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Flumetralin Adverse Effects
ACTIVITY:
Plant growth regulator (2,6-Dinitroaniline)
CAS Name:
2-chloro-N-[2,6-dinitro-4-(trifluoromethyl)phenyl]-N-ethyl-6-fluorobenzenemethanamine
Structure:
| Environmental
Effects:
Acute
aquatic toxicity |
Regulatory
Information
(only comprehensive for the US) |
| US
EPA Registered: |
Yes |
| US
EPA PC Code: |
123001 |
| California
Chemical Code |
5085 |
| FDA
LMS Code: |
834 |
US
EPA Permit Date
and Registrant: |
1983,
Ciba Geigy |
| European
Commission: |
Not
allowed to be used as an active ingredient after July 25,
2003. |
Registered
use in
(includes only a limited list of countries)
|
US |
US
approved use
|
Tobacco
plants |
| Other
Information |
| Molecular
Formula: |
C16H12Cl
F4 N3O4 |
| Entry
Year: |
1977 |
| Inventing
Company: |
Ciba
Geigy |
| Manufacturers: |
Novartis/Rhone
Poulenc, Drexel, Syngenta |
| Other
Names: |
CGA
41065
Premier
Prime
BENZENEMETHANAMINE,
2-CHLORO-N-(2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL)-N-ETHYL-6-FLUORO-
CHLORO-N-(2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL)-N-ETHYL-6-FLUOROBENZENEMETHANAMINE |
| Of
special interest: |
| PAN
Data |
2005
- Schedule for Reregistration & Tolerance Reassessment (RED)
is expected to be December 2007. Contact at EPA: Diane Isbell
(703) 308-8154; isbell.diane@epa.gov . According to EPA:
Through the pesticide reregistration and tolerance reassessment
programs, EPA is assessing risks and making risk management
decisions for older pesticides. These decisions are summarized
in documents known as REDs, IREDs, and TREDs. By making decisions
according to the schedule below, EPA will meet its statutory
deadlines for completing reregistration and tolerance reassessment.
Some of the decision dates presented in the schedule may change
due to the dynamic nature of the review process. Any pesticide
decisions that are not completed during the current fiscal year
will be rescheduled for the following year. EPA is committed
to meeting its reregistration and tolerance reassessment deadlines.
http://www.epa.gov/pesticides/reregistration/decision_schedule.htm
|
| November
26, 2002 - European
Commission: Flumetralin is one of 320 pesticides to be withdrawn
in July 2003."
Some 320 substances used in plant protection
products (PPPs) Ð including insecticides, fungicides and herbicides
Ð are to be withdrawn from the market by 25 July 2003 as part
of the European CommissionÕs new approach to the evaluation
of active substances in plant protection products. This aims
to improve safeguards to ensure that all such products in use
are safe for the environment and human health. Users, wholesalers
and retailers of plant protection products will need to be aware
of whether the products they use or sell are likely to be withdrawn,
so as to prevent them being left with stocks of unusable material.
Those concerned should contact their national authority to check
the authorisation status for any particular product. The Regulation
(n¡ 2076/2002 of 20 November 2002), with the list of the 320
substances, has now been published in the Offical Journal. Ref:
MIDDAY EXPRESS. News from the Press and Communication Service's
midday briefing. |
| 1995
-
Data on "Prime" containing
Flumetralin as the active ingredient. It
is used as a plant growth regulator on Tobacco plants. Virginia
Department of Health DIVISION OF HEALTH HAZARDS CONTROL |
| 1981
- 1998 -
US EPA Index of Cleared
Science Reviews. |
| Glossary
of Pesticide Chemicals, October 2001.
A listing of pesticides subject to analysis of residues in foods
and feeds by the US Food and Drug Administration. |
Rationale
for US EPA to add Flumetralin to the Toxic Release Inventory
Flumetralin
(2-chloro-N-(2,6-dinitro-4-(trifluoromethyl)- phenyl)-N-ethyl-6-fluorobenzenemethanamine).
Aquatic acute toxicity values for flumetralin include a
daphnid 48-hour EC 50 of greater than 2.8 ppb, a bluegill
sunfish 96-hour LC 50 of greater than 3.2 ppb, and a rainbow
trout 96-hour LC 50 of greater than 3.2 ppb. EPA believes
that there is sufficient evidence for listing flumetralin
on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C)
based on the available environmental toxicity data for this
chemical.
Ref:
USEPA/OPP. Support Document for the Addition of Chemicals
from Federal Insecticide, Fungicide, Rodenticide Act (FIFRA)
Active Ingredients to EPCRA Section 313. U. S. Environmental
Protection Agency, Washington, DC (1993).
As cited by US EPA in:
Federal
Register: January 12, 1994. Part
IV. 40 CFR Part 372. Addition of Certain Chemicals; Toxic
Chemical Release Reporting; Community Right-to-Know; Proposed
Rule.
Note:
Addition
of Certain Chemicals; Toxic Chemical Release Reporting;
Community Right-to-Know. Final
Rule.
Flumetralin
was included in the deferral of 40 chemicals: EPA
is deferring final action on 40 chemicals and one chemical
category until a later date. These chemicals and the comments
received on them raised particularly difficult technical
or policy issues which will require additional time to address.
The Agency does not believe that it would be in the spirit
of community right-to-know to delay final action on the
remaining 286 chemicals and chemical categories, pending
completion of work on the more limited group. In a future
rulemaking, EPA will make a final determination as to whether
these chemicals should be added to EPCRA section 313. The
public comment that has been received specific to these
deferred chemicals will be addressed as part of the future
rulemaking discussed above.
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