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SUBMISSION: FLUTRIAFOL: TWO GENERATION REPRODUCTION STUDY
IN RATS WITH COVER LETTER DATED 08-28-92
Name: IMPERIAL CHEM INDUS LTD
(76674-21-0) was evaluated for two-generation reproductive toxicity.
The test material was administered to Wistar rats at 0, 60,
240, or 1000 ppm in the diet continuously throughout the study.
Fifteen males and thirty females were assigned to each group
(F0 parents). The numbers of the selected F1 parents was not
reported. Reductions in body weight gain and food consumption
were seen at 1000 ppm in both sexes of the F0 parents during
the premating period. Body weight gains were reduced at 1000
ppm in F1 females only during the pre-mating period, with no
effect on food consumption ineither sex. The body weight gains
of the F1A, F1B, and F2B litters were reduced during pregnancy
at 1000 ppm. Liver weight increases were observed in the 1000
ppm groups in both generations. There were no effects on parental
ovary or testis weights in either generation. The fertility
index of the F0 females at 1000 ppm was lower than controls
but no effects on the live born index, pup weights, mean litter
size, or survival were observed. At 1000 ppm, slightly reduced
numbers of pups born and mean litter sizes were observed in
the F1B, F2A, and F2B generations. At 240 ppm, the number of
pups born was slightly reduced in the F2B generation, but no
effects on the mean litter size were observed. The reproductive
no-effect level is 240 ppm. This study was briefly summarized.
SUBMISSION: 4-HOUR ACUTE INHALATION TOXICITY STUDY IN THE
RAT OF A 37/200G/KG WP FORMULATION WITH COVER LETTER DATED
Name: IMPERIAL CHEM INDUS LTD
INITIAL SUBMISSION: FLUTRIAFOL: 2 YEAR FEEDING STUDY IN RATS
WITH COVER LETTER DATED 08-28-92
Name: IMPERIAL CHEM INDUS LTD
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
Environ. Sci. Technol., 39 (21), 8163 -8169, 2005.
Current-Use and Legacy Pesticide History
in the Austfonna Ice Cap, Svalbard, Norway
Mark H. Hermanson,* Elisabeth Isaksson,
Camilla Teixeira, Derek C. G. Muir, Kevin M. Compher, Y-F. Li,
Makoto Igarashi, and Kokichi Kamiyama
Department of Chemistry, University of Pennsylvania, Philadelphia,
Pennsylvania 19104, Norwegian Polar Institute, N-9296 Troms, Norway,
Environment Canada, Burlington, Ontario, Canada L7R 4A6, Environment
Canada, Toronto, Ontario, Canada M3H 5T4, and National Institute
for Polar Research, Tokyo 173-8515, Japan
The Svalbard archipelago in arctic Norway receives considerable
semivolatile organic contaminant (SOC) inputs from the atmosphere.
To measure the history of net SOC accumulation there, we analyzed
the upper 40 m of an ice core from Austfonna, the largest ice
cap in Eurasia, for several legacy organochlorine (OC) compounds
and current-use pesticides (CUPs) including organophosphorus (OP),
triazine, dinitroaniline, and chloroacetamide compounds. Five
OP compounds (chlorpyrifos, terbufos, diazinon, methyl parathion,
and fenitrothion), two OCs (methoxychlor and dieldrin), and metolachlor-an
herbicide-had historical profiles in the core. The highest OC
concentration observed was aldrin (69.0 ng L-1) in the surface
sample (1992-1998). The most concentrated OP was dimethoate (87.0
ng L-1) between 1986 and 1992. The surface
sample also had highest concentrations of pendimethalin
(herbicide, 18.6 ng L-1) and flutriafol,
the lone observed fungicide (9.6 ng L-1). The apparent
atmospheric persistence of CUPs likely results from little or
no oxidation by OH during the dark polar winter and in spring.
Long-range atmospheric pesticide transport to Svalbard from Eurasia
is influenced by the positive state of the North Atlantic Oscillation
Index since 1980 and also by occasional fast-moving summer air
masses from northern Eurasian croplands.
Environ Toxicol Chem. 2004 Oct;23(10):2421-32.
Empirical and modeling evidence of regional
atmospheric transport of current-use pesticides.
Muir DC, Teixeira C, Wania F.
National Water Research Institute, Environment Canada, Burlington,
Ontario L7R 4A6, Canada. email@example.com
Water samples from 30 lakes in Canada and the northeastern United
States were analyzed for the occurrence of 27 current-use pesticides
(CUPs). Eleven CUPs were frequently detected in lakes receiving
agricultural inputs as well as in remote lakes hundreds of kilometers
from known application areas. These included the triazine herbicide
atrazine and its desethylated degradation product; the herbicides
alachlor, metolachlor, and dacthal; the organophosphate insecticides
chlorpyrifos, diazinon, and disulfoton; the organochlorine insecticides
alpha-endosulfan and lindane; and the fungicides chlorothalonil
and flutriafol. For six of the pesticides,
empirical half-distances on the order of 560 to 1,820 km were
estimated from the water-concentration gradient with latitude.
For most of the pesticides, a suite of assessment models failed
to predict such atmospheric long-range transport behavior, unless
the effect of periods of lower hydroxyl radical concentrations
and dry weather were taken into account. Observations and model
results suggest that under the conditions prevailing in south-central
Canada (relatively high latitude, low precipitation rates), many
CUPs will be able to undergo regional-scale atmospheric transport
and reach lakes outside areas of agricultural application. When
assessing the potential of fairly reactive and water-soluble substances
to undergo long-range transport, it is imperative to account for
periods of no precipitation, to assure that degradation rate constants
are correct, and to apply oxidant concentrations that are valid
for the region and time period of interest.
PMID: 15511103 [PubMed - indexed for MEDLINE]