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Adverse Effects
Abstracts
ACTIVITY:
Insecticide (unclassified)
CAS Name:
tetrahydro-5,5-dimethyl-2(1H)-pyrimidinone [3-[4-(trifluoromethyl)phenyl]-1-[2-[4-
(trifluoromethyl)phenyl]ethenyl]-2-propenylidene]hydrazone
Structure:
|
Published
date |
Docket
Identification Number |
Details |
August 1, 2007 |
EPA-HQ-OPP-2004-0154 |
Proposal
to Increase tolerances. Hydramethylnon (Pyrimidinone).
EPA is increasing the following commodity tolerances in 40
CFR 180.395(a):
``grass (pasture and rangeland)'' from 0.05
ppm to 2.0 ppm
and revising the terminology to ``grass, forage''
and ``grass, hay;'' based on
available field trial data which show residues of hydramethylnon
above the current tolerance level and label amendments
which reflect parameters of use patterns for which field trials
are available; (i.e., reflect a 0 day post harvest interval)
since the Agency no longer allows a PHI (post harvest interval)
restriction on grass. The tolerance for ``grass hay (pasture
and rangeland)'' was recommended to be increased from 0.05
ppm to 0.1 ppm, based on available field trial data previously
discussed and label amendments which reflect a 0 day post
harvest interval. However, because the terminology should
be revised to ``grass, hay,'' that tolerance at 0.1 ppm is
no longer needed since it would be a duplicate covered by
the proposed tolerance at 2.0 ppm. Therefore, EPA is removing
the tolerance in 40 CFR 180.395(a) for grass hay (pasture
and rangeland).
After the hydramethylnon RED was completed in 1998, a permanent
tolerance was established in 40 CFR 180.395(a) on pineapple
(68 FR 48302, August 13, 2003)(FRL-7319-5). Since the proposal
of August 4, 2004 (69 FR 47051), the time-limited tolerance
for hydramethylnon residues on pineapple in 40 CFR 180.395(b),
for section 18 emergency exemptions, expired on June 30, 2005.
The Agency did not propose in a notice for comment to remove
the text and table with the expired tolerance and reserve
40 CFR 180.395(b). However, section 553(b)(3)(B) of the Administrative
Procedure Act provides that notice and comment is not necessary
``when the agency for good cause finds (and incorporates the
finding and a brief statement of reasons therefore in the
rules issued) that notice and public procedure thereon are
impracticable, unnecessary, or contrary to the public interest.''
Consequently, for good cause, EPA is
removing the text and table from 40 CFR 180.395(b) and reserving
that section for emergency exemptions in this document. The
reason for taking this action is because such action has no
practical impact on the use of or exposure to the pesticide
active ingredient, hydramethylnon, since the sole time-limited
tolerance in 40 CFR 180.395(b) had expired and, as
it no longer needs to be codified in that section, should
be removed for the sake of clarity.
•• Document made available with this notice:
Nov 14, 1996: Pyrimidinone. Case 2585. Chemical 118401. Product
and Residue Chemistry Chapters for the Reregistration Eligibility
Decision (RED). From K. Dockter, USEPA Chemistry Branch
II to Jane Smith, USEPA Risk Characterization & Analysis
Branch. August 1, 2007, Docket EPA-HQ-OPP-2004-0154-0013.
|
August
3, 2005 |
OPP-2005-0201 |
Cancellation
of Pesticides for Non-payment of Year 2005 Registration Maintenance
Fees.
Section
24(c) Registrations canceled for non-payment of the
2005
maintenance fee are shown in the following Table 1:
Table
1.--Section 24(c) Registrations Canceled for Non-Payment
of Maintenance Fee |
SLN no. |
Product
Name |
000241
TX-01-0016 |
Amdro
Fire Ant Insecticide |
|
Oct
27, 2004 |
OPP-2004-0338 |
Cancellation
of Pesticides for Non-payment of Year 2004 Registration Maintenance
Fees.
Table
1.--Section 24(c) Registrations Canceled for Non-Payment
of
Maintenance Fee |
Name
of Pesticide |
Product
Name |
Registrant |
SLN
No. |
Hydramethylnon |
Amdro
Fire Ant Insecticide |
BASF
Corporation |
000241
HI-02-0003 |
Hydramethylnon |
Amdro
Fire Ant Insecticide |
BASF
Corporation |
000241
HI-02-0009. |
|
August
4, 2004 |
OPP-
2004-0154 |
Tolerances
increased and terminology modified. EPA is proposing to
increase the tolerance in 40 CFR 180.395(a) on ``grass (pasture
and rangeland)''
from 0.05 to 2.0 ppm and revise the
terminology to ``grass, forage''
and ``grass, hay;'' based on
available field trial data which show
residues of hydramethylnon above the current tolerance level
and label
amendments which reflect parameters of use patterns for which
field
trials are available; i.e., reflect a zero day post harvest
interval
since that the Agency no longer allows a PHI restriction on
grass.
Section
180.395 is amended by revising the table in paragraph
(a) to read as follows: |
Commodity |
Parts
per million |
Grass,
forage |
2.0 |
Grass,
hay |
2.0 |
Pineapple |
0.05 |
|
Nov
26, 2003 |
OPP-2003-0358 |
Pesticide
Emergency Exemption. A ``specific exemption'' authorizes
use of a pesticide against specific pests on a limited acreage
in a particular State.
-- Hawaii Department of Agriculture.
Specific. EPA authorized the use of hydramethylnon
on pineapple to control
big-headed and Argentine ants; June 6, 2003 to June 24, 2004.
|
Aug
13, 2003 |
OPP-2003-0251 |
BASF.
Pesticide Tolerance
for Pineapple at 0.05 ppm. FINAL
RULE.
The US EPA Cancer Peer Review Committee
classified hydramethylnon as a Group C-possible human carcinogen,
and recommended that, for the purpose of risk characterization,
the Reference Dose approach should be used for quantification
of human risk. This classification was
based upon statistically significant increases in lung adenomas
and combined lung adenomas/carcinomas in female mice.
Subchronic,
Chronic, and Other Toxicity (from Table 1.) |
Study
Type |
Results |
Rat
-
Subchronic Feeding |
NOAEL = 2.5 mg/kg/ - Rat day LOAEL = 5.0 mg/kg/ day -
decreased testicular weights (34%),
and testicular atrophy. |
Dog
- Subchronic Gavage |
NOAEL
= 3 mg/kg/ day - LDT; decreased
food consumption (11%/ 20%, males/ females) and
body weight gain (11%/ 9%, males/ females). LOAEL
= not defined Lethal Dose = 6 mg/kg/day - decreased
food consumption and body
weight gain, ↑SGPT,
cachexia,
wasting of muscle and subcutaneous fat, testicular atrophy,
and death. |
Rabbit
-
21-Day Dermal |
NOAEL
= 250 mg/kg/day (HDT) Food consumption was depressed as
much as 38% and 45% in the high- dose males and females,
compared to controls. The high-dose
males and females weighed as much as 8% and 9% less than
the controls. The platelet count in the high-dose females
at termination was 54% less than controls, but was not
considered adverse because it is a common finding following
skin abrasion. |
Rat
- Developmental Toxicity |
Maternal
NOEL = 3 mg/kg/day Maternal NOAEL = 10 mg/kg/day - 8%
decrease in body weight and yellowish
discoloration of the fat. Maternal LOAEL = 30 mg/kg/day
- 16% decrease in body weight;
increased incidence of nasal mucus, alopecia, soft stools,
staining of the anogenital fur, yellowish
discoloration of the fat, and small thymus. Developmental
NOEL = 10 mg/kg/ day Developmental LOAEL = 30 mg/kg/ day
- decreased mean fetal weights and
increased incidence of rudimentary structures and incompletely
ossified supraoccipitals. At 30 mg/kg/day, a 16%
decrease in maternal body weight, increased incidence
of clinical signs (nasal mucus, alopecia, soft stool,
staining of anogenital fur), yellowish discoloration of
the fat, and small thymus
were observed. |
Rabbit
- Developmental Toxicity |
...
Developmental NOAEL = 5 mg/kg/ day - decreased
fetal weight (8%). Developmental LOAEL = 10 mg/kg/
day - abortions, decreased fetal
weight (16%). |
Rat
-
2-Generation Reproductive Toxicity |
Reproductive/
Systemic NOAEL = 25 ppm (1.66/2.01 mg/kg/day, male/ female)
Reproductive/ Systemic LOAEL = 50 ppm (3.32 / 4.13 mg/kg/day,
male/female) (degeneration of the
germinal epithelium (1/29) and aspermia (1/ 29) |
Mouse
-
Carcinogenicity Feeding (18 months)
|
NOAEL
= 25 ppm (3.57 mg/kg/day) in males NOAEL = not defined
in females. LOAEL = 50 ppm (6.93 mg/kg/day)
in males (testicular lesions) LOAEL = 25 ppm (4.45
mg/kg/day) in females (LDT; combined
lung adenomas and carcinomas) The high-dose females
were sacrificed after 5 weeks due to high mortality. |
Rat
-
Chronic Feeding Toxicity/ Carcinogenicity |
NOAEL
= 50 ppm (2.4 mg/kg/day in males, 3.0 mg/kg/ day in females)
LOAEL = 100 ppm (4.9 mg/kg/day in males, 6.2 mg/kg/ day
in females) (small, soft testes, decreased
testicular weights, and testicular atrophy in males; decreased
body weight gain in females) |
Conditions
The following studies are required to further characterize the
environmental effects of hydramethylnon:
-- Estuarine/marine fish LC50
(72-1),
-- Estuarine/marine invertebrate EC50 (72-2), and
-- Sediment Toxicity Testing (Harmonized guidelines 850.1735
and 850.1740).
In addition, the following studies are required for any future
expansion of hydramethylnon uses:
-- Aquatic Photodegradation (161- 2),
-- Aerobic Aquatic Metabolism (162-4), and
-- Terrestrial Field Dissipation (164-1).
|
June
25, 2003 |
OPP-2003-0179 |
Extension
of tolerances for Emergency Exemptions. FINAL RULE.
EPA
has authorized under FIFRA section 18 the use of hydramethylnon
on pineapple for control of big-headed and Argentine ants in
Hawaii. This regulation extends
a time-limited tolerance for residues of the insecticide hydramethylnon;
in or on pineapple at 0.05 ppm for an additional 2-year period.
This tolerance will expire and is revoked on June 30,
2005. A time-limited tolerance was originally published in the
Federal Register of March 4, 1998 (63 FR 10537) (FR -5767-1). |
Aug
7, 2002 |
OPP-2002-0164 |
Emergency
Exemptions for pesticide use.
- Hawaii
Department
of Agriculture - Specific: EPA authorized the use of hydramethylnon
on pineapple to control big-headed
and Argentine ants; May 31, 2002 to May 31, 2003.
|
Nov
14, 2001 |
OPP-181082 |
Pesticide
Emergency Exemptions. In Hawaii EPA authorized use on pineapples
to control big-headed and Argentine ants; May 15, 2001 to May
15, 2002. |
May
24, 2001 |
OPP-301125 |
Extension
of Tolerances for Emergency Exemptions. FINAL RULE.
EPA has authorized under FIFRA section 18 the use of hydramethynon
on pineapple for control of big-headed and Argentine ants in
Hawaii. This regulation extends
a time-limited tolerance for residues of the insecticide in
or on pineapple at 0.05 ppm for an additional
2-year, 1-month period. This tolerance will expire and
is revoked on June 30, 2003. |
Oct
6, 1999 |
PF-835 |
AMERICAN
CYANAMID - Pesticide
Tolerance Petition for residues of in or on the raw agricultural
commodity [pineapples] at 0.05 ppm. |
July
14, 1999 |
na |
- Requests
to voluntarily cancel FIVE pesticide product registrations.
- American
Cyanamid. Amdro Insecticide Roach Control Stations.
EPA Reg. No. 000241--00293
- American
Cyanamid. Amdro Ant Control Stations. EPA Reg.
No. 000241--00304
- American
Cyanamid. Amdro Insecticide Pharaoh Ant Control
PCO Stations. EPA Reg. No. 000241--00320
- Combat
Insect Control Systems. Combat Ant Killer Granular Bait
0.65%. EPA Reg. No. 064240--00028
- Maxforce
Insect Control Systems. Maxforce Ant Killer Granular Bait
0.65%. EPA Reg. No. 064248--00007
|
March
10, 1999 |
OPP-34179 |
Availability
of Reregistration Eligibility Decision (RED) Document for Comment.
|
Nov
25, 1998 |
OPP-300752 |
Extension
of Tolerance for Emergency Exemptions. - FINAL RULE.
This rule extends a time-limited tolerance for residues
of the insecticide hydramethylnon in or on pineapples at 0.05
ppm for an additional one and one-half-year period, to May 30,
2001. |
August
14, 1998 |
PF-824 |
AMERICAN
CYANAMID - Pesticide
Tolerance Petition; for residues of in or on the raw agricultural
commodity pineapples at 0.05 ppm. |
March
4, 1998 |
OPP-300606 |
Pesticide
Tolerances for Emergency Exemptions. - FINAL RULE.
This regulation establishes a time-limited tolerance for residues
of hydramethylnon in or on pineapple at 0.05 ppm. The tolerance
will expire and is revoked on January 31, 1999. |
August 4, 1997 |
OPP-300523 |
Pesticides
Subject to Tolerance Reassessment. |
Jan
12, 1994 |
OPPTS-400082 |
EPA's
proposal to add 41
fluorine and organofluorine chemicals to the Toxics Release
Inventory (TRI). See excerpt in top
box above. Also available at http://www.epa.gov/tri/frnotices/59fr1788.htm |
|