

November 10, 1989. DER. 2 Page(s).
Gail Maske. Environmental Fate & Groundwater Branch.
Mefluidide. Photolysis; 161-2.

November 10, 1989. DER. 2 Page(s).
Gail Maske. Environmental Fate & Groundwater Branch.
Mefluidide. Photolysis; 161-3.

November 10, 1989. DER. 2 Page(s).
Gail Maske. Environmental Fate & Groundwater Branch.
Mefluidide. Metabolism; 162-1.

November 15, 1989. Review. 12 Page(s).
Emil Regelman. Environmental Fate & Groundwater Branch.
Mefluidide. MBR 12325. To review status of Ground Water
Data-Call-In; screen studies for support of Subdivision N
data requirement.

October 19, 1990. Memorandum. 23 Page(s).
Phyllis Johnson. Biological Analysis Branch.
LUIS Reports
for Diethanolamine Mefluidide
Pesticide Chemical Code: 114002.

November 29, 1990. DER. 8 Page(s).
James Hetrick. Environmental Fate & Groundwater Branch.
Aerobic Soil Metabolism; 162-1. MRID 69065.
Pages 4-8 removed, registrant data.

November 29, 1990. DER. 16 Page(s).
James Hetrick. Environmental Fate & Groundwater Branch.
Hydrolysis; 161-1. MRID 416351-01.
Pages 3-16 removed, registrant data.

November 29, 1990. DER. 13 Page(s).
James Hetrick. Environmental Fate & Groundwater Branch.
Adsorption/Desorption - Aged Residues; 163-1. MRID 135365.
Pages 4-13 removed, registrant data.

November 29, 1990. DER. 13 Page(s).
James Hetrick. Environmental Fate & Groundwater Branch.
Aerobic Soil Metabolism. 162-1.
Pages 4-13 removed, registrant data.

November 29, 1990. DER. 16 Page(s).
James Hetrick. Environmental Fate & Groundwater Branch.
Terrestrial Field Dissipation. MRID 58951. 164-1
Pages 3-16 removed, registrant data.

November 29, 1990. DER. 14 Page(s).
James Hetrick. Environmental Fate & Groundwater Branch.
Confined Rotational Crop Study. MRID 135489. 165-1
Pages 4-14 removed, registrant data.

December 11, 1990. Memorandum. 24 Page(s).
Amy Rispin. Science Analysis and Coordination Staff.
Transmittal of EFED List B Review for Mefluidide & Salts
(Case # 2370; Chemical #'s 114002 & 114003).

February 6, 1991. Review. 3 Page(s).
Curtis Laird. Ecological Effects Branch.
Data Requirements for Pesticide Registration. Potassium Salt
of Mefluidide. Chemical No: 114002. Case No: 2370.
Attachment(s) following:

February 6, 1991. Review. 3 Page(s).
Curtis Laird. Ecological Effects Branch.
List B Phase 4 - Response on Existing Studies Reviewed.
Potassium Salt of Mefluidide. Case No: 2370. Chemical No:
114002.

February 4, 1991. DER. 3 Page(s).
Norman Cook. Ecological Effects Branch.
Mefluidide. Avian Acute Oral LD50. Bobwhite Quail.
MRID 416021-01.

February 1, 1991. DER. 3 Page(s).
Norman Cook. Ecological Effects Branch.
Mefluidide. Avian Eight-Day Dietary LC50. Bobwhite Quail.
MRID 416021-02.

February 1, 1991. DER. 2 Page(s).
Norman Cook. Ecological Effects Branch.
Mefluidide. Eight-Day Dietary LC50. Mallard Duck.
MRID 416021-03.

February 1, 1991. DER. 3 Page(s).
Norman Cook. Ecological Effects Branch.
Diethanolamine Salt of Mefluidide. Avian Acute Oral LD50.
Bob White Quail. MRID 416019-01.

February 4, 1991. DER. 3 Page(s).
Norman Cook. Ecological Effects Branch.
Diethanolamine salt of Mefluidide. Eight-Day Dietary LC50.
Bob White Quail. MRID 416019-02.

February 1, 1991. DER. 3 Page(s).
Norman Cook. Ecological Effects Branch.
Diethanolamine salt of Mefluidide. Eight-Day Dietary LC50.
Mallard Duck. MRID 416019-03.

March 4, 1991. Memorandum. 5 Page(s).
Doug Urban. Ecological Effects Branch.
Transmittal of EFED List B Review to SRRD.

July 29, 1991. Memorandum. 4 Page(s).
Douglas Urban. Ecological Effects Branch.
Review of PBI Gordon Non-Target Plant Phytotoxicity
Data Waiver Request for Mefluidide and Salts (Embark).

September 5, 1991. DER. 6 Page(s).
Ann Stavola. Ecological Effects Branch.
Diethanolamine salt of Mefluidide: A 96-hour
flow-through toxicity test with the Bluegill.
Pages 5-6 removed, registrant data.
MRID 418937-01.

September 5, 1991. DER. 6 Page(s).
Ann Stavola. Ecological Effects Branch.
Diethanolamine salt of Mefluidide: A 96-hour
flow-through acute toxicity test with the Rainbow trout.
Pages 5-6 removed, registrant data.
MRID 418937-02.

September 5, 1991. DER. 6 Page(s).
Ann Stavola. Ecological Effects Branch.
Diethanolamine salt of Mefluidide: A 48-hour
flow-through acute toxicity test with the cladoceran.
Pages 5-6 removed, registrant data.
MRID 418937-03.

September 13, 1991. Memorandum p.2. 3 Page(s).
Douglas Urban. Ecological Effects Branch.
Review of Studies for Diethanolamine Salt of Mefluidide
(114002) submitted by PBI Gordon Corporation. MRID 418937-01
MRID 418937-02. MRID 418937-03.

September 13, 1991. Memorandum. 2 Page(s).
Douglas Urban. Ecological Effects Branch.
Review of Studies for Mefluidide (114003) submitted by
PBI Gordon Corporation.
MRID 418938-01, 02, 03.

September 13, 1991. DER. 6 Page(s).
Ann Stavola. Ecological Effects Branch.
Mefluidide. A 96-hour flow-through acute toxicity test
with the Bluegill. Pages 5-6 removed, registrant data.
MRID 418938-01.

March 17, 1992. Memorandum. 26 Page(s).
SanYvette Williams. Toxicology Branch II.
Review of a range-finding and a full teratology study for
Diethanolamine Salt of Mefluidide. (Rats. 83-3)
MRID 420261-01, 02.
Tox review 009363.

January 28, 1993. Memorandum. 8 Page(s).
Elizabeth Doyle. Toxicology Branch II.
Potassium Mefluidide - Review of a Chromasomal
Aberrations Study in Chinese Hamster Ovary Cells in
Support of Reregistration
MRID 425624-04
Tox review 009990.