Fluoxastrobin
CAS Nos. 361377-29-9 and 193740-76-0
US Federal Register
 
 

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ACTIVITY: Fungicide (strobin)

CAS Name: (1E)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimidinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyloxime

Structure:

US Federal Register
Date Published Docket Number Details
Sept 16, 2005 OPP-2003-0129

BAYER. Pesticide Tolerances. FINAL RULE.

Sec. 180.609 Fluoxastrobin; tolerances for residues.
(a) General. (1) Tolerances are established for the combined residues of fluoxastrobin, (1E)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimydinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyloxime,
and its Z isomer, (1Z)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimydinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyloxime, in or on the following raw agricultural commodities:
Commodity Parts per million

Leaf petioles subgroup 4B

This subgroup includes 8 commodities:
amaranth, leafy • cardoon • celery • celery, chinese • celtuce • fennel, florence • rhubarb • swiss chard

4.0
Peanut 0.010
Peanut, hay 20.0
Peanut, refined oil 0.030
Tomato, paste 1.5

Vegetable, fruiting, group 8

This group includes 17 commodities:
chili, postharvest • eggplant • groundcherry • pepino • pepper • pepper, bell • pepper, nonbell • pepper, nonbell, sweet • tomatillo • tomato • tomato, concentrated products • tomato, dried pomace • tomato, paste • tomato, puree • tomato, wet pomace • vegetable, fruiting • vegetable, fruiting, group

1.0

Vegetable, tuberous and corm, subgroup 1C

This subgroup includes 22 commodities:
arracacha • arrowroot • artichoke, chinese • artichoke, jerusalem • canna, edible • cassava • chayote root • chufa • dasheen • ginger • leren • potato • potato culls • potato granules flakes • potato peel, wet • potato processed potato waste • potato, specialty • sweet potato • tanier • turmeric • yam bean • yam, true

0.010

Tolerances are established for the combined residues of
fluoxastrobin,
(1E)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimydinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyloxime,
its Z isomer, (1Z)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimydinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyloxime,
and its phenoxy-hydroxypyrimidine metabolite, 6-(2-chlorophenoxy)-5-fluoro-4-pyrimidinol,
in or on the following raw agricultural commodities:
Commodity Parts per million
Cattle, fat 0.10
Cattle, meat 0.05
Cattle, meat byproducts 0.10
Goat, fat 0.10
Goat, meat 0.05
Goat, meat byproducts 0.10
Horse, fat 0.10
Horse, meat 0.05
Horse, meat byproducts 0.10
Milk 0.02
Milk, fat 0.50
Sheep, fat 0.10
Sheep, meat 0.05
Sheep, meat byproducts 0.10

(d) Indirect or inadvertent residues. Tolerances are established for the indirect or inadvertent combined residues of fluoxastrobin, (1E)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimydinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyloxime,
and its Z isomer, (1Z)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimydinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyloxime,
in or on the following raw agricultural commodities when present therein as a result of the application of fluoxastrobin to the growing crops listed in paragraph (a)(1) of this section:
Commodity Parts per million
Alfalfa, forage 0.050
Alfalfa, hay 0.10
Cotton, gin byproducts 0.020

Grain, cereal, forage, fodder, and straw, group 16

This group includes 50 commodities:
barley, hay • barley, straw • corn, field • corn, field, aspirated grain fractions • corn, field, forage • corn, field, hay • corn, field, stover • corn, pod • corn, pod, stover • corn, pop • corn, pop, stover • corn, sweet, cannery waste • corn, sweet, forage • corn, sweet, stover • grain, cereal, forage, fodder and straw, group, for forage, except sweet corn, forage • grain. cereal, group • grass, hay • millet, forage • millet, hay • millet, pearl, forage • millet, pearl, hay • millet, pearl, straw • millet, proso, forage • millet, proso, hay • millet, proso, straw • millet, straw • oat • oat, forage • oat, hay • oat, straw • rice, forage • rice, hulls • rice, straw • rice, wild • ricegrass, indian • rye, forage • rye, straw • sorghum, forage • sorghum, forage, forage • sorghum, forage, hay • sorghum, forage, silage • sorghum, grain • sorghum, grain, forage • sorghum, grain, stover • wheat, forage • wheat, hay • wheat, straw • wheat, vavilovi, straw • wheat, wild einkorn, straw • wheat, wild emmer, straw

0.10
Grass, forage 0.10
Grass, hay 0.50

Vegetable, foliage of legume, group 7

This group includes 21 commodities:
bean, dry, forage • bean, dry, hay • bean, forage • bean, hay • bean, lima, forage • bean, lima, hay • bean, snap, forage • bean, straw • cowpea, forage • cowpea, hay • legume, forage • legume, forage, except soybean and peanut • lupin, grain, forage • lupin, grain, hay • pea, field, hay • pea, field, silage • pea, field, vines • pea, pigeon, forage • vegetable, seed and pod, fodder • vegetable, seed and pod, forage • vegetable, seed and pod, hay

0.050
April 23, 2003 OPP-2003-0129

BAYER. Pesticide petition to establish tolerances for residues in and on the following raw agricultural commodities:

Fluoxastrobin; 2-[[6-(2- chlorophenoxy)-5-fluoro-4-pyrimidinyl]oxy]phenyl (5,6-dihydro-1,4,2- dioxazin-3-yl)methanone-O-methyloxime
Commodity ppm Commodity ppm
alfalfa, forage 0.05
legume, forage
0.05
alfalfa, hay 1.0 legume, hay 0.05
cotton, gin byproducts 0.02 peanut 0.01
grain, cereal, forage 0.10 peanut, hay 20
grain, cereal, hay 0.10 peanut, refined oil 0.10
grain, cereal, straw 0.10 tomato, paste 2.0
grain, cereal, stover 0.10 vegetable, fruiting, group 1.0
grass, forage 0.10 vegetable, leafy, petioles, except brassica, subgroup 5.0
grass, hay 0.50 vegetable, tuberous and corm, subgroup 0.01
legume, seed 0.01 - - 

Fluoxastrobin and its phenoxy- hydroxypyrimidine metabolite; 6-(2-chlorophenoxy)-5-fluoro-4- pyrimidinol
Commodity ppm Commodity ppm
cattle, fat 0.10 milk 0.01
cattle, meat 0.05 milk, fat 0.10
cattle, meat byproducts 0.20 - - 

-- The residue of concern is parent fluoxastrobin (sum of E and Z isomers).
-- Subchronic toxicity. A subchronic toxicity feeding study with rats over 90 days demonstrated a NOAEL of 7.3 and 18.3 mg/kg bwt/day for males and females, respectively, based on reduced body weights and alterations in several urinary tract-related clinical chemistry parameters, at the higher dose levels. In a subchronic feeding study in mice over 14 weeks, a NOAEL was not established based on decreased alanine aminotransferase (ALAT) and increased absolute and relative liver weights at the low dose level (21.7 and 35.3 mg/kg bwt/day for males and females respectively). A 14-week feeding study in dogs demonstrated a NOAEL of 3.0 mg/kg bwt/day based on decreased body weights and food consumption, and liver effects (enzyme induction, increased liver weights, cytoplasmic change), and thyroid effects (decreased T3)
-- Chronic toxicity. A 24-month chronic/oncogenicity feeding study in rats demonstrated a NOAEL of 53.0 and 35.2 mg/kg bwt/day for males and females, respectively. An oncogenicity study in the mouse revealed a NOAEL of 18.5 and 29.5 mg/kg bwt/day for males and females, respectively based on liver effects. There was no indication in the rat or mouse for an oncogenic effect of fluoxastrobin. A 1-year feeding study with dogs demonstrated a NOAEL of 1.7 and 1.5 mg/kg bwt/day for males and females, respectively based on decreased body weights and slight liver effects (increased alkaline phosphatase (Aph) and liver weights).
-- Animal metabolism. Metabolism and pharmacokinetic studies in the rats, lactating goats, and laying hens demonstrate that fluoxastrobin residues are rapidly absorbed, metabolized, and eliminated. There was no evidence of accumulation of residues in any tissues or organs. The metabolic pattern was always complex and numerous metabolites were identified. The main metabolic reactions, however, are very comparable for all tested animal species and most metabolites were present at low levels. Based on the available metabolism data, fluoxastrobin and phenoxy-hydroxypyrimidine are the proposed residues of concern in animals.
-- Non-dietary exposure. Residential (non-dietary) exposure is limited to post-application exposure of fluoxastrobin from professional applications to residential turf and golf courses.

April 23, 2003 OPP-2003- 0131

BAYER. Pesticide Products; Registration Applications.

File Symbol Applicant Product Name Use
264-TIA Bayer CropScience
P.O. Box 12014 2TW Alexander Drive,
Research Triangle Park, NC 27709

HEC 480 SC Fungicide

Active ingredient: Fluoxastrobin at 40.3%

On peanuts, potato and tuber vegetables, leafy vegetables (non-brassica, petioles subgroup), fruiting vegetables, seed treatment (potato, peanut, and turf).
264-TIT Bayer CropScience
P.O. Box 12014 2TW Alexander Drive,
Research Triangle Park, NC 27709

HEC 480 SC Fungicide

Active ingredient: Fluoxastrobin at 94.8%.

For formulation purposes only.

 

 
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