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Adverse Effects
Abstracts
MSDS /Labels
ACTIVITY:
Fungicide (pyrrole)
NOTE:
Chlorfenapyr
is also classified as a Pyrrole
CAS Name:
4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile
Structure:
Adverse
Effects:
Body
Weight Decrease
Cancer:
"currently unclassifiable" -
statistically significant trend for malignant
LYMPHOMAS in female mice; statistically significant increases
in LIVER tumors in female rats
Cholesterol
Endocrine:
Ovary
Endocrine:
Thymus
Genotoxic
Kidney
Liver
Spleen
|
Environmental
Effects:
Fludioxonil
is classed as 'very persistent' in soil
Relatively
high aquatic toxicity to fish, aquatic invertebrates and aquatic
plants |
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
Yes |
US
EPA PC Code: |
071503 |
California
Chemical Code |
5027 |
US
Tolerances: |
CFR
180.516 |
FDA
LMS Code: |
B23 |
US
EPA Permit Date
and Registrant: |
1996,
Ciba Geigy |
Registered
use in
(includes only a limited list of countries)
|
Australia,Canada,Japan,
US
EU (all except Austria) |
Japan's
Maximum Residue Levels (MRLs) |
Apricot,
Barley, Beans (dry), Broad beans, Buckwheat, Cherry, Corn, Cucumber,
Eggplant, Grape, Lettuce, Nectarine, Onion, Other Legumes/ pulses,
Peach, Peanuts (dry), Peas, Plum, Potato, Rice, Rye, Soybeans
(dry), Strawberry, Tomato, Wheat |
US
Maximum Residue Levels permitted
in food commodities |
US
-
permitted in or on 948 food commodities. |
Maximum
Residue Levels permitted
in food commodities
(includes
only a limited list of countries)
|
Australia:
Grape
Canada:
Too many to list - see
list as reported on
July 19, 2005
UK
Import Tolerances: click
here
Strawberry: 2 ppm (as
of 2003)
Table & wine grapes: 2 ppm (as
of 2003)
Plum, Cherry, Peach: 1 ppm (as
of 2005)
Kiwi fruit: 10 ppm (as
of 2005)
|
Other
Information |
Molecular
Formula: |
C12H6
F2 N2O2 |
Entry
Year: |
1995 |
Inventing
Company: |
1996,
Ciba Geigy |
Manufacturers: |
Syngenta
(Novartis) |
Other
Names: |
CGA
173506
Fludioxonyl |
Manufacture
site: |
SWITZERLAND:
formerly: Novartis, Werk Schweizerhalle, Pratteln
As
of April 2003
SWITZERLAND:
Syngenta
Crop Protection Schwiezerhalle AG Werk Schweizerhalle Rheinfelderstrasse
CH-4133 Pratteln |
Of
special interest: |
PAN
Data |
•
new - Fludioxonil:
Material Safety Data Sheets and Labels |
2006.
Switch
62.5 WG fungicide product containing fludioxonil: Regulatory
Note. REG 2006-08. Canada Pest Management Regulatory Agency.
|
July
19, 2005 - Canada.
Reduced-Risk Update. Report: RR2005-02. Canada Pest Management
Regulatory Agency (PMRA).
See excerpted list of
fluorinated pesticides. |
December
1, 2004 - Regulations Amending the Food and Drug Regulations
(1371 — Fludioxonil). Canada Gazette Part II. Vol. 138,
No. 24, pages 1775 - 1777.
http://canadagazette.gc.ca/partII/2004/20041201/pdf/g2-13824.pdf
|
1995
- Evaluation of Fludioxonil. UK
Department for Environment, Food and Rural Affairs, Pesticides
Safety Directorate, Mallard House, Kings Pool, 3 Peasholme Green,
York YO1 7PX. March 1995. Note: this pdf document is large with
no search engine Available at:
http://www.pesticides.gov.uk/PSD_PDFs/Evaluations/126_fludioxonil.pdf
|
April
29, 2000. UK Department for Environment, Food & Rural Affairs
in the online report, "Design
of a Tax or Charge Scheme for Pesticides." Annex C3:
Overview of Pesticide Industry |
April
2002 -
Beer in the UK: 23 organofluorine
pesticides approved for use on malting barley.
Published by the British Beer and Pubs
Association and Brewing Research International. |
March
14, 2002 -
Findings above the maximum concentration
in lettuce grown in EU countries:
An oak leaf lettuce exceeded the tolerance
values for the fungicides fludioxonil
and cyprodinil and was also the subject
of a complaint for this reason.
á Clear residues of fludioxonil
and cyprodinil were detected in an organic
endive lettuce. Both pesticides are not allowed in organic farming.
Ref: Report No. 6, Joint campaign for Basel city (specialist
laboratory) and Basel country (Switzerland). http://www.kantonslabor-bs.ch/files/75/E_PesticideResidues.pdf |
Fungicide
products - partial list |
September
19, 2001 -
Schedule No. 1255. Canada. Food and Drug Regulations.- Maximum
Residue Limits on potatoes, mustard, rapeseed, (canola). This
amendment will also establish MRLs in fat, kidney, liver and
meat of cattle, goats, hogs, horses and sheep; and milk to cover
residues in food derived from animals fed with crops treated
with fludioxonil. |
1999
-
Levels
of Fludioxonil Allowed in Wine (by country) -
The Australian Wine Research Institute |
One
of 8 fluorinated pesticides used to cultivate grapes in Australia. |
April
22, 2003 -
Registration of Syngenta's
SCHOLAR FUNGICIDE in New York State |
April
2000 - Food
and Drug Administration Pesticide Residue Monitoring.
- Table 3. Pesticides detectable by methods used in 1999 regulatory
monitoring. |
Abstracts |
August
2001 - IR-4:
New Products/Transitional
Solution List - This
list contains brief descriptions of numerous new pest control
materials that have been introduced over the last several years.
Additionally, it contains information on some "older"
crop protection chemicals that are believed to have room for
new uses. This List includes:Fludioxonil
|
Table
1. Combinations of crops and pesticides that exceed the MRLs
most frequently.
Ref: Report
of Pesticide Residue Monitoring Results of the Netherlands for
2001. Concerning Directive 90/642/EEC, 86/362/EEC and Recommendation
2001/42/EU. |
Product |
Pesticide |
number
of samples |
% samples
>MRL |
MRL |
main country
of origin |
Cucumber |
oxadixyl |
53 |
7.5 |
0,05 * |
Spain |
Grape |
fludioxonil
|
180
|
10,6
|
0,05
* |
Italy |
Grape |
penconazole |
180 |
6,1 |
0,02 * |
Italy |
Grape |
pyrimethanil
|
180 |
9,4 |
0,05 * |
Italy,
South Africa |
Grape |
tebuconazole |
180 |
2,2 |
0,05 * |
Italy |
Pepper
|
cypermethrin |
54 |
7,4 |
0,5 * |
Thailand
|
Pepper
|
methamidophos
|
54 |
16,7 |
0,01 * |
Thailand |
Pineapple |
triadimefon |
22 |
27,3 |
0,05 * |
Costa Rica |
Pineapple |
triadimenol |
22 |
22,7 |
0,1 * |
Costa Rica |
*
MRL at LOD |
US
Federal Register
••
Note: Due to length, the following is a partial
list. Click here
to see full list of FR entries.
|
Published
Date |
Docket
Identification Number |
Details |
October 24, 2007 |
EPA-HQ-OPP-2007-0940 |
IR-4. Petition for New Tolerances. Pesticide Petition: PP 7E7234. Proposal for tolerances in or on food commodities
-- tomato - 0.4 ppm
-- tomatillo- 0.4 ppm
--
tomato, paste - 1.0 ppm
--
avocado - 0.45 ppm
-- black sapote - 0.45 ppm
--
canistel - 0.45 ppm
--
mamey sapote - 0.45 ppm
--
mango - 0.45 ppm
--
papaya - 0.45 ppm
--
sapodilla - 0.45 ppm
-- star apple - 0.45 ppm
-- • herb, subgroup 19A, fresh - 13 ppm (currently 10 ppm)
-- • herb, subgroup 19A, dried - 55 ppm (currently 65 ppm)
--
leaves of root and tuber vegetables - 40 ppm
-- •• root vegetables, except sugar beet subgroup - 0.5 ppm
--
lemon - 0.25 ppm
--
lime - 0.25 ppm
--
cucurbits - 0.6 ppm
-- ••• tuberous and corm vegetables, except potato subgroup - 4.0 ppm
• Subgroup 19a includes 42 commodities: angelica • balm • basil • borage • burnet • camomile • catnip • chervil dried • chive • chive, chinese • clary • coriander, leaf • costmary • culantro leaf • culantro leaf • culantro leaf • curry • dillweed • dillweed herbs, dried • herbs, fresh • horehound • hyssop • lavender • lemongrass • lovage leaf • marigold • marjoram • nasturtium • parsley dried • pennyroyal • rosemary • rue • sage • savory, summer • savory, winter • sweet bay • tansy • tarragon • thyme • wintergreen • woodruff • wormwood
•• This subgroup (1B) includes 19 commodities: beet, garden • burdock, edible • carrot • carrot culls • celeriac • chervil, turnip rooted • chicory root • ginseng • horseradish • parsley, turnip rooted • parsnip • radish • radish, oriental • rutabaga • salsify • salsify, black • salsify, spanish • skirret • turnip
••• This subgroup (1D) includes 16 commodities: arracacha • arrowroot • artichoke, chinese • artichoke, jerusalem • canna, edible • cassava • chayote root • chufa • dasheen • ginger • leren • sweet potato • tanier • turmeric • yam bean • yam, true
Syngenta has developed and validated analytical methodology for enforcement purposes. This method (Syngenta Crop Protection Method AG-597B) has passed an Agency petition method validation for several commodities, and is currently the enforcement method for fludioxonil. |
October 24, 2007 |
EPA-HQ-OPP-2007-0940 |
IR-4. Amendment to Existing Tolerances. Pesticide Petition: PP 7E7234. Upon approval of request of new tolerances (see above), this proposal requests an amendment of tolerances in 40 CFR 180.516 by removing the established tolerances for residues of the fungicide fludioxonil in or on the food commodities
-- herb, subgroup 19A, fresh at 10 ppm
-- herb, subgroup 19A, dried at 65 ppm
--
carrot at 0.75 ppm
-- turnip, greens at 10 ppm |
May
18, 2005 |
OPP-2005-0095 |
IR-4.
Pesticide
tolerance for pomegranate (post-harvest) at 5 ppm.
FINAL RULE.
In the
Federal Register of March 17, 2004, EPA issued a notice announcing
the filing of a pesticide petition (PP
3E6803) by IR-4, 681 US Highway #1 South, North Brunswick,
NJ 08902-3390. The petition requested
that 40 CFR 180.516 be amended by establishing a tolerance
for residues of the fungicide fludioxonil
in or on pomegranate at 2.0 parts per million (ppm).
This petition has subsequently been
amended to propose
pomegranate (post-harvest) at 5.0 ppm.
That notice included a summary of the
petition prepared by Syngenta Crop Protection, the
registrant. There were no comments received
in response to the notice of filing.
Commodity |
PPM
Final Rule |
PPM
Proposed March
17, 2004 |
Pomegranate
(post-harvest) |
5.0 |
2.0 |
|
Nov
10, 2004 |
OPP-2004-0232 |
Pesticide
Emergency Exemption.
• California
- EPA authorized the use of fludioxonil
on pomegranates to control
gray mold; August 1, 2004 to December 15, 2004. Contact: (Andrew
Ertman)
|
Sept
29, 2004 |
OPP-2004-0321 |
IR-4.
Pesticide Tolerances.
FINAL RULE. The
nature of the toxic effects caused by fludioxonil as well
as the no observed adverse effect level (NOAEL) and the lowest
observed adverse effect level (LOAEL) from the toxicity studies
reviewed are discussed in the Federal
Register of December 29, 2000. In
the Federal Register of March
17, 2004, EPA issued a notice announcing the filing of
pesticide petitions (PP 3E6551, 3E6639, 3E6701, 3E6742, and
3E6803) by IR-4. That notice included a summary of the petitions
prepared by Syngenta Crop Protection,
Incorporated, the registrant. Subsequently,
PP 3E6803 has been amended to delete citrus, dried pulp at
20 ppm, and pomegranate at 2.0 ppm. In addition, ``citrus,
oil'' at 500 ppm, and ``yam'' at 8.0 ppm has been translated
to ``grapefruit, oil'' at 500 ppm, and ``yam, true'' at 8.0,
respectively.
Commodity
|
Parts
per million |
Bean,
dry |
0.4 |
Bean,
succulent |
0.4 |
Citrus,
crop group 10
This
group includes:
calamondin • citron, citrus • citrus •
citrus hybrids • citrus hybrids, dried pulp •
citrus hybrids, juice • citrus hybrids, oil •
citrus, dried pulp • citrus, juice • citrus,
meal • citrus, molasses • citrus, oil •
fruit • fruit, citrus • fruit, citrus, dried
pulp • fruit, citrus, except mandarin •
fruit, citrus, postharvest • grapefruit •
grapefruit, dried pulp • grapefruit, juice •
grapefruit, oil • kumquat • lemon •
lemon, dried pulp • lemon, juice • lemon,
oil • lime • lime, dried pulp • lime,
juice • lime, oil • mandarin, satsuma •
orange, sour • orange, sour, dried pulp •
orange, sour, juice • orange, sour, oil •
orange, sweet • orange, sweet, dried pulp •
orange, sweet, juice • orange, sweet, oil •
pummelo • tangelo • tangerine |
10 |
Fruit,
pome, group 11
This
group includes:
apple • apple, dried pomace • apple, juice
• apple, wet pomace • crabapple •
fruit, pome • loquat • mayhaw • pear
• pear, oriental • quince |
5.0 |
Grapefruit,
oil |
500 |
Kiwifruit
|
20 |
Leafy
greens subgroup 4A, except spinach
This
group includes:
amaranth, grain • arugula • chervil •
chrysanthemum, edible leaved • chrysanthemum,
garland • corn salad • cress, garden •
cress, upland • dandelion • dock •
endive • lettuce • lettuce, head •
lettuce, leaf • orach • parsley •
purslane, garden • purslane, winter • radicchio
• spinach • spinach, chinese • spinach,
new zealand • spinach, vine • tampala |
30 |
Melon
subgroup 9A
This
group includes:
cantaloupe • citron melon • melon •
melon, citron • muskmelon • watermelon |
0.03 |
Yam,
true |
8.0 |
|
••
Note: Due to length, the above is a partial list.
Click here
to see full list of FR entries.
|
|