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ACTIVITY:
Fungicide (strobin)
CAS Name:
(1E)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimidinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone
O-methyloxime
Structure:
US
Federal Register |
Date
Published |
Docket
Number |
Details |
Sept
16, 2005 |
OPP-2003-0129 |
BAYER.
Pesticide Tolerances.
FINAL RULE.
Sec.
180.609 Fluoxastrobin; tolerances for residues.
(a) General. (1) Tolerances are
established for the combined residues of fluoxastrobin,
(1E)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimydinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone
O-methyloxime,
and its Z isomer, (1Z)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimydinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone
O-methyloxime, in or on the following raw agricultural
commodities: |
Commodity |
Parts
per million |
Leaf
petioles subgroup 4B
This
subgroup includes 8 commodities:
amaranth, leafy • cardoon • celery •
celery, chinese • celtuce • fennel, florence
• rhubarb • swiss chard
|
4.0 |
Peanut |
0.010 |
Peanut,
hay |
20.0 |
Peanut,
refined oil |
0.030 |
Tomato,
paste |
1.5 |
Vegetable,
fruiting, group 8
This
group includes 17 commodities:
chili, postharvest • eggplant • groundcherry
• pepino • pepper • pepper, bell
• pepper, nonbell • pepper, nonbell, sweet
• tomatillo • tomato • tomato, concentrated
products • tomato, dried pomace • tomato,
paste • tomato, puree • tomato, wet pomace
• vegetable, fruiting • vegetable, fruiting,
group
|
1.0 |
Vegetable,
tuberous and corm, subgroup 1C
This
subgroup includes 22 commodities:
arracacha • arrowroot • artichoke, chinese
• artichoke, jerusalem • canna, edible
• cassava • chayote root • chufa
• dasheen • ginger • leren •
potato • potato culls • potato granules
flakes • potato peel, wet • potato processed
potato waste • potato, specialty • sweet
potato • tanier • turmeric • yam
bean • yam, true
|
0.010 |
Tolerances
are established for the combined
residues of
fluoxastrobin, (1E)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimydinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone
O-methyloxime,
its Z isomer, (1Z)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimydinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone
O-methyloxime,
and its phenoxy-hydroxypyrimidine
metabolite, 6-(2-chlorophenoxy)-5-fluoro-4-pyrimidinol,
in or on the following raw agricultural commodities: |
Commodity |
Parts
per million |
Cattle,
fat |
0.10 |
Cattle,
meat |
0.05 |
Cattle,
meat byproducts |
0.10 |
Goat,
fat |
0.10 |
Goat,
meat |
0.05 |
Goat,
meat byproducts |
0.10 |
Horse,
fat |
0.10 |
Horse,
meat |
0.05 |
Horse,
meat byproducts |
0.10 |
Milk |
0.02 |
Milk,
fat |
0.50 |
Sheep,
fat |
0.10 |
Sheep,
meat |
0.05 |
Sheep,
meat byproducts |
0.10 |
(d)
Indirect or inadvertent residues. Tolerances are established
for the indirect or inadvertent
combined residues of fluoxastrobin, (1E)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimydinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone
O-methyloxime,
and its Z isomer, (1Z)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimydinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone
O-methyloxime,
in or on the following raw agricultural commodities when
present therein as a result of the application of fluoxastrobin
to the growing crops listed in paragraph (a)(1) of this
section: |
Commodity |
Parts
per million |
Alfalfa,
forage |
0.050 |
Alfalfa,
hay |
0.10 |
Cotton,
gin byproducts |
0.020 |
Grain,
cereal, forage, fodder, and straw, group
16
This
group includes 50 commodities:
barley, hay • barley, straw • corn, field
• corn, field, aspirated grain fractions •
corn, field, forage • corn, field, hay •
corn, field, stover • corn, pod • corn,
pod, stover • corn, pop • corn, pop, stover
• corn, sweet, cannery waste • corn, sweet,
forage • corn, sweet, stover • grain,
cereal, forage, fodder and straw, group, for forage,
except sweet corn, forage • grain. cereal, group
• grass, hay • millet, forage •
millet, hay • millet, pearl, forage •
millet, pearl, hay • millet, pearl, straw •
millet, proso, forage • millet, proso, hay •
millet, proso, straw • millet, straw •
oat • oat, forage • oat, hay • oat,
straw • rice, forage • rice, hulls •
rice, straw • rice, wild • ricegrass,
indian • rye, forage • rye, straw •
sorghum, forage • sorghum, forage, forage •
sorghum, forage, hay • sorghum, forage, silage
• sorghum, grain • sorghum, grain, forage
• sorghum, grain, stover • wheat, forage
• wheat, hay • wheat, straw • wheat,
vavilovi, straw • wheat, wild einkorn, straw
• wheat, wild emmer, straw
|
0.10 |
Grass,
forage |
0.10 |
Grass,
hay |
0.50 |
Vegetable,
foliage of legume, group 7
This
group includes 21 commodities:
bean, dry, forage • bean, dry, hay • bean,
forage • bean, hay • bean, lima, forage
• bean, lima, hay • bean, snap, forage
• bean, straw • cowpea, forage •
cowpea, hay • legume, forage • legume,
forage, except soybean and peanut • lupin, grain,
forage • lupin, grain, hay • pea, field,
hay • pea, field, silage • pea, field,
vines • pea, pigeon, forage • vegetable,
seed and pod, fodder • vegetable, seed and pod,
forage • vegetable, seed and pod, hay
|
0.050 |
|
April
23, 2003 |
OPP-2003-0129 |
BAYER.
Pesticide petition to establish tolerances for residues in
and on the following raw agricultural commodities:
Fluoxastrobin;
2-[[6-(2- chlorophenoxy)-5-fluoro-4-pyrimidinyl]oxy]phenyl
(5,6-dihydro-1,4,2- dioxazin-3-yl)methanone-O-methyloxime |
Commodity |
ppm |
Commodity |
ppm |
alfalfa,
forage |
0.05 |
legume, forage |
0.05 |
alfalfa,
hay |
1.0
|
legume,
hay |
0.05 |
cotton,
gin byproducts |
0.02 |
peanut
|
0.01 |
grain,
cereal, forage |
0.10 |
peanut,
hay |
20
|
grain,
cereal, hay |
0.10 |
peanut,
refined oil |
0.10 |
grain,
cereal, straw |
0.10 |
tomato,
paste |
2.0 |
grain,
cereal, stover |
0.10 |
vegetable,
fruiting, group |
1.0
|
grass,
forage |
0.10 |
vegetable,
leafy, petioles, except brassica, subgroup |
5.0
|
grass,
hay |
0.50 |
vegetable,
tuberous and corm, subgroup |
0.01 |
legume,
seed |
0.01 |
- |
- |
Fluoxastrobin
and
its phenoxy- hydroxypyrimidine metabolite;
6-(2-chlorophenoxy)-5-fluoro-4-
pyrimidinol |
Commodity |
ppm |
Commodity |
ppm |
cattle,
fat |
0.10 |
milk |
0.01 |
cattle,
meat |
0.05
|
milk,
fat |
0.10 |
cattle,
meat byproducts |
0.20 |
- |
- |
--
The residue of concern is parent fluoxastrobin (sum of E and
Z isomers).
-- Subchronic toxicity. A subchronic toxicity feeding study
with rats over 90 days demonstrated a NOAEL of 7.3 and 18.3
mg/kg bwt/day for males and females, respectively, based
on reduced body weights and alterations in several urinary
tract-related clinical chemistry parameters, at the
higher dose levels. In a subchronic feeding study in mice
over 14 weeks, a NOAEL was not established based on decreased
alanine aminotransferase (ALAT) and increased absolute and
relative liver weights at the low dose level (21.7
and 35.3 mg/kg bwt/day for males and females respectively).
A 14-week feeding study in dogs demonstrated
a NOAEL of 3.0 mg/kg bwt/day based on decreased body weights
and food consumption, and liver effects (enzyme induction,
increased liver weights, cytoplasmic change), and thyroid
effects (decreased T3)
-- Chronic toxicity. A 24-month chronic/oncogenicity feeding
study in rats demonstrated a NOAEL of 53.0
and 35.2 mg/kg bwt/day
for males and females,
respectively. An oncogenicity study in the mouse revealed
a NOAEL of 18.5 and 29.5 mg/kg bwt/day for males and females,
respectively based on liver effects.
There was no indication in the rat or mouse for an oncogenic
effect of fluoxastrobin. A 1-year feeding study with dogs
demonstrated a NOAEL of 1.7 and 1.5 mg/kg bwt/day for males
and females, respectively based on decreased
body weights and slight liver effects (increased alkaline
phosphatase (Aph) and liver weights).
-- Animal metabolism. Metabolism and pharmacokinetic studies
in the rats, lactating goats, and laying hens demonstrate
that fluoxastrobin residues are rapidly absorbed, metabolized,
and eliminated. There was no evidence of accumulation of residues
in any tissues or organs. The metabolic
pattern was always complex and numerous metabolites were identified.
The main metabolic reactions, however, are very comparable
for all tested animal species and most metabolites were present
at low levels. Based on the available metabolism data, fluoxastrobin
and phenoxy-hydroxypyrimidine are the proposed residues of
concern in animals.
-- Non-dietary exposure. Residential
(non-dietary) exposure is limited to post-application exposure
of fluoxastrobin from professional applications to residential
turf and golf courses. |
April
23, 2003 |
OPP-2003-
0131 |
BAYER.
Pesticide
Products; Registration Applications.
File
Symbol |
Applicant |
Product
Name |
Use |
264-TIA |
Bayer
CropScience
P.O. Box 12014 2TW Alexander Drive,
Research Triangle Park, NC 27709
|
HEC
480 SC Fungicide
Active
ingredient: Fluoxastrobin at 40.3% |
On
peanuts, potato and tuber vegetables, leafy vegetables
(non-brassica, petioles subgroup), fruiting vegetables,
seed treatment (potato, peanut, and turf). |
264-TIT |
Bayer
CropScience
P.O. Box 12014 2TW Alexander Drive,
Research Triangle Park, NC 27709 |
HEC
480 SC Fungicide
Active
ingredient: Fluoxastrobin at 94.8%.
|
For formulation purposes only. |
|
|