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| Order
No. |
Title |
Absract
/ Keywords |
NTIS/OTS0545346
EPA/OTS;
Doc #88-920006943 |
1992
-
INITIAL
SUBMISSION: 13 WEEK DIETARY TOXICITY STUDY WITH PP009
IN RATS (FINAL REPORT) WITH
COVER LETTER DATED 08-28-92
LIFE
SCI RESEARCH
|
Fluazifop-butyl
(CAS # 69806-50-4)
was evaluated for subchronic dietary toxicity in Wistar
rats (20/sex/treatment groups) receiving 0, 10, 100 and
2000 ppm by dietary inclusion for 13 weeks. Mean achieved
dosages during 13-week treatment were 0, 0.7, 7.1 and
144.5 mg/kg/day in males of the respective treatment groups
and 0, 0.8, 8.0 and 161.9 mg/kg/day in females. No mortality
or pharmacotoxic signs were documented throughout treatment
at any exposure level. In males of a 2000 ppm dietary
exposure, treatment was associated with depressed food
intake and bodyweight gains; Less efficient food utilization
was noted in these rats relative to controls. High-dose
males also exhibited abnormalities in hematological values
(Weeks 5 and 11), including slightly depressed packed
cell volume, hemoglobin concentration and red blood cell
count. The serum chemistry in this group was characterized
by elevated alkaline phosphatase values, and higher alanine
amino-transferase and aspartate amino-transferase activities;
Cholesterol and total protein concentrations were low
as compared to controls. The plasma of 2000 ppm females
was found at Week 11 with depressed total protein and
albumin contents relative to controls. Again at Week 11,
isolated instances of elevated urinary protein levels
were identified among high-dose males and females.
Upon terminal necropsy, only high-dose males had evidence
of hepatic enlargement or swelling (7/20), although higher
absolute and relative liver weights were significant (p
< 0.01, Student's t-test) in both males and females
of the 2000 ppm group; Relative kidney weights were also
significantly elevated in the high-dose males. Histopathology
confirmed a specific liver toxicity in male rats, marked
by significant dose-related hepatocytic hypertrophy with
isolated instances of vesicular nuclei and or periacinal
hepatocytic necrosis. Renal tubular degeneration, 70%
and 20% in 2000 and 100 ppm males respectively, correlated
with elevated kidney weights in these groups.
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl] |
NTIS/OTS0543854
EPA/OTS;
Doc #88-920006849 |
1992
-
INITIAL
SUBMISSION: FLUAZIFOP BUTYL:
EFFECTS UPON REPRODUCTIVE PERFORMANCE
OF RATS TREATED CONTINUOUSLY THROUGH
2 GENERATIONS (FINAL REPORT) WITH
COVER SHEET & LETTER DATED 08-28-92
IMPERIAL
CHEM INDUS LTD |
Keywords:
ICI AMERS INC
FLUAZIFOP BUTYL
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
COMBINED TERATOGENICITY
/REPRODUCTIVE EFFECTS
MAMMALS
RATS
ORAL
DIET
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl]
|
NTIS/OTS0545395
EPA/OTS;
Doc #88-920007020 |
1992
-
INITIAL SUBMISSION: TERATOLOGY STUDY
WITH FLUAZIFOP BUTYL
IN RATS WITH COVER LETTER DATED 08-28-92
LIFE
SCI RESEARCH |
Fluazifop
butyl
was evaluated for developmental toxicity in adult virgin
Sprague-Dawley CD rats (160/treatment group) administered
oral doses of 0, 1, 5, 10 and 200 mg/kg/day during gestation
days 6-20. No increased maternal mortality or overt toxicity
was attributed to treatment. At gestation Day 21 sacrifice
of the dams, a slight but significantly depressed mean
bodyweight gain among those of a 200 mg/kg/day dosage
was indicative of dose- related
and significant (p < 0.05; Student's t-test) reduction
in gravid uterus weights. Significant (p <
0.01; Student's t-tests) dosage-related reductions in
fetal weights in association with treatment from 5 mg/kg/day
were found to correlate with increased incidence of small
fetuses; Placental weights
were also significantly low in association with
treatment at 200 mg/kg/day relative to controols. Gross
pathological changes included increased
incidence of diaphragmatic hernia (4.4% in association
with 200 mg/kg/day) noted at all treatment levels relative
to controls (0%), and slight dosage-related increased
occurrence of hydroureter,
partnered with a marginal increase in hydronephrosis
in 200 mg/kg/day fetuses. Micropathological investigation
validated dosage-related incidence of hydroureter, hydronephrosis
in association with a 200 mg/kg/day regimen, and subcutaneous
edema among 200 mg/kg/day fetuses. Skeletal examinations
further revealed retarded ossification
that was dosage-related in fetuses of gestational treatment
levels at 5 mg/kg/day and above. Treatment levels
of 1 mg/kg/day were associated with no toxic, reproductive
or developmental consequences relative to controls under
the conditions of this study.
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl] |
NTIS/OTS0545392
EPA/OTS;
Doc #88-920007017
Abstract:
|
1992
- INITIAL SUBMISSION: 14 DAY SUBACUTE ORAL TOXICITY STUDY
WITH PP009 IN RATS WITH COVER LETTER DATED 08-28-92
LIFE
SCI RESEARCH
|
Fluazifop-butyl
(CAS # 69806-50-4)
was evaluated for subacute oral toxicity in Wistar albino
rats (10/sex/treatment group) administered 10 ml/kg doses
in corn oil of 0, 4, 20, 100 and 500 mg/kg/day by oral
gavage, 5 days/week for 2 weeks. Five-day weekly treatment
periods were each followed by 2-day recovery. High-dose
males only displayed overt toxicity and comprised the
2 study lethalities: Two 500 mg/kg/day males were sacrificed
in extremis on Days 11 and 14 with severe pharmacotoxic
signs including piloerection, reduced motor activity,
retinal pallor, and a prone or hunched posture. One rat
was bleeding from the penis. High-dose males consumed
less food than control rats and their growth rate was
depressed from Day 10, although mean bodyweights by the
end of study were not significantly lower than controls.
Hematology and serum chemistries suggested a primary toxicity
of the liver, mostly in high-dose males: Males
of the 500 mg/kg/day dosage group were found with statistically
significant deficiencies in group mean hemoglobin concentration,
packed cell volume, mean cell volume and erythrocyte count;
Neutrophil counts were elevated and activated thromboplastin
times were also increased in a dose-related manner. Blood
chemistry indicated a dose-related elevation of alkaline
phosphatase activity in 100 and 500 mg/kg/day males, elevated
aspartate amino-transferase activity in 500 mg/kg/day
males, and elevated cholesterol concentrations in 500
mg/kg/day males and females. Conversely, enzyme activity
was depressed in rats of lower dosages. Blood samples
from 1 rat killed in extremis showed still greater stimulation
of enzyme activity, with reduced plasma proteins and electolyte
imbalance. Bone marrow cytology was negative for any treatment-related
changes. Upon gross necropsy, no gross lesions related
to treatment were identified. The
decedent animals were found with abnormal upper gastrointestinal
contents, and one exhibited congestion of mesenteric lymph
nodes with pallor of kidneys, liver and spleen. Male rats
of 100 and 500 mg/kg/day dosages had higher absolute and
relative liver weights that was not seen in their female
counterparts. Microscopic examination confirmed a particular
liver pathology of treated males, characterized by dosage-related
hepatocytic hypertrophy and necrosis (study lethalities),
and dosage-related slight to moderate periacinar hepatocytic
hypertrophy. Females of the 2 highest dosage groups
only demonstrated dosage-related, slight increases in
periacinar hypertrophy. Micropathological
changes also included decreased periacinar hepatocytic
anoxic vacuolation in males but those of the highest dosage
group and a universal treatment-related extramedullary
hemopoiesis.
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl] |
| NTIS/OTS0538457
EPA/OTS;
Doc #88-920007324 |
1992
- INITIAL SUBMISSION: THE ACUTE AND CHRONIC TOXICITY OF
PP009 TO MYSID SHRIMP WITH COVER LETTER DATED 08-28-92
|
Keywords:
ICI AMERICAS INC.
BUTYL 2-(4-(5-
TRIFLUOROMETHYL-2-
PYRIDYLOXY)PHENOXY)
ENVIRONMENTAL EFFECTS
ACUTE TOXICITY
INVERTEBRATES
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl]
|
NTIS/OTS0538579
EPA/OTS;
Doc #88-920007496 |
1992
- INITIAL
SUBMISSION: DETERMINATION OF THE ACUTE TOXICITY OF GFU
064 A 4LB/US GALLON FORMULATION (46.7% W/W) TO RAINBOW
TROUT (SALMO GAIRDNERI) WITH COVER LETTER DATED
08-28-92
IMPERIAL
CHEM INDUS LTD |
Keywords:
ICI AMERICAS INC.
BUTYL2-(4-(5-
TRIFLUOROMETHYL
-2PYRIDYLOXY)
PHENOXY)PROPIONATE
ENVIRONMENTAL EFFECTS
ACUTE TOXICITY
FISH-FRESHWATER
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl]
|
NTIS/OTS0543844
EPA/OTS;
Doc #88-920006839 |
1992
-
PROPIONATE
BUTYL: EFFECTS OF ORAL ADMINISTRATION UPON PREGNANCY IN
RATS WITH COVER LETTER DATED 08-28-92
LIFE
SCI RES LTD |
Keywords:
ICI AMERS INC
2-(4-(5-TRIFLUOROMETHYL-
2-PYRIDYLOXY) PHENOXY)
PROPIONATE
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
ORAL
GAVAGE
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl]
|
NTIS/OTS0543851
EPA/OTS;
Doc #88-920006846 |
1992
- INITIAL
SUBMISSION: BUTYL 2-(4-(5-
TRIFLUOROMETHYL-2-
PYRIDYLOXY) PHENOXY)
PROPIONATE: 13-WEEK ORAL TOXICITY STUDY IN BEAGLE
DOGS WITH COVER LETTER DATED 08-28-92
.
IMPERIAL
CHEM INDUS LTD |
Keywords:
ICI AMERS INC
2-(4-(5-TRIFLUOROMETHYL-
2-PYRIDYLOXY) PHENOXY)
PROPIONATE
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
DOGS
ORAL
GAVAGE
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl]
|
NTIS/OTS0545352
EPA/OTS;
Doc #88-920006949 |
1992
- INITIAL SUBMISSION: ACUTE TOXICITY STUDY WITH 1-
(8-METHOXY-4,8-
DIMETHYLNONYL)-4-(1-
METHYLETHYL)BENZENE IN DAPHNIA MAGNA
STRAUS WITH COVER LETTER DATED 08-28-92
BIOSPHERICS
INC |
Keywords:
ICI AMERS INC
1-(8-METHOXY-4,8-
DIMETHYLNONYL)-4-(1-
METHYLETHYL)BENZENE
ENVIRONMENTAL EFFECTS
ACUTE TOXICITY
INVERTEBRATES
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl]
|
NTIS/OTS0545353
EPA/OTS;
Doc #88-920006950 |
1992
- INITIAL SUBMISSION: ACUTE TOXICITY STUDY WITH PP009 FORMULATION
GFU063 IN PINK SHRIMP WITH COVER LETTER DATED 08-28-92
|
Keywords:
ICI AMERS INC
PP009 FORMULATION GFU063
ENVIRONMENTAL EFFECTS
ACUTE TOXICITY
INVERTEBRATES
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl]
|
NTIS/OTS0545354
EPA/OTS;
Doc #88-920006951 |
1992
- INITIAL
SUBMISSION: TOXICITY STUDY WITH PP009 IN FATHEAD
MINNOW EMBRYOS AND LARVAE WITH COVER LETTER DATED
08-28-92 |
Keywords:
ICI AMERS INC
PP009
ENVIRONMENTAL EFFECTS
CRITICAL LIFE STAGE TEST
FISH-FRESHWATER
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl]
|
NTIS/OTS0545362
EPA/OTS;
Doc #88-920006959 |
1992
-
INITIAL
SUBMISSION: ACUTE TOXICITY STUDY WITH GFU 064 IN BLUEGILL
SALMON (LEPOMIS MACROCHIRUS) WITH COVER LETTER
DATED 08-28-92
IMPERIAL
CHEM INDUS LTD |
Keywords:
ICI AMERS INC
GFU 064
ENVIRONMENTAL EFFECTS
ACUTE TOXICITY
FISH-FRESHWATER
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl]
|
NTIS/OTS0545822
EPA/OTS;
Doc #88-920007630 |
1992
-
INITIAL
SUBMISSION: DETERMINATION OF THE ACUTE TOXICITY OF GFU 063
TO BLUEGILL SUNFISH WITH COVER
LETTER DATED 08-28-92 |
Keywords:
ICI AMERS INC
GFU 063
ENVIRONMENTAL EFFECTS
ACUTE TOXICITY
FISH-FRESHWATER
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl]
|
NTIS/OTS0545823
EPA/OTS;
Doc #88-920007631 |
1992
- INITIAL
SUBMISSION: TOXICITY OF FORMULATION GFU063 TO FIRST INSTAR
DAPHNIA MAGNA WITH COVER LETTER
DATED 08-28-92 |
Keywords:
ICI AMERS INC
GFU063
ENVIRONMENTAL EFFECTS
ACUTE TOXICITY
INVERTEBRATES
CAS
Registry Numbers:
69806-50-4 [fluazifop-butyl]
|
| NTIS/MIC-90-01442,
48p |
1992
- Herbicide
efficacy trials in Alberta and Manitoba, 1980-85.
Author:
Drouin JA
Northern
Forest Research Centre, Edmonton (Alberta).
Information
report no. -X-306.
|
Vegetation
control trials in Alberta and Manitoba in 1980-85 tested
9 herbicides to determine their capabilities for conifer
release, chemical thinning, and site preparation. The herbicides
tested were hexazinone in liquid, grid ball (10% and 20%)
and granular (10% and 20%) formulations, metasulfuron methyl,
fluazifop-butyl, bromacil,
and fosamine ammonium. Data were obtained on conifer growth
and tolerance to the herbicides, weed control, optimum timing
of application, techniques, and equipment performance. |
| NTIS/OTS0538456
EPA/OTS;
Doc #88-920007323 |
1992
- INITIAL
SUBMISSION: THE ACUTE TOXICITY OF PP009 FORMULATION GFU063
TO FIDDLER CRABS WITH COVER
LETTER DATED 08-28-92 |
Keywords:
ICI AMERICAS INC.
BUTYL 2-(4-(5-
TRIFLUOROMETHYL-2-
PYRIDYLOXY)PHENOXY)
ENVIRONMENTAL EFFECTS
ACUTE TOXICITY
INVERTEBRATES
CAS
Registry Numbers:
69806-50-4
|
NTIS/PB82-113465
- 68p
Also
pub. as ISSN-0511-4136. |
1981
- The Activity and Pre-Emergence Selectivity of Some Recently
Developed Herbicides: UBI S-734, SSH-43, ARD 34/02 (=
NP 55), PP 009 and DPX 4189
Authors:
Richardson WG,
West TM,
Parker C
Agricultural
Research Council, Oxford (England). Weed Research Organization.
|
This report gives pre-emergence selectivity data on UBI
S-734, SSH-43, ARD 34/02, PP 009 and DPX 4189. Results
of activity experiments are also included for UBI S-734
and SSH-43 to provide information on levels of phytotoxicity,
type and route of action. Technical rept.
Fluazifop
butyl |
NTIS/PB82-111857
- 67p
Also
pub. as ISSN-0511-4136. |
1980
- The Activity and Post-Emergency Selectivity of Some
Recently Developed Herbicides: R 40244, DPX 4189, Acifluorfen,
ARD 34/02 (NP 55) and PP 009
Authors:
Richardson WG, West TM, Parker C
Agricultural
Research Council, Oxford (England). Weed Research Organization.
|
The
present report gives indications of the post-emergence selectivity
of five new herbicides. Results of activity experiments
are also included for DPX 4189, ARD 34/02 (NP 55) and PP
009 [fluazifop-butyl] to provide
information on levels of phytotoxicity, type and route of
action. Technical rept. |
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12167308
Toxicology.
2002 Sep 16;178(3):221-8.
Hepatocellular peroxisome proliferation and
DNA synthesis in Wistar rats treated with herbicide
fluazifop.
Kostka
G, Palut D, Ludwicki JK, Kopec-Szlezak J, Wiadrowska
B, Lembowicz K.
Department
of Environmental Toxicology, National Institute of Hygiene,
Chocimska 24, 00-791 Warsaw, Poland.
The
aim of this study was to determine the effect of herbicide
fluazifop, on the early occurring changes in rat liver
regarded as hepatic markers of peroxisome proliferators
(PPs). Fluazifop was administered orally to male Wistar
rats at increasing doses from 5.6 to 891 mg/kg body
weight per day for 1, 2, 4, 7 and 14 consecutive days
and peroxisome proliferation, induction of some peroxisome-associated
enzymes and mitogenesis (S-phase, M-phase and percentage
of binucleated hepatocytes) were studied. Short-term
treatment of rats with fluazifop resulted in hepatomegaly
due to time dependent proliferation of smooth endoplasmic
reticulum (SER) and peroxisomes. The increase
in the number of peroxisomes in the hepatocytes was
supported by an increase in peroxisomal palmitoyl-CoA
oxidation and catalase activity. In contrast to other
PPs fluazifop induced low rate of rcplicative DNA synthesis
and did not affect mitoses (M-phase). DNA synthesis
was accompanied by the appearance of binucleated hepatocytes.
Thus, we can conclude that fluazifop produces in male
Wistar rats hepatomegaly due to cellular hypertrophy.
The threshold dose for palmitoyl-CoA oxidation and DNA
synthesis was 112 and 223 mg/kg body weight per day,
respectively. The value for hepatomegaly and catalase
activity was 56 mg/kg body weight per day. The
results presented in this paper demonstrated that fluazifop
can be classified as a weak rodent PPs.
PMID:
12167308 [PubMed - indexed for MEDLINE]
|
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10566198&dopt=Abstract
Arh
Hig Rada Toksikol 1999 Jun;50(2):201-10
["More
is not better"--evaluation of toxicologic risks of the
heavy metals, lead and cadmium, and the herbicides, linuron,
fluazifop-P-butyl and cycloxydim
in dried Chamomile flowers (Chamomilla recutita L. Rauschert)]
[Article in Serbo-Croatian (Roman)]
Momcilovic B, Ivicic N, Bosnjak I, Stanic
G, Ostojic Z, Hrlec G.
Institut za medicinska istrazivanja i medicinu rada, Zagreb.
momcilovic@imi.hr
Cadmium and all three enumerated herbicide residues in dried
samples of industrially grown true chamomile were found to be
above the suggested and accepted tolerance values. The results
are discussed with regard to the current Croatian regulation
and FAO/WHO recommendations on herbicides and to human toxicology
risk assessment. The paper gives a critical evaluation of the
herbicide overuse in agricultural practice and strongly discouraged
such practice. The authors advocate prospective use of plants
as natural indicators of environmental contamination and toxicological
burden of the human food chain.
PMID: 10566198 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10213937
Acta Vet Hung. 1999;47(1):123-8.
Embryonic toxicity of insecticide Sumithion
50 EC and herbicide Fusilade S in pheasants after individual
or combined administration.
Varga T, Hlubik I, Varnagy L, Budai P,
Molnar E.
Department of Agrochemical Hygiene, Georgikon Faculty, Pannon
University of Agricultural Sciences, Keszthely, Hungary.
The purpose of this work was to determine the individual and
combined effects of insecticide Sumithion 50 EC (50% fenitrothion)
and herbicide Fusilade S (12.5% fluazifop-P-butyl)
on the development of pheasant embryos. Eggs were treated by
injection of various concentrations of pesticides into the air
space on day 12 of incubation. Pathological examination of embryos
was carried out on day 23 of the hatching period. Mortality
rate, body weight data and morphological alterations were evaluated
after the macroscopic examination. The skeletal staining method
was used to detect deformities. The two
pesticides used in combination moderated the toxic/teratogenic
effects of individual treatment.
PMID: 10213937 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9055461
Acta Vet Hung. 1996;44(3):363-76.
Toxicity of the herbicides Flubalex,
Fusilade S and Maloran 50 WP to chicken embryos after administration
as single compounds or in combination.
Varnagy L, Varga T, Hlubik I, Budai P,
Molnar E.
Department of Agrochemical Hygiene, Georgikon Faculty, Pannon
University of Agricultural Sciences, Keszthely, Hungary.
The teratogenic effects of three herbicides (Flubalex, Fusilade
S and Maloran 50 WP) were studied in chicken embryos.
Each of the three test substances was administered on days 0
and 12 of incubation. Treatment was followed by evaluation on
day 19. The compounds were injected into the air-chamber of
eggs at three different concentrations. The medium concentration
corresponded to that usually applied in chemical plant protection.
In order to determine the combined toxicity of the three herbicides,
the medium concentration of Maloran 50 WP and three different
concentrations of Flubalex of Fusilade S each were administered
simultaneously at a final volume of 0.1 ml per egg, at similar
times. Evaluation was done on day 19. In tests of individual
toxicity, after injection on day 0 of incubation Maloran 50
WP and Flubalex caused a significant reduction in body mass,
while Maloran 50 WP and Fusilade S resulted
in marked embryonic mortality. After injection on day
12, the medium and the highest concentration of Flubalex and
the highest concentration of Fusilade
S caused a marked increase in embryonic mortality. The
developmental anomalies were of sporadic nature: their incidence
increased only after Flubalex treatment, irrespective of the
time of administration. The combined administration of Maloran
50 WP and Flubalex on day 0 resulted in a significant or marked
body mass reduction in all groups. Embryonic
mortality increased substantially after treatment with the highest
dose of Flubalex, while all three concentrations of the other
two herbicides led to similar results. When
treatment was performed on day 12, the two highest concentrations
of Flubalex and the highest concentration of Fusilade S caused
expressed embryonic mortality. The developmental anomalies
did not show a dose-dependent effect in any of the test series.
PMID: 9055461 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7579935&dopt=Abstract
Bull
Environ Contam Toxicol 1995 Aug;55(2):276-82
Residues
of fluazifop-p-butyl following
application to soybean.
Kulshrestha G, Singh SB, Gautam KC.
Division of Agricultural Chemicals, Indian Agricultural Research
Institute, New Delhi.
PMID: 7579935 [PubMed - indexed for MEDLINE]
Chem
Biol Interact 1993 Jun;87(1-3):183-5
Peripheral
esterases in the rat: effects of classical inducers.
McCracken NW, Blain PG, Williams FM.
Toxicology Unit, Medical School, Newcastle University, UK.
Liver microsomal paraoxonase, aryl esterase and fluazifop
butyl esterase (carboxylesterase) were induced
by pretreatment of rat with phenobarbitone but not by beta-naphthoflavone
or clofibric acid. In the extrahepatic tissues lung cytosolicfluazifop
butyl and phenylacetate esterase were induced.
PMID: 8343974 [PubMed - indexed for MEDLINE]
Environ Pollut. 1993;80(1):31-9.
Pesticides in rainfall
and air in Italy
Trevisan M, Montepiani C,
Ragozza L, Bartoletti C, Ioannilli E, Del Re AA.
Istituto di Chimica Agraria ed Ambientale, Facolta
di Agraria, Universita Cattolica del Sacro Cuore, Via Emilia
Parmense 84, 29100 Piacenza, Italy
The presence of pesticide residues in rain, throughfall,
stemflow and in ambient air in two Italian forests affected
by the forest damage phenomenon were investigated. Pesticides
measured were: alachlor, atrazine, carbaryl, 2,4-d, diazinon,
dichlobenil, fluazifop-butyl, MCPA,
parathion, phorate and trifluralin. Rainwater samples were collected
from May to October 1988 at Vallombrosa and Renon, air and atmospheric
particulates were sampled during April-June 1989, only at Vallombrosa.
A total of 146 samples of rainfall and 20 samples of ambient
air were analysed and 49 out of 166 samples contained at least
one active ingredient. Herbicides were more frequent than insecticides,
and their concentrations were also higher (max 3.44 microg litre(-1))
PMID: 15091869 [PubMed - in process]
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1354971&dopt=Abstract
Hum
Exp Toxicol 1992 Jul;11(4):247-54
Pharmacokinetics
of fluazifop-butyl in human volunteers.
II: Dermal dosing.
Ramsey JD, Woollen BH, Auton TR, Batten
PL, Leeser JE.
ICI Central Toxicology Laboratory,
Macclesfield, Cheshire, UK.
1. The absorption of the herbicide fluazifop-butyl (f-b), has
been determined from plasma and urine measurements in groups
of six male volunteers following dermal administration of 2.5,
25 and 250 micrograms cm-2 from standardized formulations containing
0.05, 0.5 and 5.0% (w/v) fluazifop-butyl to a skin area of 800
cm2.
2. Urinary excretion rate of the principal metabolite fluazifop,
following dosing with the 5% formulation, was described by a
two-compartment pharmacokinetic model; the average elimination
half-lives of initial and terminal phases were 18 h and approximately
70 h, respectively. For the other dose levels the elimination
half-life was estimated to be 17 h; urine concentrations at
later time points were too low to characterize a second compartment.
3. The estimated total fluazifop-butyl absorbed was 8.0, 3.4
and 1.6% of the applied dose for the 0.05, 0.5 and 5.0% formulations,
respectively.
4. Up to 50% of the applied fluazifop-butyl was readily removed
by skin washing and the majority of the remainder was transferred
to clothing during the 24 h following application.
5. When six volunteers were given a daily dermal dose of the
0.5% formulation for five consecutive days, the plasma and urinary
excretion kinetics of fluazifop could be accurately predicted
by simple mathematical extrapolation of the kinetic data from
the single exposure study at the equivalent daily dose.
6. It is concluded that fluazifop-butyl is only slowly and poorly
absorbed through human skin and has a low potential to accumulate
in man.
PMID: 1354971 [PubMed - indexed for MEDLINE]
Hum
Exp Toxicol 1991 Jan;10(1):39-43
Oral
pharmacokinetics of fluazifop-butyl
in human volunteers.
Woollen BH, Hart TB, Batten PL, Laird
WJ, Davies DS, Dollery CT.
ICI Central Toxicology Laboratory,
Alderley Park, Macclesfield, Cheshire, UK.
1. Fluazifop-butyl, the active ingredient of FUSILADE, a selective
herbicide, was administered orally to three male volunteers
at a dose level of 0.07 mg kg-1 body weight. Over a period of
6 d between 80 and 93% of the dose was excreted in urine as
the metabolite fluazifop, the majority within the first 24 h.
Peak plasma concentrations of fluazifop occurred 1-2.5 h after
administration.
2. The elimination of fluazifop from plasma and urine can be
described by a one-compartment pharmacokinetic model and the
elimination half-life was estimated from blood and urine data
to be within the range 9-37 h. Fluazifop was found to bind to
serum proteins.
3. The study indicates that the amount of fluazifop-butyl absorbed
in exposed persons can be assessed by measuring fluazifop concentrations
in urine.
PMID: 1673623 [PubMed - indexed for MEDLINE]
From Toxline at Toxnet
Nippon Noyaku Gakkai Shi 1990;15(2):305-10
Summary of toxicity studies
on fluazifop-butyl.
Agrochemicals & Development Division, Ishihara
Sangyo Kaisha, Ltd.
A wide variety of toxicological studies on fluazifop-butyl have
been conducted to assess its safety. The results of these studies
support the view that this herbicide will be safe if used following
the recommended use instruction. Onecide EC herbicide containing
fluazifop-butyl as its a.i., was registered to JMAFF at October
1986, the "Standard for withholding registration"
were established with 0.1 ppm for peas, potatoes, sugar beet
and fruits, 0.2 ppm for vegetables.
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3607313&dopt=Abstract
Bull
Environ Contam Toxicol 1987 Jul;39(1):150-5
Persistence
studies with the herbicide fluazifop-butyl
in Saskatchewan soils under laboratory and field conditions.
Smith AE.
PMID: 3607313 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3775813&dopt=Abstract
Toxicol
Lett 1986 Oct;33(1-3):137-49
Biological
monitoring of a herbicide applied through backpack and vehicle
sprayers.
Chester G, Hart TB.
Field studies have been done with the herbicide, fluazifop-butyl,
to assess exposure and systemic absorption following application
by backpack and vehicle sprayers. The data have been used to
assess the usefulness of a model for predicting the systemic
absorption of a pesticide. The model uses the concept of the
'rate of absorption' through skin and this model is compared
with the 'percent absorption' concept in their ability to predict
systemic absorption following application with vehicle sprayers.
The field study of vehicle sprayers showed that the 'rate of
absorption' model was a better predictor of systemic absorption.
PMID: 3775813 [PubMed - indexed for MEDLINE]
