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Adverse
Effects
Abstracts
NTIS Reports
Local
battles
ACTIVITY:
Herbicide (unclassified)
CAS Name:
1-methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone
Structure:
Adverse
Effects:
Body
Weight Decrease
Bone
Dermal
Endocrine: Testicular
Eye
Kidney
Liver |
Environmental
Effects:
Toxic
to fish |
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
Yes |
US
EPA PC Code: |
112900
215900 (Old US EPA PC Code) |
California
Chemical Code |
2279 |
US
Tolerances: |
CFR
180.420 |
FDA
LMS Code: |
736 |
US
EPA Permit Date
and Registrant: |
1986,
Elanco |
European
Commission: |
Not
allowed to be used as an active ingredient after July 25,
2003. |
Registered
use in
(includes only a limited list of countries)
|
US |
US
Maximum Residue Levels permitted
in food commodities |
Permitted
in or on over 50 food commodities, including:
Avocado, Cattle, Citrus, Cotton, Crayfish,
Cucurbits, Egg, Fish, Fruit, Goat, Grain Crops, Grass (Forage),
Hog, Horse, Sheep, Legume (Forage), Milk, Nuts, Poultry, Vegetable:
(Leafy; Root Crop; Seed & Pod) |
Other
Information |
Molecular
Formula: |
C19H14
F3 NO |
Entry
Year: |
1976
|
Inventing
Company: |
Elanco
|
Manufacturers: |
Dow
Agro |
Other
Names: |
Avast
EL-171
Flurochloridone
Sonar X |
Of
special interest: |
PAN
Data |
New
-
Index to local battles. Newspaper
reports on community reactions to fluoridone proposals. |
New
- National
Technical Information Service (NTIS) Reports |
Material
Safety Data Sheets & Labels |
2002
- The effect of fluridone and flurochloridone on the incidence
of albinism in pea (Pisum sativum)
and on the abscission of leaves of privet (Ligustrum vulgare);
by S Klicova, J Sebanek, M Hudeova, H Vitkova, H Vlasinova,
Mendel University of Agriculture and Forestry in Brno, Czeck
Republic. Full
report. |
November
26, 2002 - European
Commission: Fluridone is one of 320 pesticides to be withdrawn
in July 2003. "Some 320 substances
used in plant protection products (PPPs) Ð including insecticides,
fungicides and herbicides Ð are to be withdrawn from the market
by 25 July 2003 as part of the European CommissionÕs new approach
to the evaluation of active substances in plant protection products.
This aims to improve safeguards to ensure that all such products
in use are safe for the environment and human health. Users,
wholesalers and retailers of plant protection products will
need to be aware of whether the
products they use or sell are likely to be withdrawn, so as
to prevent them being left with stocks of unusable material.
Those concerned should contact their national authority to check
the authorisation status for any particular product. The Regulation
(n¡ 2076/2002 of 20 November 2002), with the list of the 320
substances, has now been published in the Offical Journal. Ref:
MIDDAY EXPRESS. News from the Press and Communication Service's
midday briefing. |
1990
- Summary
of Toxicolgy Data. California EPA. |
1990
- US
EPA IRIS (Integrated Risk Information
System) |
EPA
Index of Cleared Science Reviews: 1978 to 1994. |
March
31, 1986 -
Chemical Fact Sheet
- Cornell Pesticide Management Education
Program |
June
29, 2001 - NY
State Environmental Quality Review (SEQR) statement of findings
of Lake George Park Commission for the Lake George Sonar demonstration
project. Note from EC. Caution: rarely
does NY SEQR find a problem with chemicals or proposals for
polluting industries. |
Abstracts |
Herbicide
Products - partial list |
Table
2 - Active Registrations for Fluridone as of 6/01/04
From: Aug 17, 2004 Human
Health Risk Assessment for Fluridone TRED. |
Product
|
Formulation
|
Reg Number
|
Company
Name |
% of Active
Ingredient |
Fluridone
Technical |
|
1812-426
|
Griffin
L.L.C. |
99.2 |
Fluridone
SC |
Liquid
Concentrate |
1812-435
|
Griffin
L.L.C. |
41.7 |
Fluridone
SRP |
Granular
|
1812-447
|
Griffin
L.L.C. |
5 |
Sonar |
Technical
|
67690-4
|
SePRO Corporation
|
99.2 |
Sonar SRP/5P
|
Granular
|
67690-3 |
SePRO Corporation
|
5 |
Sonar A.S.
|
Liquid
Concentrate |
67690-3
|
SePRO Corporation
|
41.7 |
Sonar X
|
Granular
|
67690-3 |
SePRO Corporation
|
5 |
Sonar*
Q Quick Release |
Granular
|
67690-3
|
SePRO Corporation
|
5 |
US
Federal Register |
Date
Published |
Docket
Identification Number |
Details |
October 5, 2007 |
No docket number |
Notice of Availability of the Record of Decision for the Final Programmatic Environmental Impact Statement for Vegetation Treatments Using Herbicides on Bureau of Land Management Lands in 17 Western States. The fluorinated herbicides included for use are diflufenzopyr and fluridone. (Of the six herbicides rejected for use is the fluorinated mefluidide.) As part of the Proposed Action and this decision, the BLM also adopts the protocol for identifying, evaluating and approving herbicides. Copies of the Record of Decision are available in hard copy or CD upon request from Brian Amme, Nevada State Office, P.O. Box 12000, 1340 Financial Blvd., Reno, NV 89520, or via the Internet at the BLM National Web site http://www.blm.gov/. The Record of Decision is available for review in either hard copy or on compact disks (CDs) at all BLM State, District, and Field Office public rooms.
This national, FPEIS provides a comprehensive analysis of BLM's use of chemical herbicides in its various vegetation treatment programs related to hazardous fuels reduction; noxious weed, invasive terrestrial and aquatic plant species management; resource rehabilitation following catastrophic fires, and other disturbances. The FPEIS addresses human health and ecological risk for use of chemical herbicides on public lands and provides a cumulative impact analysis of the use of chemical herbicides in conjunction with other treatment methods. The decision area includes public lands administered by 11 BLM state offices: Alaska, Arizona, California, Colorado, Idaho, Montana (North Dakota/South Dakota), New Mexico (Oklahoma/Texas/Nebraska), Nevada, Oregon (Washington), Utah and Wyoming.
• Draft PEIS, Part 1 AND Draft PEIS, Part 2. The PEIS provides a comprehensive programmatic NEPA document that addresses the primary controversial issue identified through scoping: the BLM’s continuing use and proposed increased use of herbicides in vegetation treatment programs that would implement the National Fire Plan and other related initiatives.
• Draft PER describes the environmental effects of using non-herbicide treatment methods, including prescribed fire and mechanical, manual and biological controls, on vegetation, watersheds, and fish and wildlife habitat on surface lands administered by the BLM in the western United States, including Alaska.
• Human Health Risk Assessment
• Ecological Risk Assessment Protocol and Assessments
• Draft Biological Assessment |
Sept 29,
2004 |
OPP-2004-0235 |
Tolerance
Reassessment Decision (TRED) documents for Low Risk Pesticide;
Notice of Availability.
-- N-methyl Formamide (NMF) is the most toxic and prevalent
of the fluridone metabolites and degradates. It is formed in
water by the photolysis of fluridone. The toxicology database
for NMF is limited to one developmental study that was reported
in the literature. This study indicated that NMF causes skeletal
malformations in both rats and rabbits with NOAEL of 10 mg/kg/day.
NMF is not a metabolite in foods
-- Nature of the Residue in Foods: Fluridone is not applied
directly to crops. However, residues of fluridone may get into
the U.S. food supply when water from treated ponds or lakes
is used to water crops. Fluridone residues could end up in livestock
commodities if livestock drink water that has been treated with
fluridone or if livestock consume crops that have been irrigated
with fluridone-treated water.
-- Fluridone and 4-hydroxyfluridone are the major degradates
in fish and are assumed to have approximately equivalent toxicity,
so both are included in the risk assessment and tolerance expression.
Benzoic acid and its 3-trifluroromethyl benzoic acid are aqueous
photolysis products found in laboratory studies conducted with
lake water. Although it would not have a toxicity profile similar
to the parent, there is not a concern for adverse health effects
at the levels found as a result of fluridone applications. Finally,
another aqueous photoproduct found in laboratory studies, N-methylformamide
(NMF), is more toxic than the parent compound and requires a
separate assessment.
(Aug 17, 2004 Human
Health Risk Assessment for Fluridone TRED.)
TRED
documents available for public comment |
Aug
17, 2004 |
Human
Health Risk Assessment for Fluridone TRED.
35
pages |
From:
Timothy
C. Dole,
CIH, Industrial Hygienist
Christine Olinger, Chemist
Paul Chin, Ph.D., Toxicologist
Reregistration Branch,
Health Effects Div. (7509C) |
PC
Code 112900.
DP Barcode D306456. |
Aug
12 , 2004 |
Fluridone
Acute and Chronic Dietary Exposure Assessments for the
Reregistration Eligibility Decision
8
pages |
REVIEWER:
Christine
L. Olinger, Chemist
Reregistration Branch,
Health Effects Div. (7509C) |
PC
Code: 112900
DP Barcode: D299947 |
April
1, 2004 |
Fluridone
and its major degradate, N-methyl formamide - Drinking
Water Assessment for the Health Effects Division (HED)
Reregistration Eligibility
Decision Document
7
pages |
From:
Ibrahim Abdel-Saheb, Ph.D.,
Agronomist
Peer
Reviewed By:
James Breithaupt, Agronomist
Approved By:
Tom Bailey,
Ph.D., Branch Chief,
Environmental Risk Branch, Environmental Fate and Effects
Div. (7507C) |
PC
Code: 112900
DP Barcode: D300012 |
Aug
30, 2004 |
FLURIDONE:
Toxicology Chapter for RED and Updating Executive Summaries
for 11 Studies
39
pages |
From:
Paul
Chin,
Ph.D.
Reregistration Branch,
Health Effects Div. 7509C |
PC
CODE: 112900
DP
BARCODE: D291522 |
Sept
20, 2004 |
Report
of the Food Quality Protection Act (FQPA) Tolerance
Reassessment
Progress and Risk Management Decision (TRED) for Fluridone
6
pages |
Submitted
by
Debbie Edwards, Ph.D.
Director
Special Review and Reregistration Div.
Contact
for futher information:
Wilhelmena Livingston |
US
EPA OPPT (7508C) |
|
Aug
4, 1997 |
OPP-300523 |
|
|