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Adverse Effects
ACTIVITY:
Herbicide (n-phenylphthalimide
or dicarboximide)
CAS Name
for
Flumiclorac:
[2-chloro-4-fluoro-5-(1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)phenoxy]acetic
acid
Structure
for
Flumiclorac:

Adverse
Effects:
Blood
Kidney
Liver
Phototoxic |
Environmental
Effects:
Highly
toxic to Zooplankton |
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
Yes |
US
EPA PC Code: |
128724 |
California
Chemical Code |
5090 |
US
Tolerances: |
CFR
180.477
CFR 186.3325 |
Registered
use in
(includes only a limited list of countries)
|
US
Australia (pending as of June 2005) |
US
Maximum Residue Levels permitted
in food commodities
|
Corn,
field, forage
Corn, field, grain
Corn, field, stover
Soybean, hulls
Soybean, seed |
Other
Information |
Entry
Year: |
1989 |
Inventing
Company: |
Sumitomo
/ Valent |
Manufacturers: |
Valent |
Pesticide
imported from: |
Sumitomo
Chemical Company, Ltd.
Tokyo, Japan |
Other
Names: |
Resource
S-23031
Stellar
Sumivere
V-23031 |
Of
special interest: |
PAN
Data |
Material
Safety Data Sheets & Labels |
December
2, 2005 - Comments
submitted to US EPA on new pesticide petition. |
June
7, 2005 - AUSTRALIA: Notice published by the Australian Pesticides
and Veterinary Medicines Authority (APVMA) soliciting comments
relating to the approval of flumiclorac-pentyl, "a new
active constituent for use in agricultural chemical products...
Initially, it is to be used in Australia as a pre-harvest
cotton defoliant... Comments must be received byAPVMA
within 28 days of the date of this Gazette."
Ref: Commonwealth
of Australia Gazette no. 6, 7 June 2005. |
US
EPA identifies Flumiclorac-pentyl in the category of a "Reduced-Risk
Pesticide" |
June
4, 2002 - A letter
from Valent to US Congressional Committee on Ways & Means
to support duty suspension on flumiclorac-pentyl. Includes
details on amount Valent imports each year (In 1995 = 56,129
kgs.) and the Duty paid by Valent. |
March
7, 2001 - Phototoxic
Pesticides: US EPA Memo Requesting
Phototoxicity Study Protocol for Light-Dependent Peroxidizing
Herbicides |
October
2001 - Glossary
of Pesticide Chemicals. A listing
of pesticides subject to analysis of residues in foods and feeds
by the US Food and Drug Administration. |
US
Federal Register |
Date |
Docket
No. |
Details |
March
8, 2006.
|
EPA-HQ-OPP-2005-0311 |
VALENT
U.S.A. Corporation.
Pesticide
Tolerance. FINAL
RULE.
Commodity |
Parts
per million |
Corn,
field, forage |
0.01 |
Corn,
field, grain |
0.01 |
Corn,
field, stover |
0.01 |
Cotton
gin by products |
3.0 |
Cotton,
undelinted seed |
0.2 |
Soybean,
hulls |
0.02 |
Soybean,
seed |
0.01 |
90-Day
oral toxicity-- nonrodents (dog) - increased
clotting time in females
Reproduction
and fertility effects (rat) - increased
kidney weight in males and females and nephropathy in males;
decreased body weight/body weight in
F2 pups
Chronic
toxicity-- dogs - decreased body weight
gain in male; increased clotting time, increased globulin
levels, and increased alpha-2 fraction of the serum protein
electrophoresis in females
Cytogenetics
- weak, positive response without activation |
Nov
30 , 2005 |
OPP-2005-0311 |
VALENT
U.S.A. Corporation.
Pesticide petition
PP 3F6767. Proposal to establish a tolerance for residues
of the herbicide flumiclorac pentyl ester, pentyl [2-chloro-4-
fluoro-5-(1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)phenoxy]-
acetate in or on
Commodity |
Parts
Per Million |
cotton,
undelinted seed |
0.1
ppm |
cotton,
gin by products |
2.0
ppm |
The residue
analytical method for enforcement purposes uses gas-liquid
chromatography with a thermionic-specific detector. The enforcement
method has been validated at an independent laboratory and
by EPA. The method has been submitted to the Food and Drug
Administration for publication in the Pesticide Analytical
Manual, Vol. II (PAM II).
Note:
see Comments
submitted to US EPA on this pesticide petition. |
Oct
19, 2005 |
OPP-2005-0229 |
This
notice announces the availability of EPA's Tolerance Reassessment
Decision (TRED) for the pesticide flumiclorac pentyl, and
opens a public comment period on this
document, related risk assessments, and other support documents.
EPA has reviewed the low risk
pesticide flumiclorac pentyl through a modified, streamlined
version of the public participation process that the Agency
uses to involve the public in developing pesticide tolerance
reassessment and reregistration decisions.
Flumiclorac
pentyl is a post-emergence herbicide used on field corn, soybeans
and non-crop areas, such as: industrial sites, airports, military
installations, roadsides and associated rights-of-way, and
other similar areas to control a selected group of broadleaf
weeds, specifically morning-glory and velvet leaf. Although
there are no labeled residential homeowner uses,
there is potential risk for non-occupational exposure from
other treated areas, such as golf courses, athletic fields,
recreational areas, schools, apartment buildings, etc.
Documents
made available for public comment: |
Title
of Report |
Docket
No. |
8-23-2005:
Report of the Food Quality Protection Act (FQPA) Tolerance
Assessment Progress and Risk Management Decision (TRED)
- 7 pages |
OPP-2005-0229-0002 |
6-28-2005:
HED [Health Effects Division] Chapter of the TRED
- 53 pages |
OPP-2005-0229-0003 |
6-24-2005:
Flumiclorac Pentyl. Residue Chem for the TRED
- 153 pages |
OPP-2005-0229-0005 |
6-24-2005:
Flumiclorac Pentyl TRED Product Chem Considerations -
8 pages |
OPP-2005-0229-0006 |
3-17-2005: Flumiclorac pentyl Tier 1 Drinking Water Assessment
- 13 pages
|
OPP-2005-0229-0007 |
3-17-2005…
Flumiclorac pentyl EFED Addendum No.1 to MRID#42169844
- 5 pages |
OPP-2005-0229-0008 |
|
May
24, 2000 |
OPP-300756 |
Consolidation
of Certain Food and Feed Additive Tolerance Regulations.
FINAL RULE. This final rule transfers certain
of the pesticide food and feed additive regulations that are
now in 40 CFR parts 185 and 186 to part 180. EPA is consolidating
these regulations because as a matter of law all of pesticide
tolerances are now considered to be regulated under section
408 of the Federal Food, Drug, and Cosmetic Act as amended
by the Food Quality Protection Act (Pub. L. 104-17) and they
no longer need to be separate. EPA is also amending 40 CFR
180.1 by adding a definition for the term ``food commodity.''
Commodity |
Parts
per million |
Corn,
field, grain |
0.01 |
Corn,
field, fodder |
0.01 |
Corn,
field, forage |
0.01 |
Soybean,
hulls |
0.02 |
Soybean,
seed |
0.01 |
|
August
4, 1997 |
OPP-300523 |
Pesticides
Subject to Tolerance Reassessment. |
Nov
30, 1994 |
PP
3F4234 and
FAP 3H5682/R2091 |
VALENT
- Pesticide
Tolerances and Feed Additive Regulation.. - FINAL RULE.
These rules establish tolerances for residues of the herbicide
flumiclorac pentyl in or on the raw agricultural commodities
field corn, grain; field corn, fodder; field corn, forage;
and soybean, seed at 0.01 ppm, and in or on the feed additive
commodity soybean hulls at 0.02 ppm. |
1993 |
|
VALENT
- Pesticide
Petition Tolerance for a feed additive regulation to permit
residues of Resource Herbicide in or on soybean hulls at 0.02
ppm. [Note from EC: The FR is not online for 1993. This comes
from a USDA bulletin on the PMEP website. |
RESOURCE
TM HERBICIDE
COMPOSITION/INFORMATION ON INGREDIENTS
Ref: Material Safety Data
Sheet |
Ingredient
Name (CAS #)
[Chemical Name] |
Weight
|
PercentExposure
Limit |
Ref. |
FLUMICLORAC
PENTYL ESTER*
(87546-18-7)
[Pentyl [2-chloro-4-fluoro-5-(1,3,4,5,6,7- hexahydro-1,3-dioxo-2H-isoindol-2-
yl)phenoxy]acetate] |
10.600 |
None |
- |
INERT
INGREDIENTS** |
89.400
|
None |
- |
*Active Ingredient
**Inert ingredients, which are maintained as trade secrets,
are any substance other than an active ingredient contained
in this product. Some of these may be hazardous, but their identity
is withheld because they are considered trade secrets. The hazards
associated with the inert ingredients are addressed in this
document. Specific information on inert ingredients for the
management of exposures, spills, or safety assessments can be
obtained by a treating physician or nurse by calling 1-800-892-0099
at any time. |
Stellar
(R) Herbicide
COMPOSITION/INFORMATION ON INGREDIENTS
Ref: Material
Safety Data Sheet |
Ingredient
Name (CAS #)
[Chemical Name] |
Weight
Percent |
Exposure
Limit |
Ref. |
Flumiclorac
Pentyl (7.6%) and Lactofen (26.6%)*
( ) [-] |
34.230 |
None |
- |
INERT
INGREDIENTS** |
65.770 |
None |
- |
*Active
ingredient.
**Inert Ingredients, which are maintained as trade secrets,
are any substance other than an active ingredient contained
in this product. Some of these may be hazardous, but their identity
is withheld because they are considered trade secrets. The hazards
associated with the inert ingredients are addressed in this
document. Specific information on inert ingredients for the
management of exposures, spills, or safety assessments can be
obtained by a treating physician or nurse by calling 1-800-892-0099
at any time. |
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