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Adverse Effects
Abstracts
ACTIVITY:
Herbicide
(cyclopropylisoxazole)
CAS Name:
(5-cyclopropyl-4-isoxazolyl)[2-(methylsulfonyl)-4-(trifluoromethyl)phenyl]methanone
Structure:
| Adverse
Effects:
Amyloidosis
-
Systemic
Blood
Body
Weight Decrease
Bone
Cancer: Probable Human Carcinogen -
LIVER, THYROID
Cholesterol
Endocrine: Pituitary - disruption
in the thyroid-pituitary hormonal feedback mechanisms
Endocrine: Thyroid
Eye
Liver
Lymph node
Sciatic nerve |
| Environmental
Effects:
Very
Phytotoxic
Expected
to Persist and Accumulate in surface and groundwater
Highly
toxic to Mysid shrimp |
Regulatory
Information
(only comprehensive for the US) |
| US
EPA Registered: |
Yes |
| US
EPA PC Code: |
123000 |
| US
Tolerances: |
CFR
180.537 |
| FDA
LMS Code: |
B15 |
Registered
use in
(includes only a limited list of countries)
|
Australia,
Canada, Germany, Hungary, Netherlands, Portugal, US
Africa: Burkina Faso, Cameroon,
Cape Verde, Chad, Gambia, Guinea-Bissau, Mali, Mauritania,
Niger, Senegal, South Africa |
| US
Maximum Residue Levels permitted
in food commodities
|
US
and Canada:
Cattle, Corn, Egg, Goat, Hog,
Horse, Milk, Poultry, Sheep
US
- permitted
in or on 28 food commodities
US
- As of 2003, Wisconsin,
Minnesota, and Michigan have not agreed
to allow use of isoxaflutole due to concerns of "possible
water contamination and effects on non-target plants, including
vegetable crops." |
| Other
Information |
| Molecular
Formula: |
C15H12
F3 NO4S |
| Entry
Year: |
1993 |
| Inventing
Company: |
Rhone-Poulenc
|
| Manufacturers: |
Bayer
CropScience,
Rhone-Poulenc |
| Other
Names: |
Balance
Balance WDG
Epic
Merlin
EXP-30953
RP-201772
264-EUP-99
264-EUP-110
264-EUP-123
264-EUP-129 |
| Of
special interest: |
| PAN
BAD ACTOR - Carcinogen |
| April
2003 - Review
report for the active substance isoxaflutole. Isoxaflutole Sanco/3136/99-Final.
7 April 2003. Finalised in the Standing
Committee on the Food Chain and Animal Health at its meeting
on 15 April 2003 in view of the inclusion of isoxaflutole in
Annex I of Directive 91/414/EEC. |
| January
30, 2003 - Opinon
of the Scientific Committee on Plants on
additional questins from the Commission concerning the evaluation
of Isoxaflutole. European Commission. SCP/ISOXAFLUTOLE-BIS/002
Final |
2003
- WISCONSIN: "Pesticides containing the active ingredient
isoxaflutole will not be sold in Wisconsin in 2003.
The need to protect Wisconsin’s water resources led the
Department of Agriculture, Trade and Consumer Protection to
require special restrictions and conditions if the corn herbicide,
Balance Pro, was to be used in
Wisconsin. Because of the added environmental requirements,
Bayer CropScience, the pesticide
manufacturer, has decided not to distribute the product in Wisconsin
in 2003" ... Wisconsin,
Minnesota, and Michigan
have not agreed to allow use of isoxaflutole
due to concerns of "possible water contamination and effects
on non-target plants, including vegetable crops.""
Wisconsin Department of
Agriculture, Trade and Consumer Protection. |
February
18, 2002 -
European Commission
decision to extend provisional authorisation granted
for new active substances: carfentrazone-ethyl,
cinidon-ethyl, cyhalofop-butyl,
ethoxysulfuron, famoxadone, flazasulfuron,
flufenacet, flumioxazine,
flurtamone, fosthiazate, isoxaflutole,
metalaxyl-M, prosulfuron, Pseudomonas
chlororaphis, quinoxyfen, Spodoptera
exigua nuclear polyhedrosis virus and sulfosulfuron
--
organofluorine pesticides highlighted in red |
| October
24, 2001 -
Schedule No. 1219.
Canada's Food and Drug Regulations approved
Maximum Residue Limits for Corn; eggs; liver of cattle and poultry;
meat and meat by-products of cattle, hogs, horses, poultry &
sheep; and milk to cover residues in food derived from animals
fed with treated crops. |
| August
25, 2000 - CHEMICALS
MEETING THE CRITERIA FOR LISTING AS CAUSING CANCER VIA
THE AUTHORITATIVE BODIES MECHANISM PACKAGE. Reproductive and
Cancer Hazard Assessment, Section Office of Environmental Health
Hazard Assessment, California Environmental Protection Agency
|
| September
1998 - Pesticide
Fact Sheet - US EPA |
| September
1998 - Q&A
about Isoxaflutole - US EPA |
| Classified
by the State of California: "Known to Cause Cancer" |
| Abstracts |
| August
2001 -
IR-4: New
Products/Transitional Solution List - This
list contains brief descriptions of numerous new pest control
materials that have been introduced over the last several years.
Additionally, it contains information on some "older"
crop protection chemicals that are believed to have room for
new uses. This List includes:
Isoxaflutole |
| October
2001 -
Glossary of Pesticide Chemials.
A listing of pesticides subject to analysis of residues in foods
and feeds by the US Food and Drug Administration. |
| April
2000 -
Food and Drug Administration
Pesticide Residue Monitoring. - Table
3. Pesticides detectable by methods used in 1999 regulatory
monitoring. |
US
Federal Register
••
Note: Due to length, the following is a partial
list. Click here
to see full list of FR entries.
|
| Published
Date |
Docket
Identification Number |
Details |
| August
3, 2005 |
OPP-2005-0201 |
Cancellation
of Pesticides for Non-payment of Year 2005 Registration Maintenance
Fees.
| Section
24(c) Registrations canceled for non-payment of the
2005
maintenance fee are shown in the following Table 1:
Table
1.--Section 24(c) Registrations Canceled for Non-Payment
of Maintenance Fee |
|
SLN no. |
Product
Name |
| 000264
CO-99-0005 |
Epic
DF Herbicide |
| 000264
OR-02-0001 |
Axiom
DF Herbicide |
|
Section 3 registrations canceled for non-payment of
the 2005
maintenance fee are shown in the following table 2:
Table
2.--Section 3 Registrations Canceled for Non-Payment
of
Maintenance Fee |
|
Registration no. |
Product
Name |
| 000264-00573
|
EXP
31340ATZ Herbicide |
|
| Aug
9, 2000 |
na |
AVENTIS
- Issuance
of Experimental Use Permit 264-EUP-129. This experimental
use permit allows the use of 280 pounds of the herbicide on
2,000 acres of field corn to evaluate the control of broadleaf
and grass weeds under a range of environmental conditions.
The program is authorized only in the States of Michigan and
Pennsylvania. The experimental use permit is effective from
April 6, 2000, to April 6, 2001. |
| March
31, 1999 |
na |
RHONE-POULENC
- Issuance
of Experimental Use Permit: 264-EUP-123. This experimental
use permit allows the use of 280 pounds of the herbicide isoxaflutole
on 2,000 acres of field corn to evaluate the control of various
weeds. The program is authorized only in the States of Alabama,
Delaware, Georgia, Idaho, Louisiana, Maryland, Michigan, Minnesota,
Mississippi, Oregon, Pennsylvania, Utah, Virginia, Washington,
and Wisconsin. The experimental use permit is effective from
March 1, 1999 to March 1, 2000. |
| July
27, 1998 |
PF-701A |
RHONE-POULENC
- Pesticide
Petition Filing to establish a tolerance for the combined
residues of the herbicide isoxaflutole in or on the raw agricultural
commodities field corn at 0.20 ppm, field corn, fodder, at
0.50 ppm, field corn, forage at 1.0 ppm; and establishing
a tolerance for combined residues of the herbicide isoxaflutole
in or on the meat of cattle, goat, hogs, horses, and sheep
at 0.20 ppm, liver of cattle, goat, hogs, horses and sheep
at 0.50 ppm, meat byproducts (except liver) of cattle, goat,
hogs, horses, and sheep at 0.1 ppm, fat of cattle, goat, hogs,
horses, and sheep at 0.20 ppm, liver of poultry at 0.3 ppm,
eggs at 0.1 ppm and milk at 0.02 ppm. Rhone Poulenc's is amending
its February 26, 1997 petition. |
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