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Fluchloralin. Chemical Fact Sheet. Cornell U. PMEP. June 30, 1985.
CHEMICAL FACT SHEET FOR: FLUCHLORALIN FACT SHEET NUMBER: 52 DATE ISSUED: JUNE 30, 1985 1. DESCRIPTION OF CHEMICAL - Generic Name: Fluchloralin - Common Name: fluchloralin - Trade Name: Basalin - EPA Shaughnessy Code: 108701 - Chemical Abstracts Service (CAS) Number: 33245-39-5 - Year of Initial Registration: 1970 - Pesticide Type: Herbicide - Chemical Family: chloroaniline - U.S. and Foreign Producers: BASF Wyandotte, Inc. 2. USE PATTERNS AND FORMULATIONS - Application sites: Dry and succulent peas and beans, cotton, okra, peanuts, soybeans, and sunflowers. - Types of formulations: Emulsifiable concentrate (4 lbs. a.i. per gallon). - Types and methods of application: Preplant broadcast or banded spray, using ground equipment. Soil incorporation recommended. - Application rates: 0.5-1.5 lbs. a.i./A on beans (including soybeans), okra, peas, peanuts, and sunflowers. - Usual carriers: Water 3. SCIENCE FINDINGS Chemical Characteristics - Physical state: crystalline solid - Color: orange-yellow - Odor: faint, unusual - Melting point: 42-43 C - Solubility (at 20 C): ethyl acetate >100 g/100 g, benzene 100 g/ 100 g, cyclohexane 25.1 g/100 g, ether >100 g/100 g, acetone >100 g/100 g, chloroform >100 g/100 g, ethanol 17.7 g/100 g, water <7 g/100 g. - Vapor pressure: 6 x 10(-6) mm Hg at 20 degrees C, 2.5 x 10(-5) mm Hg at 30 degrees C - Stability: Sensitive to ultraviolet light. Stable in aqueous solution over range of pH 5 to 9. Toxicological Characteristics - Acute effects: - Acute oral LD50: data gap - Acute dermal LD50: data gap - Dermal irritation: data gap - Acute inhalation toxicity: data gap - Primary eye irritation: data gap - Chronic effects: - Oncogenicity: data gap - Teratology: data gap - Reproductive effects: data gap - Mutagenicity: data gap - Feeding studies: data gap - Major routes of exposure: dermal, ocular, and ingestion. Physiological and Biochemical Behavioral Characteristics - Foliar absorption: Not applicable; fluchloralin is soil- incorporated. - Translocation: Residues are taken up and translocated through the roots and shoots of cotton and soybean plants. Parent compound and some metabolites have been identified in cotton and soybean foliage following exposure of the roots to fluchloralin. - Mechanism of pesticidal action: Believed to affect seed germination and other physiological growth processes. - Metabolism and persistence in plants and animals: Plant metabolism is not adequately understood. Fluchloralin residues did not transfer to ruminant tissues at exaggerated rates (67 X the expected intake by beef cattle). Degradation in animals is stepwise through N-dealkylation and N-hydrolysis. Environmental Characteristics - Adsorption and leaching in basic soil types: Fluchloralin (unaged) and fluchloralin residues (aged 30 days) are relatively immobile to slightly mobile in loamy sand and sandy soils, but the degradate 2,6-dinitro-4-trifluoromethylphenol is highly mobile in loamy sandy soil and mobile in sandy clay loam soil. Fluchloralin is slightly mobile in runoff from plots (5-12% slope) of silt loam soil. - Microbial breakdown: No data - Loss from photodecomposition and/or volatilization: Fluchloralin photodegrades rapidly (half-life 27 minutes) in water (pH 5.6) when exposed to artificial sunlight. Photodegradation of solid fluchloralin film is slower (half-life 48 hours in artificial sunlight). No valid volatilization data are available. - Bioaccumulation: No valid data - Resultant average persistence: Half-life ranges from <32 to 120 days, depending on soil type. - Half-life in water: Stable in water over pH range from 5.0 to 9.0, if not exposed to light Ecological Characteristics - Hazards to birds: data gap - Hazards to aquatic invertebrates: data gap - Hazards to fish: High toxicity poses potential threat to fish populations. Hazard cannot be evaluated until receipt of certain environmental fate data. - Potential problems with endangered species: USDI has made a jeopardy assessment, finding threats to slackwater darter and 11 freshwater mussels from use of fluchloralin on soybeans. Tolerance Assessment - List of crops and tolerances: Crop Tolerance (ppm) Cotton, seed 0.05N Peanuts 0.05 Peanuts, forage 0.05 Peanuts, hay 0 05 Peanuts, hulls 0.1 Soybeans 0.05N Sunflower, seeds 0.05 Vegetables, seed & pod (dry/succulent) 0.05 Vegetables, seed & pod, forage 0.1 Vegetables, seed & pod, hay 0.1 NOTE: N = negligible - List of food contact uses: beans (dry and succulent), okra, peas (dry and succulent), peanuts, soybeans, and sunflower seeds. - Results of tolerance assessment: Current PADI is 0.0026 mg/kg/day, based on a NOEL of 5.250 mg/kg/day (210 ppm) and an LEL of 15.75 mg/kg/day (hemisiderosis in the liver) using a safety factor of 2000. The portion of the PADI currently occupied is <3%. However, the feeding study on which the PADI was based has been declared invalid, and no other toxicological data are available. Problems Known to have Occurred from Use - No PIMS data available. Summary Science Statement No valid acute or chronic toxicity data are available. One metabolite has shown potential for leaching through soil, but the toxicological properties of this metabolite are unknown. Toxicity to fish is very high. 4. SUMMARY OF REGULATORY POSITION AND RATIONALE - Use classification: Not classified - Use, formulation, or geographic restrictions: Manufacturing-use products may only be formulated into end-use products intended for use as a herbicide on dry and succulent peas and beans, cotton, okra, peanuts, soybeans, and sunflowers. - Unique label warning statements: - Use pattern statements: Labels of manufacturing-use products must bear the statement: For formulation into end-use herbicide products intended only for use on kidney, lima, navy, green, pinto, or Great Northern beans, or edible soybeans, blackeyed, cow, field, or garden peas, cotton, okra, peanuts, or sunflowers. - Precautionary statements: - Labels of manufacturing-use products must bear the statement: Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or public waters unless this product is specifically identified and addressed in an NPDES permit. Do not discharge effluent containing this product to sewer systems without notifying the sewage treatment plant authority. For guidance, contact your State Water Board or Regional Office of the EPA. - The labels of all end-use products must bear the statement: Do not apply directly to water. Do not contaminate water by cleaning of equipment or disposal of wastes. 5. SUMMARY OF MAJOR DATA GAPS Data Requested Due Date* Statement of composition 6 months Discussion of formation of impurities 6 months Preliminary analysis 12 months Certification of limits 12 months Analytical methods for enforcement of limits 12 months Density, bulk density, or specific gravity 6 months Dissociation constant 6 months Octanol/water partition coefficient 6 months pH 6 months Stability 6 months Metabolism in plants 24 months Residue, dill, crop field trials 24 months Residue, okra, crop field trials 24 months Hydrolysis 9 months Photodegradation on soil 9 months Anaerobic soil 27 months Leaching and adsorption/desorption 12 months Field dissipation, soil 27 months Accumulation, confined rotational crops 39 months Accumulation, field rotational crops 50 months Accumulation in fish 12 months Acute oral toxicity 9 months Acute dermal toxicity 9 months Acute inhalation toxicity 9 months Primary eye irritation 9 months Primary dermal irritation 9 months Dermal sensitization 9 months 21-day dermal toxicity 12 months Chronic toxicity, rodent and non-rodent 50 months Oncogenicity, 2 species 50 months Teratogenicity 15 months Reproduction, 2-generation 39 months Gene mutation 9 months Chromosomal aberration 12 months Other mechanisms of mutagenicity 12 months General metabolism 24 months NOTES: *Number of months after issuance of the Standard. **A study has been submitted, but not yet reviewed. 6. CONTACT PERSON AT EPA Robert Taylor TS-767C U.S. EPA 401 M Street S.W. Washington, DC 20460 (703) 557-1800 DISCLAIMER: THE INFORMATION PRESENTED IN THIS CHEMICAL INFORMATION FACT SHEET IS FOR INFORMATIONAL PURPOSES ONLY AND NOT TO BE USED TO FULFILL DATA REQUIREMENTS FOR PESTICIDE REGISTRATION AND REREGISTRATION.
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