DFP (Diisopropyl fluorophosphate)
CAS No. 55-91-4
 
 

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Adverse Effects
Abstracts
NTIS Reports

ACTIVITY: Former Insecticide (Organophosphate)

Structure:

Adverse Effects:

Adverse Effects:
Apoptosis

Ataxia
Blood
Brain
CNS
Endocrine: Pituitary
Heart
Sciatic Nerve

Regulatory Information
(only comprehensive for the US)
US EPA Registered: No
US EPA PC Code: 356100
Other Information
Molecular Formula: C6H14 F O3P
Other Names:

DFP
Difluorophate,
Diisopropyl fluorophosphate
Diisopropoxyphosphoryl fluoride
Diisopropyl phosphorofluoridate
Diisopropylfluorophosphoric acid ester
DIPF
Dyflos
Dyphlos
Floropryl
Fluophosphoric acid, diisopropyl ester
Fluorodiisopropyl phosphate
Fluostigmine
Isofluorphate
Isopropyl fluophosphate ((C3H7O)2FPO)
Isopropyl phosphorofluoridate ((C3H7O)2FPO)
Neoglaucit 
PF-3
Phosphorofluoridic acid bis(1-methylethyl) ester
T-1703
TL 466

Of special interest:
PAN Data
TOXNET from Hazardous Substances Data Bank
Extremely Hazardous Substance. Chemical Profile - US EPA. 1987  
Included in The List of Extremely Hazardous Substances US 40 CFR - CHAPTER I - PART 355 - updated October 3, 2003
79 Reports available from The National Technical Information Service (NTIS)
Abstracts

Diisopropyl fluorophosphate (DFP) is an organophosphate compound used as an insecticide, a substrate for the production of organophosphate military "nerve" gases and formerly as a topical miotic medication in ophthalmology.

DFP has been used as an experimental agent in neuroscience because of its ability to inhibit cholinesterase and cause delayed peripheral neuropathy. It has been also used as a miotic agent in the treatment of glaucoma. Although DFP has caused experimental distal anoxopathy, no cases of peripheral neuropathy have been reported in patients treated with this agent for glaucoma.

For Diisopropyl Fluorophosphate (USEPA/OPP PC Code: 356100) Not registered for current use in the U.S.

Insecticide (former use) [Hawley, G.G. The Condensed Chemical Dictionary. 10th ed. New York: Van Nostrand Reinhold Co., 1981. 360]

Ref: TOXNET Hazardous Substances Data Base for DIISOPROPYL FLUOROPHOSPHATE.
http://www.fluoridealert.org/pesticides/Isofluorphate-TOXNET.htm

 
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