Abstracts
Flutriafol
CAS No. 76674-21-0
 
 

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NTIS Order No. Title Abstract / Keywords

NTIS/OTS0543843

EPA/OTS; Doc #88-920006838

08-28-92: INITIAL SUBMISSION: FLUTRIAFOL: TWO GENERATION REPRODUCTION STUDY IN RATS WITH COVER LETTER DATED 08-28-92

Corporate Name: IMPERIAL CHEM INDUS LTD

Flutriafol (76674-21-0) was evaluated for two-generation reproductive toxicity. The test material was administered to Wistar rats at 0, 60, 240, or 1000 ppm in the diet continuously throughout the study. Fifteen males and thirty females were assigned to each group (F0 parents). The numbers of the selected F1 parents was not reported. Reductions in body weight gain and food consumption were seen at 1000 ppm in both sexes of the F0 parents during the premating period. Body weight gains were reduced at 1000 ppm in F1 females only during the pre-mating period, with no effect on food consumption ineither sex. The body weight gains of the F1A, F1B, and F2B litters were reduced during pregnancy at 1000 ppm. Liver weight increases were observed in the 1000 ppm groups in both generations. There were no effects on parental ovary or testis weights in either generation. The fertility index of the F0 females at 1000 ppm was lower than controls but no effects on the live born index, pup weights, mean litter size, or survival were observed. At 1000 ppm, slightly reduced numbers of pups born and mean litter sizes were observed in the F1B, F2A, and F2B generations. At 240 ppm, the number of pups born was slightly reduced in the F2B generation, but no effects on the mean litter size were observed. The reproductive no-effect level is 240 ppm. This study was briefly summarized.

NTIS/OTS0538570

EPA/OTS; Doc #88-920007487

08-28-92: INITIAL SUBMISSION: 4-HOUR ACUTE INHALATION TOXICITY STUDY IN THE RAT OF A 37/200G/KG WP FORMULATION WITH COVER LETTER DATED 08-28-92

Corporate Name: IMPERIAL CHEM INDUS LTD

ICI AMERICAS INC.
(RS)-1-(2-FLUOROPHENYL)-1-(4-FLUOROPHENYL)-2-(1H-1,2,4-TRIA*
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION

NTIS/OTS0538469

EPA/OTS; Doc #88-920007336

08-28-92: INITIAL SUBMISSION: FLUTRIAFOL: 2 YEAR FEEDING STUDY IN RATS WITH COVER LETTER DATED 08-28-92

Corporate Name: IMPERIAL CHEM INDUS LTD

ICI AMERICAS INC.
(RS)-1-(2-FLUOROPHENYL)-1-(4-FLUOROPHENYL)-2-(1H-1,2,4-TRIA*
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
ORAL
DIET


http://pubs.acs.org/cgi-bin/abstract.cgi/esthag/2005/39/i21/abs/es051100d.html

Environ. Sci. Technol., 39 (21), 8163 -8169, 2005.

Current-Use and Legacy Pesticide History in the Austfonna Ice Cap, Svalbard, Norway

Mark H. Hermanson,* Elisabeth Isaksson, Camilla Teixeira, Derek C. G. Muir, Kevin M. Compher, Y-F. Li, Makoto Igarashi, and Kokichi Kamiyama

Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, Norwegian Polar Institute, N-9296 Troms, Norway, Environment Canada, Burlington, Ontario, Canada L7R 4A6, Environment Canada, Toronto, Ontario, Canada M3H 5T4, and National Institute for Polar Research, Tokyo 173-8515, Japan

The Svalbard archipelago in arctic Norway receives considerable semivolatile organic contaminant (SOC) inputs from the atmosphere. To measure the history of net SOC accumulation there, we analyzed the upper 40 m of an ice core from Austfonna, the largest ice cap in Eurasia, for several legacy organochlorine (OC) compounds and current-use pesticides (CUPs) including organophosphorus (OP), triazine, dinitroaniline, and chloroacetamide compounds. Five OP compounds (chlorpyrifos, terbufos, diazinon, methyl parathion, and fenitrothion), two OCs (methoxychlor and dieldrin), and metolachlor-an herbicide-had historical profiles in the core. The highest OC concentration observed was aldrin (69.0 ng L-1) in the surface sample (1992-1998). The most concentrated OP was dimethoate (87.0 ng L-1) between 1986 and 1992. The surface sample also had highest concentrations of pendimethalin (herbicide, 18.6 ng L-1) and flutriafol, the lone observed fungicide (9.6 ng L-1). The apparent atmospheric persistence of CUPs likely results from little or no oxidation by OH during the dark polar winter and in spring. Long-range atmospheric pesticide transport to Svalbard from Eurasia is influenced by the positive state of the North Atlantic Oscillation Index since 1980 and also by occasional fast-moving summer air masses from northern Eurasian croplands.


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15511103&query_hl=1

Environ Toxicol Chem. 2004 Oct;23(10):2421-32.

Empirical and modeling evidence of regional atmospheric transport of current-use pesticides.

Muir DC, Teixeira C, Wania F.

National Water Research Institute, Environment Canada, Burlington, Ontario L7R 4A6, Canada. derek.muir@ec.gc.ca

Water samples from 30 lakes in Canada and the northeastern United States were analyzed for the occurrence of 27 current-use pesticides (CUPs). Eleven CUPs were frequently detected in lakes receiving agricultural inputs as well as in remote lakes hundreds of kilometers from known application areas. These included the triazine herbicide atrazine and its desethylated degradation product; the herbicides alachlor, metolachlor, and dacthal; the organophosphate insecticides chlorpyrifos, diazinon, and disulfoton; the organochlorine insecticides alpha-endosulfan and lindane; and the fungicides chlorothalonil and flutriafol. For six of the pesticides, empirical half-distances on the order of 560 to 1,820 km were estimated from the water-concentration gradient with latitude. For most of the pesticides, a suite of assessment models failed to predict such atmospheric long-range transport behavior, unless the effect of periods of lower hydroxyl radical concentrations and dry weather were taken into account. Observations and model results suggest that under the conditions prevailing in south-central Canada (relatively high latitude, low precipitation rates), many CUPs will be able to undergo regional-scale atmospheric transport and reach lakes outside areas of agricultural application. When assessing the potential of fairly reactive and water-soluble substances to undergo long-range transport, it is imperative to account for periods of no precipitation, to assure that degradation rate constants are correct, and to apply oxidant concentrations that are valid for the region and time period of interest.

PMID: 15511103 [PubMed - indexed for MEDLINE]


 
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