Bayer CropScience. Pesticide Petition PP 6F7024. Proposal to establish a tolerance for residues of the fungicide trifloxystrobin in or on food commodities

-- grass, forage at 10.0 ppm
-- grass, hay at 14.0 ppm.

A practical analytical methodology for detecting and measuring levels of trifloxystrobin in or on raw agricultural commodities has been submitted. The limit of detection (LOD) for each analyte of this method is 0.08 ng injected, and the limit of quantitation (LOQ) is 0.02 ppm. The method is based on crop specific cleanup procedures and determination by gas chromatography with nitrogen-phosphorus detection.

IR-4. Pesticide petition: PP 6E7088.
Proposing the establishment of new tolerances in or on
-- asparagus at 0.07 ppm
-- papaya at 0.4 ppm
-- sapote, black at 0.4 ppm
-- canistel at 0.4 ppm
-- sapote, mamey at 0.4 ppm
-- mango at 0.4 ppm
-- sapodilla at 0.4 ppm
-- star apple at 0.4 ppm
-- radish, tops at 20 ppm

-- vegetable, root, except sugar beet, subgroup 1B at 0.2 ppm

This subgroup includes 19 commodities.
beet, garden • burdock, edible • carrot • carrot culls • celeriac • chervil, turnip rooted • chicory root • ginseng • horseradish • parsley, turnip rooted • parsnip • radish • radish, oriental • rutabaga • salsify • salsify, black • salsify, spanish • skirret • turnip

Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations.

• Specific information on the studies received and the nature of the toxic effects caused by trifloxystrobin and CGA-321113 as well as the no-observed adverse effect level (NOAEL) and the lowest observed adverse effect level (LOAEL) from the toxicity studies can be found in the Federal Register of May 22, 2002

• Effects cited only from rat studies: decreases in body weight, body weight gains, reduced food consumption and histopathological lesions in the liver, kidneys and spleen

• Cancer. EPA determined that trifloxystrobin should be classified as a ``Not Likely Human Carcinogen.'' Due to the classification, no cancer exposure assessment was performed.

• Conclusion. EPA determined that the 10X SF to protect infants and children should be reduced to 1X. The FQPA, SF is reduced because ...
iii. EPA determined that a developmental neurotoxicity study in rats is not required;
iv. Although an acute neurotoxicity study is required (the submitted study was unacceptable), the lack of an acute neurotoxicity study does not impact EPA's ability to make an FQPA safety factor decision because upgrading the study would not result in a lower NOAEL than what is present for the acute RfD ...

IR-4. Amendment to Existing Tolerance. PP 3E6769.
IR-4, 681 U.S. Highway #1 South, North Brunswick, NJ 08902, proposes to amend 40 CFR 180.555 by establishing tolerances for the combined residues of the fungicide trifloxystrobin and the free form of its acid metabolite (CGA-32113) in or on the following food commodities. A practical analytical methodology for detecting and measuring levels of trifloxystrobin in or on food commodities has been submitted to the EPA. The limit of detection (LOD) for each analyte of this method is 0.08ng injected, and the limit of quantitation (LOQ) is 0.02 ppm. The method is based on crop specific cleanup procedures and determination by gas chromatography with nitrogen-phosphorus detection. A description of the analytical method available for the detection and measurement of the pesticide chemical residues is available on EPA's Electronic Docket at http://www.regulations.gov/.

Bayer CropScience. Pesticide Petitions for New Tolerances for Residues of Trifloxystrobin in or on Corn and Soybeans.

Bayer CropScience, P.O. Box 12014, 2 T.W. Alexander Drive, Research Triangle Park, NC 27709, proposes the following new tolerances. The limit of detection (LOD) for each analyte of this method is 0.08 ng injected, and the limit of quantitation (LOQ) is 0.02 ppm. The method is based on crop-specific cleanup procedures and determination by gas chromatography with nitrogen-phosphorus detection.

Pesticide Emergency Exemptions:

• Colorado. EPA authorized the use of trifloxystrobin on soybeans to control soybean rust; April 8, 2005 to November 10, 2007. Contact: (Andrew Ertman).
• Georgia. Quarantine: EPA authorized the use of trifloxystrobin on soybeans to
control soybean rust; April 8, 2005 to November 10, 2007. Contact: (Andrew Ertman).
• New Jersey. Quarantine: EPA authorized the use of trifloxystrobin on soybeans to
control soybean rust; April 8, 2005 to November 10, 2007. Contact: (Andrew Ertman).
• Tennessee. Quarantine: EPA authorized the use of trifloxystrobin on soybeans to
control soybean rust; April 8, 2005 to November 10, 2007. Contact: (Andrew Ertman).
• Vermont. Quarantine: EPA authorized the use of trifloxystrobin on soybeans to
control soybean rust; June 23, 2005 to November 10, 2007. Contact: (Andrew Ertman).
• West Virginia. EPA authorized the use of trifloxystrobin on soybeans to control
soybean rust; April 8, 2005 to November 10, 2007. Contact: (Andrew Ertman).
• Wisconsin. EPA authorized the use of trifloxystrobin on soybeans to control
soybean rust; April 8, 2005 to November 10, 2007. Contact: (Andrew Ertman).

Cancellation of Pesticides for Non-payment of Year 2005 Registration Maintenance Fees.

Pesticide Tolerance. FINAL RULE.
-- Trifloxystrobin is currently registered for use on the following residential non-dietary sites: Turfgrass and ornamental (CompassTM).
-- EPA determined that a developmental neurotoxicity study in rats is not required.
-- Although an acute neurotoxicity study is required (the submitted study was unacceptable), the lack of an acute neurotoxicity study does not impact EPA's ability to make an FQPA SF decision.
-- For the toxic effects caused by trifloxystrobin EPA directs you to the May 22, 2002, Federal Registe.
-- Developmental toxicity- Rat. LOAEL = 500 mg/kg/day,. based upon increased fetal skeletal anomalies
-- 2-generation reproduction study-Rat. LOAEL = 55.3 mg/kg/day, based upon decreases in body weight, body weight gains, reduced food consumption and histopathological lesions in the liver, kidneys and spleen and pup body weights during lactation
-- 28-Day dermal toxicity study-Rat. LOAEL = 1,000 mg/kg/day, based upon increases in mean absolute and relative liver and kidney weights

BAYER - Pesticide Tolerance. FINAL RULE. This regulation establishes tolerances for trifloxystrobin regulated as trifloxystrobin and the free form of its acid metabolite CGA-321113 in or on fruit, stone, group (2 ppm); nut, tree, group (o.04 ppm); pistachio (0.04 ppm); corn, field, grains (0.05 ppm); corn, field, forage (0.2 ppm); corn field stover (7 ppm); corn, field, refined oil (0.1 ppm); corn, pop, grain (0.05 ppm); corn, pop, stove (7 ppm)r; rice, grain (3.5 ppm); rice, hulls (8 ppm); rice, straw (7.5 ppm); citrus, dried pulp (0.8 ppm); citrus oil (30 ppm); fruit, citrus, group (0.3 ppm) ; egg (0.04 ppm); poultry, fat (0.04 ppm); poultry, meat (0.04 ppm); and poultry, meat by products (0.04 ppm).

BAYER - Pesticide Petition to Establish Tolerances in or on: barley grain at 0.05 ppm, straw at 0.05 ppm, barley hay at 0.2 ppm; citrus fruits crop group at 0.3 ppm, citrus oil at 7.0 ppm; corn grain at 0.05 ppm, corn forage at 0.05 ppm, corn stover at 7.0 ppm; aspirated grain fractions at 0.1 ppm, popcorn grain at 0.05 ppm, popcorn stover at 7.0 ppm; rice grain at 3.5 ppm, rice straw at 7.5 ppm; tree nuts crop group at 0.05 ppm; stone fruits crop group at 2.0 ppm; poultry (fat, kidney, liver, meat by-products, meat) at 0.05 ppm; and pistachio at 0.05 ppm. Docket control number PF-1048

BAYER - Petition for Pesticide Residue Tolerances in or on the raw agricultural commodity barley grain at 0.05 ppm, straw at 0.05 ppm, barley hay at 0.2 ppm, citrus fruits group at 0.3 ppm, citrus oil at 7.0 ppm, corn forage at 0.05 ppm, corn stover at 7.0 ppm, aspirated grain fractions at 0.1 ppm, popcorn grain at 0.05 ppm, popcorn stover at 7.0 ppm, pecans at 0.05 ppm, rice grain at 3.5 ppm, rice straw at 7.5 ppm, stone fruits crops group at 2.0 ppm, and poultry (fat, kidney, liver, meat by-products, meats at 0.5 ppm).

NOVARTIS - Petition for Tolerances for the combined residues of trifloxystrobin and its metabolite, CGA-321113, in or on the raw agricultural commodities almond nutmeat at 0.04 parts per million (ppm); almond hulls at 3.0 ppm; hops dried cones at 11.0 ppm; sugar beet roots at 0.1 ppm; sugar beet tops at 4.0 ppm; sugar beet dried pulp at 0.4 ppm; sugar beet molasses at 0.2 ppm; potato tubers at 0.04 ppm; fruiting vegetables at 0.5 ppm; wheat grain at 0.05 ppm; wheat forage at 0.3 ppm; wheat hay at 0.2; wheat straw at 5.0 ppm; wheat bran 0.15 ppm; and asperated grain fractions at 5.0 ppm.

NOVARTIS - Petition for tolerance for residues in or on the raw agricultural commodities almond nutmeats at 0.02 ppm, almond hulls at 1.5 ppm, fruiting vegetables crop group at 0.7 ppm, hops - dried cones at 11 ppm, potato tubers at 0.02 ppm, sugarbeet roots at 0.05 ppm, sugarbeet tops at 2.5 ppm, sugarbeet dried pulp at 0.25 ppm, wheat grain at 0.05 ppm, wheat forage at 0.03 ppm, wheat hay at 0.2 ppm, wheat straw at 0.05 ppm, and wheat aspirated grain fractions at 0.5 ppm.

NOVARTIS - Pesticide Tolerance. - FINAL RULE. This regulation establishes tolerances for trifloxystrobin regulated as trifloxystrobin and the free form of its acid metabolite CGA-321113 in or on pome fruit, cucurbit vegetables, grapes, raisins, peanuts, peanut hay, wet apple pomace, milk, meat, fat and meat by- products of cattle, goats, hogs, horses and sheep and bananas.

NOVARTIS - Amended Petition to increase the tolerance levels for residues in or on the raw agricultural commodities pome fruit at 0.50 ppm, cucurbit vegetables at 0.50 ppm, grapes at 2.0 ppm, raisins at 5.0 ppm, peanuts at 0.05 ppm, peanut hay at 4.0 ppm, wet apple pomace at 5.0 ppm, milk at 0.02 ppm, meat, fat and meat by-products of cattle, goats, hogs, horses and sheep at 0.05 ppm and imported bananas at 0.1 ppm.

• NOVARTIS - Application to Register 3 pesticide products.
• File Symbol: 100-ORO. Product Name: CGA-279202 WG. Fungicide. Active ingredient: Trifloxystrobin 50.0%. Proposed classification/Use: General. For control of certain diseases on pome fruits, peanuts, grapes, curcurbits, and bananas.
• File Symbol: 100-ORI. Product Name: CGA-279202 Technical. Fungicide. Active ingredient: Trifloxystrobin 98%. Proposed classification/Use: General. For formulating use only.
• File Symbol: 100-OEN. Product Name: CGA-279202 WG Turf. Fungicide. Active ingredient: Trifloxystrobin 50.0%. Proposed classification/Use: General. For use on turf grass.

NOVARTIS - Pesticide Tolerance Petition for residues of CGA-279202 in or on the raw agricultural commodity on pome fruit at 0.4 ppm, cucurbit vegetables at 0.25 ppm, grapes at 1.5 ppm, peanuts at 0.02 ppm, peanut hay at 4.0 ppm, apple pomace at 1.5 ppm and imported bananas at 0.1 ppm.