SYNGENTA - Pesticide Tolerance Petition; for residues in or on the raw agricultural commodities

-- Acute toxicity. EPA has set an acute reference dose of 0.1 milligram/kilogram/day (mg/kg/day) based upon a no observed adverse effect level (NOAEL) of 10 mg/kg/day from the rat acute neurotoxicity study (lowest observed adverse effect level (LOAEL) of 250 mg/kg/day due to reduced motor activity and body temperature in males and impaired righting reflex in females) and a 100-fold uncertainty factor (UF).
-- In a rat teratology study, evidence of maternal toxicity (decreased body weight gain and reduced food consumption) and developmental toxicity (increased incidence of skeletal variations that was not significantly different from the historical control) was found at the maximum tolerated dose of 400 mg/kg.
-- Chronic toxicity. In the 1-year dog chronic dosing study, the NOAEL was 1.84 mg/kg/day based on hematologic and clinical chemistry effects and incidence of lipofuscin accumulation in the liver at 18.6 mg/kg/day.
-- In the 18-month mouse carcinogenicity study, there was no evidence of carcinogenic effects up to the highest dose tested (HDT) of 1,062 mg/kg/day. The NOAEL was 1.71 mg/kg/day in males, and 100 mg/kg/ day in females based on increased incidence/severity of centrilobular hepatocellular hypertrophy.
-- A 2-year chronic feeding/carcinogenicity study in rats indicated systemic NOAEL of 7.9 mg/kg/day was based on decreased body weight and body weight gain, hematopoietic effects (males), and possibly increased serum GGT and decreased liver, kidney, and adrenal weights (females) at 79.9 mg/kg/ day. There was uncertain evidence of carcinogenicity with slight increases in the incidence of mammary gland adenocarcinomas in females at 95.7 and 205.8 mg/kg/day, slight increase in incidence of benign testicular interstitial cell tumors at 79.9 and 160.9 mg/kg/day (significant trend only). Considering the weight of the evidence, the EPA Reference Dose Committee previously concluded that the chemical should be classified as a Group D carcinogen (inadequate evidence), not classifiable as to human carcinogenicity. The HIARC (meeting December 2, 1999) accepted the previous conclusions and updated the cancer classification to the new classification: ``data are inadeqate,'' with no new studies required. EPA has set a chronic reference dose of 0.02 mg/kg based on a NOAEL of 1.84 mg/kg in a dog feeding study and a 100-fold UF.

Cancellation of Pesticides for Non-payment of Year 2002 Registration Maintenance Fees:
Table 2.--Section 3 Registrations Canceled for Non-Payment of Maintenance Fee:
Prosulfuron + Atrazine Herbicide - EPA Registration number 000100-00956

NOVARTIS - Pesticide Tolerance Petition; for residues of prosulfuron in or on the raw agricultural commodities cereal grains group (except rice and wild rice) grain at 0.01 ppm; cereal grains group (except rice and wild rice) forage at 0.10 ppm; cereal grains group (except rice and wild rice) fodder at 0.01 ppm; cereal grains group (except rice and wild rice) straw at 0.02 ppm; cereal grains group (except rice and wild rice) hay at 0.20 ppm; milk at 0.01 ppm; and meat, fat, kidney, liver and meat by-products of cattle, goats, hogs, horses, and sheep at 0.05 ppm.

NOVARTIS - Petition to extend time-limited tolerances for residues of prosulfuron, in or on the cereal grains group (except rice and wild rice) grain at 0.01 ppm; cereal grains group (except rice and wild rice) forage at 0.10 ppm; cereal grains group (except rice and wild rice) fodder at 0.01 ppm; cereal grains group (except rice and wild rice) straw at 0.02 ppm; cereal grains group (except rice and wild rice) hay at 0.20 ppm; milk at 0.01 ppm; and meat, fat, kidney, liver and meat byproducts of cattle, goats, hogs, horses, and sheep at 0.05 ppm until December 31, 2001.

CIBA-GEIGY - Extension of Pesticide Tolerance. - FINAL RULE. This rule establishes tolerances for residues of the herbicide in or on the raw agricultural commodities corn (forage, fodder, grain and fresh [including sweet kernels plus cobs with husks removed]), milk, and meat, fat and meat by-products, of cattle, goats, hogs, horses, and sheep. The regulation establishes the maximum permissible level for residues of the herbicide in or on corn. These tolerances will expire on December 31, 1999.

CIBA-GEIGY - Time-Limited Pesticide Tolerance. - FINAL RULE. US EPA is establishing time-limited tolerances for residues of the herbicide in or on the raw agricultural commodities cereal grains group (except rice and wild rice), grain; cereal grains group (except rice and wild rice), forage; cereal grains group (except rice and wild rice), fodder, cereal grains group (except rice and wild rice), straw; and cereal grains group (except rice and wild rice), hay. These tolerances will expire on December 31, 1999.

CIBA-GEIGY - Petition for Proposed Pesticide Tolerance. EPA proposes to extend the tolerances for residues of the herbicide in or on the raw agricultural commodities corn (forage, fodder, grain and fresh [including sweet kernels plus cobs with husks removed]) at 0.01 ppm, milk at 0.01 ppm, and fat, kidney, liver, meat by-products, of cattle, goats, hogs, horses, and sheep at at 0.05 ppm. The Agency has not completed the regulatory assessment of our science findings; therefore, the Agency is proposing to extend these tolerances until December 1999.

CIBA-GEIGY - Correction of May 24, 1995 Federal Register. Notice of filing of petition by American Cyanamid Co. for the herbicide prosulfuron is corrected to state that the filing is by Ciba-Geigy Corp., not American Cyanamid Co. The notice appeared in the Federal Register of May 24, 1995

CIBA-GEIGY - Approval of Pesticide Product Registrations. This notice announces Agency approval of applications submitted by Ciba-Geigy Corporation, to conditionally register the pesticide products Peak; (formerly Exceed WG) for weed control in field corn (grown for grain, silage, or seed), popcorn, and sweet corn (EPA Registration Number 100-763). Exceed, for weed control in field corn (grown for grain, silage, or seed), and popcorn (EPA Registration Number 100-774). Prosulfuron Technical; for formulation into herbicides for the use on corn (EPA Registration Number 100-762).

AMERICAN CYANAMID - Petition for Pesticide Tolerance for combined residues on cereal grains, cereal grains forage, fodder, and straw (except rice and wild rice) at 0.02 ppm.

CIBA-GEIGY - Pesticide Tolerances. - FINAL RULE. This rule establishes time-limited tolerances, to expire on December 31, 1995, for residues in or on the raw agricultural commodities corn (fodder, forage, grain and fresh [including sweet kernels plus cobs with husks removed]) at 0.01 ppm, milk at 0.01 part per million (ppm), and fat, kidney, liver, meat, and meat byproducts of cattle, goats, hogs, horses, and sheep at 0.05 ppm.

CIBA-GEIGY - Tolerance Petition Filing for residues of the new herbicide prosulfuron in or on the following raw agricultural commodities: corn, forage at 0.02 ppm; corn, fodder at 0.02 ppm; corn, grain at 0.02 ppm; corn, fresh (including sweet kernels plus cobs with husks removed) at 0.02 ppm; milk at 0.02 ppm; meat, fat and meat byproducts, kidney and liver of cattle, goats, hogs, horses, and sheep at 0.10 ppm; poultry, fat, kidney, liver, meat and meat byproducts at 0.10 ppm; eggs at 0.10 ppm.

CIBA-GEIGY - Product Applications for: Exceed WG Herbicide; for postemergence weed control in field corn (grown for grain, silage, or seed), popcorn, and sweet corn. Prosulfuron Technical; for formulation into herbicides.