CAS No. 101463-69-8

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Adverse Effects

ACTIVITY: Acaricide, Insecticide (Benzoylurea)

CAS Name: N-[[[4-[2-chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl]amino]carbonyl]-2,6-difluorobenzamide


Adverse Effects:


Endocrine: Adrenal
Endocrine: Ovary
Endocrine: Testicular
Endocrine: Thyroid


Environmental Effects:

Persists in soil

Extremely toxic to Daphnia (Aquatic Invertebrate)

Potential to bioaccumulate in fish and aquatic gastropods

Regulatory Information
(only comprehensive for the US)
US EPA Registered: YES
(for certain imports)
US EPA PC Code: 108203 
Registered use in
(includes only a limited list of countries)

Australia, Hungary, India, Japan, Philippines, Portugal, Tanzania, South Africa, US, Vietnam
US Imported-- Apple, Cattle, Goat, Grape, Horse, Milk, Orange, Pear, Raisin, Sheep
Japan's Maximum Residue Levels (MRLs)

Apple, Brussel Sprouts, Cabbage, Celery, Cherry, Cotton seeds, Cucumber, Eggplant, Grape, Grapefruit, Multiplying onion (inc Shallot), Lemon, Lime, Melons, Mushrooms (other than Shitake or Button), Natsudaidai (whole), Other Citrus fruits, Orange, Peach, Japenese pear, Pear, Radish (Japanese), Strawberry, Sugar beet, Tea, Tomato, Unshu orange, Welsh (inc Leek)

-- Note very high levels - 15 ppm - in Tea (Green, Black, Oolong, Wulung) 

Other Information
Molecular Formula: C21H11Cl F6 N2O3 
Entry Year: 1993 
Manufacturers: SOREX, Cyanamid, BASF
Other Names: Casade, Europe, Sigona,
Tenopa, WL-115110
Manufacture site: FRANCE: SNPE, Toulouse 
Of special interest:
PAN Data 
September 2006: USEPA Fact Sheet on flufenoxuron.

August 15, 2006. US EPA Human Health Risk Assessment for proposed tolerances on apples, pears, grapes, organges and livestock commodities imported into US. 63 pages.

2,6,-difluorobenzoic acid
4-(2-chloro,á, á, á trifluoro-p-tolyoxy)-2-fluorophenyl urea (WL129183)
4-(2-chloro,á, á, á rifluoro-p-tolyoxy)-2-fluoroaniline (WL15096)

• The database is adequate for establishment of tolerances on the requested commodities, except for a developmental toxicity study in rat which was classified as unacceptable/guideline. However, this study provides adequate information to conclude that flufenoxuron was not fetotoxic at doses up to the limit dose. Only an acute oral toxicity study in rat was submitted, which was placed in Toxicity Category IV. Acute toxicity studies are not required for import tolerance.

December 1995 - Evaluation of Flufenoxuron use as a public hygiene insecticide. UK: Health and Safety Executive, Biocides & Pesticides Assessment Unit, Magdalen House, Stanley Precinct, Bootle, Merseyside L20 3QZ. Available at http://www.pesticides.gov.uk/citizen/evaluations/143_confirm-box.htm 
Glossary of Pesticide Chemicals, October 2001. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration. 
Active ingredient in TENOPA-- Data Safety Sheet at http://www.sorex.com/site/home.htm 

European Union: Rapid Alert System for Food and Feed

Alert Notifications are sent when the food or feed presenting the risk is on the market and when immediate action is required. Alerts are triggered by the Member State that detects the problem and has initiated the relevant easures, such as withdrawal/recall. The notification aims at giving all the members of the network the information to verify whether the concerned product is on their market, so that they also can take the necessary measures.

The following information was released in June 2005 - see

Date: Notified By: Ref: Reason for Notifying Country of Origin:
03/06/2005 Germany 2005.BND flufenoxuron in sultanas TURKEY

US Federal Register

Published date Docket Identification Number Details
September 29, 2006 EPA-HQ-OPP-2005-0543

BASF. Pesticide Tolerance. FINAL RULE.

Commodity PPM
Apple\1\ 0.50
Cattle, fat\1\ 4.5
Cattle, meat\1\ 0.10
Cattle, meat byproducts\1\. 0.50
Goat, fat\1\. 4.5
Goat, meat\1\ 0.10
Goat, meat byproducts\1\ 0.50
Grape\1\ 0.70
Grape, raisin\1\ 2.0
Horse, fat\1\ 4.5
Horse, meat\1\ 0.10
Horse, meat byproducts\1\ 0.50
Milk 0.20
Milk, fat\1\ 4.0
Orange\1\ 0.30
Orange, oil\1\ 60
Pear\1\ 0.50
Sheep, fat\1\ 4.5
Sheep, meat\1\ 0.10
Sheep, meat byproducts\1\ 0.50
\1\There are no U.S. registrations as of September 30, 2006.

• August 15, 2006. US EPA Human Health Risk Assessment for proposed tolerances on apples, pears, grapes, organges and livestock commodities imported into US. 63 pages.
• September 2006: USEPA Fact Sheet on flufenoxuron.

April 19, 2006 EPA-HQ-OPP-2005-0543

BASF. Pesticide petition: PP 8E4943.
in or on food commodities
-- apple and pear at 1.0 ppm
-- orange at 0.3 ppm
-- orange oil at 60.0 ppm
-- grape at 0.2 ppm
-- raisin at 0.8 ppm
-- cattle meat at 0.30 ppm
-- cattle meat by-products at 1.5 ppm
-- fat at 6.0 ppm
-- milk at 0.6 ppm
-- milk fat at 3.0 ppm


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