Adverse Effects:

Body Weight Decrease
Bone
Eye
Liver

Environmental Effects:

Extremely persistent in soil

Water contamination is likely

RS)-1-(2-FLUOROPHENYL)-1-(4-FLUOROPHENYL)-2-(1,2,4-TRIAZOL-1-YL)ETHANOL

RS)-2',4-DIFLUORO-ALPHA-((1H-1,2,4-TRIAZOL-1-YL)METHYL)BENZHYDRYL ALCOHOL

TRIAZOLE-1-ETHANOL, ALPHA-(2-FLUOROPHENYL)-ALPHA-(4-FLUOROPHENYL)-

FLUOROPHENYL)-ALPHA-(4-FLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-ETHANOL

CHINA:
Changzhou Nanjing Chemical Factory, No. 1 Xun Xi South Road, Changzhou District

UK:
Zeneca, Stiringshire

Flutriafol ranked number 20 for "Most Widely used pesticides in the UK (by Area Treated)" and "Chlorothalonil/flutriafol" ranked no. 48 in the same category.

Ref: April 29, 2000. UK Department for Environment, Food & Rural Affairs in the online report, "Design of a Tax or Charge Scheme for Pesticides. " Annex C3: Overview of Pesticide Industry
http://www.fluorideaction.org/pesticides/pesticides.ranks.uk.2000.htm

June 14, 2001 - Implementation of the Community Strategy for Endocrine Disruptors - a range of substances suspected of interfering with the hormone systems of humans and wildlife. Communication from the Commission to the Council and the European Parliament. Commission of the European Communities, Brussels COM (2001) 262 final. (More information available at: http://europa.eu.int/comm/environment/docum/01262_en.htm )

This document presents a "priority list of substances for further evaluation of their role in endocrine disruption. During 2000, a candidate list of 553 man-made substances and 9 synthetic/natural hormones has been identified." Organofluorine pesticides in this list include:

Request for Emergency Exemption. EPA has received a quarantine exemption request from the
Minnesota and South Dakota Departments of Agriculture to use the pesticide product flutriafol (Impact 125SC), (CAS No. 76674-21-0), on soybeans to control Asian soybean rust. The Applicant proposes the use of a new chemical which has not been registered by EPA. EPA is soliciting public comment before making the decision whether or not to grant the exemption.

• See March 2005 request from the states of Minnesota and South Dakota (Docket No. OPP-2005-0242-0002):

-- Flutriafol has a low toxicity to mammals, birds, and insects (see Appendix 5, this addendum). Flutriafol may be toxic to fish and aquatic invertebrates. In Minnesota the endangered Higgins Eye and Winged Mapleleaf mussels are found in the St. Croix River between Minnesota and Wisconsin. The counties adjacent to the St. Croix River in Minnesota account for less than one percent of the total soybean acres and are not in the primary soybean production areas of Minnesota. It is not likely that flutriafol would reach the mussel habitat and would not be expected to be continuously or recurrently present in water as a result of use under this exemption. The endangered Topeka shiner fish live in small to mid-sued prairie streams and is found only in sub-watersheds of the Missouri River basin. In Minnesota, this includes the counties of Lincoln, Murray, Nobles, Pipestone, and Rock. To mitigate risk to Topeka shiners from use of flutriafol under this sec. 18, the Minnesota sec. 18 flutriafol use directions would include a statement 'To prevent risk to the endangered species Topeka shiner, flutriafol should not be applied in Lincoln, Murray, Nobles, Pipestone, or Rock counties if heavy rainfall is imminent." Based on the above discussion, the use of flutriafol under this exemption would not be a risk to threatened and endangered mammals, birds, insects, fish or aquatic organisms in Minnesota (pp 28-29).

-- Cyproccnazole, metconazole, flusilazole, prothioconazole, and flutriafol are triazole fungicides. EPA is evaluating the toxicological significance of triazole metabolites 1,2,4-triazole, triazolylalanine (TA) and triazolylacetic acid (TAA). Of the three metabolites, only 1,2,4-triazole can be considered toxicologically significant and EPA has identified developmental toxicity as the endpoint of concern. An industry Triazole Task Force has submitted worst-case studies (Appendix J, original submission) to EPA demonstrating a reasonable certainty of no harm for 1,2,4-triazole stemming from triazole detivative fungicides for food only, as well as for food and water (p 29).

-- The manufacturers of flusilazole (Punch) and flusilazole + famoxadone (Charisma) -DuPont Crop Protection, Inc.; and, flutriafol (Impact) -Cheminova, are aware of and supportive of this request. Letters of support and draft labels for soybeans have been received (Appendix 3, this addendum) (p 30).

-- This request is the first request for the use of each of the requested products; Alto, Quadris Xtra, Caramba, Headline-Caramba, Operetta, Punch, Charisma, JAU 6476, and Impact on soybean by all states (p 30).

-- Flusilazole - DuPont is actively pursuing registration of flusilazole on soybeans. See Appendlx 1. this addendum for studies on product chemistry, toxicology and ecotoxicology, environmental fate and residues (p 30).

-- Flutriafol - Cheminova will submit its first application for registration of flutriafol to EPA this summer. Field residue and processing studies on soybeans in the U.S. are underway (p 31).

• See

• October 5, 2005 - Comments submitted to EPA by the Agricultural Retailers Association. Docket No. OPP-2005-0243-0004. From James D. Thrift, V.P., Regulatory Policy and Corporate Relations. 

• October 6, 2005: Comments on Flutriafol submitted to US EPA. Docket No. OPP-2005-0243. Submitted by Fluoride Action Network Pesticide Project. OPP-2005-0243-0005.