Return to
Index Page
Adverse Effects
ACTIVITY: Herbicide
(aryloxyphenoxy propionic acid)
Structure for Cyhalofop:
|
Date
Published |
Docket
Identification Number |
Details |
June
4. 2002 |
OPP-2002-0087 |
5-Year
pesticide tolerance for combined residues
of cyhalofop
(cyhalofop-butyl plus cyhalofop-acid) and the di-acid metabolite
in or on rice grain at 0.03 ppm and
rice straw at 8.0 ppm.
Final Rule.
- Dermal,
Long-Term, Carcinogenicity in Mice: Kidney
effects in females including tubular dilatation, chronic
glomerulonephritis, and hyaline casts at the LOAEL of 10.06
/ 10.28 mg/kg/day, M/F.
- Inhalation,
Short- Term (1-30 days), Subchronic
Feeding Mice: Enlarged kidneys in Enlarged kidneys in swelling
of the proximal tubule cells in 4/12 mice at the LOAEL of
14.1 mg/kg/ day.
- Inhalation,
Long- Term ( 6 months), Carcinogenicity in Mice:
Kidney effects in females including tubular dilatation,
chronic glomerulonephritis, and hyaline casts at the LOAEL
of 10.06 / 10.28 mg/kg/day, M/F.
- Cancer:
This herbicide has not been classified.
The rat and mouse carcinogenicity studies are identified
as data gaps. Since the doses tested in these studies were
too low to assess the carcinogenic potential of cyhalofop-
butyl, the cancer dietary risk assessment was conducted
using the potency factor (Q1*) of 2.3 x 10-\1\ for the structural
analog diclofop- methyl.
- Special
Study Hepatocellular Proliferation in Rats:
In a subchronic oral toxicity study in rats (MRID 45000413),
satellite rats dosed for 4 weeks had hepatocellular hypertrophy
and focal necrosis at all dose levels... An initial dramatic
increase in DNA synthesis during the first week of treatment
was followed by hepatocellular hypertrophy at subsequent
observations. This
was the reason for enlarged livers.
- In
Vitro Chromosomal Aberration in Chinese Hamster Lung:
Polyploidy was induced when
CHL (V79) cells were treated for 48 hours in the absence
of S9, but there was no clastogenic effect on DNA.
[FAN Note: Polyploidy is when the
number of chromosomes in a cell becomes doubled. One obvious
consequence is that the resulting creature has no one it
can breed with. Ref: http://www.cs.colorado.edu/~lindsay/creation/polyploidy.html
]
- Acute
Dermal (Rat):
Chromodacryorrhea was
observed in 2/ 5 males on day 2 only. Delayed weight gain
was observed in all rats, with the females being most affected.
[FAN
Note:
Chromodacryorrhea or red tears
due to excessive production of Harderian gland secretions.
The glands, named after the Swiss physician Johann Jakob
Harder, are exocrine glands located deep within the orbit.
The Harderian gland secretes mostly lipids in the rat.
Further products include porphyrin and melatonin. Various
physiological functions have been attributed to the rat
Harderian gland. The lipid-containing part of the secretion
may serve to lubricate the eye. Some observations suggest
a behavior related odoriferous (pheromonal) role. The
Harderian gland is also considered to serve, like the
pineal gland, as an extraretinal photoreceptor. Harderian
porphyrin may have a photoprotective role, as it is increasingly
secreted in response to light exposure and as porphyrins
show an intense absorption of light. Chromodacryorrhea
is a consequence of acute-onset stress such as pain, illness,
restraint, or poisoning. Red tears are often an indication
of a chronic underlying disease, and warrant a thorough
evaluation of affected animals. Ref: http://www.labanimal.com/col/diag1.html
]
|
Feb
13, 2002 |
na |
Cyhalofop-butyl:
Emergency Exemptions:
Arizona. EPA authorized the use of cyhalofop-buty on rice to
control bearded sprangletop; April 15, 2002 to August 15, 2002.
|
Sept
27, 2001 |
OPP-301167 |
Pesticide
Tolerances for Emergency Exemptions. - FINAL RULE.
Cyhalofop-butyl is a new chemical, this is the first tolerance
established for the combined residues of cyhalofop-butyl plus
the cyhalofop-acid and di-acid metabolites, in or on a raw
agricultural commodity rice grain at 0.03 ppm and rice straw
at 8.0 ppm. These tolerances will expire and are revoked on
June 30, 2002.
- Chronic
dietary all populations: Carcinogenicity in mice LOAEL =
10.06 mg/kg/day based on kidney effects in females including
tubular dilatation, chronic glomerulonephritis, and hyaline
casts.
- Long-term
dermal (greater than 6 months): Carcinogenicity in mice
LOAEL = 10.06 mg/kg/day based on kidney effects in females
including tubular dilatation, chronic glomerulonephritis,
and hyaline casts.
- Short-term
inhalation (1 to 30 days) and intermediate-term inhalation
(1-6 months) (residential): Subchronic feeding study in
mice LOAEL = 14.1 mg/kg/day based on enlarged kidneys in
females accompanied by swelling of the proximal tubule cells.
- Long-term
inhalation (greater than 6 months) (residential): LOAEL
= 10.06 mg/kg/day based on kidney effects in females including
tubular dilatation, chronic glomerulonephritis, and hyaline
casts.
- Objections
and requests for hearings, identified by docket control
number OPP-301167, must be received by EPA on or before
November 26, 2001.
|
April
25, 2001 |
PF-1009 |
DOW
AGRO - Petition
to Establish Tolerances for residues of cyhalofop-butyl in
or on rice grain, rice hull, rice bran, and polished rice
at 0.03 ppm for grain and 8.0 ppm for straw. |
|